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Presented by:
ROSHNI MAURYA
FINAL YEAR PGT
CONTENTS
• Introduction
• Definition
• Rationale
• Objectives
• Indication
• Contraindication
• Classification
• Medicaments used
• Techniques
• Formocresol pulpotomy
• Electrosurgical pulpotomy
• Laser pulpotomy
• Calcium hydroxide pulpotomy
• Glutarldehyde pulpotomy
• Ferric sulphate pulpotomy
• Recent concepts
• Bone morphogenetic protein
• Lyophilized freeze dried
platelet derived preparation
• Enamel matrix derivatives
• Reasons for failure of
pulpotomy therapy
INTRODUCTION
• Primary tooth pulp therapy is aimed at preserving the
primary teeth until normal exfoliation.
• Management of the cariously involved primary tooth where
the carious lesion approximates the pulp requires a
knowledgeable approach to pulp therapy, and a successful
outcome depends on accurate diagnosis of the status of the
pulp prior to therapy.
• Preliminary data gathering and interpretation must be
focused on determining whether the primary tooth pulp is
normal, reversibly inflamed, irreversibly inflamed or
necrotic.
• If it is determined to be vital or reversibly inflamed,
the vital pulp therapy techniques of pulpotomy or
indirect pulp treatment (IPT) are indicated.
• If the pulp is determined to be irreversibly inflamed
or necrotic, either a pulpectomy or extraction would
be appropriate.
• This presentation is limited to a discussion of
the vital pulp therapy procedure of pulpotomy
for primary teeth.
Definition:
• Complete removal of the coronal portion of the dental pulp,
followed by placement of a suitable dressing or medicament
that will promote healing and preserve the vitality of the
tooth (Finn,1985).
• Pulpotomy is defined as the amputation of vital pulp from the
coronal pulp chamber followed by placement of a
medicament over the radicular pulp stumps to stimulate
repair, fixation or mummification of the remaining vital
radicular pulp (Braham and Morris)
Rationale:
 When the coronal pulp is exposed by trauma or operative procedures, or
caries ingress of bacteria, it produces inflammatory changes in the
tissue.The surgical excision of the infected and inflamed coronal pulp,
the vital uninfected pulpal tissue can be left behind and preserved in the
root canal.
 The removal of the inflamed portion of the pulp affords temporary, rapid
relief of pulpalgia and further may undergo repair while completing
apexogenesis that is root end development and calcification.
 Materials used for this procedure either mummify or fix the tissue or
promote healing by formation of a bridge.
Objectives (AAPD Guidelines )
 The radicular pulp should remain asymptomatic without adverse
clinical signs or symptoms such as sensitivity, pain, or swelling.
 There should be no postoperative radiographic evidence of
pathologic external root resorption.
 Internal root resorption can be self limiting and stable.
 The clinician should monitor the internal resorption, removing
the affected tooth if perforation causes loss of supportive bone
and/or clinical signs of infection and inflammation.
 There should be no harm to the succedaneous tooth.
• A correct diagnosis of pulp conditions in primary and young
permanent teeth is important for treatment planning.
• McDonald and Avery have outlined several diagnostic aids in
selecting teeth for vital pulp therapy.
• Eidelman et al and Prophet and Miller have emphasized that
no single diagnostic means can be relied on for determining a
diagnosis of pulp conditions.
CASE SELECTION
• A suggested outline for determining the pulpal status of cariously involved
teeth in children involves the following:
1.Visual and tactile examination of carious dentin and
associated periodontium
2. Radiographic examination of
a. periradicular and furcation areas
b. pulp canals
c. periodontal space
d. developing succedaneous teeth
3. History of spontaneous unprovoked pain
4. Pain from percussion
5. Pain from mastication
6. Degree of mobility
7. Palpation of surrounding soft tissues
8. Size, appearance, and amount of hemorrhage associated with pulp
exposures
Endodontics : Ingle 5th edi
Electric pulp tests are not valid in primary teeth.
• Andreasen et al. Textbook and color atlas of traumatic
injuries to the teeth. 4th ed, 2007
Thermal tests are usually not conducted on primary teeth
because of their unreliability.
• Cohen S, Hargreaves K : 9th ed. 2006:822– 82.
Numerous studies have reported the unreliability of electric
pulp tests in permanent teeth with open and developing
apices.
• J Dent Child 1978;45:199 –202.
• J Endod 1986;12:301–5.
• Aust Dent J 1977;22:272–9.
Laser Doppler flowmetry might be of greater help in
determining vitality.
• Endod Dent Traumatol 1999;15:284 –90.
• Dent Traumatol 2001;17:63–70
• Endod Top 2003;5:12–25.
 Cariously exposed primary teeth, when their retention is more
advantageous than extraction.
 Vital tooth with healthy periodontium
 Pain, if present not spontaneous nor persists after removal of the
stimulus
 Tooth which is restorable
 Tooth with-2/3rd root length
 Hemorrhage from the amputation site is pale red & easy to
control
INDICATION
 Absence of abscess and fistula
 No inter-radicular bone loss
 No inter-radicular radiolucency
 On young permanent tooth
with vital exposed pulp and
incompletely formed apices
CONTRAINDICATION
 Persistent tooth ache.
 Tenderness on percussion / mobility present.
 Root resorption more than 1/3rd of root length.
 Large carious lesion with non-restorable crown.
 Highly viscous, sluggish hemorrhage from canal orifice which is
uncontrollable.
 Evidence of internal resorption
 Presence of inter radicular bone loss
 Tooth close to natural exfoliation
 Medical contraindications ; immuno-
-compromised patient.
FACTORS THAT AFFECT
PROGNOSIS OF PULPOTOMY:
 Size of exposure
 Location of exposure
 Exposure to saliva
 Marginal leakage
 Age and status of the pulp (Stahl et al 1970)
Evidence of success in therapy includes the
following:
 Vitality of the majority of the radicular pulp
 No prolonged adverse clinical signs or symptoms,
such as prolonged sensitivity, pain, or swelling
 No radiographic evidence of internal resorption
 No breakdown of periradicular tissue
 No harm to succedaneous teeth
 Pulp canal obliteration (abnormal calcification)
CLASSIFICATION
• Pulpotomy can be classified according to treatment objectives
given by Ranley et al:
• Vital pulpotomy
I. Devitalization Pulpotomy (Mummification, Cauterization)
a. Formocresol pulpotomy.
b. Electrosurgical pulpotomy.
c. Laser pulpotomy.
II. Preservation (Minimal devitalization, Non – inductive)
• Gluteraldehyde.
• Ferric sulfate.
III. Regeneration (Inductive, Reparative)
• Calcium Hydroxide.
• Bone morph genetic Protein.
• Mineral trioxide aggregate
II.NON –VITAL PULPOTOMY:
- Beechwood cresol
– Formocresol
Devitalisation:
• The first approach to be used with the intention of
“mummifying’ the radicular pulp tissue.
• The term “mummified” has been ascribed to chemically
treated pulp tissue that is inert, sterilized, metabolically
suppressed, and incapable of autolysis. This approach
involved the original two- sitting formocresol
pulpotomy, which resulted in complete devitalization of
the radicular pulp.
• Also included were the 5- minute formocresol and 1:5
diluted formocresol techniques, which both result in
partial devitalization with persistent chronic
inflammation.
Preservation:
• This approach involved medicaments and techniques
that provide minimal insult to the orifice tissue and
maintain the vitality and normal histologic appearance
of the entire radicular pulp.
• Pharmacotherapeutic agents included in this category
are corticosteroids, glutaraldehyde and ferric sulfate.
• Nonpharamcotherpeutic techniques in this category
include electrosurgical and laser pulpotomy.
Regeneration:
• This approach includes pulpotomy agents that have cell-
inductive capacity to either replace lost cells or induces
existent cells to differentiate into hard tissue forming
elements.
Examples of true cell- inductive agents include:
– Transforming growth factor- (TGF- ) in the form
of bone morphogenetic
– Proteins freeze dried bone
– Mineral trioxide aggregate (MTA)
PULPOTOMY MEDICAMENTS
• Formocresol (Buckley’s
formocresol).
• Glutaraldehyde.
• Calcium hydroxide.
• Zinc oxide eugenol.
• Ferric sulphate
• Gysi’s paste
• Easlick’s paste
• Paraform paste
• Cresol
• Enriched collagen
phosphate gel
• Collagen calcium
phosphate gel
• Freeze Dried bone
• Enamel matrix derivative
Easlick’s Paraformaldehyde Paste
• Paraformaldehyde 1g
• Procaine base 0.03g
• Powered asbestos 0.50g
• Petroleum jelly 125g
• Carmine To color
Materials used for visit pulpotomy
Gysi Triopaste
• Tricresol 10ml
• Cresol 20ml
• Glycerin 4ml
• Paraformaldehyde 20g
• Zinc Oxide eugenol 60g
Paraform Devitalizing paste (Modified
Easlick’s Paste)
• Paraformaldehyde 1g
• Lignocaine 0.06g
• Propylene glycol 0.50ml
• Carbowax 1.3g
• Carmine to color
Recent materials
• Propolis.
• Bone Morphegenic Protien
• Lyophilized Freeze Dried Platelet Derived Preperation
• Hydroxy appatite
• Mineral trioxide aggregate
• Bioactive Molecules
• New endodontic cement.
• Calcium enriched cement.
Pulpotomy Techniques:
There Are Three Pulpotomy Techniques:
• Vital Formocresol pulpotomy technique: also known as the 1-minute
formocresol.
• Devitalization pulpotomy: This is two- stage technique and relied
upon paraformaldehyde to fix the coronal and radicular pulp tissue.
• Non –vital Pulpotomy: This technique is carried out when the
inflammatory process affecting the coronal pulp extends to the
radicular pulp leading to an irreversible change in the pulp tissue .
•
Aramentarium For The Pulptomy Technique
• Topical and local Anaesthesia.
• Burs No 330 FG high speed and No 8 RA Slow speed.
• Rubber dam kit.
• Mouth mirror, probe and tweezers.
• Cotton pellets (small).
• Large and small excavators.
• Mixing spatula, flat plastic instrument.
• Formocresol, 1/5 dilution.
• Dappens pot, syringe.
• Zinc oxide eugenol.
• Glass ionomer cement for lutting
• Stainless steel crown
Single Visit Pulpotomy
• Step 1: Administration of local anesthesia
• Step 2: Apply a rubber dam
• Step 3: Use a sterile No.4 or 8 round bur (slow speed) to
remove all carious dentin .If possible, remove all carious dentin
before exposing the pulp horns
• Step 4: Place a No. 330' bur in the high-speed hand piece. Gain
occlusal access to the pulp chamber by preparing a Class 1
cavity preparation. It is better to make too large an opening
than one that is too small. Remove all overhanging enamel.
• Step 5: Excise the pulpal tissue to the orifices of the root
canal. Use a large spoon excavator to remove any
remaining pulpal tissue.The pulpal tissue should be
amputated to the entrance of the root canals.
• Step 6: After completing the amputation, evaluate the
hemorrhage. If the pulpal tissue has been removed
completely, hemorrhage should be minimal.A vital pulp
with minimal chronic inflammation should achieve
hemostasis in 3 to 5 minutes.
• Step 7: Over the exposed pulp stump, place sterile cotton
pellet moistened (but not saturated) with formocresol,
20% dilution.
• Step 8:Leave the formocresol in place for 1 minute, and then
remove the pellet. The pulp stump should appear blackish
brown .If there is bleeding, check for residual pulpal tissue.
Reapply formocresol for 2 minutes.
• Step 9: Fill the pulp chamber to about half its volume with a
thick mixture of zinc oxide-eugenol.
• Step 10:Prepare the tooth for a stainless steel crown
Procedure
Pulpotomy
Pulpotomy
Pulpotomy
Two Visit Pulpotomy
Indications for two-visit pulpotomy procedure in
primary teeth are
• Inability to arrest hemorrhage from the
amputated pulp stumps during a single visit
formocresol pulpotomy.
• Non-vital coronal and/or radicular pulp without
the presence of an abscess.
• In two-stage procedure, this involves the use of
paraformaldehyde to fix the entire coronal and
radicular pulp tissue. The paraformaldehyde
paste is most commonly used (Hobson 1970)
• The paste is placed over the pulpal exposure on a small pledget of cotton
wool, the larger the exposure then the more successful the outcome.
• The paraformaldehyde paste is sealed into the cavity with a thin mix of
zinc eugenol and left for 1-2 weeks.
• Formaldehyde gas liberated from the paraformaldehyde permeates
through the coronal and radicular pulp, fixing the tissues.
• On the second visit, the dressing is removed, there is no need to
administer a local anesthetic as the pulp contents should be nonvital,
pulpotomy is carried out and then covered with hard setting zinc oxide
cement or alternatively an antiseptic paste (equal parts of eugenol and
formocresol with zinc oxide) over the radicular pulp before restoring the
tooth.
• Hobson (1970) reported a success rate of 77% after 3 years.
Non Vital Pulpotomy (Mortal Pulpotomy)
• Indications
• When the inflammatory process affecting the
coronal pulp extends to the radicular pulp leading
to an irreversible change in the pulp tissue.
• When the pulp is completely non-vital, where
there may be an abscess present with or without
acute cellulites
MEDICAMENTS USED:
Constituents of Beechwood cresol
• 2 Methoxy, 4 methyl phenol (Cresol) : 13%
• Methoxyl phenol (Guaicol) : 47%
• M-Methoxy phenol : 7%
• P-Methoxy phenol : 26%
• Unknown : 7%
Technique
Ist visit:
• The necrotic coronal pulp is first removed, as
recommended in the vital pulpotomy technique.
• The necrotic debris in the pulp chamber is then
cleared. If there is sufficient access to the radicular pulp
canals then as much as possible of the necrotic tissue is
removed with a small excavator.
• A small pledget of cotton wool dipped in beechwood
cresol is then sealed into the cavity with temporary zinc
oxide eugenol cement.
• IInd visit:
• Usually 1-2 weeks later the dressing is removed, provided the signs
and symptoms of infection have cleared,
• The cavity is then restored in the same manner as used in the vital
pulpotomy technique.
• If it appears that there is no resolution of the symptoms then the
beechwood cresol should be replaced for a further 1-2 weeks,
• Other medcaments like formocresol and camphorated
monochlorophenol (Arnold and Rock, 1993) have been equally
effective, at the second visit, after one to two weeks an antiseptic paste
that is placed over the radicular pulp remnants before restoring the
tooth replaces the antiseptic solution.
• Hobson (1970) reported a success rate of 66% after 3 years.
Partial Pulpotomy (Cvek’s Pulpotomy)
• Definition: It is the removal of only the outer layer of
damaged and hyperemic tissue in exposed pulps, is considered
to be a procedure staged between pulp capping and complete
pulpotomy. It is a mode of treatment which is widely used in
the permanent dentition but less so in primary teeth.
Radionale And Advantages
• The main advantage of Partial pulpotomy is that a successful
outcome will allow the continuation of normal development of
the tooth, including further root development and maturation.
Apex formation and thickening of thin root walls may occur in
young teeth.
• The tooth following a partial pulpotomy will retain its natural
color and translucency in comparison to the coronal
discoloration in many teeth undergo after pulpectomy.
• Partial pulpotomy have advantage over complete pulpotomy is
the preservation of cell rich coronal pulp tissue.
Indications• A small and recent pulpal exposure of up to approximately 14 days in a non
carious primary incisor.
• A sufficient tooth structure is present to allow proper restoration and full
coverage of the crown with a bonded resin- composite strip crown.
• Partial pulpotomy is highly indicated in a very young tooth with a wide- open
apex and very thin root dentin walls.
• The decisive factor for selection of the partial pulpotomy and its success is a
healthy, non inflammed and asymptomatic vital pulp.
• During the procedure, an operative diagnosis should be made by assessing the
pulpal with regard to the bleeding from the amputation site, including the
color, viscosity, and ability of the tissue to achieve hemostasis
Contraindications
• Exposure is very large or when more than 2 weeks have passes
between injury and treatment time allowing oral contaminants
to cause extensive infection or inflammation beyond 2 to 3
mm of the exposure.
• Purulent drainage.
• History of prolonged pain.
• Necrotic debris in canal.
• Periapical radiolucency.
Technique
The clinical procedure is described as follows
• Proper patient management should be achieved with or without
premedication.
• Local anesthesia and rubber dam placement should be
administered with the slit technique.
• A no. 330 tungsten bur is used to ampute the pulp close to the
exposure site to a depth of 2mm.
• Continuous rinsing of the amputed pulp with saline will assist
in achieving hemostasis without blood clot formation within 4
minutes (if hemostasis is not achieved, all the coronal tissue
should be removed and a cervical pulpotomy should be
performed).
• A dressing of calcium hydroxide paste should be
placed followed by base/line of glass ionomer
such as Vitrebond.
• The tooth is restored using a bonded resin-
composite strip crown.
• Scheduled follow- ups should be made after 1
month and then every 6 months. A dentin bridge
will begin to form, separating the exposure site
from the rest of the pulp. The bridge may be
evidenced radio graphically after 6 to 8 weeks in
future occlusal/ periapical view.
Pulpotomy
Formocresol Pulpotomy
• Formocresol was introduced in 1904 by Buckley, who
contended that equal parts of formalin and tricresol would
react chemically with the intermediate and end products of
pulp inflammation to form a “new, colorless, and non-
infective compound of harmless nature.
• Buckley’s formula of formocresol, consists of tricresol,
aqueous formaldehyde, glycerine, and water.
Composition
pH - 5.1
Dilution of formocresol
• Loos and Han have led to the conclusion that a dilute (1: 5
concentration) of Buckley’s formocresol applied to tissue
achieved the desired cellular response.
• The orginal buckley’s formula for formocresol calls for
equal parts of formaldehyde and cresol. The 1:5
concentration of this formula is prepared by first
thoroughly mixing three parts of glycerin with one part of
distilled water, then adding four parts of this diluent to
one part of Buckley’s Formocresol and thoroughly mixing
again.
Formocresol concentration
• It is therefore recommended that 1/5th concentration formocresol
be utilized for pulpotomy procedure since it is as effective as and
less damging than the traditional preparation.
• In recent years formocresol has been extensively evaluated using
animal models. It was concluded that 20% dilution causes the
least histologic damage and that a 1 minute application of
formocresol is adequate to produce the desired results.
• Garcia – Godoy (1984) advocated the use of 20% dilution of
formocresol for partial pulpotomies. He showed a success rate
96%.
Step 1: Access opening of the carious tooth.
Step 2: Removal of coronal part of the carious tooth.
Step 3: Formocresol dressing placed on the amputed pulp.
Step 4 : Stainless steel crown placed on the pulpotomised tooth.
PRE AND POSTOPERATIVE
RADIOGRAPHS
Berger- compared effect of formocresol medication with those
ZnOE paste
97% success - formocresol
58% success - ZnOE
Rolling and Thylstrup –(1975) 3 year follow up
91% -3months
83% - 12 months
78% - 24 months
70% - 36 months
• Buckley 1904 – recommended for treating the
putrescent pulp
• 5 visit therapy was reduced to 3 visit(1955)
• Sweet (1960), advocated single visit, and
placement of ZnOE cement containing some
formocresol over the pulp stumps– widely
accepted
• Miyamoto 1974 – suggested 2 visit technique
for unco-operative children
• Verco and Allen 1984- no difference between
single visit and two visit technique
• Kennedy and Curzon highlighted the
convenience of single visit technique for child
and parent
Effect on succedaneous tooth
YES –
• Pruhs et al 1977 ,
• Messer et al 1980
NO --
• Wright & Widmer 1979,
• Rolling & Poulsen 1978,
• Fuks & Bimstein 1981,
• Mulder et al 1987
Histologic investigation of the effect of formocresol
on the pulp
• Massler and Mansukhani conducted a detailed histologic
investigation of the effect of formocresol on the pulps of 43 human
primary and permanent teeth in multiple treatment intervals.
• Fixation of the tissue directly under the medicament was apparent.
After a 7 to 14-day application, the pulps developed three distinctive
zones:
• A broad eosinophilic zone of fixation
• A broad pale-staining zone with
poor cellular definition
• A zone of inflammation diffusing
apically into normal pulp tissue
• After 60 days, in a limited number of samples, the remaining tissue
was believed to be completely fixed, appearing as a standard of
eosinophilic fibrous tissue.In general, the results of many histologic
studies on the formocresol pulpotomy have shown that several distinct
zones are usually present in the pulp following the application of the
medicaments.
• Superficial debris along with the dentinal chips at the amputation site
• Eosinophil-stained and compressed tissue
• A palely stained zone with loss of cellular definition
• An area of fibrotic and inflammatory activity
• An area of normal-appearing pulp tissue considered to be vital
Advantages
• Commonly available medicament
• Stable at room temperature
• Long shelf life
• High clinical and radiographic success of
formocresol pulpotomy
Disadvantages
• It is a very caustic medicament.
• In high doses it is toxic.
• Potential systemic absorption and distribution
throughout the body.
• It has a mutagenic and carcinogenic potential .
Toxicity• Local toxicity
• The classical description of a 5 minute application is
• Immediately beneath the site of amputation there is
eosinophilic tissue interpreted as the zone of fixation.
• The next zone is the pale staining amorphous zone with
diminished cellular and fiber definition which is the result of
lipid dissolving property of cresol. Stagnation necrosis as a
consequence of formocresol induced vascular thrombosis.
• Broad zone with inflammatory cells first of acute variety and
then of chronic variety.
• Muller 1978 stated topical application of formalin causes
leukoplakia and lesions resembling carcinoma in situ.
• Formocresol seeps in through accessory canals into
developing tooth germ and causes enamel defects like
hypoplasia and might alter position of underlying
permanent tooth (Messler 1980)
• Jerell and Ronk 1982 described arrested development of
bicuspid while Grundy and coworkers in 1984 described
cyst in primary teeth treated with formaldehyde
Systemic toxicity
• After systemic administration of formocresol in experimental
animals, formocresol is distributed throughout the body.
Metabolism and excretion of a portion of the absorbed
formocresol occur in the kidneys and lungs.
• The remaining drug bound to tissue predominantly in the
kidney and lungs. When administered systemically in large
doses, acute toxic effects (e.g., cardiovascular changes, plasma
and urinary enzyme changes, histologic evidence of cellular
injury to the vital organs) were noted.
• The degree of tissue injury appeared to be closely related, with
some of the changes being reversible in the early stages.
• With the use of isotope-labeled, 19% formaldehyde, the
presence of the drug was demonstrated in the lung, liver,
kidney, muscle, serum, urine and carbon dioxide after 5-minute
application of pulpotomy sites. The concentrations achieved in
the tissues were equivalent to those found after an infusion of
30% of the amount placed in the pulp chamber.
• Pashley and Myers et al (1980) in their study on dogs
determined the fate of the C-formaldehyde following an
application to pulpotomy sites and confirmed (with their
previous finding) that C-formaldehyde containing formocresol
was absorbed from pulpotomy sites and appeared in body
fluids. They concluded that formocresol is absorbed and
distributed rapidly and widely throughout the body within
minutes after being placed on a pulpotomy site.
• Menstrual and reproductive disorder.
• Eye , ear and nose irritation.
• Asthamatic bronchitis
• Dermatitis, rhinitis, wheezing
• Pharyngitis, chronic cough
• Shortness of breath
• Sexual dysfunction
• Possible cancer.
Electrosurgical Pulpotomy
• The rationale of this technique is the tissue of the
coronal pulp is removed during pulpal amputation, a
layer of coagulation necrosis carried by the electro
surgery application provides a barrier between healthy
radicular tissue and any base material placed in the
pulp chamber.
• The odontoblasts are stimulated to form a denim
bridge and the tooth is maintained in the arch with
vital radicular tissue until it exfoliates.
ADVANTAGES:
•Quick
•Self limiting
•Hemostasis
•Good visibility
•No systemic effects
DISADVANTAGES:
•Heat leads to tissue destruction
•Persistent inflammation
•Root resorption
Electrosurgical Pulpotomy
• Step1: Local anesthesia and isolation with a rubber dam
• Step2 :Pulp chamber opened
• Step 3 : Coronal pulp removed
• Step 4: Radicular pulp amputated
• Step 5 : Pulp hemostasis obtained
• Step 6 : Electrosurgical current applied for 2 - 5sec to
pulp stump
• Step 7 : Calcium hydroxide paste placed
• Step 8: Light-cured glass ionomer cement seal obtained
• Step 9: Stainless steel crown .
Histological Findings Of Electrosurgical
Pulpotomy
• The study done by Sheller B et al on eleven human caries –free
deciduous cuspid teeth showed following histological features
• One Hour Posttreatment
• Teeth were free of acute inflammation. Mild signs of chronic
inflammation were restricted to the coronal third of the
radicular pulp. Slight fibrosis was observed in the coronal third
of the teeth.
Six Days Posttreatment
• Histological evaluation revealed acute inflammatory cells limited to the
apical third of the radicular pulp, diffuse edema and necrosis replacing the
entire pulp tissue, and external resorption involving the apical and middle
thirds of the roots.
Thirteen Days Posttreatment
• Acute inflammatory cells were observed in the apical area and there was
external resorption of the apical third of the root.
• Edema, chronic inflammatory cells and localized necrosis involving
apical third .Pulpal calcifications were located in the coronal third of the
radicular pulp.
• Apparently unaffected vital tissue may be present in the middle and apical
thirds of the pulp. Secondary dentin deposits were located on the canal
walls in the coronal portion of the radicular pulp.
Seventeen Days Posttreatment
• There will be acute and chronic inflammatory cells present along with
edema restricted to the coronal third of the pulp. Necrosis was
localized to the pulp to the pulp chamber interface.
• Secondary dentin deposits on the canal walls in the coronal and middle
third of the root.
Seventy Days Posttreatment
• The teeth showed small number of acute and chronic inflammatory cells
restricted to the coronal third of the radicular pulp.
• Secondary dentin deposits were present both as canal wall deposits and
pulpal stones.
One Hundred Days Posttreatment
• Chronic inflammatory infiltrate and edema can be present in the tissue
sub adjacent to pulp amputation.
• Secondary dentin formation includes canal deposits
Laser Pulpotomy
• Patient selection criteria
• Clinically
• Primary teeth required a pulpotomy because of
pulpal exposure to caries.
• Teeth have normal mobility.
• No tenderness to percussion.
• No swelling or fistulation
• Radiographically
• Teeth presented a carious pulpal exposure
without furcation or periapical pathology.
• Root resorption was confirmed to less than
one third of the root.
Laser pulpotomy…
Ebimara (1985) Nd:YAG laser
CO2 LASERS:
PROCEDURE ;
• L.A & isolation
• Excavation & hemorrhage control
• Complete hemostasis by exposure
to Nd:YAG laser at 2 W,20 Hz (100 mJ)
• IRM & composite
• Stainless steel crown
Histological Findings
• In 1996, Wlkerson et al evaluated the clinical,
radiographic and histologic effects of argon laser on vital
pulpotomy of swine teeth. The results showed that
• All soft tissue remained normal
• All teeth exhibited normal mobility
• Reparative dentine formation was noted histologically
• They concluded that use of argon laser for pulpotomy did
not appear to be detrimental to pulp tissues. These studies
led to the use of Nd: YAG laser for pulpotomy in primary
teeth.
Jeng –fen liu (1999)
• Treated 23 teeth – 6 months evaluation, one teeth
showed internal resorption
Peschek et al 2002 -- CO2 laser
Wildersmith 1997 and Day 1998 found CO2 laser
pulpotomy to be very successful
Calcium hydroxide pulpotomy
• Most favored in 1940s and mid 1950s
• Teuscher & Zander (1938)- termed vital
technique; demonstrated necrosis of pulp lying
close to Ca(OH)2 and secondary dentin formation
3 distinct zones :
• Coagulation necrosis
• Deep staining basophilic areas of varied
osteodentin
• Relatively normal pulp( slightly hyperemic)
Indications
• Young permanent tooth owing to its less
cellular activity than the primary
• Mechanical, Carious, Traumatic exposure with
incomplete apical closure
Contraindications
• Not recommended for primary teeth
-Diffuse inflammation
-Internal resorption– Tronstad1988
Procedure
• Anesthesia, isolation
• Caries removed with out pulp exposure
• Deroofing the pulp chamber
• Coronal pulp amputation
• Control of haemorrhage
• Ca(OH)2 placed over the orifice and dried with
cotton pellet
• Quick setting ZOE cement placed over it
• Stainless steel crown (post. teeth)
• Restoration / composite (ant. teeth)
Calcium Hydroxide Pulpotomy Outcomes In Primary
Teeth
• Internal resorption may result from over stimulation of the primary
pulp by the highly alkaline calcium hydroxide. This alkaline
induced over stimulation could cause metaplasia within the pulp
tissue, leading to the formation of odontoclasts. In addition,
undetected microleakage could allow large number of bacterial to
overwhelm the pulp and nullify the beneficial effects of calcium
hydroxide.
• Via, in a 2 year study of calcium hydroxide pulpotomies in primary
teeth, had only a 31% success.
• Law reported only a 49% success in a 1 year study. In year study,
in all investigations, failure rates with hydroxide in pulpotomized
primary molars.
Histological Findings Of Calcium Hydroxide
Pulpotomy –By Siu et al
Short Term Study (Seven Days)
• For seven days in comparison between Life, Dycal
, Nu-Cap and calcium hydroxide in 28 teeth. It
showed that the calcium hydroxide saline paste
causes a greater inflammatory response within
the pulp, and also resulted in wide zone of
mummification. This finding may be associated
with greater alkalinity of the calcium hydroxide
paste.
LONG TERM STUDY (sixty-three days)
• Here, the trend showed increased inflammation with the calcium
hydroxide- saline paste was noted.
• Specific instances of high inflammatory reaction were associated
with deep maceration of the pulp during the initial preparation and
inclusion of dentinal chips and medicaments.
• All medicaments stimulated dentinal bridges , there were important
differences in quality and position. The calcium hydroxide – saline
paste consistently formed thick bridges, but they occurred deep
within the pulp at the junction of the mummified zone and the
normal pulp tissue.
• Excessive and deep bridge formation may result in the areas of
necrotic pulpal tissue, secondary to vascular constriction.
Glutaraldehyde
Advantages
1) Reaction to pulp is irreversible.
2)Molecules of glutaraldehyde do not diffuse out of
apical foramen.
3)It fixes tissue instantly and excess solution is
unnecessary.
4)It is not known to be cytotoxic, mutagenic or
carcinogenic.
5) It has no systemic toxic effects.
• Disadvantages
– Short shelf life.
– It has to be freshly prepared.
– Buffered solution has to be refrigerated.
Properties Of Glutaraldehyde
(Ranly1982,Kennedy1986)
• Superior fixation with relatively little
immunogenecity
• Mild effects on pulp tissue
• Lesser Systemic Distribution
• Positive clinical results (Garcia-Godoy1986,
Fuks et al 1986)
Histologic Features
• Less damage apically and less necrosis
• Less clearly demarcated zones within radicular
tissue.
• No evidence of in growth of granulation tissue.
• Less intense dystrophic calcification limited to
coronal portion of canal
• Fibroblastic proliferation observed
immediately below Glutaraldehyde fixed tissue
in coronal 3rd indicating repair replacement.
Pulpotomy
Glutaradehyde Vs Formocresol
• Ranly and associates recommened 4% buffered
glutaraldehyde with a 4 minute application time or 8% for 2
minutes. Glutaraldehyde seems to be superior to
formaldehyde for pulp canal therapy in many respects.
• Most formaldehyde reactions are reversible , glutaraldehyde
reactions are not as they are bound to protein tissue.
• Formaldehyde is a small molecule and pentrates the
periapical end easily .Glutaraldehyde being a large molecule
does not penetrate into the periapical tissue. Less pulpal
irritation is seen because of less apical diffusion.
• Formaldehyde fixes tissue with a long reaction time and an
excess of solution , glutaraldehyde fixes tissue
instantaneously and an excess of solution is not necessary.
• Zone of inhibition is more restricted following
its application.
• Formocresol caused lysis of PMN and at high
concentration but activation of PMN adherence
at low concentration.
• In contrast glutaraldehyde did not produce
PMN lysis at high concentration, nor did it
cause activation of PMN adherence at low
concentration.
• Ranley has mentioned that it is hard to agree that
two drugs are similarly toxic at equimolar
concentrations.
• Gluteraldehyde excels over formocresol relative to
Cytotoxicity because it is an effective fixative at a
lesser concentration and it does not have
compound cresol, a repulsive ,caustic chemical
that ravages the tissues.
• The effect of glutaraldehyde from available
studies appears to be gentle and, localized.
Pulpotomy
Ferric Sulfate
• Monsels Solution
[20% ferric subsulfate]
• Strong styptic,1st used in military
hospital in Bordeaux ,France 1857 [Larson 1988]
• It was proposed as a Pulpotomy medicament for vital primary
teeth.
• Feraculum Solution 1% [prabhu etal 1997]
• Advantage Over FC
15 sec for manipulation compared to 5 min FC
Histological Findings
• Landau and Johnsen in which ferric sulphate was
used to control hemorrhage before calcium
hydroxide placement.
• Vital pulpal tissue was found at the apical third of all
teeth with ferric sulphate after 60 days, compared
to four of seven teeth in the sterile water calcium
hydroxide control group.
• However, the sample sizes were small and the recall
period was short. Although, the ferric sulphate
technique appeared successful histologically, the
long term effect of this drug on the teeth and rest of
the body was not addressed.
Advantages Of Ferric Sulfate Over Formocresol
• According to Bimstein - replacement of Formocresol with
ferric sulfate in general anesthesia cases, where several
puipotomies have to be done, can reduce systemic toxic
effects caused by Formocresol.
• Manipulation time of 15 seconds for Ferric suifate is
advantageous when compared to 5 min for formocresol,
with same success rates. Systemic distribution of Ferric
suifate is unknown, because the clot avoids distribution
Lemon Additional long-term studies with increased sample
sizes should be conducted before ferric suifate can be
recommended as a substitute for the "gold standard"
formocresol technique.
• Burnett and Walker conducted a retrospective radiographic survey
in order to compare the success rates of ferric sulfate pulpotomies
versus formocresol pulpotomies in a Native American population in
Arizona. The results of comparison shows over 3 times the clinical
failure rate in Ferric sulfate pulpotomies compared to Formocresol
pulpotomies long term success in best with Formocresol and worst
with a combination of formocresol and Ferric sulfate technique.
Results also conformed that radiographic failures are significantly
higher than clinical failures.
• Ibricevic H, AI-Jame Q compared the effects of ferric sulphate to
that of full strength of formocresol as pulpotomy agents in primary
teeth and after long term follow up concluded that ferric sulphate
showed similar clinical and radiographic success rate as
formocresol.
Bone Morphegenic Protien
• In 1938 Levander reported that there must be some
stimulating agent which originated from bone and possibly
a substance which was soluble in lymph tissue.
• Urist referred the bone inducing substance to “Bone
Morphogenic Proteins” which were originally identified by
their presence in bone inductive extracts of demineralized
bone in 1965.
• Inducing substance i.e. Bone Morphorgenic Protein acting
upon a responding cell i.e. - undifferentiated mesenchymal
cell to become progenitor cell. Levander thus concluded
that there is an extractable substance from bone which is
able to activate mesenchymal cells to form tissue.
• Due to their amino acid sequences BMP-2 through BMP-9 are
classified as belonging to the Transforming Growth Factor-
(TGF-B) superfamily.
• Bone Morphogenic proteins are divided into 3 groups
• BMP –2 and BMP-4 form one group having 92% identical
amino acid.
• BMP –5 through BMP-9 form a second group having 82%
identical amino acid.These two groups have 59%homology
with one another and only 45%homology with BMP-3.
• BMP –7 and BMP-8 are also known as osteogenic protein OP-
1 AND OP-2 respectively.
Sources Of Bone Morphogenic Protiens
• BMP exists in the bone matrix (Sampath and
Reddi 1983, Muthukumaran et al 1985)
• Osteosarcoma tissue (Takaaka etal 1980)
• In dentin matrix (Butler et al 1977, Conover and
Urist 1979)
• In wound tissue after tooth extraction (Bessho et
al 1990).
Carrier For Bone Morphogenic Proteins
For the delivery ideally, the carrier for Bone
Morphogenic Protein should be,
-Non collagenous
- Immunogenically inert
- Osteocoiiductive
- Bioabsorbable
Factors influencing the inductive process of
BMP
• Timing of the response (considering both the exposure time
required as well as the time the inducer is capable of
inducing.)
• Location or proximity of competent cells able to respond.
• Concentration.
• In case of Vital Pulp Therapy we have inducing substance
(BMP) acting upon a responding cell (an undifferentiated
mesenchymal cell) to become an osteoprogenitor cell
capable of forming reparative dentin.
• Dental pulp consists of several types of cell including
odontoblast, fibroblasts and undifferentiated mesenchymal
cells. Pulpal fibroblast can be regarded as odontoprogenitor
cells.
Lyophilized Freeze Dried Platelet Derived
Preperation
• Platelet derived growth factor ,insulin growth factor
derived from platelet have generated considerable
intreast in the past.these compounds act as signaling
proteins that could be directly involved in the regulation
of cell proliferation,migration and extra cellular matrix
production in the dental pulp.
• These proteins have been extensively used in oral and
maxillofacial reconstruction adjunctive procedures
related to the placement of osseo integrated implant in
humans and periodontal regeneration.animal and human
invivo and invitro studies have shown that these proteins
stimulates differentiated cell of the pulp to diffrenciate
into odontoblast to deposit a layer of dentin.
• Damle and R. R. Kalaskan et al Compared the
efficiency of lyophilized freeze dried platelet derived
with calcium hydroxide as pulpotomy agents in
primary molars. It was found that success rate of
lyophilized freeze dried platelet derived pulpotomy
proved to be more efficient.
Enamel Matrix Derivatives
• Syngcuk Kim et al in 2004 conducted a study on
enamel matrix derivative induced reparative dentin
formation in a pulpotomy model in pig incisors. The
findings demonstrated that enamel matrix molecules
have the capacity to induce rapid pulpal wound healing
in pulpotomized teeth, and suggest that the longevity
and continued presence of enamel matrix
maromolecules at the application site can be utilized to
stimulate growth and repair of dentin over a period
consistent with a favorable treatment outcome.
PULPOTOMY IN PRIMARY MOLARS USING FORMOCRESOL, FERRIC
SULFATE AND MINERAL TRIOXIDE AGGREGATE
Tajik et al Journal of Dentistry (2006; Vol:3, No.1)
ENAMEL MATRIX DERIVATIVE
Causes bio induction of dentin formation
Method:
Success rate:
Clinical: 90%
Radiographic: 60%
JOE 2008, 34:3 Jumana Sabbarani
MTA vs FC
Ped dent 2005 27:2 ; 145
MTA FC
Success rate: 97% 83%
Pulp canal obliteration: 58% 52%
Pulpotomy
Reasons for failure of pulpotomy therapy
• Erroneous diagnosis of a chronically inflamed radicular pulp as non-
inflame and non-infected.
• The irritating effect of eugenol as a component of the pulp space
filling material.
• Attempt to preserve a tooth with a deep proximal carious lesion a
condition leading to leakage due to incomplete coverage.
• Signs of a failure can be seen on radiographic pathologic signs in
pulp canal obliteration (sometime termed “cacific metamorphosis”),
which can be seen in root canal of pulpotomized primary molars. In
presence, however is not considered as a failure.
CONCLUSION
• No area of treatment in pediatric dentistry has been more
controversial than pulp therapy. In particular, the vital
pulpotomy procedure has been a topic of debate for decades.
• Pulpotomy therapy for the primary dentition has developed a
long three lines: devitalization, preservation, and
regeneration.
• Devitalization, where the intent is to destroy vital tissue, is
typified by formocresol and electrocautery.
• Preservation, the retention of maximum vital tissue with no
induction of reparative dentin, is exemplified by
glutaraldehyde and ferric sulfate treatment.
• Regeneration, the stimulation of a dentin bridge, has long
been associated with calcium hydroxide.
.
• Of the three categories, regeneration is expected to
develop the most rapidly in the coming years.
Advancesin the field of bone morphogenetic protein
(BMP) have opened new vistas in pulp therapy.
Human BMPs with dentinogenic properties are
becoming available through recombinant technology.
• We are now entering an era of pulpotomy therapy
with healing as the guiding principle.
Thank U!

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Pulpotomy

  • 2. CONTENTS • Introduction • Definition • Rationale • Objectives • Indication • Contraindication • Classification • Medicaments used • Techniques • Formocresol pulpotomy • Electrosurgical pulpotomy • Laser pulpotomy • Calcium hydroxide pulpotomy • Glutarldehyde pulpotomy • Ferric sulphate pulpotomy • Recent concepts • Bone morphogenetic protein • Lyophilized freeze dried platelet derived preparation • Enamel matrix derivatives • Reasons for failure of pulpotomy therapy
  • 3. INTRODUCTION • Primary tooth pulp therapy is aimed at preserving the primary teeth until normal exfoliation. • Management of the cariously involved primary tooth where the carious lesion approximates the pulp requires a knowledgeable approach to pulp therapy, and a successful outcome depends on accurate diagnosis of the status of the pulp prior to therapy. • Preliminary data gathering and interpretation must be focused on determining whether the primary tooth pulp is normal, reversibly inflamed, irreversibly inflamed or necrotic.
  • 4. • If it is determined to be vital or reversibly inflamed, the vital pulp therapy techniques of pulpotomy or indirect pulp treatment (IPT) are indicated. • If the pulp is determined to be irreversibly inflamed or necrotic, either a pulpectomy or extraction would be appropriate.
  • 5. • This presentation is limited to a discussion of the vital pulp therapy procedure of pulpotomy for primary teeth.
  • 6. Definition: • Complete removal of the coronal portion of the dental pulp, followed by placement of a suitable dressing or medicament that will promote healing and preserve the vitality of the tooth (Finn,1985). • Pulpotomy is defined as the amputation of vital pulp from the coronal pulp chamber followed by placement of a medicament over the radicular pulp stumps to stimulate repair, fixation or mummification of the remaining vital radicular pulp (Braham and Morris)
  • 7. Rationale:  When the coronal pulp is exposed by trauma or operative procedures, or caries ingress of bacteria, it produces inflammatory changes in the tissue.The surgical excision of the infected and inflamed coronal pulp, the vital uninfected pulpal tissue can be left behind and preserved in the root canal.  The removal of the inflamed portion of the pulp affords temporary, rapid relief of pulpalgia and further may undergo repair while completing apexogenesis that is root end development and calcification.  Materials used for this procedure either mummify or fix the tissue or promote healing by formation of a bridge.
  • 8. Objectives (AAPD Guidelines )  The radicular pulp should remain asymptomatic without adverse clinical signs or symptoms such as sensitivity, pain, or swelling.  There should be no postoperative radiographic evidence of pathologic external root resorption.  Internal root resorption can be self limiting and stable.  The clinician should monitor the internal resorption, removing the affected tooth if perforation causes loss of supportive bone and/or clinical signs of infection and inflammation.  There should be no harm to the succedaneous tooth.
  • 9. • A correct diagnosis of pulp conditions in primary and young permanent teeth is important for treatment planning. • McDonald and Avery have outlined several diagnostic aids in selecting teeth for vital pulp therapy. • Eidelman et al and Prophet and Miller have emphasized that no single diagnostic means can be relied on for determining a diagnosis of pulp conditions. CASE SELECTION
  • 10. • A suggested outline for determining the pulpal status of cariously involved teeth in children involves the following: 1.Visual and tactile examination of carious dentin and associated periodontium 2. Radiographic examination of a. periradicular and furcation areas b. pulp canals c. periodontal space d. developing succedaneous teeth 3. History of spontaneous unprovoked pain 4. Pain from percussion 5. Pain from mastication 6. Degree of mobility 7. Palpation of surrounding soft tissues 8. Size, appearance, and amount of hemorrhage associated with pulp exposures Endodontics : Ingle 5th edi
  • 11. Electric pulp tests are not valid in primary teeth. • Andreasen et al. Textbook and color atlas of traumatic injuries to the teeth. 4th ed, 2007 Thermal tests are usually not conducted on primary teeth because of their unreliability. • Cohen S, Hargreaves K : 9th ed. 2006:822– 82. Numerous studies have reported the unreliability of electric pulp tests in permanent teeth with open and developing apices. • J Dent Child 1978;45:199 –202. • J Endod 1986;12:301–5. • Aust Dent J 1977;22:272–9.
  • 12. Laser Doppler flowmetry might be of greater help in determining vitality. • Endod Dent Traumatol 1999;15:284 –90. • Dent Traumatol 2001;17:63–70 • Endod Top 2003;5:12–25.
  • 13.  Cariously exposed primary teeth, when their retention is more advantageous than extraction.  Vital tooth with healthy periodontium  Pain, if present not spontaneous nor persists after removal of the stimulus  Tooth which is restorable  Tooth with-2/3rd root length  Hemorrhage from the amputation site is pale red & easy to control INDICATION
  • 14.  Absence of abscess and fistula  No inter-radicular bone loss  No inter-radicular radiolucency  On young permanent tooth with vital exposed pulp and incompletely formed apices
  • 15. CONTRAINDICATION  Persistent tooth ache.  Tenderness on percussion / mobility present.  Root resorption more than 1/3rd of root length.  Large carious lesion with non-restorable crown.  Highly viscous, sluggish hemorrhage from canal orifice which is uncontrollable.  Evidence of internal resorption  Presence of inter radicular bone loss  Tooth close to natural exfoliation  Medical contraindications ; immuno- -compromised patient.
  • 16. FACTORS THAT AFFECT PROGNOSIS OF PULPOTOMY:  Size of exposure  Location of exposure  Exposure to saliva  Marginal leakage  Age and status of the pulp (Stahl et al 1970)
  • 17. Evidence of success in therapy includes the following:  Vitality of the majority of the radicular pulp  No prolonged adverse clinical signs or symptoms, such as prolonged sensitivity, pain, or swelling  No radiographic evidence of internal resorption  No breakdown of periradicular tissue  No harm to succedaneous teeth  Pulp canal obliteration (abnormal calcification)
  • 18. CLASSIFICATION • Pulpotomy can be classified according to treatment objectives given by Ranley et al: • Vital pulpotomy I. Devitalization Pulpotomy (Mummification, Cauterization) a. Formocresol pulpotomy. b. Electrosurgical pulpotomy. c. Laser pulpotomy. II. Preservation (Minimal devitalization, Non – inductive) • Gluteraldehyde. • Ferric sulfate.
  • 19. III. Regeneration (Inductive, Reparative) • Calcium Hydroxide. • Bone morph genetic Protein. • Mineral trioxide aggregate II.NON –VITAL PULPOTOMY: - Beechwood cresol – Formocresol
  • 20. Devitalisation: • The first approach to be used with the intention of “mummifying’ the radicular pulp tissue. • The term “mummified” has been ascribed to chemically treated pulp tissue that is inert, sterilized, metabolically suppressed, and incapable of autolysis. This approach involved the original two- sitting formocresol pulpotomy, which resulted in complete devitalization of the radicular pulp. • Also included were the 5- minute formocresol and 1:5 diluted formocresol techniques, which both result in partial devitalization with persistent chronic inflammation.
  • 21. Preservation: • This approach involved medicaments and techniques that provide minimal insult to the orifice tissue and maintain the vitality and normal histologic appearance of the entire radicular pulp. • Pharmacotherapeutic agents included in this category are corticosteroids, glutaraldehyde and ferric sulfate. • Nonpharamcotherpeutic techniques in this category include electrosurgical and laser pulpotomy.
  • 22. Regeneration: • This approach includes pulpotomy agents that have cell- inductive capacity to either replace lost cells or induces existent cells to differentiate into hard tissue forming elements. Examples of true cell- inductive agents include: – Transforming growth factor- (TGF- ) in the form of bone morphogenetic – Proteins freeze dried bone – Mineral trioxide aggregate (MTA)
  • 23. PULPOTOMY MEDICAMENTS • Formocresol (Buckley’s formocresol). • Glutaraldehyde. • Calcium hydroxide. • Zinc oxide eugenol. • Ferric sulphate • Gysi’s paste • Easlick’s paste • Paraform paste • Cresol • Enriched collagen phosphate gel • Collagen calcium phosphate gel
  • 24. • Freeze Dried bone • Enamel matrix derivative
  • 25. Easlick’s Paraformaldehyde Paste • Paraformaldehyde 1g • Procaine base 0.03g • Powered asbestos 0.50g • Petroleum jelly 125g • Carmine To color Materials used for visit pulpotomy
  • 26. Gysi Triopaste • Tricresol 10ml • Cresol 20ml • Glycerin 4ml • Paraformaldehyde 20g • Zinc Oxide eugenol 60g
  • 27. Paraform Devitalizing paste (Modified Easlick’s Paste) • Paraformaldehyde 1g • Lignocaine 0.06g • Propylene glycol 0.50ml • Carbowax 1.3g • Carmine to color
  • 28. Recent materials • Propolis. • Bone Morphegenic Protien • Lyophilized Freeze Dried Platelet Derived Preperation • Hydroxy appatite • Mineral trioxide aggregate • Bioactive Molecules • New endodontic cement. • Calcium enriched cement.
  • 29. Pulpotomy Techniques: There Are Three Pulpotomy Techniques: • Vital Formocresol pulpotomy technique: also known as the 1-minute formocresol. • Devitalization pulpotomy: This is two- stage technique and relied upon paraformaldehyde to fix the coronal and radicular pulp tissue. • Non –vital Pulpotomy: This technique is carried out when the inflammatory process affecting the coronal pulp extends to the radicular pulp leading to an irreversible change in the pulp tissue . •
  • 30. Aramentarium For The Pulptomy Technique • Topical and local Anaesthesia. • Burs No 330 FG high speed and No 8 RA Slow speed. • Rubber dam kit. • Mouth mirror, probe and tweezers. • Cotton pellets (small). • Large and small excavators. • Mixing spatula, flat plastic instrument. • Formocresol, 1/5 dilution. • Dappens pot, syringe. • Zinc oxide eugenol. • Glass ionomer cement for lutting • Stainless steel crown
  • 31. Single Visit Pulpotomy • Step 1: Administration of local anesthesia • Step 2: Apply a rubber dam • Step 3: Use a sterile No.4 or 8 round bur (slow speed) to remove all carious dentin .If possible, remove all carious dentin before exposing the pulp horns • Step 4: Place a No. 330' bur in the high-speed hand piece. Gain occlusal access to the pulp chamber by preparing a Class 1 cavity preparation. It is better to make too large an opening than one that is too small. Remove all overhanging enamel.
  • 32. • Step 5: Excise the pulpal tissue to the orifices of the root canal. Use a large spoon excavator to remove any remaining pulpal tissue.The pulpal tissue should be amputated to the entrance of the root canals. • Step 6: After completing the amputation, evaluate the hemorrhage. If the pulpal tissue has been removed completely, hemorrhage should be minimal.A vital pulp with minimal chronic inflammation should achieve hemostasis in 3 to 5 minutes. • Step 7: Over the exposed pulp stump, place sterile cotton pellet moistened (but not saturated) with formocresol, 20% dilution.
  • 33. • Step 8:Leave the formocresol in place for 1 minute, and then remove the pellet. The pulp stump should appear blackish brown .If there is bleeding, check for residual pulpal tissue. Reapply formocresol for 2 minutes. • Step 9: Fill the pulp chamber to about half its volume with a thick mixture of zinc oxide-eugenol. • Step 10:Prepare the tooth for a stainless steel crown
  • 38. Two Visit Pulpotomy Indications for two-visit pulpotomy procedure in primary teeth are • Inability to arrest hemorrhage from the amputated pulp stumps during a single visit formocresol pulpotomy. • Non-vital coronal and/or radicular pulp without the presence of an abscess.
  • 39. • In two-stage procedure, this involves the use of paraformaldehyde to fix the entire coronal and radicular pulp tissue. The paraformaldehyde paste is most commonly used (Hobson 1970)
  • 40. • The paste is placed over the pulpal exposure on a small pledget of cotton wool, the larger the exposure then the more successful the outcome. • The paraformaldehyde paste is sealed into the cavity with a thin mix of zinc eugenol and left for 1-2 weeks. • Formaldehyde gas liberated from the paraformaldehyde permeates through the coronal and radicular pulp, fixing the tissues. • On the second visit, the dressing is removed, there is no need to administer a local anesthetic as the pulp contents should be nonvital, pulpotomy is carried out and then covered with hard setting zinc oxide cement or alternatively an antiseptic paste (equal parts of eugenol and formocresol with zinc oxide) over the radicular pulp before restoring the tooth. • Hobson (1970) reported a success rate of 77% after 3 years.
  • 41. Non Vital Pulpotomy (Mortal Pulpotomy) • Indications • When the inflammatory process affecting the coronal pulp extends to the radicular pulp leading to an irreversible change in the pulp tissue. • When the pulp is completely non-vital, where there may be an abscess present with or without acute cellulites
  • 42. MEDICAMENTS USED: Constituents of Beechwood cresol • 2 Methoxy, 4 methyl phenol (Cresol) : 13% • Methoxyl phenol (Guaicol) : 47% • M-Methoxy phenol : 7% • P-Methoxy phenol : 26% • Unknown : 7%
  • 43. Technique Ist visit: • The necrotic coronal pulp is first removed, as recommended in the vital pulpotomy technique. • The necrotic debris in the pulp chamber is then cleared. If there is sufficient access to the radicular pulp canals then as much as possible of the necrotic tissue is removed with a small excavator. • A small pledget of cotton wool dipped in beechwood cresol is then sealed into the cavity with temporary zinc oxide eugenol cement.
  • 44. • IInd visit: • Usually 1-2 weeks later the dressing is removed, provided the signs and symptoms of infection have cleared, • The cavity is then restored in the same manner as used in the vital pulpotomy technique. • If it appears that there is no resolution of the symptoms then the beechwood cresol should be replaced for a further 1-2 weeks, • Other medcaments like formocresol and camphorated monochlorophenol (Arnold and Rock, 1993) have been equally effective, at the second visit, after one to two weeks an antiseptic paste that is placed over the radicular pulp remnants before restoring the tooth replaces the antiseptic solution. • Hobson (1970) reported a success rate of 66% after 3 years.
  • 45. Partial Pulpotomy (Cvek’s Pulpotomy) • Definition: It is the removal of only the outer layer of damaged and hyperemic tissue in exposed pulps, is considered to be a procedure staged between pulp capping and complete pulpotomy. It is a mode of treatment which is widely used in the permanent dentition but less so in primary teeth.
  • 46. Radionale And Advantages • The main advantage of Partial pulpotomy is that a successful outcome will allow the continuation of normal development of the tooth, including further root development and maturation. Apex formation and thickening of thin root walls may occur in young teeth. • The tooth following a partial pulpotomy will retain its natural color and translucency in comparison to the coronal discoloration in many teeth undergo after pulpectomy. • Partial pulpotomy have advantage over complete pulpotomy is the preservation of cell rich coronal pulp tissue.
  • 47. Indications• A small and recent pulpal exposure of up to approximately 14 days in a non carious primary incisor. • A sufficient tooth structure is present to allow proper restoration and full coverage of the crown with a bonded resin- composite strip crown. • Partial pulpotomy is highly indicated in a very young tooth with a wide- open apex and very thin root dentin walls. • The decisive factor for selection of the partial pulpotomy and its success is a healthy, non inflammed and asymptomatic vital pulp. • During the procedure, an operative diagnosis should be made by assessing the pulpal with regard to the bleeding from the amputation site, including the color, viscosity, and ability of the tissue to achieve hemostasis
  • 48. Contraindications • Exposure is very large or when more than 2 weeks have passes between injury and treatment time allowing oral contaminants to cause extensive infection or inflammation beyond 2 to 3 mm of the exposure. • Purulent drainage. • History of prolonged pain. • Necrotic debris in canal. • Periapical radiolucency.
  • 49. Technique The clinical procedure is described as follows • Proper patient management should be achieved with or without premedication. • Local anesthesia and rubber dam placement should be administered with the slit technique. • A no. 330 tungsten bur is used to ampute the pulp close to the exposure site to a depth of 2mm. • Continuous rinsing of the amputed pulp with saline will assist in achieving hemostasis without blood clot formation within 4 minutes (if hemostasis is not achieved, all the coronal tissue should be removed and a cervical pulpotomy should be performed).
  • 50. • A dressing of calcium hydroxide paste should be placed followed by base/line of glass ionomer such as Vitrebond. • The tooth is restored using a bonded resin- composite strip crown. • Scheduled follow- ups should be made after 1 month and then every 6 months. A dentin bridge will begin to form, separating the exposure site from the rest of the pulp. The bridge may be evidenced radio graphically after 6 to 8 weeks in future occlusal/ periapical view.
  • 52. Formocresol Pulpotomy • Formocresol was introduced in 1904 by Buckley, who contended that equal parts of formalin and tricresol would react chemically with the intermediate and end products of pulp inflammation to form a “new, colorless, and non- infective compound of harmless nature. • Buckley’s formula of formocresol, consists of tricresol, aqueous formaldehyde, glycerine, and water.
  • 54. Dilution of formocresol • Loos and Han have led to the conclusion that a dilute (1: 5 concentration) of Buckley’s formocresol applied to tissue achieved the desired cellular response. • The orginal buckley’s formula for formocresol calls for equal parts of formaldehyde and cresol. The 1:5 concentration of this formula is prepared by first thoroughly mixing three parts of glycerin with one part of distilled water, then adding four parts of this diluent to one part of Buckley’s Formocresol and thoroughly mixing again.
  • 55. Formocresol concentration • It is therefore recommended that 1/5th concentration formocresol be utilized for pulpotomy procedure since it is as effective as and less damging than the traditional preparation. • In recent years formocresol has been extensively evaluated using animal models. It was concluded that 20% dilution causes the least histologic damage and that a 1 minute application of formocresol is adequate to produce the desired results. • Garcia – Godoy (1984) advocated the use of 20% dilution of formocresol for partial pulpotomies. He showed a success rate 96%.
  • 56. Step 1: Access opening of the carious tooth. Step 2: Removal of coronal part of the carious tooth.
  • 57. Step 3: Formocresol dressing placed on the amputed pulp. Step 4 : Stainless steel crown placed on the pulpotomised tooth.
  • 59. Berger- compared effect of formocresol medication with those ZnOE paste 97% success - formocresol 58% success - ZnOE Rolling and Thylstrup –(1975) 3 year follow up 91% -3months 83% - 12 months 78% - 24 months 70% - 36 months
  • 60. • Buckley 1904 – recommended for treating the putrescent pulp • 5 visit therapy was reduced to 3 visit(1955) • Sweet (1960), advocated single visit, and placement of ZnOE cement containing some formocresol over the pulp stumps– widely accepted
  • 61. • Miyamoto 1974 – suggested 2 visit technique for unco-operative children • Verco and Allen 1984- no difference between single visit and two visit technique • Kennedy and Curzon highlighted the convenience of single visit technique for child and parent
  • 62. Effect on succedaneous tooth YES – • Pruhs et al 1977 , • Messer et al 1980 NO -- • Wright & Widmer 1979, • Rolling & Poulsen 1978, • Fuks & Bimstein 1981, • Mulder et al 1987
  • 63. Histologic investigation of the effect of formocresol on the pulp • Massler and Mansukhani conducted a detailed histologic investigation of the effect of formocresol on the pulps of 43 human primary and permanent teeth in multiple treatment intervals. • Fixation of the tissue directly under the medicament was apparent. After a 7 to 14-day application, the pulps developed three distinctive zones: • A broad eosinophilic zone of fixation • A broad pale-staining zone with poor cellular definition • A zone of inflammation diffusing apically into normal pulp tissue
  • 64. • After 60 days, in a limited number of samples, the remaining tissue was believed to be completely fixed, appearing as a standard of eosinophilic fibrous tissue.In general, the results of many histologic studies on the formocresol pulpotomy have shown that several distinct zones are usually present in the pulp following the application of the medicaments. • Superficial debris along with the dentinal chips at the amputation site • Eosinophil-stained and compressed tissue • A palely stained zone with loss of cellular definition • An area of fibrotic and inflammatory activity • An area of normal-appearing pulp tissue considered to be vital
  • 65. Advantages • Commonly available medicament • Stable at room temperature • Long shelf life • High clinical and radiographic success of formocresol pulpotomy
  • 66. Disadvantages • It is a very caustic medicament. • In high doses it is toxic. • Potential systemic absorption and distribution throughout the body. • It has a mutagenic and carcinogenic potential .
  • 67. Toxicity• Local toxicity • The classical description of a 5 minute application is • Immediately beneath the site of amputation there is eosinophilic tissue interpreted as the zone of fixation. • The next zone is the pale staining amorphous zone with diminished cellular and fiber definition which is the result of lipid dissolving property of cresol. Stagnation necrosis as a consequence of formocresol induced vascular thrombosis. • Broad zone with inflammatory cells first of acute variety and then of chronic variety.
  • 68. • Muller 1978 stated topical application of formalin causes leukoplakia and lesions resembling carcinoma in situ. • Formocresol seeps in through accessory canals into developing tooth germ and causes enamel defects like hypoplasia and might alter position of underlying permanent tooth (Messler 1980) • Jerell and Ronk 1982 described arrested development of bicuspid while Grundy and coworkers in 1984 described cyst in primary teeth treated with formaldehyde
  • 69. Systemic toxicity • After systemic administration of formocresol in experimental animals, formocresol is distributed throughout the body. Metabolism and excretion of a portion of the absorbed formocresol occur in the kidneys and lungs. • The remaining drug bound to tissue predominantly in the kidney and lungs. When administered systemically in large doses, acute toxic effects (e.g., cardiovascular changes, plasma and urinary enzyme changes, histologic evidence of cellular injury to the vital organs) were noted. • The degree of tissue injury appeared to be closely related, with some of the changes being reversible in the early stages.
  • 70. • With the use of isotope-labeled, 19% formaldehyde, the presence of the drug was demonstrated in the lung, liver, kidney, muscle, serum, urine and carbon dioxide after 5-minute application of pulpotomy sites. The concentrations achieved in the tissues were equivalent to those found after an infusion of 30% of the amount placed in the pulp chamber. • Pashley and Myers et al (1980) in their study on dogs determined the fate of the C-formaldehyde following an application to pulpotomy sites and confirmed (with their previous finding) that C-formaldehyde containing formocresol was absorbed from pulpotomy sites and appeared in body fluids. They concluded that formocresol is absorbed and distributed rapidly and widely throughout the body within minutes after being placed on a pulpotomy site.
  • 71. • Menstrual and reproductive disorder. • Eye , ear and nose irritation. • Asthamatic bronchitis • Dermatitis, rhinitis, wheezing • Pharyngitis, chronic cough • Shortness of breath • Sexual dysfunction • Possible cancer.
  • 72. Electrosurgical Pulpotomy • The rationale of this technique is the tissue of the coronal pulp is removed during pulpal amputation, a layer of coagulation necrosis carried by the electro surgery application provides a barrier between healthy radicular tissue and any base material placed in the pulp chamber. • The odontoblasts are stimulated to form a denim bridge and the tooth is maintained in the arch with vital radicular tissue until it exfoliates.
  • 73. ADVANTAGES: •Quick •Self limiting •Hemostasis •Good visibility •No systemic effects DISADVANTAGES: •Heat leads to tissue destruction •Persistent inflammation •Root resorption
  • 74. Electrosurgical Pulpotomy • Step1: Local anesthesia and isolation with a rubber dam • Step2 :Pulp chamber opened • Step 3 : Coronal pulp removed • Step 4: Radicular pulp amputated • Step 5 : Pulp hemostasis obtained
  • 75. • Step 6 : Electrosurgical current applied for 2 - 5sec to pulp stump • Step 7 : Calcium hydroxide paste placed • Step 8: Light-cured glass ionomer cement seal obtained • Step 9: Stainless steel crown .
  • 76. Histological Findings Of Electrosurgical Pulpotomy • The study done by Sheller B et al on eleven human caries –free deciduous cuspid teeth showed following histological features • One Hour Posttreatment • Teeth were free of acute inflammation. Mild signs of chronic inflammation were restricted to the coronal third of the radicular pulp. Slight fibrosis was observed in the coronal third of the teeth.
  • 77. Six Days Posttreatment • Histological evaluation revealed acute inflammatory cells limited to the apical third of the radicular pulp, diffuse edema and necrosis replacing the entire pulp tissue, and external resorption involving the apical and middle thirds of the roots. Thirteen Days Posttreatment • Acute inflammatory cells were observed in the apical area and there was external resorption of the apical third of the root. • Edema, chronic inflammatory cells and localized necrosis involving apical third .Pulpal calcifications were located in the coronal third of the radicular pulp. • Apparently unaffected vital tissue may be present in the middle and apical thirds of the pulp. Secondary dentin deposits were located on the canal walls in the coronal portion of the radicular pulp.
  • 78. Seventeen Days Posttreatment • There will be acute and chronic inflammatory cells present along with edema restricted to the coronal third of the pulp. Necrosis was localized to the pulp to the pulp chamber interface. • Secondary dentin deposits on the canal walls in the coronal and middle third of the root. Seventy Days Posttreatment • The teeth showed small number of acute and chronic inflammatory cells restricted to the coronal third of the radicular pulp. • Secondary dentin deposits were present both as canal wall deposits and pulpal stones. One Hundred Days Posttreatment • Chronic inflammatory infiltrate and edema can be present in the tissue sub adjacent to pulp amputation. • Secondary dentin formation includes canal deposits
  • 79. Laser Pulpotomy • Patient selection criteria • Clinically • Primary teeth required a pulpotomy because of pulpal exposure to caries. • Teeth have normal mobility. • No tenderness to percussion. • No swelling or fistulation
  • 80. • Radiographically • Teeth presented a carious pulpal exposure without furcation or periapical pathology. • Root resorption was confirmed to less than one third of the root.
  • 81. Laser pulpotomy… Ebimara (1985) Nd:YAG laser CO2 LASERS: PROCEDURE ; • L.A & isolation • Excavation & hemorrhage control • Complete hemostasis by exposure to Nd:YAG laser at 2 W,20 Hz (100 mJ) • IRM & composite • Stainless steel crown
  • 82. Histological Findings • In 1996, Wlkerson et al evaluated the clinical, radiographic and histologic effects of argon laser on vital pulpotomy of swine teeth. The results showed that • All soft tissue remained normal • All teeth exhibited normal mobility • Reparative dentine formation was noted histologically • They concluded that use of argon laser for pulpotomy did not appear to be detrimental to pulp tissues. These studies led to the use of Nd: YAG laser for pulpotomy in primary teeth.
  • 83. Jeng –fen liu (1999) • Treated 23 teeth – 6 months evaluation, one teeth showed internal resorption Peschek et al 2002 -- CO2 laser Wildersmith 1997 and Day 1998 found CO2 laser pulpotomy to be very successful
  • 84. Calcium hydroxide pulpotomy • Most favored in 1940s and mid 1950s • Teuscher & Zander (1938)- termed vital technique; demonstrated necrosis of pulp lying close to Ca(OH)2 and secondary dentin formation 3 distinct zones : • Coagulation necrosis • Deep staining basophilic areas of varied osteodentin • Relatively normal pulp( slightly hyperemic)
  • 85. Indications • Young permanent tooth owing to its less cellular activity than the primary • Mechanical, Carious, Traumatic exposure with incomplete apical closure Contraindications • Not recommended for primary teeth -Diffuse inflammation -Internal resorption– Tronstad1988
  • 86. Procedure • Anesthesia, isolation • Caries removed with out pulp exposure • Deroofing the pulp chamber • Coronal pulp amputation • Control of haemorrhage • Ca(OH)2 placed over the orifice and dried with cotton pellet • Quick setting ZOE cement placed over it • Stainless steel crown (post. teeth) • Restoration / composite (ant. teeth)
  • 87. Calcium Hydroxide Pulpotomy Outcomes In Primary Teeth • Internal resorption may result from over stimulation of the primary pulp by the highly alkaline calcium hydroxide. This alkaline induced over stimulation could cause metaplasia within the pulp tissue, leading to the formation of odontoclasts. In addition, undetected microleakage could allow large number of bacterial to overwhelm the pulp and nullify the beneficial effects of calcium hydroxide. • Via, in a 2 year study of calcium hydroxide pulpotomies in primary teeth, had only a 31% success. • Law reported only a 49% success in a 1 year study. In year study, in all investigations, failure rates with hydroxide in pulpotomized primary molars.
  • 88. Histological Findings Of Calcium Hydroxide Pulpotomy –By Siu et al Short Term Study (Seven Days) • For seven days in comparison between Life, Dycal , Nu-Cap and calcium hydroxide in 28 teeth. It showed that the calcium hydroxide saline paste causes a greater inflammatory response within the pulp, and also resulted in wide zone of mummification. This finding may be associated with greater alkalinity of the calcium hydroxide paste.
  • 89. LONG TERM STUDY (sixty-three days) • Here, the trend showed increased inflammation with the calcium hydroxide- saline paste was noted. • Specific instances of high inflammatory reaction were associated with deep maceration of the pulp during the initial preparation and inclusion of dentinal chips and medicaments. • All medicaments stimulated dentinal bridges , there were important differences in quality and position. The calcium hydroxide – saline paste consistently formed thick bridges, but they occurred deep within the pulp at the junction of the mummified zone and the normal pulp tissue. • Excessive and deep bridge formation may result in the areas of necrotic pulpal tissue, secondary to vascular constriction.
  • 90. Glutaraldehyde Advantages 1) Reaction to pulp is irreversible. 2)Molecules of glutaraldehyde do not diffuse out of apical foramen. 3)It fixes tissue instantly and excess solution is unnecessary. 4)It is not known to be cytotoxic, mutagenic or carcinogenic. 5) It has no systemic toxic effects.
  • 91. • Disadvantages – Short shelf life. – It has to be freshly prepared. – Buffered solution has to be refrigerated.
  • 92. Properties Of Glutaraldehyde (Ranly1982,Kennedy1986) • Superior fixation with relatively little immunogenecity • Mild effects on pulp tissue • Lesser Systemic Distribution • Positive clinical results (Garcia-Godoy1986, Fuks et al 1986)
  • 93. Histologic Features • Less damage apically and less necrosis • Less clearly demarcated zones within radicular tissue. • No evidence of in growth of granulation tissue. • Less intense dystrophic calcification limited to coronal portion of canal • Fibroblastic proliferation observed immediately below Glutaraldehyde fixed tissue in coronal 3rd indicating repair replacement.
  • 95. Glutaradehyde Vs Formocresol • Ranly and associates recommened 4% buffered glutaraldehyde with a 4 minute application time or 8% for 2 minutes. Glutaraldehyde seems to be superior to formaldehyde for pulp canal therapy in many respects. • Most formaldehyde reactions are reversible , glutaraldehyde reactions are not as they are bound to protein tissue. • Formaldehyde is a small molecule and pentrates the periapical end easily .Glutaraldehyde being a large molecule does not penetrate into the periapical tissue. Less pulpal irritation is seen because of less apical diffusion. • Formaldehyde fixes tissue with a long reaction time and an excess of solution , glutaraldehyde fixes tissue instantaneously and an excess of solution is not necessary.
  • 96. • Zone of inhibition is more restricted following its application. • Formocresol caused lysis of PMN and at high concentration but activation of PMN adherence at low concentration. • In contrast glutaraldehyde did not produce PMN lysis at high concentration, nor did it cause activation of PMN adherence at low concentration.
  • 97. • Ranley has mentioned that it is hard to agree that two drugs are similarly toxic at equimolar concentrations. • Gluteraldehyde excels over formocresol relative to Cytotoxicity because it is an effective fixative at a lesser concentration and it does not have compound cresol, a repulsive ,caustic chemical that ravages the tissues. • The effect of glutaraldehyde from available studies appears to be gentle and, localized.
  • 99. Ferric Sulfate • Monsels Solution [20% ferric subsulfate] • Strong styptic,1st used in military hospital in Bordeaux ,France 1857 [Larson 1988] • It was proposed as a Pulpotomy medicament for vital primary teeth. • Feraculum Solution 1% [prabhu etal 1997] • Advantage Over FC 15 sec for manipulation compared to 5 min FC
  • 100. Histological Findings • Landau and Johnsen in which ferric sulphate was used to control hemorrhage before calcium hydroxide placement. • Vital pulpal tissue was found at the apical third of all teeth with ferric sulphate after 60 days, compared to four of seven teeth in the sterile water calcium hydroxide control group. • However, the sample sizes were small and the recall period was short. Although, the ferric sulphate technique appeared successful histologically, the long term effect of this drug on the teeth and rest of the body was not addressed.
  • 101. Advantages Of Ferric Sulfate Over Formocresol • According to Bimstein - replacement of Formocresol with ferric sulfate in general anesthesia cases, where several puipotomies have to be done, can reduce systemic toxic effects caused by Formocresol. • Manipulation time of 15 seconds for Ferric suifate is advantageous when compared to 5 min for formocresol, with same success rates. Systemic distribution of Ferric suifate is unknown, because the clot avoids distribution Lemon Additional long-term studies with increased sample sizes should be conducted before ferric suifate can be recommended as a substitute for the "gold standard" formocresol technique.
  • 102. • Burnett and Walker conducted a retrospective radiographic survey in order to compare the success rates of ferric sulfate pulpotomies versus formocresol pulpotomies in a Native American population in Arizona. The results of comparison shows over 3 times the clinical failure rate in Ferric sulfate pulpotomies compared to Formocresol pulpotomies long term success in best with Formocresol and worst with a combination of formocresol and Ferric sulfate technique. Results also conformed that radiographic failures are significantly higher than clinical failures. • Ibricevic H, AI-Jame Q compared the effects of ferric sulphate to that of full strength of formocresol as pulpotomy agents in primary teeth and after long term follow up concluded that ferric sulphate showed similar clinical and radiographic success rate as formocresol.
  • 103. Bone Morphegenic Protien • In 1938 Levander reported that there must be some stimulating agent which originated from bone and possibly a substance which was soluble in lymph tissue. • Urist referred the bone inducing substance to “Bone Morphogenic Proteins” which were originally identified by their presence in bone inductive extracts of demineralized bone in 1965. • Inducing substance i.e. Bone Morphorgenic Protein acting upon a responding cell i.e. - undifferentiated mesenchymal cell to become progenitor cell. Levander thus concluded that there is an extractable substance from bone which is able to activate mesenchymal cells to form tissue.
  • 104. • Due to their amino acid sequences BMP-2 through BMP-9 are classified as belonging to the Transforming Growth Factor- (TGF-B) superfamily. • Bone Morphogenic proteins are divided into 3 groups • BMP –2 and BMP-4 form one group having 92% identical amino acid. • BMP –5 through BMP-9 form a second group having 82% identical amino acid.These two groups have 59%homology with one another and only 45%homology with BMP-3. • BMP –7 and BMP-8 are also known as osteogenic protein OP- 1 AND OP-2 respectively.
  • 105. Sources Of Bone Morphogenic Protiens • BMP exists in the bone matrix (Sampath and Reddi 1983, Muthukumaran et al 1985) • Osteosarcoma tissue (Takaaka etal 1980) • In dentin matrix (Butler et al 1977, Conover and Urist 1979) • In wound tissue after tooth extraction (Bessho et al 1990).
  • 106. Carrier For Bone Morphogenic Proteins For the delivery ideally, the carrier for Bone Morphogenic Protein should be, -Non collagenous - Immunogenically inert - Osteocoiiductive - Bioabsorbable
  • 107. Factors influencing the inductive process of BMP • Timing of the response (considering both the exposure time required as well as the time the inducer is capable of inducing.) • Location or proximity of competent cells able to respond. • Concentration. • In case of Vital Pulp Therapy we have inducing substance (BMP) acting upon a responding cell (an undifferentiated mesenchymal cell) to become an osteoprogenitor cell capable of forming reparative dentin. • Dental pulp consists of several types of cell including odontoblast, fibroblasts and undifferentiated mesenchymal cells. Pulpal fibroblast can be regarded as odontoprogenitor cells.
  • 108. Lyophilized Freeze Dried Platelet Derived Preperation • Platelet derived growth factor ,insulin growth factor derived from platelet have generated considerable intreast in the past.these compounds act as signaling proteins that could be directly involved in the regulation of cell proliferation,migration and extra cellular matrix production in the dental pulp. • These proteins have been extensively used in oral and maxillofacial reconstruction adjunctive procedures related to the placement of osseo integrated implant in humans and periodontal regeneration.animal and human invivo and invitro studies have shown that these proteins stimulates differentiated cell of the pulp to diffrenciate into odontoblast to deposit a layer of dentin.
  • 109. • Damle and R. R. Kalaskan et al Compared the efficiency of lyophilized freeze dried platelet derived with calcium hydroxide as pulpotomy agents in primary molars. It was found that success rate of lyophilized freeze dried platelet derived pulpotomy proved to be more efficient.
  • 110. Enamel Matrix Derivatives • Syngcuk Kim et al in 2004 conducted a study on enamel matrix derivative induced reparative dentin formation in a pulpotomy model in pig incisors. The findings demonstrated that enamel matrix molecules have the capacity to induce rapid pulpal wound healing in pulpotomized teeth, and suggest that the longevity and continued presence of enamel matrix maromolecules at the application site can be utilized to stimulate growth and repair of dentin over a period consistent with a favorable treatment outcome.
  • 111. PULPOTOMY IN PRIMARY MOLARS USING FORMOCRESOL, FERRIC SULFATE AND MINERAL TRIOXIDE AGGREGATE Tajik et al Journal of Dentistry (2006; Vol:3, No.1)
  • 112. ENAMEL MATRIX DERIVATIVE Causes bio induction of dentin formation Method: Success rate: Clinical: 90% Radiographic: 60% JOE 2008, 34:3 Jumana Sabbarani
  • 113. MTA vs FC Ped dent 2005 27:2 ; 145 MTA FC Success rate: 97% 83% Pulp canal obliteration: 58% 52%
  • 115. Reasons for failure of pulpotomy therapy • Erroneous diagnosis of a chronically inflamed radicular pulp as non- inflame and non-infected. • The irritating effect of eugenol as a component of the pulp space filling material. • Attempt to preserve a tooth with a deep proximal carious lesion a condition leading to leakage due to incomplete coverage. • Signs of a failure can be seen on radiographic pathologic signs in pulp canal obliteration (sometime termed “cacific metamorphosis”), which can be seen in root canal of pulpotomized primary molars. In presence, however is not considered as a failure.
  • 116. CONCLUSION • No area of treatment in pediatric dentistry has been more controversial than pulp therapy. In particular, the vital pulpotomy procedure has been a topic of debate for decades. • Pulpotomy therapy for the primary dentition has developed a long three lines: devitalization, preservation, and regeneration. • Devitalization, where the intent is to destroy vital tissue, is typified by formocresol and electrocautery. • Preservation, the retention of maximum vital tissue with no induction of reparative dentin, is exemplified by glutaraldehyde and ferric sulfate treatment. • Regeneration, the stimulation of a dentin bridge, has long been associated with calcium hydroxide. .
  • 117. • Of the three categories, regeneration is expected to develop the most rapidly in the coming years. Advancesin the field of bone morphogenetic protein (BMP) have opened new vistas in pulp therapy. Human BMPs with dentinogenic properties are becoming available through recombinant technology. • We are now entering an era of pulpotomy therapy with healing as the guiding principle.