Transfusion Medicine

Tranfusion Medicine Amanda J. Wheeler, MD Trauma/Critical Care Stanford University Medical Center May 7, 2007

Tranfusion Medicine ,[object Object]

Transfusion Triggers/Indications: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemoglobin Concentration ,[object Object],[object Object],[object Object],[object Object],[object Object]

Blood Transfusion Protocol at Stanford Surgery ICU ,[object Object],[object Object],[object Object],[object Object]

Blood Transfusion Protocol at Stanford Surgery ICU ,[object Object]

Massive Transfusion Guidelines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other Alternatives: Blood Substitute Slides by Mary-Ann Purtill, MD ,[object Object],[object Object],[object Object],[object Object]

Three primary reasons driving the quest for a substitute for Blood: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Types of Replacement Products ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Oxygen Carrying Solutions ,[object Object],[object Object],[object Object],[object Object]

Oxygen Carrying Solutions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemoglobin Based Oxygen Carrying Solutions (HBOCs) ,[object Object],[object Object],[object Object],[object Object],Historical Perspective

Problems with HBOCS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Comparison of HBOCs Hemolink PolyHeme Hemopure & Oxyglobin Product Name: 14 hours 24 hours 18-22 hours Half-life: Refrigerated/ RoomTemp Refrigerated Room Temp Storage: 1 year 1 year 3 years Shelf-life: Expired Human RBCs Expired Human RBCs Bovine Hgb Source: Hemosol Northfield Biopure

Perflourocarbon Oxygen Carriers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Perflourocarbon Oxygen Carriers (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Problems with Perflourocarbons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antigen Camouflage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antigen Camouflage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Recombinant Plasma Proteins ,[object Object],[object Object],[object Object],[object Object]

Transgenic Therapeutic Proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Platelet Substitutes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Platelet Substitutes (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Transfusion Medicine

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