The lecture has been given on Feb. 5th, 2011 by Dr. Mohammad Shaikhani.

1. Motor neuron disease MND:ALS Dr. Mohammad Shaikhani.

9. MND (ALS):

14. Clinical features: course Signs Signs Symptoms often begin focally in one part & spread gradually but eventually become widespread

15. Clinical features: involvement patterns Signs Signs 1.Progressive muscular atrophy Predominantly spinal motor neurons affected Weakness / wasting of distal limb muscles at first Fasciculation in muscles Tendon reflexes may be absent

18. DD: Signs Signs

27. TYPES OF SPINAL MUSCULAR ATROPHY Good Facial / bulbar weakness, proximal limb weakness, gynaecomastia X-linked Adult life, males only Bulbospinal Good, seldom disabling Distal weakness and wasting of hands and feet Autosomal dominant Early adult life Distal forms Slowly progressive disability Proximal weakness and wasting, EMG shows denervation Autosomal recessive Childhood, adolescence Kugelberg-Welander Poor Severe muscle-wasting/weakness Autosomal recessive Infancy Werdnig-Hoffmann Prognosis Features Inheritance Onset Type