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Genetics and Heredity
Probability
Probability ,[object Object],[object Object],[object Object],[object Object]
Probability ,[object Object],[object Object]
Probability ,[object Object],[object Object],[object Object],[object Object]
Inherited Traits
Are these inherited traits? Your eye color Your height Your hair color and texture
Are these inherited traits? Your personality Your musical, athletic, and artistic abilities
Think about this…. ,[object Object],[object Object],[object Object]
Gregor Mendel ,[object Object],[object Object],[object Object],[object Object],Father of Genetics
Mendel’s studies led to: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Concepts in Inheritance
Theory of Heredity ,[object Object],Inherited allele for purple P HOMOZYGOUS purple flower PP
Theory of Heredity ,[object Object],Inherited allele for pink flower ( p ) HETEROZYGOUS purple flower (P p )
Theory of Heredity ,[object Object],Inherited for pink flower ( p ) HOMOZYGOUS pink flower ( pp )
PREDICTING HEREDITY
PUNNETT SQUARES ,[object Object],[object Object],[object Object]
Monohybrid Cross ,[object Object],[object Object],[object Object],[object Object],Parent Aa has what gentotype? Parent Aa can produce a gamete with either an “A” or with an “a”
Monohybrid Cross ,[object Object],[object Object],[object Object],[object Object],[object Object],A a A a ,[object Object],[object Object]
Monohybrid Cross ,[object Object],[object Object],[object Object],[object Object],[object Object],A a A a AA Aa Aa aa
Genotypic Ratios ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GR = 1 : 2 : 1 A a A a AA Aa Aa aa
Phenotypic Ratios ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PR = 3 : 1 A a A a AA Aa Aa aa
Practice! Cross a HOMOZYGOUS dominant female with a HETEROZYGOUS male using the same trait. AA AA Aa Aa What is the genotypic ratio? What is the phenotypic ratio? 2:2 or 50% 4 white fur A A A a
Dihybrid Cross ,[object Object],[object Object],Fur Color:   B:  Black    b:  White Coat Texture:   R: Rough   r:  Smooth BbRr x BbRr BR bR br bR Br BR br Br BBRR BbRR BbRr BBRr BBrr BbRr Bbrr BbRR BbRr bbRR bbRr BbRr Bbrr bbRr bbrr BBRr
Dihybrid Crosses ,[object Object],[object Object],[object Object],[object Object],16 Phenotypic Ratio: # dom/dom : # dom/rec : # rec/dom : # rec/rec Phenotypic Ratio: 9:3:3:1 BR bR br bR Br BR br Br BBRR BbRR BbRr BBRr BBrr BbRr Bbrr BbRR BbRr bbRR bbRr BbRr Bbrr bbRr bbrr BBRr
Dihybrid Crosses ,[object Object],[object Object],[object Object],16 1 ,[object Object],[object Object],[object Object],[object Object],Fur Color:   B:  Black    b:  White Coat Texture:   R: Rough   r:  Smooth BR bR br bR Br BR br Br BBRR BbRR BbRr BBRr BBrr BbRr Bbrr BbRR BbRr bbRR bbRr BbRr Bbrr bbRr bbrr BBRr
More Complex Patterns  of Heredity ,[object Object],[object Object],[object Object]
Codominance ,[object Object],C R C R C W C W C R C W
Codominance ,[object Object],N A =Normal RBC N S =Sickle Cell RBC National Institute of Health, http://www.cc.nih.gov/ccc/ccnews/nov99/ Photo attributed to Drs. Noguchi, Rodgers, and Schechter of NIDDK. N A N A N S N A N S N A N S N A N A N A N A N A
Multiple Alleles ,[object Object],[object Object],[object Object],[object Object],Phenotype Genotype Can Receive From Can Donate To A I A I A , I A i A, O A, AB B I B I B , I B i B, O B, AB AB I A I B A, B, AB,O AB O ii O A, B, AB, O
What are Sex-Linked Traits? ,[object Object],Hemophilia:  Failure of blood to clot Muscular Dystrophy:  wasting away of muscles Alix and Nicholas II
Can I inherit a sex-linked disease? Fathers (XY) can only pass disorders to daughters (XX) Mothers (XX) can pass disorders to both sons (XY) and daughters (XX) Most disorders are carried on the X chromosome, so males are more likely to inherit them.
How can I tell if I have a genetic disorder? ,[object Object]
What’s wrong with this Karyotype? Is this a male or a female?
What’s wrong with this Karyotype? Turner’s Syndrome
What’s wrong with this Karyotype? Klinefelter’s Syndrome
What’s wrong with this Karyotype? Down Syndrome
Pedigree Analysis ,[object Object],male female Female Carrier Marriage Offspring
Royal Hemophilia Pedigree http://www.sciencecases.org/hemo/hemo.asp
Pedigree for Colorblindness

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4.16.24 Poverty and Precarity--Desmond.pptx4.16.24 Poverty and Precarity--Desmond.pptx
4.16.24 Poverty and Precarity--Desmond.pptx
 

Genetics and heredity

Notes de l'éditeur

  1. After this slide you should do the Genetics Overview and Genetics Problems #1.
  2. In humans, the term sex-linked traits usually refers to X-linked traits. The human X-chromosome is much larger than the Y. Thus, there are more X-linked than Y-linked traits. Most X-linked genes have no homologous loci on the Y chromosome. Most genes on the Y chromosome not only have no X counterparts, but they encode traits found only in males (e.g. testis- determining factor). Examples of sex-linked traits in humans are color blindness and hemophilia. Fathers pass X-linked alleles to only and all of their daughters. Males receive their X chromosome only from their mothers. Fathers cannot, therefore, pass sex-linked traits to their sons. Mothers can pass sex-linked alleles to both sons and daughters. Females receive two X-chromosomes, one from each parent. Mothers pass on one X-chromosome (either the maternal or paternal homologue) to every daughter and son.
  3. The link to the website at the bottom gives a complete history and breakdown of royal hemophilia
  4. Colorblindness is a sex-linked trait. You can ask questions about each individual, you could also ask genotypes/phenotypes. (See below for sample questions) Questions you can ask: Individual 2 is most likely a: carrier female If individual 8 is not color blind, what is the probability that this individual is a carrier?: 0 Let us say individual 12 marries a normal, non-carrier female.  What is the probability that one of his sons will be color-blind? : 0 (males don’t donate X to sons)