4. Expected Action:
· β-lactam – destroys bacteria by weakening cell wall
Therapeutic Uses:
· Med of choice for G+ cocci (Strep pneumoniae, S. viridans, S. pyogenes)
· Med of choice for
syphilis · First choice for meningitis
· Prophylaxis against bacterial endocarditis ·
· Extended spectrum against Pseudomonas, Proteus, Klebsiella
Adverse Effects:
· Anaphylaxis / Renal Impairment / Hyperkalemia (w doses)
Contraindications:
· Allergies to Penicillin, Cephalosporin, or Imipenem / Kidney Dysfunction
Interactions:
· Aminoglycosides / η Oral Contraceptives
Education:
· Take orals ĉ H2O, ŝ food (some may be taken ĉ food)
14. Expected Action:
· Bacteriostatic by inhibiting protein synthesis – Bactericidal at high doses
Therapeutic Uses:
· Use for pts with penicillin allergies / pertussis / diphtheria / Legionnaires’
· Chlamydia, Mycoplasma pneumoniae, Streptococcus pyogenes
Adverse Effects:
· GI discomfort / thrombophlebitis
Contraindications/Precautions:
· Pre-existing liver disease
Interactions:
· Toxic with: antihistamines, theophylline (asthma med), carbamazepine
(anticonvulsant), warfarin
Education:
· Administer on empty stomach with water – IV is rarely used