Medicine 5th year, 8th lecture/part one (Dr. Sabir)

Hemolysis and Hemolytic Anemias Dr. Sabir

Hemolytic Anemias-Introduction ,[object Object],[object Object],[object Object]

General Clinical Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemolytic Anemias - Classification Schemes ,[object Object],[object Object],[object Object]

Hemolytic Anemias - Sites of Red Cell Destruction ,[object Object],[object Object],[object Object],[object Object]

Laboratory Evidence for Presence of Hemolysis ,[object Object],[object Object]

Evidence for increased red cell production ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Polychromatophilic cell on Wright-Giemsa staining Reticulocytes (supravital staining)

Erythroid Hyperplasia ,[object Object],[object Object],[object Object]

Frontal Bossing Results from increased erythropoietic activity and marrow space expansion

Evidence for Increased Red Cell Destruction ,[object Object],[object Object],[object Object],[object Object],[object Object]

Biochemical consequences of hemolysis in general ,[object Object],[object Object],[object Object],[object Object]

Biochemical Consequences of Intravascular Hemolysis ,[object Object],[object Object],[object Object],[object Object]

Hemolytic Anemias - Classification by Etiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Congenital Hemolytic Anemias- Membrane Defects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hereditary Spherocytosis ,[object Object],[object Object]

Hereditary Spherocytosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HEREDITARY SPHEROCYTOSIS Osmotic Fragility

Osmotic Fragility Normal Abnormal- HS cells lyse more readily at low ionic strength

Congenital Hemolytic Anemias Enzyme Defects

Red Cell Enzyme Defects ,[object Object],[object Object],[object Object]

RBC Metabolism Simplified Glucose Anaerobic glycolysis Aerobic metabolism Glucose-6-P G6PD ,[object Object],[object Object],F-6-P

G6PD Deficiency Pathophysiology ,[object Object],[object Object],[object Object]

G6PD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

G6PD Deficiency Agents to avoid ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Blister cell

Favism ,[object Object],[object Object],[object Object]

G6PD Deficiency Clinical Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object]

Congenital Hemolytic Anemias Hemoglobinopathies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acquired Hemolytic Anemias Immune-Mediated Hemolysis

Pathophysiology ,[object Object],[object Object],[object Object]

Immune hemolytic anemias - Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Auto-Immune Hemolytic Anemias ,[object Object],[object Object],[object Object],[object Object]

Coomb’s Test ,[object Object],[object Object]

Direct Coomb’s Test Patient’s RBCs coated with IgG or C3 Antibodies to human IgG/C3 (Coomb’s reagent) Agglutinationin the test tube

Indirect Coomb’s Test Agglutinationin the test tube Patient serum containing anti RBC Abs Normal RBCs and Coomb’s reagent

Warm-Antibody Hemolytic Anemias ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Spherocyte Formation Progressive loss of membrane, loss of surface area, more spherocytic shape

Warm-Antibody Hemolytic Anemias Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Warm Autoimmune Hemolytic Anemia - spherocytes

Warm-Antibody Hemolytic Anemias Treatment ,[object Object],[object Object]

Warm-Antibody Hemolytic Anemias Immunosuppressive Treatment ,[object Object],[object Object],[object Object],[object Object]

Cold Agglutinin Disease ,[object Object],[object Object],[object Object]

Digital ischemia from cold-agglutinin disease

Cold Agglutinin Disease Clinical features ,[object Object],[object Object],[object Object],[object Object],[object Object]

Paroxysmal Nocturnal Hemoglobinuria ,[object Object],[object Object],[object Object],[object Object]

Paroxysmal Nocturnal Hemoglobinuria - Clinical features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Non-Immune Hemolytic Anemia Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Microangiopathic Hemolytic Anemias ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Macroangiopathic Hemolytic Anemias ,[object Object],[object Object],[object Object],[object Object]

March Hemoglobinuria ,[object Object],[object Object],[object Object]

Hemolysis from Infections ,[object Object],[object Object],[object Object],[object Object]

Hemolysis Associated with Chemical and Physical Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]

Medicine 5th year, 8th lecture/part one (Dr. Sabir)

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Medicine 5th year, 8th lecture/part one (Dr. Sabir)