7. Action of Steroid Hormones versus
Peptide Hormones
Peptide Hormones Steroids
Half-life in circulation short long
Speed of action fast slow
Duration of effect short long
Location of receptor membrane inside
Post-receptor regulation high low
Signal amplification high low
9. Steroid Receptor Action
Roles of Heat Shock Proteins and HREs
hsp90
hsp70
H
hsp70
H H
R
hsp56
dimerize
H H
P?
H H
Gene
Transcription HRE target gene
5’ flanking region
12. Nuclear hormone receptor: domain structure
Zinc finger
DNA binding
domain…
inserts into
major groove
of DNA
14. Role of Phosphorylation in Steroid Receptor Activation
8-bromo cyclic AMP
PKA?
+ Phosphate
hypervariable DBD HBD
transcription