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Case presentation Suad Al-Sulimani
outline Case presentation Case discussion Topic review
23 years old male sudden onset of SOB         & palpitation   1 day duration
Primary survey
Generally: A:patent  no secretion Anxious , Irritable , sweaty Contious , orianted
B: Dyspnic RR:22/min spo2  100% in RA Chest : clear  Generally: Anxious hyperventilating Contious , orianted A: patent  no secretion
B: Dyspnic RR:22/min spo2 100% in RA Chest : bilaterally clear Generally Anxious hyperventilating Contious , orianted A: patent  no secretion C: Pr:140/min (regular , good volume) bp164/90 mmhg
B: Dyspnic RR:22/min spo2 98%  in RA Chest : clear  Generally: Anxious hyperventilating Contious , orianted A: patent  no secretion C: Pr:140/min  ( regular , good volume) Bp 164/90mmhg D: Reflow:6.8 Pupils: bilaterally reactive  GCS: 15/15
B: Dyspnic RR:22/min spo2 98% with 100% o2 Chest : clear  Generally: Anxious hyperventilating Contious , orianted A: patent  no secretion E: No obvious external injuries or bleeding  Temp:afebrile C: Pr:140/min (regular , good volume ) bp150/60 D: Reflow:6.8 Pupils:bilaterally reactive  GCS: 15/15
history = young male , unmarried , work as water tank driver  = after stressful event at home, was driving his car , suddenly has sob , palpitation , became dizzy  = stopped the car , call for help  = associated chest pain :unspecific , left sidedchest , burning , withsweating
Since 3 mounths , have onn/off chest pain , mainly after stress , not related to excertions , associated with sweating & palpitation
No cough or fever No GI symptoms No h/o contact with sick person No recent travel. Never smoke or drink alcohol. Denying h/o drug intake  No FH of sudden death or CAD
Examination: Hyperventilating  Not ecteric , no skin rash , not dehydrated  , no neck stiffness  Fundoscopy : no papilodema JVP:not raised, no pedal edema Chest:, clear CVS: normal s1s2, no added sounds  Abdomen is soft, no hepatomegaly.
Differential diagnosis Cardiac :Arrhythmias ,ACS ,Cardiomyopathy Pericarditis  Respiratory :Pulmonary embolism  Endocrine : Hyperthyrodism ( thyroid storm ) , Phyochromocytoma Drug overdose : sympethatomimatic , anticholenergic Psychological :Hyperventilation , anxiety disorders
ECG
Chest x-ray
Trop T  < .014, repeated Trop T <.014
Action taking Midazolam total of 13 mg         ABG : Po2 118 , PH 7.4 , Pco2 22
Bedside Echo ( done by cardiologist ): Normal , good EF , no evidence of pericarditis
[object Object]
Urea:3.8, creat:68, K: 4.3, Na:143
Salicylate level :normal
TSH < .003 (.35-4.9 )
Free T4  42 .6 (8.2 – 22.6 )
LFT : normal  , CK : normal , bone profile WNR ,[object Object]
Admitted in HiDe , monitored for 48 hrs Remain tachycardia ,PR 128/min , high BP 180/70 , maintaining sat , c/o sweating  His BP controlled with IV Labetelol  Started on Propranolol  Carbimazol & lugol’s iodenine solution 1 ml tid for 1 week
BP controlled , PR improved 100/min , 80/min 24-hour urine catecholamines and metanephrines was done , came as normal Discharged home after 4 days on Carbimazol &n Propranolol with f/u appointment in Endocrine clinic
Thyroid Storm
Thyroid Storm The overall incidence of hyperthyroidism is estimated between 0.05% and 1.3% Thyroid storm is a rare disorder. Approximately 1-2% of patients with hyperthyroidism progress to thyroid storm  Mortality approximately 10-20%, but it has been reported to be as high as 75% in hospitalized populations. Underlying precipitating illness may contribute to high mortality.
[object Object],symptoms get worse One major sign of thyroid storm that differentiates it from plain hyperthyroidism is a marked elevation of body temperature, which may be as high as 105-106 ºF a life-threatening emergency
Thyroid Storm Causes Untreated hyperthyrodism Infections, especially of the lung   Thyroid surgery in patients with overactive thyroid gland Stopping medications given for hyperthyroidism  Too high of thyroid dose  Treatment with radioactive iodine Pregnancy Heart attack or heart emergencies  Emotional stress 
Thyroid Storm Symptoms Rapid heart beats  Greatly increased body temperatur Chest pain Shortness of breath  Anxiety and irritability  Disorientation  Increased sweating  Weakness  Heart failure
Fever ranges from 100.4-105.5.  The pulse rate may range between 120 and 200 beats per minute but has been reported as high as 300 . . . sweating so profuse  as to lead to dehydration from insensible fluid loss . . .

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Case presentation raa

  • 2. outline Case presentation Case discussion Topic review
  • 3. 23 years old male sudden onset of SOB & palpitation 1 day duration
  • 5. Generally: A:patent no secretion Anxious , Irritable , sweaty Contious , orianted
  • 6. B: Dyspnic RR:22/min spo2 100% in RA Chest : clear Generally: Anxious hyperventilating Contious , orianted A: patent no secretion
  • 7. B: Dyspnic RR:22/min spo2 100% in RA Chest : bilaterally clear Generally Anxious hyperventilating Contious , orianted A: patent no secretion C: Pr:140/min (regular , good volume) bp164/90 mmhg
  • 8. B: Dyspnic RR:22/min spo2 98% in RA Chest : clear Generally: Anxious hyperventilating Contious , orianted A: patent no secretion C: Pr:140/min ( regular , good volume) Bp 164/90mmhg D: Reflow:6.8 Pupils: bilaterally reactive GCS: 15/15
  • 9. B: Dyspnic RR:22/min spo2 98% with 100% o2 Chest : clear Generally: Anxious hyperventilating Contious , orianted A: patent no secretion E: No obvious external injuries or bleeding Temp:afebrile C: Pr:140/min (regular , good volume ) bp150/60 D: Reflow:6.8 Pupils:bilaterally reactive GCS: 15/15
  • 10. history = young male , unmarried , work as water tank driver = after stressful event at home, was driving his car , suddenly has sob , palpitation , became dizzy = stopped the car , call for help = associated chest pain :unspecific , left sidedchest , burning , withsweating
  • 11. Since 3 mounths , have onn/off chest pain , mainly after stress , not related to excertions , associated with sweating & palpitation
  • 12. No cough or fever No GI symptoms No h/o contact with sick person No recent travel. Never smoke or drink alcohol. Denying h/o drug intake No FH of sudden death or CAD
  • 13. Examination: Hyperventilating Not ecteric , no skin rash , not dehydrated , no neck stiffness Fundoscopy : no papilodema JVP:not raised, no pedal edema Chest:, clear CVS: normal s1s2, no added sounds Abdomen is soft, no hepatomegaly.
  • 14. Differential diagnosis Cardiac :Arrhythmias ,ACS ,Cardiomyopathy Pericarditis Respiratory :Pulmonary embolism Endocrine : Hyperthyrodism ( thyroid storm ) , Phyochromocytoma Drug overdose : sympethatomimatic , anticholenergic Psychological :Hyperventilation , anxiety disorders
  • 15. ECG
  • 17. Trop T < .014, repeated Trop T <.014
  • 18. Action taking Midazolam total of 13 mg ABG : Po2 118 , PH 7.4 , Pco2 22
  • 19. Bedside Echo ( done by cardiologist ): Normal , good EF , no evidence of pericarditis
  • 20.
  • 23. TSH < .003 (.35-4.9 )
  • 24. Free T4 42 .6 (8.2 – 22.6 )
  • 25.
  • 26. Admitted in HiDe , monitored for 48 hrs Remain tachycardia ,PR 128/min , high BP 180/70 , maintaining sat , c/o sweating His BP controlled with IV Labetelol Started on Propranolol Carbimazol & lugol’s iodenine solution 1 ml tid for 1 week
  • 27. BP controlled , PR improved 100/min , 80/min 24-hour urine catecholamines and metanephrines was done , came as normal Discharged home after 4 days on Carbimazol &n Propranolol with f/u appointment in Endocrine clinic
  • 29. Thyroid Storm The overall incidence of hyperthyroidism is estimated between 0.05% and 1.3% Thyroid storm is a rare disorder. Approximately 1-2% of patients with hyperthyroidism progress to thyroid storm Mortality approximately 10-20%, but it has been reported to be as high as 75% in hospitalized populations. Underlying precipitating illness may contribute to high mortality.
  • 30.
  • 31. Thyroid Storm Causes Untreated hyperthyrodism Infections, especially of the lung  Thyroid surgery in patients with overactive thyroid gland Stopping medications given for hyperthyroidism Too high of thyroid dose Treatment with radioactive iodine Pregnancy Heart attack or heart emergencies  Emotional stress 
  • 32. Thyroid Storm Symptoms Rapid heart beats Greatly increased body temperatur Chest pain Shortness of breath Anxiety and irritability Disorientation Increased sweating Weakness Heart failure
  • 33. Fever ranges from 100.4-105.5.  The pulse rate may range between 120 and 200 beats per minute but has been reported as high as 300 . . . sweating so profuse  as to lead to dehydration from insensible fluid loss . . .
  • 34. Medical Treatment A complete evaluation to determine the cause of thyroid storm Intravenous fluids and electrolytes Oxygen if needed  Fever control with antipyretics (fever-reducing medications) and if needed cooling blankets Intravenous corticosteroids such as hydrocortisone
  • 35. Defenitivetratment Medications to block the production of thyroid hormones, such as propylthiouracil (PTU) or methimazole Iodide to block thyroid hormone release Block the action of thyroid hormones on the cells by drugs called beta-blockers, such as propranolol (Inderal)  Treatment of heart failure if present
  • 36. Next Steps Following the start of treatment, careful monitoring, usually in the intensive care unit, is necessary. Following recovery from thyroid storm, options for definitive treatment are radioactiveiodine or antithyroid medications; surgery is rarely needed.
  • 37. Rescue PCI Rescue PCI is reasonable for selected patients 75 years or older with ST elevation or LBBB or who develop shock within 36 hours of MI It is reasonable to perform rescue PCI for patients with one or more of the following: a. Hemodynamic or electrical instability b. Persistent ischemic symptoms.