A 4 Year Trial Of Tiotropium In Chronic Obstructive Pulmonary Disease
1. A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease Donald P. Tashkin, M.D., Bartolome Celli, M.D., Stephen Senn, Ph.D., Deborah Burkhart, B.S.N., Steven Kesten, M.D., Shailendra Menjoge, Ph.D., Marc Decramer, M.D., Ph.D., for the UPLIFT Study Investigators Bassel Ericsoussi, PG-Y3 Internal Medicine Advocate Christ Medical Center N Engl J Med Volume 359(15):1543-1554 October 9, 2008
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11. Baseline characteristics and concomitant use of respiratory medications were similar in the two study groups > 45 yr At least 10 packs-yr Moderate to very severe Moderate Severe Very severe According to criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD)
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15. In the tiotropium group, FVC significantly improved before and after bronchodilation