The NMDP and Be The Match Registry provide an overview of their work facilitating bone marrow and cord blood transplants. They maintain the world's largest registry of potential donors to help the 70% of patients needing a transplant who do not have a matching donor in their family. While transplants from unrelated donors were once rare, over the past few decades the NMDP has expanded access internationally and for diverse patient populations through growing the donor registry and advancing research.
NMDP and Be The Match Registry Overview for Cord Blood Transplantation
1. NMDP and Be The Match
Registry™ Overview
John P. Miller, MDPhD
Cord Blood Symposium, San Francisco
June 5, 2013
2. About Transplant
A marrow or umbilical cord
blood transplant is often the
best or only hope of a cure
for many patients with
leukemia, lymphoma and
other
life-threatening diseases.
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3. 70% of all patients who
need a transplant do not
have a matching donor in
their family.
They turn to the NMDP’s
Be The Match Registry®
to find an unrelated donor.
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4. National Marrow Donor
Program is a nonprofit
organization dedicated to
creating an opportunity for
all patients to receive the
marrow or umbilical
cord blood transplant
they need, when they
need it.
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5. Overview of Our Work
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Support Patients
Conduct &
Support Research
Manage the
Be The Match
Registry®
Educate Doctors
Facilitate
Transplants
7. Cord Blood Bank Network
Membership Types US Number
International
Number
NMDP Member Cord Blood Banks 19 NA
NMDP Affiliated Listing CBBs 1
(has own IND)
5
CBBs Qualified under NMDP IND 19 63
Total CBBs accessible
through NMDP
20 63
8. 8
International Activity
• 45% of transplants we facilitate have either an
international donor or recipient
• More than 18.5 million potential adult donors and
more than 590,000 cord blood units available
worldwide
FY 2011
9. Be The Match Registry 2012
AdultDonors
CordBloodUnits
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10. Growth of Cord Blood Units on the
Be The Match Registry®
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15. 15
Minority includes those patients with race of CAU, DEC, OTH, and UNK in combination with Hispanic ethnicity.
NMDP Transplants for Minority and
Caucasian Patients
17. Role of Cord Blood in Transplants
by Patient Race
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18. Meeting Need of Minority Patients
• 44% of CBUs on the registry are from a minority donor
(compared to 27% of adult donors)
• Over last 5-6 years cord blood has
been product source for ~20% of
all transplants
• In 2012 thirty-nine percent of minority
patients who received a transplant
used cord blood
• In 2012, 33 percent of cord blood
transplants were for minority patients
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22. • With expanded indications and age ranges, the
calculated “need” for unrelated transplant has increased
by 25%
• NMDP facilitated transplants have grown by 200%
overall and 250% for minorities during that same
timeframe
• Challenge – Meeting only 25% of the need in Minority
communities and 50% of the need in the Caucasian
population
.22
Access has improved since 2006
23. We advance transplant science
through our research partner, CIBMTR
®
(Center for International Blood and
Marrow Transplant Research)
• Improved matching: making
it easier and faster to find
the best donor or cord blood
unit
• Improved timing: earlier
transplant is leading to
better outcomes
• Advances in treatment:
making transplant a better
option for patients 51-75
years old.
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24. We will continue to:
• Increase recruitment
and availability of
adult donors, cord blood
and new cell sources.
• Help all patients get the
transplant they need,
when they need it.
• Improve outcomes
through advances
in research and
clinical practice.
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Future Goals
25. • Join the Be The Match
Registry®
• Make a donation to:
- grow the registry
- help patients cover
uninsured costs
- advance research
• Spread the word about
the opportunity to help
save a life
• Help collect high quality
cord blood units (CBUs)
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You Can Help
