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Skeletal
Physiology

             ©5
1.    Bone Types
2.    Typical Long Bone
3.    Bone Breakdown
4.    Break Down the Haversian
5.    The Three Bone Cells
6.    Homeostatic Functions
7.    Bone Development
8.    Mending a Broken Bone
9.    Comparing Bone and Cartilage
10.   Types of Cartilage
11.   Mechanism of Growth
12.   Joints Classified
13.   Synovial




Skeletal physiology
(1)
       This song has eight alternating versus:
1. Long Bones: Bones that have extended longitudinal axes and expanded and
often uniquely shapes articular ends.
2. Short Bones: Have cubed-or box-shaped structures. they are as broad as they
are long.
3. Flat Bones: Broad and thin with a flattened and often curved surface.
4. Irregular Bones: Clustered in groups and come in various sizes and shapes.

                                    Examples:
1. Long Bones: Femur of the thigh and humorous of the arm.
2. Short Bones: Wrist (carpals) and ankle (tarsal) bones.
3. Flat Bones: Certain skull bones, the shoulder blades (scapulae), ribs, and
breastbone (sternum).
4. Irregular Bones: Vertebral bones that form the spine and the facial bones.


       Bone Types
(1)
• Written and preformed by Buildabone, Typical Long Bone
  consists of six versus that alternate throughout the song
1. Diaphysis: Shaft of a long bone. It’s hollow, cylindrical shape and is thick.

2. Epiphyes: Both ends of a long bone. Have a bulbous shape that provides space near joints for muscle
attachments and also gives stability to joints.

3. Articular Cartilage: Layer of hyaline cartilage covering the joint surfaces of epiphyes. It cushions joints
and blows.

4. Periosteum: Tough, connective tissue covering the bone. Depending on its location, its contains bone
forming and destroying cells, and blood vessels.

5. Medullary (or marrow) Cavity: Hollow area inside the diaphysis of the bone that contains yellow bone
marrow. Adults cavity is filled with connective tissue rich in a fat substance called yellow m arrow.

6. Endosteum: Fibrous membrane that lines the medullary cavity of long bones.




         Typical Long Bone
(1)   • In Bone Breakdown Buildabone illustrates the constituents of
        bone tissue through facts stated in three verses, each describing
        one of the major types of cells in bone.

• Osteoblast
   • Small cells that synthesize and secrete a specialized organic matrix, osteoid
   • Framework for deposition of calcium
   • Found in endosteum and lining of the haversian canals
• Osteoclasts
   • Giant multinucleate cells
   • Responsible for active erosion of bone minerals
   • Formed by fusion of several precursor cells and contain large numbers of
      mitochondria and lysosomes
   • Undergoes continuous change and remodeling
• Osteocytes
   • Mature non-dividing osteoblasts that have become surrounded by matrix and
      now lie within lacunae


      Bone Breakdown
(1)
      • Break Down the Haversian describes the major components of a
        Haversian system, which are explained below:
      • Lamellae- concentric, cylinder shaped layers of calcified matrix
      • Lacunae- “little lakes” small spaces containing tissue fluid in which
        bone cells lie imprisoned between hard layers of lamellae
      • Canaliculi- ultra small canals radiating to form lacunae and
        connecting them to each other and into a larger canal, the haversian
        canal
      • Haversian canal- extends lengthwise through center of each haversian
        system, contains blood vessels, lymphatic vessels, lymphatic vessels
        and nerves from the haversian canal; nutrients and oxygen move
        through canaliculi to lacunae and their bone cells. The canal is a short
        distance of about 0.1mm or less.

      Break Down the
      Haversian
(1)
      • Written and preformed by Buildabone, The Three Bone
        Cells consists of three alternating versus

         1. Osteoblasts
                   -small cells that synthesize and secrete a specialized organic
                   matrix called osteioid
                   -collagen fibrils line up in regular arrays in the osteoid and
                   serve as framework for the disposition of calcium and
                   phosphate
         2. Osteoclasts
              -Giant multinucleate cells
              -Responsible for the active erosion of bone miners
              -Contain large numbers of mitochondria and lysosomes
         3. Osteocytes
                   -mature, nonliving osteoblast surrounding by matrix lying
                   within lacunae.


      The Three Bone Cells
(1)   • Homeostatic Functions is written and preformed by
        Buildabone, and consists of 5 versus that alternate
        throughout the song.
      1.   Support- bones serve as supporting framework of the body and
           contribute to shape, alignment and positioning of the body parts
      2.   Protection- hard, bony boxes serve to protect the delicate organs
           underneath
      3.   Movement-bones with their joints constitute levers. Muscles are
           anchored firmly to bones, and muscles contract and shorten, they
           pull on the bones and produce movement.
      4.   Mineral storage- bones serve as the major reservoir for calcium,
           phosphorous and other minerals
      5.   Hematopoiesis- also known as blood cell formation- a vital process
           carried on by red blood marrow or myeloid tissue.



      Homeostatic Functions
(1)
      • Buildabone teaches us about how bones are formed in their song
         Bone Development
      Intramembranous bone:
              a) occurs within a connective tissue membrane
              b) Trabeculae appear and join in a network to form spongy
      bone
              c) flat bones begin when groups of cells differentiate into
      osteoblasts
              d) Apposition growth occurs by adding osseous tissue
        Endochondral bone:
              a)Primary ossification center forms
              b) blood vessels enters the cartilage model at the mid point of the
        diaphysis
              c) Bone grows in length as endochondral ossification progresses
        from the diaphysis toward each epiphysis
              d) Most bones begin as a cartilage model with bone formation
        spreading essentially from the center to the ends

      Bone Development
(1)
  The song Mending a Broken Bone is based off of the following facts concerning
  bone fractures:
  Fracture- a break in the continuity of a bone

  When healing a fracture:
  • Fracture tears and destroys blood vessels that carry nutrients to osteocytes
  • Vascular damage initiates repair sequence
  • Callus-specialized repair tissue that binds the broken ends of the fracture together
  • Fracture hematoma-blood clot occurring immediately after the fracture, is then resorbed
    and replaced by callus

      Steps involved in Bone Fracture
               a) Fracture of femur
               b) Formation of fracture hematoma
               c) Formation if internal and external callus
         • Written and preformed by Buildabone
               d) Bone remodeling complete



         Mending a Broken Bone
(1)    • Comparing Bone and Cartilage was written to teach the
         audience about types of bone an cartilage, below is a
         summary of the information in the song.
      Bones and cartilages are types of connective tissue in the body. The
      difference between bone and cartilage is that while bones are hard
      tissue that form the skeletal structure of the human body, cartilages are
      not as hard and rigid as bones, and present in areas of the body like the
      ear, nose and joints.
      • Bones- Bones are classified into long, short, flat, irregular,
          sesamoid and sutural bones.
      • Cartilage- Types of cartilage include hyaline cartilage,
          fibrocartilage and elastic cartilage.



       Comparing Bone and
       Cartilage
(1)
  • Written and preformed by Buildabone, the lyrics of
    Types of cartilage are explained below.
  •         Hyaline Cartilage- Hyaline cartilage consists of living cells, chondrocytes,
    which are situated far apart in fluid-filled spaces, the lacunae. There is an extensive
    amount of rubbery matrix between the cells and the matrix contains a number of
    collagenous fibers. Hyaline cartilage is the most abundant type of cartilage and can
    be found lining bones in joints and inside the bones.
  •         Fibrocartilage- fibrocartilage is an extremely tough tissue. The orientation of
    the bundles depends upon the stresses acting on the cartilage. The collagenous
    bundles take up a direction parallel to the cartilage. Fibrocartilage is found in areas
    requiring tough support or great tensile strength, like intervertebral discs and sites
    where ligaments and tendons connect to bones
  •         Elastic Cartilage- Basically elastic cartilage is similar to hyaline cartilage, but
    in addition to the collagenous fibers, the matrix of the elastic also contains an
    abundant network of branched yellow elastic fibers. They run through the matrix in
    all directions. Elastic cartilage is found in the pinna of the ear and several tubes, like
    the auditory canals and the larynx.
  •           EX - in the ear for example, elastic cartilage helps to maintain the shape
    and flexibility of the organ.


      Types of Cartilage
(6)   • Written and preformed by Buildabone
      • Here are some of the facts included in the song Mechanism
        of Growth

      •   cartilage growth-
                Interstitial-cells in lacunae grow and are proliferated within
                          the lacuna and get trapped together
                Appositional- cells from inner edge of perichondrium will
                          produce cartilage
      •    Bone Growth-
                Osteoblast- secrete new bone based off disuse of bone.




      Mechanism of Growth
(6)
      • Written and preformed by Buildabone
      • The song Joints Classified is about the different
        classifications of joints:   • Uniaxial
      • Fibrous- immobile                  • Ginlymus
           • Sutures                       • Trochioid
           • Syndesmosis                 • Biaxial
           • Gomphoses                     • Gingylymus
                                           • Trochoid
      • Cartilagionous-immobile
           • Synchodroses(hyaline        • Triaxial
             fibrous)                      • Ball & Socket
           • Symphyses(Fibrocartilage)     • Planar


      • Synovial- movement
      Joints Classified
(6)   • Written and preformed by Buildabone, Synovial is a
        song about the various joints describes below.
 • Ball in socket- freedom of rotation, and back in forth, has the most freedom
    • Hip and Shoulder
 • Condyloid-bones move about, but cannot rotate.
    • Between radius and carpals
 • Gliding – not great distance but lots of flexibility
    • Vertebra
 • Hinge- ease in movement only provide movement on plane- no rotation
    • Elbow
 • Pivot-rotation, one spins on another
    • Between first and second cervical vertebra
 • Saddle- one bone concave and one convex
    • Thumb joint between first metacarpal and carpal bone



      Synovial
•   Cancer treatment may generate a need for a bone marrow transplant. Osteoporosis is a
    condition characterized by an excessive loss of calcium in bone. These 2 conditions
    are disruptions or failures of 2 bone functions. Identify these 2 functions and explain
    what their normal function should be.
     • 1. Creation of blood cells
     • 2. Calcium helps the bones to grow normally and develop better.

•   Explain why a bone fracture along the epiphyseal plate may have serious implications
    among children and young adults.
     • 1. It can have serious implications because the bone is still growing. It needs space
       to grow and if it is fractured it will stop the process.

•   During the aging process, adults face the issue of a changing skeletal framework.
    Describe these changes and explain how these skeletal framework changes affect the
    health of older adults.
    • 1. Osteoporosis is one change, as you increase in age the bone density decreases
        which will result in osteoporosis and bone breakage.



Discussion

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Artifact #2 skeletal physiology

  • 2. 1. Bone Types 2. Typical Long Bone 3. Bone Breakdown 4. Break Down the Haversian 5. The Three Bone Cells 6. Homeostatic Functions 7. Bone Development 8. Mending a Broken Bone 9. Comparing Bone and Cartilage 10. Types of Cartilage 11. Mechanism of Growth 12. Joints Classified 13. Synovial Skeletal physiology
  • 3. (1) This song has eight alternating versus: 1. Long Bones: Bones that have extended longitudinal axes and expanded and often uniquely shapes articular ends. 2. Short Bones: Have cubed-or box-shaped structures. they are as broad as they are long. 3. Flat Bones: Broad and thin with a flattened and often curved surface. 4. Irregular Bones: Clustered in groups and come in various sizes and shapes. Examples: 1. Long Bones: Femur of the thigh and humorous of the arm. 2. Short Bones: Wrist (carpals) and ankle (tarsal) bones. 3. Flat Bones: Certain skull bones, the shoulder blades (scapulae), ribs, and breastbone (sternum). 4. Irregular Bones: Vertebral bones that form the spine and the facial bones. Bone Types
  • 4. (1) • Written and preformed by Buildabone, Typical Long Bone consists of six versus that alternate throughout the song 1. Diaphysis: Shaft of a long bone. It’s hollow, cylindrical shape and is thick. 2. Epiphyes: Both ends of a long bone. Have a bulbous shape that provides space near joints for muscle attachments and also gives stability to joints. 3. Articular Cartilage: Layer of hyaline cartilage covering the joint surfaces of epiphyes. It cushions joints and blows. 4. Periosteum: Tough, connective tissue covering the bone. Depending on its location, its contains bone forming and destroying cells, and blood vessels. 5. Medullary (or marrow) Cavity: Hollow area inside the diaphysis of the bone that contains yellow bone marrow. Adults cavity is filled with connective tissue rich in a fat substance called yellow m arrow. 6. Endosteum: Fibrous membrane that lines the medullary cavity of long bones. Typical Long Bone
  • 5. (1) • In Bone Breakdown Buildabone illustrates the constituents of bone tissue through facts stated in three verses, each describing one of the major types of cells in bone. • Osteoblast • Small cells that synthesize and secrete a specialized organic matrix, osteoid • Framework for deposition of calcium • Found in endosteum and lining of the haversian canals • Osteoclasts • Giant multinucleate cells • Responsible for active erosion of bone minerals • Formed by fusion of several precursor cells and contain large numbers of mitochondria and lysosomes • Undergoes continuous change and remodeling • Osteocytes • Mature non-dividing osteoblasts that have become surrounded by matrix and now lie within lacunae Bone Breakdown
  • 6. (1) • Break Down the Haversian describes the major components of a Haversian system, which are explained below: • Lamellae- concentric, cylinder shaped layers of calcified matrix • Lacunae- “little lakes” small spaces containing tissue fluid in which bone cells lie imprisoned between hard layers of lamellae • Canaliculi- ultra small canals radiating to form lacunae and connecting them to each other and into a larger canal, the haversian canal • Haversian canal- extends lengthwise through center of each haversian system, contains blood vessels, lymphatic vessels, lymphatic vessels and nerves from the haversian canal; nutrients and oxygen move through canaliculi to lacunae and their bone cells. The canal is a short distance of about 0.1mm or less. Break Down the Haversian
  • 7. (1) • Written and preformed by Buildabone, The Three Bone Cells consists of three alternating versus 1. Osteoblasts -small cells that synthesize and secrete a specialized organic matrix called osteioid -collagen fibrils line up in regular arrays in the osteoid and serve as framework for the disposition of calcium and phosphate 2. Osteoclasts -Giant multinucleate cells -Responsible for the active erosion of bone miners -Contain large numbers of mitochondria and lysosomes 3. Osteocytes -mature, nonliving osteoblast surrounding by matrix lying within lacunae. The Three Bone Cells
  • 8. (1) • Homeostatic Functions is written and preformed by Buildabone, and consists of 5 versus that alternate throughout the song. 1. Support- bones serve as supporting framework of the body and contribute to shape, alignment and positioning of the body parts 2. Protection- hard, bony boxes serve to protect the delicate organs underneath 3. Movement-bones with their joints constitute levers. Muscles are anchored firmly to bones, and muscles contract and shorten, they pull on the bones and produce movement. 4. Mineral storage- bones serve as the major reservoir for calcium, phosphorous and other minerals 5. Hematopoiesis- also known as blood cell formation- a vital process carried on by red blood marrow or myeloid tissue. Homeostatic Functions
  • 9. (1) • Buildabone teaches us about how bones are formed in their song Bone Development Intramembranous bone: a) occurs within a connective tissue membrane b) Trabeculae appear and join in a network to form spongy bone c) flat bones begin when groups of cells differentiate into osteoblasts d) Apposition growth occurs by adding osseous tissue Endochondral bone: a)Primary ossification center forms b) blood vessels enters the cartilage model at the mid point of the diaphysis c) Bone grows in length as endochondral ossification progresses from the diaphysis toward each epiphysis d) Most bones begin as a cartilage model with bone formation spreading essentially from the center to the ends Bone Development
  • 10. (1) The song Mending a Broken Bone is based off of the following facts concerning bone fractures: Fracture- a break in the continuity of a bone When healing a fracture: • Fracture tears and destroys blood vessels that carry nutrients to osteocytes • Vascular damage initiates repair sequence • Callus-specialized repair tissue that binds the broken ends of the fracture together • Fracture hematoma-blood clot occurring immediately after the fracture, is then resorbed and replaced by callus Steps involved in Bone Fracture a) Fracture of femur b) Formation of fracture hematoma c) Formation if internal and external callus • Written and preformed by Buildabone d) Bone remodeling complete Mending a Broken Bone
  • 11. (1) • Comparing Bone and Cartilage was written to teach the audience about types of bone an cartilage, below is a summary of the information in the song. Bones and cartilages are types of connective tissue in the body. The difference between bone and cartilage is that while bones are hard tissue that form the skeletal structure of the human body, cartilages are not as hard and rigid as bones, and present in areas of the body like the ear, nose and joints. • Bones- Bones are classified into long, short, flat, irregular, sesamoid and sutural bones. • Cartilage- Types of cartilage include hyaline cartilage, fibrocartilage and elastic cartilage. Comparing Bone and Cartilage
  • 12. (1) • Written and preformed by Buildabone, the lyrics of Types of cartilage are explained below. • Hyaline Cartilage- Hyaline cartilage consists of living cells, chondrocytes, which are situated far apart in fluid-filled spaces, the lacunae. There is an extensive amount of rubbery matrix between the cells and the matrix contains a number of collagenous fibers. Hyaline cartilage is the most abundant type of cartilage and can be found lining bones in joints and inside the bones. • Fibrocartilage- fibrocartilage is an extremely tough tissue. The orientation of the bundles depends upon the stresses acting on the cartilage. The collagenous bundles take up a direction parallel to the cartilage. Fibrocartilage is found in areas requiring tough support or great tensile strength, like intervertebral discs and sites where ligaments and tendons connect to bones • Elastic Cartilage- Basically elastic cartilage is similar to hyaline cartilage, but in addition to the collagenous fibers, the matrix of the elastic also contains an abundant network of branched yellow elastic fibers. They run through the matrix in all directions. Elastic cartilage is found in the pinna of the ear and several tubes, like the auditory canals and the larynx. • EX - in the ear for example, elastic cartilage helps to maintain the shape and flexibility of the organ. Types of Cartilage
  • 13. (6) • Written and preformed by Buildabone • Here are some of the facts included in the song Mechanism of Growth • cartilage growth- Interstitial-cells in lacunae grow and are proliferated within the lacuna and get trapped together Appositional- cells from inner edge of perichondrium will produce cartilage • Bone Growth- Osteoblast- secrete new bone based off disuse of bone. Mechanism of Growth
  • 14. (6) • Written and preformed by Buildabone • The song Joints Classified is about the different classifications of joints: • Uniaxial • Fibrous- immobile • Ginlymus • Sutures • Trochioid • Syndesmosis • Biaxial • Gomphoses • Gingylymus • Trochoid • Cartilagionous-immobile • Synchodroses(hyaline • Triaxial fibrous) • Ball & Socket • Symphyses(Fibrocartilage) • Planar • Synovial- movement Joints Classified
  • 15. (6) • Written and preformed by Buildabone, Synovial is a song about the various joints describes below. • Ball in socket- freedom of rotation, and back in forth, has the most freedom • Hip and Shoulder • Condyloid-bones move about, but cannot rotate. • Between radius and carpals • Gliding – not great distance but lots of flexibility • Vertebra • Hinge- ease in movement only provide movement on plane- no rotation • Elbow • Pivot-rotation, one spins on another • Between first and second cervical vertebra • Saddle- one bone concave and one convex • Thumb joint between first metacarpal and carpal bone Synovial
  • 16. Cancer treatment may generate a need for a bone marrow transplant. Osteoporosis is a condition characterized by an excessive loss of calcium in bone. These 2 conditions are disruptions or failures of 2 bone functions. Identify these 2 functions and explain what their normal function should be. • 1. Creation of blood cells • 2. Calcium helps the bones to grow normally and develop better. • Explain why a bone fracture along the epiphyseal plate may have serious implications among children and young adults. • 1. It can have serious implications because the bone is still growing. It needs space to grow and if it is fractured it will stop the process. • During the aging process, adults face the issue of a changing skeletal framework. Describe these changes and explain how these skeletal framework changes affect the health of older adults. • 1. Osteoporosis is one change, as you increase in age the bone density decreases which will result in osteoporosis and bone breakage. Discussion