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why life birth rate after ART declined?
- 5. I.EmbryoSelection
1.BSC:
▪2/3offreshIVFcyclesutilizedBSC(CDC,2016).
▪Developedasanembryoselectionmethodin
goodprognosispatients
▪Fornoobviousreasonsbecamearoutinefor
almosteverybody.
▪NoimprovementincumulativePRor
implantationratesinfirsttransfersinanypatient
populationbutgoodprognosispatients(DeVoset
al.,2016;Glujovskyetal.,2016)
2.eSET
▪uniformincreasesinAustralia/NewZealand,Japan,
UK,Canada{Kushniretal.,2017):
▪eSET,vsdoubleET:
▪reducesCPR(McLernonetal.,2010).
▪compensatoryincreasesinIVFcyclesstarted
(Kushniretal.,2017).
- 8. 4.PGS/PGT-A.
▪IneffectiveinimprovingIVFoutcomes{ASRMand
SocietyforART2018).
▪Highfalse-positivityrate(Munnéetal.,2017;Victoretal.,2019).
▪largenumberofperfectlynormalembryosare
nowroutinelydiscardedwhich,iftransferred:high
percentagesofnormalbirths
▪Inpoorerprognosispatients,PGS/PGTAaffects
IVFpregnancychancesnegatively.
▪Inunselectedpatientpopulations,PGS/PGT-A
actuallyreducesLBR(Kushniretal.,2016).
II.MildOvarianStimulation
▪:greatlyreducedeggnumbersincomparisonto
standardovarianstimulations(Kushniretal.,2016,2017).
▪Afterawoman’sage,transferrableembryo
numbersarethebestpredictorsofIVFsuccess
(Gleicheretal.,2016).
- 12. ❑YoucangetThislecture&455lecturesfrom:
1.MyscientificpageonFacebook:
AboubakrElnasharLectures.
https://www.facebook.com/groups/227744884
091351/
2.Slidesharewebsite
3.elnashar53@hotmail.com
▪Alllecturesfrom:
Myclinic,3AlthawraSt.Almansura
AboubakrElnashar
▪As‘Forbes’reported(Helft,2016),serialentrepreneur
MartinVarsavsky,witha$200millionbudget,launched
‘Prelude’,describedasa‘comprehensivefertilitycompany
focusedonproactivefertilitycaretoimprovepeople’s
chancesofhavinghealthybabieswhenthey’reready’ina
four-stepprocess:
1.fertilitypreservationthroughfreezingofeggsandsperm
atpeakfertility(ages20stoearly30s);
2.embryocreationinthelaboratorywhenclientsareready
tostartafamily(inotherwords,whatisproposedisthe
endofconceptionviaintercourse),and
3.eggsandspermareunfrozenandembryosarecreated;
4.geneticscreening,whereembryosaretestedfor
chromosomalabnormalitiesandgeneticmutationsbefore
transfer;andeSET.
▪Preludeis,thus,aremarkableaccumulationofrecentadd-