2. INTRODUCTION
ā¢ Leading cause of infective blindness globally
ā¢ >150 million people have been affected
ā¢ Associated with poor hygiene and inadequate
sanitation
ā¢ Recent estimates show 59 countries are
endemic and India has high burden
ā¢ Egyptian ophthalmia , north western belt of
india
3. DEFINITION
ā¢ Chronic granulomatous kerato-conjunctivitis
ā¢ Caused by Chlamydia trachomatis (A,B,Ba,C)
ā¢ Mainly affects children at early age who
develop blindness later
ā¢ Cause of 3.6% of global blindness(WHO)
ā¢ Highly contagious
ā¢ Spread by transfer of conjunctival secretions
through fingers, towels, flies etc
4. PATHOLOGY
ā¢ C. Trachomatis- prokaryotic, obligatory
intracellular parasite
ā¢ Halberstaedter-Prowazek inclusion bodiesā in
epithelial cells of conjunctiva( not pathognomic)
ā¢ Primary infection- epithelia of conjunctiva &
cornea
ā¢ Diffuse inflammation- congestion, papillary
enlargement, follicles
ā¢ Recurrent infection- type IV hypersensitivity to Ag
5.
6. ā¢ Lymphocytic infiltration of adenoid layer
ā¢ LEBER cells ā necrosed and multinucletaed
giant cells
ā¢ Cicatricial bands- in late stages, characteristic
ā¢ Arlt line- white conjunctival scar at junction of
lower third and upper two-third of superior
tarus, characteristic
10. PREDISPOSING FACTORS
ā¢ Age- more in infancy/ childhood
ā¢ Sex- commoner in females
ā¢ Dry and dusty environment
ā¢ Low socio economic status, unhygienic
conditions, lack of sanitation
11. SPREAD OF INFECTIONS
ā¢ DIRECT- contact with airborne or waterborne
infections
ā¢ VECTOR- flies ( Musca domestica)
ā¢ MATERIAL- most important
12. CLINICAL FEATURES
ā¢ Incubation period- 5 to 21 days
ā¢ Onset ā subacute , but on massive outbreaks
can be acute
ā¢ Symptoms ā watering, fb sensation, redness,
mucopurulent discharge, photophobia,
blurring, mild pain
13. ļSigns ā
ā¢ Upper tarsal conjunctiva ā mc affected , appears
red velvety, congested
ā¢ Trachomatous follicle- essential lesion, upto 5mm
size
- characteristic distribution- upper fornix(mc),
upper margin of tarsus, palprebral conjunctiva
ā¢ Scarring of conjunctiva
ā¢ Arltās line
ā¢ Limbal follicles
ā¢ Herbert pits- oval/pitted scars in limbus
14.
15.
16. ļCornea-
ā¢ Early- superficial keartitis on SLE( flourescence
staining), in upper part due to erosion
ā¢ Later- trachomatous pannus, starts in upper half
then spreads centrally to involve whole cornea
ā¢ Vascularisation- in between BM and epithelium
ā¢ Pannus- a) progressive- vessels parallel, directed
vt downwards, infiltration ahead of vessels
b) regressive- vessels ahead of infiltartion
ā¢ Ulcers- mc at advancing edge of pannus
ā¢ Corneal opacity
19. WHO CLASSIFICATION(FISTO)
ā¢ developed for use by trained personnel other
than ophthalmologists to assess the prevalence
and severity of trachoma in population-based
surveys in endemic areas.
ļTRACHOMATOUS FOLLICULAR(TF)
ā¢ Active disease
ā¢ 5 or more follicles of > 0.5mm on upper tarsus
ā¢ Deep conjunctival vessels seen
ā¢ If treated properly- no scarring
20. ļTRACHOMA INTENSE
ā¢ Severe disease, needs urgents rx
ā¢ diffuse involvement of the tarsal conjunctiva,
obscuring 50% or more of the normal deep
tarsal vessels; papillae are present
22. ļ TRACHOMATOUS TRICHIASIS
ā¢ at least one lash touching the globe
ā¢ Needs corrective surgery
ļ CORNEAL OPACITY
ā¢ sufficient to blur details of at least part of the pupillary margin
23. Mc CALLANS CLASSIFICTION
ļSTAGE 1- incipient trachoma/ stage of
infiltration
ā¢ Hyperemia of palpebral conjunctiva &
immature follicles
ļSTAGE 2- stage of florid infiltration
ā¢ mature follicles, papillae, progressive pannus
ļSTAGE 3- cicatarizing trachoma/ stage of
scarring
ļSTAGE 4- healed trachoma/ stage of sequale
24. DIAGNOSIS
ļRequires at least 2 of the following clinical
features:
ā¢ follicles on the upper tarsal conjunctiva
ā¢ limbal follicles and their sequelae (Herbert
pits)
ā¢ typical tarsal conjunctival scarring
ā¢ vascular pannus most marked on the superior
limbus
28. MANAGEMENT
A)Treatment ā of active disease and sequalae
B) Prevention
ļ Rx of active disease
Antibiotics- main stay
ā¢ oral- Azithromycin 1gm stat(20mg/kg) ā DOC
Tetracycline or erythromycin 250mg
QID for 4 weeks
Doxycycline 100mg BD for 4 weeks
29. ā¢ Topical ā best for indiviual cases, cheaper, no
systemic side effects
Regimes ā 1% tetracyclines/ erythtromycin
eye ointment QID for 6 weeks
20% sulfacetamide eye drops thrice daily with
1% tetracycline oint at bedtime for 6 weeks
ā¢ Other topical antibiotics for secondary
bacterial infections
ā¢ Lubricants
ā¢ Analgescics
33. PROPHYLAXIS
ā¢ Good personal hygeine and environmental
sanitation
ā¢ Health education
ā¢ Use of common towels, hankerchiefs are
discouraged
ā¢ Clean water supply for washing
ā¢ Flies control- insecticides, good sewerage,
garbage disposal, window screen protectors
ā¢ Prevention of recurrent infections
ā¢ Early detection and rx
36. ļNational trachoma control program-
ā¢ Launched in 1963
ā¢ Under NPCB
ā¢ Centrally sponsored
ā¢ SAFE strategy
ā¢ Training at root level
ā¢ Health education
37. GET 2020
ā¢ Global Elimination of Trachoma by 2020
ā¢ Launched by WHO
ā¢ Objective- to eliminate trachoma as blinding
disease
ā¢ ICTC- international coalation of trachoma control
ā¢ WHO defines blinding trachoma elimination as:
āTF prevalence <5% in 1-9 year old children
āTT prevalence <1 per 1000 in total population