toxicology management

1. TOXICOLOGY
POISONING, GENERAL MANAGEMENT,
ROLE OF PHARMACIST

2. CONTENTS
Toxicology
Epidemiology
Types
Management Of Poisoning
Supportive Care
GIT Decontamination
Role of Pharmacist

3. Toxicology
• Latin “Toxicum”
• Greek “Toxikom”
• Poison:
“Producing harmful effects
on living organism”

4. Epidemiology
Under 5:
75%
Over 5:
15%
Adults:
10%
WHO:
3, 46,000
deaths

5. Types
• ACUTE
• CHRONIC

6. Fundamentals of Management
• “What To Do, In What Order To Do”
• Initial resuscitation & stabilization
• Removal of toxin
• Prevention of further absorption
• Increase elimination

7. Management of Poisoning
• Supportive care:
Airway protection
Oxygenation/ventilation
Hemodynamic support
Treatment of seizures
Correction of temperature abnormalities
Prevention of secondary complications

8. GIT Decontamination
Dilution of Poison:

9. Emesis

10. Adsorption
Activated
charcoal
100-120
g for
adults
15-30 g
for
children
Drug
charcoal
complex

11. Gastric Lavage
• Washing out of stomach
• 50-100 ml for children
• 200-300 ml for adults
• Water, saline solution

12. • Whole Bowel Irrigation
• Forced Diuresis
• Hemodialysis
• Hemoperfusion

13. Role Of Pharmacist
• Management of poisoning
• Poison control center
• Information concerning poisons
• antidotes management
• Provide prevention services
• Educate community, other health care
professionals
• Organized database management