Here is an in depth analysis on how Ayahuasca affects the brain. There is a lot more to it than the active DMT compound. Learn the scientific benefits of Aya Ayahuasca, an ancestral medicinal brew of the native peoples of the Amazon, has been gaining popularity and use over the past years. Its use in cities, where it was almost impossible to find about 20 years ago, has become increasingly common. This has led to more frequent research on its components and has sparked interest within the scientific community regarding its potential therapeutic uses, considering the numerous reports about its benefits, primarily in the fields of psychiatry and neurology. In the last decade, research on Ayahuasca has been on the rise, especially regarding its main components, DMT (Dimethyltryptamine), and the Beta-carbolines (Harmine, Tetrahydroharmine, and Harmaline), which has led to a better understanding of the mechanisms of action and its effects at the cerebral level.