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PHYTOMEDICINE AND AYURVEDA

  VAIDYA ANIRUDDHA S. KULKARNI
  SHREE ATMARAJ AYURVEDEEYA CHIKITSALAYA,
           SHANIWAR PETH, MIRAJ.
INTRODUCTION
IN PAST DECADE A TREMENDOUS RESURGENECE IN THE
INTEREST AND USE OF MEDICINAL PLANT PRODUCTS IS
SEEN

BOOST DUE TO MEDIA COVERAGE AND ENTRANCE OF
SEVERAL MAJOR PHARMA COMPANIES



NEUTRACUTICALS AND PHYTOMEDICINES
FOCUS AREAS OF RESEARCH

PHYTOCHEMISTRY-IDENTIFICATION OF ACTIVE PRINCIPLES


PHARMACOGNOSY-ASSAYS OF BIOACTIVITY, IDENTIFICATION
OF POTENTIAL MODES OF ACTION, TARGET SITES FOR ACTIVE
PHYTOCHEMICAL COMPOUNDS

HORTICULTURE-DEVELOPING THE CAPACITY FOR OPTIMAL
GROWTH
PLANT PHYSIOLOGY
PRIMARY PRODUCTS
                   SECONDARY PRODUCTS
CARBOHYDRATES
                   ALKALOIDS
LIPIDS
                   POLYPHENOL
PROTEINS
                   TERPENOIDS
CHLOROPHYLL
                   GLYCOSIDES
NUCLEIC ACID
SYNERGISTIC ACTION

THE BENEFITS OF PHYTOMEDICINES OFTEN RESULT FROM SYNERGISTIC
ACTIONS OF MULTIPLE ACTIVE CHEMICALS



IT IS BENEFICIAL BY ELIMINATING THE BAD SIDE EFFECTS ASSOCIATED WITH
THE PREDOMINANCE OF A SINGLE XENOBIOTIC COMPOUND IN THE BODY


THESE CAN BE PRODUCED IF THE CONSTITUENTS OF AN EXTRACT AFFECT
DIFFERENT TARGETS OR INTERACT WITH ONE ANOTHER TO IMPROVE
SOLUBILITY AND THEREBY ENHANCE THE BIOAVAILABILITY OF ONE OR
SEVERAL SUBSTANCES OF AN EXTRACT
PHYTOMEDICINE

PHYTOMEDICINE IS MODERN AND SCIENCE BASED HERBAL MEDICINE


QUALIFIED PHYTOTHERAPISTS USE HERBS TO TREAT THE DISEASES

THE METHODS USED TO EVALUATE PLANT BASED MEDICINES ARE SIMILAR TO THOSE USED BY
ORTHODOX MEDICINE

THEY ARE SAFE FOR MANY CONDITIONS

PHYTOTHERAPISTS CONDUCT INDIVIDUAL CONSULTATION AND THEN DISPENSE A MEDICINE. IT
DOES NOT USE ANY OTHER THERAPIES LIKE ACCUPUNCTURE, PANCHKARMA ETC.

PHARMACOGNOSY IS AT THE HEART OF PHYTOMEDICINE
WELL KNOWN ACTIVE PRINCIPLES
       DERIVED FROM PLANTS
SHIKIMIC ACID FROM ANIS SEED

TAXUS BREVIFOLIA IS THE ACTIVE CONSTITUENT OF TAXOL

MORPHINE FROM OPIUM POPPY

QUININE FROM CINCHONA BARK

SALICIN FROM WILLOW BARK KNOWN AS ASPIRIN

ATROPINE FROM BELLADONA

STRYCHNINE FROM STRYCHHNOS

DIGOXIN FROM FOXGLOVE
AYURVEDA
ANCIENT MEDICAL SCIENCE OF INDIA


SCIENCE OF LIFE – PREVENTIVE AND CURATIVE ASPECTS

ABUNDANT MENTIONS, STUDIES AND USES OF MEDICINAL PLANTS IN ALL
DISEASES

HUMAN BEING IS MADE UP OF SAME CONSTITUENTS AS THE NATURE.
SO, THEY BOTH INFLUENCE EACH OTHER.

PLANTS ARE USED FOR NUTRITIONAL AS WELL AS MEDICINAL PURPOSE
PLANT DESCRIPTION BY AYURVEDA

MORPHOLOGICAL

PHYSIOLOGICAL

MEDICINAL
ACTIVE INGREDIENTS OF PLANTS

                                              RASA (TASTE) –
                                    SWEET, SOUR, SALTY, PUNGENT, BITTER
                                             AND ASTRINGENT




   TREATMENT IS
   NOTHING BUT
  RESTORATION OF
  DERANGED BODY                                                               VEERYA (POTENCY) – COLD AND HOT
    ELEMENTS –
   ANATOMICALLY
        AND
  PHYSIOLOGICALLY




    PRABHAVA (UNIQUE AND SPECIFIC                                         VIPAKA (TASTE AFTER DIGESTION) –
              ACTIONS)                                                       SWEET, SOUR AND PUNGENT
SPECIFIC PARTS OF PLANTS SPECIES
             AERIAL
             PARTS
   RHIZOME              LEAF


    ROOT                FLOWER


      BARK            FRUIT
EXTRACTION OF PHYTOCHEMICALS

MAINLY USE ALCOHOL TO EXTRACT THE PLANT’S ACTIVE
CONSTITUENTS FROM DRY OR FRESH PLANTS


ALCOHOLIC EXTRACTS ARE PREPARED BY MACERATION
AND/OR PERCOLATION

MOST PHYTOMEDICINES ARE PRESCRIBED AS ALCOHOLIC
TINCTURES, TAKEN TWICE DAILY WITH A DOSE OF 15 ML
EACH TIME
ROLE OF PHYTOMEDICINES

UNIQUE INDIVIDUAL DIAGNOSIS IS MUST
BEFORE DECIDING THE APPROPRIATE DRUGS


THEY STIMULATE OR STRENGTHEN THE BODY’S
OWN FUNCTIONS AND IMMUNE
SYSTEM, HENCE SUPPORT THE BODY TO
RESTORE ITSELF TO HEALTH
PHYTOMEDICINE CONSULTATION

ASSESSMENT OF THE PERSON AS A WHOLE


DETAILED MEDICAL HISTORY, LIFESTYLE, DIET, OTHER
CAUSES ARE CONSIDERED RATHER THAN FOCUSING ON
DISEASE OR SYMPTOMS


REQUIRED INVESTIGATIONS ARE DONE
STANDERDISATION
IDENTIFICATION – BASIS OF PART USED/SYNONYM/LOCATION OF EXISTENT/TIME OF THE YEAR/ TASTE/
ODOUR/ COLOUR/ ACTION/ USE

COLLECTION AND STORAGE – MAHABHUTA PREDOMINANT TERAIN/ NORTH DIRECTION


STEMS AND LEAVES- VARSHA AND VASANTRITU


ROOT – GRISHMA AND SHISHIR


BARK/SKIN – SHARAD


FLOWERS/FRUITS – ACCORDINGLY


STORE PROPERLY
QUALITY

DEPENDS ON SPECIES, COLLECTION AND
STORAGE


IN MODERN TIMES PROCESSES LIKE
HPCL, GC, UV/VIS OR AA ARE USED TO IDENTIFY
SPECIES, MEASURE BACTERIOLOGICAL
CONTAMINATION AND POTENCY
SAFETY

ADULTERATION, INAPPROPRIATE FORMULATION
OR LACK OF UNDERSTANDING OF PLANT AND
DRUG REACTIONS THAT ARE SOMETIMES LIFE
THREATENING OR LETHAL


IMPURITIES AND PURIFICATION –
PHYSICAL, CHEMICAL AND NATURAL
METHODS OF PURIFICATION
•   WASHING       •   DECOLORATION
•   SIFTING       •   BOILING
•   ELUTRIATION   •   RUBBING
•   LIXIVIATION   •   DIPPING
•   PERCOLATION   •   SUBLIMATION
•   MACERATION    •   BACHNAG
•   DIALYSIS      •   DHATURA SEED
•   DESPUMATION
ROUTES OF ADMINISTRATION
TINCTURES       TOPICALS
HERBAL WINES    ESSENTIAL OILS
TISANES
                OILS, BALMS
DECOCTIONS
                CREAMS, LOTIONS
MACERATES
                POULTICES
VINEGARS

SYRUPS          COMPRESSIONS

EXTRACTS        INHALATIONS
SIMILARITIES BETWEEN
    PHYTOTHERAPY AND AYURVEDA
BOTH ARE BASED ON TRADITIONAL HERBAL MEDICINES

INSTEAD OF FOCUSING ON SYMPTOMATIC RELIEF, BOTH TRY TO CORRECT
THE IMBALNCE IN BODY ELEMENTS

HERBS CONSTITUTE MAINSTREAM OF TREATMENT


MANY TYPES OF DRUG PREPARATION METHODS ARE MENTIONED


THEY BOTH BELIEVE IN SYNERGISTIC ACTION AND MULTIFUNCTIONALITY
DIFFERENCES BETWEEN
     PHYTOTHERAPY AND AYURVEDA

AYURVEDA IS A COMPLETE MEDICAL SCIENCE WHILE PHYTOTHERAPY IS A BRANCH OF
MEDICINE


EVALUATION OF MEDICINAL PALNTS AND PATIENTS ARE COMPLETELY DIFFERENT

AYURVEDA OFFERS PURIFICATION AND PALLIATIVE TREATMENTS WHILE PHYTOTHERAPY
AVOIDS USE OF CO-THERAPIES

PHYTOTHERAPY MAJORITILY USE ALCOHOL FOR EXTRACTING ACTIVE PRINCIPLES, WHILE
AYURVEDA USES WATER, OIL, GHEE AND SELF GENERATED ALCOHOL AS THE SOLVENTS

PHYTOMEDICINES ARE PRESCRIBED IN 15ML DOSE TWO TIMES DAILY, WHILE AYURVEDA
USES VARIOUS DRUG DOSAGE AND TIME SCHEDULES
THANK YOU!!!
HAPPY NEW YEAR
     2012

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Phytomedicine and Ayurveda insights

  • 1. PHYTOMEDICINE AND AYURVEDA VAIDYA ANIRUDDHA S. KULKARNI SHREE ATMARAJ AYURVEDEEYA CHIKITSALAYA, SHANIWAR PETH, MIRAJ.
  • 2. INTRODUCTION IN PAST DECADE A TREMENDOUS RESURGENECE IN THE INTEREST AND USE OF MEDICINAL PLANT PRODUCTS IS SEEN BOOST DUE TO MEDIA COVERAGE AND ENTRANCE OF SEVERAL MAJOR PHARMA COMPANIES NEUTRACUTICALS AND PHYTOMEDICINES
  • 3. FOCUS AREAS OF RESEARCH PHYTOCHEMISTRY-IDENTIFICATION OF ACTIVE PRINCIPLES PHARMACOGNOSY-ASSAYS OF BIOACTIVITY, IDENTIFICATION OF POTENTIAL MODES OF ACTION, TARGET SITES FOR ACTIVE PHYTOCHEMICAL COMPOUNDS HORTICULTURE-DEVELOPING THE CAPACITY FOR OPTIMAL GROWTH
  • 4. PLANT PHYSIOLOGY PRIMARY PRODUCTS SECONDARY PRODUCTS CARBOHYDRATES ALKALOIDS LIPIDS POLYPHENOL PROTEINS TERPENOIDS CHLOROPHYLL GLYCOSIDES NUCLEIC ACID
  • 5. SYNERGISTIC ACTION THE BENEFITS OF PHYTOMEDICINES OFTEN RESULT FROM SYNERGISTIC ACTIONS OF MULTIPLE ACTIVE CHEMICALS IT IS BENEFICIAL BY ELIMINATING THE BAD SIDE EFFECTS ASSOCIATED WITH THE PREDOMINANCE OF A SINGLE XENOBIOTIC COMPOUND IN THE BODY THESE CAN BE PRODUCED IF THE CONSTITUENTS OF AN EXTRACT AFFECT DIFFERENT TARGETS OR INTERACT WITH ONE ANOTHER TO IMPROVE SOLUBILITY AND THEREBY ENHANCE THE BIOAVAILABILITY OF ONE OR SEVERAL SUBSTANCES OF AN EXTRACT
  • 6. PHYTOMEDICINE PHYTOMEDICINE IS MODERN AND SCIENCE BASED HERBAL MEDICINE QUALIFIED PHYTOTHERAPISTS USE HERBS TO TREAT THE DISEASES THE METHODS USED TO EVALUATE PLANT BASED MEDICINES ARE SIMILAR TO THOSE USED BY ORTHODOX MEDICINE THEY ARE SAFE FOR MANY CONDITIONS PHYTOTHERAPISTS CONDUCT INDIVIDUAL CONSULTATION AND THEN DISPENSE A MEDICINE. IT DOES NOT USE ANY OTHER THERAPIES LIKE ACCUPUNCTURE, PANCHKARMA ETC. PHARMACOGNOSY IS AT THE HEART OF PHYTOMEDICINE
  • 7. WELL KNOWN ACTIVE PRINCIPLES DERIVED FROM PLANTS SHIKIMIC ACID FROM ANIS SEED TAXUS BREVIFOLIA IS THE ACTIVE CONSTITUENT OF TAXOL MORPHINE FROM OPIUM POPPY QUININE FROM CINCHONA BARK SALICIN FROM WILLOW BARK KNOWN AS ASPIRIN ATROPINE FROM BELLADONA STRYCHNINE FROM STRYCHHNOS DIGOXIN FROM FOXGLOVE
  • 8. AYURVEDA ANCIENT MEDICAL SCIENCE OF INDIA SCIENCE OF LIFE – PREVENTIVE AND CURATIVE ASPECTS ABUNDANT MENTIONS, STUDIES AND USES OF MEDICINAL PLANTS IN ALL DISEASES HUMAN BEING IS MADE UP OF SAME CONSTITUENTS AS THE NATURE. SO, THEY BOTH INFLUENCE EACH OTHER. PLANTS ARE USED FOR NUTRITIONAL AS WELL AS MEDICINAL PURPOSE
  • 9. PLANT DESCRIPTION BY AYURVEDA MORPHOLOGICAL PHYSIOLOGICAL MEDICINAL
  • 10. ACTIVE INGREDIENTS OF PLANTS RASA (TASTE) – SWEET, SOUR, SALTY, PUNGENT, BITTER AND ASTRINGENT TREATMENT IS NOTHING BUT RESTORATION OF DERANGED BODY VEERYA (POTENCY) – COLD AND HOT ELEMENTS – ANATOMICALLY AND PHYSIOLOGICALLY PRABHAVA (UNIQUE AND SPECIFIC VIPAKA (TASTE AFTER DIGESTION) – ACTIONS) SWEET, SOUR AND PUNGENT
  • 11. SPECIFIC PARTS OF PLANTS SPECIES AERIAL PARTS RHIZOME LEAF ROOT FLOWER BARK FRUIT
  • 12. EXTRACTION OF PHYTOCHEMICALS MAINLY USE ALCOHOL TO EXTRACT THE PLANT’S ACTIVE CONSTITUENTS FROM DRY OR FRESH PLANTS ALCOHOLIC EXTRACTS ARE PREPARED BY MACERATION AND/OR PERCOLATION MOST PHYTOMEDICINES ARE PRESCRIBED AS ALCOHOLIC TINCTURES, TAKEN TWICE DAILY WITH A DOSE OF 15 ML EACH TIME
  • 13. ROLE OF PHYTOMEDICINES UNIQUE INDIVIDUAL DIAGNOSIS IS MUST BEFORE DECIDING THE APPROPRIATE DRUGS THEY STIMULATE OR STRENGTHEN THE BODY’S OWN FUNCTIONS AND IMMUNE SYSTEM, HENCE SUPPORT THE BODY TO RESTORE ITSELF TO HEALTH
  • 14. PHYTOMEDICINE CONSULTATION ASSESSMENT OF THE PERSON AS A WHOLE DETAILED MEDICAL HISTORY, LIFESTYLE, DIET, OTHER CAUSES ARE CONSIDERED RATHER THAN FOCUSING ON DISEASE OR SYMPTOMS REQUIRED INVESTIGATIONS ARE DONE
  • 15. STANDERDISATION IDENTIFICATION – BASIS OF PART USED/SYNONYM/LOCATION OF EXISTENT/TIME OF THE YEAR/ TASTE/ ODOUR/ COLOUR/ ACTION/ USE COLLECTION AND STORAGE – MAHABHUTA PREDOMINANT TERAIN/ NORTH DIRECTION STEMS AND LEAVES- VARSHA AND VASANTRITU ROOT – GRISHMA AND SHISHIR BARK/SKIN – SHARAD FLOWERS/FRUITS – ACCORDINGLY STORE PROPERLY
  • 16. QUALITY DEPENDS ON SPECIES, COLLECTION AND STORAGE IN MODERN TIMES PROCESSES LIKE HPCL, GC, UV/VIS OR AA ARE USED TO IDENTIFY SPECIES, MEASURE BACTERIOLOGICAL CONTAMINATION AND POTENCY
  • 17. SAFETY ADULTERATION, INAPPROPRIATE FORMULATION OR LACK OF UNDERSTANDING OF PLANT AND DRUG REACTIONS THAT ARE SOMETIMES LIFE THREATENING OR LETHAL IMPURITIES AND PURIFICATION – PHYSICAL, CHEMICAL AND NATURAL
  • 18. METHODS OF PURIFICATION • WASHING • DECOLORATION • SIFTING • BOILING • ELUTRIATION • RUBBING • LIXIVIATION • DIPPING • PERCOLATION • SUBLIMATION • MACERATION • BACHNAG • DIALYSIS • DHATURA SEED • DESPUMATION
  • 19. ROUTES OF ADMINISTRATION TINCTURES TOPICALS HERBAL WINES ESSENTIAL OILS TISANES OILS, BALMS DECOCTIONS CREAMS, LOTIONS MACERATES POULTICES VINEGARS SYRUPS COMPRESSIONS EXTRACTS INHALATIONS
  • 20. SIMILARITIES BETWEEN PHYTOTHERAPY AND AYURVEDA BOTH ARE BASED ON TRADITIONAL HERBAL MEDICINES INSTEAD OF FOCUSING ON SYMPTOMATIC RELIEF, BOTH TRY TO CORRECT THE IMBALNCE IN BODY ELEMENTS HERBS CONSTITUTE MAINSTREAM OF TREATMENT MANY TYPES OF DRUG PREPARATION METHODS ARE MENTIONED THEY BOTH BELIEVE IN SYNERGISTIC ACTION AND MULTIFUNCTIONALITY
  • 21. DIFFERENCES BETWEEN PHYTOTHERAPY AND AYURVEDA AYURVEDA IS A COMPLETE MEDICAL SCIENCE WHILE PHYTOTHERAPY IS A BRANCH OF MEDICINE EVALUATION OF MEDICINAL PALNTS AND PATIENTS ARE COMPLETELY DIFFERENT AYURVEDA OFFERS PURIFICATION AND PALLIATIVE TREATMENTS WHILE PHYTOTHERAPY AVOIDS USE OF CO-THERAPIES PHYTOTHERAPY MAJORITILY USE ALCOHOL FOR EXTRACTING ACTIVE PRINCIPLES, WHILE AYURVEDA USES WATER, OIL, GHEE AND SELF GENERATED ALCOHOL AS THE SOLVENTS PHYTOMEDICINES ARE PRESCRIBED IN 15ML DOSE TWO TIMES DAILY, WHILE AYURVEDA USES VARIOUS DRUG DOSAGE AND TIME SCHEDULES