This document discusses chronic progressive lymphedema (CPL) in draft horses. CPL is likely caused by a congenital malformation of the lymphatic system that causes a buildup of fluid in the tissues over time. Clinical signs of CPL include swelling in the distal limbs that progresses to hard, nodular skin with folds and ulcerations prone to secondary infections. Diagnosis is based on clinical signs, and treatment focuses on good skin care, exercise, bandages, and manual lymph drainage to push fluid out of the tissues and prevent further damage. Histology of affected skin shows extremely dilated and degenerated lymphatics.