SlideShare une entreprise Scribd logo
1  sur  5
Télécharger pour lire hors ligne
THE REGULATORY T
CELLS (TREGS
Eman youssif
F O R M E R L Y K N O W N A S S U P P R E S S O R T C E L L S , A R E A
S U B P O P U L A T I O N O F T C E L L S W H I C H M O D U L A T E T H E
I M M U N E S Y S T E M , M A I N T A I N T O L E R A N C E T O S E L F -
A N T I G E N S , A N D A B R O G A T E A U T O I M M U N E D I S E A S E .
M O U S E M O D E L S H AV E S U G G E S T E D T H A T
M O D U L A T I O N O F T R E G S C A N T R E A T A U T O I M M U N E
D I S E A S E A N D C A N C E R , A N D F A C I L I T A T E O R G A N
T R A N S P L A N T A T I O N .
T R E G U L A T O R Y C E L L S A R E A C O M P O N E N T O F T H E
I M M U N E S Y S T E M T H A T S U P P R E S S I M M U N E
R E S P O N S E S O F O T H E R C E L L S . T H I S I S A N
I M P O R T A N T " S E L F - C H E C K " B U I L T I N T O T H E I M M U N E
S Y S T E M T O P R E V E N T E X C E S S I V E R E A C T I O N S .
R E G U L A T O R Y T C E L L S C O M E I N M A N Y F O R M S W I T H
T H E M O S T W E L L - U N D E R S T O O D B E I N G T H O S E T H A T
E X P R E S S C D 4 , C D 2 5 , A N D F O X P 3 ( C D 4 + C D 2 5 +
R E G U L A T O R Y T C E L L S , O R " T R E G S " ) . [ 1 ] T H E S E C E L L S
A R E I N V O L V E D I N S H U T T I N G D O W N I M M U N E
R E S P O N S E S A F T E R T H E Y H AV E S U C C E S S F U L L Y
E L I M I N A T E D I N VA D I N G O R G A N I S M S , A N D A L S O I N
P R E V E N T I N G A U T O I M M U N I T Y
C D 4 + F O X P 3 + R E G U L A T O R Y T C E L L S H AV E B E E N
C A L L E D " N A T U R A L L Y - O C C U R R I N G " R E G U L A T O R Y T
C E L L S T O D I S T I N G U I S H T H E M F R O M " S U P P R E S S O R " T
C E L L P O P U L A T I O N S T H A T A R E G E N E R A T E D I N V I T R O .
A D D I T I O N A L S U P P R E S S O R T C E L L P O P U L A T I O N S
I N C L U D E T R 1 , T H 3 , C D 8 + C D 2 8 - , A N D Q A - 1 R E S T R I C T E D
T C E L L S . T H E C O N T R I B U T I O N O F T H E S E P O P U L A T I O N S
T O S E L F - T O L E R A N C E A N D I M M U N E H O M E O S T A S I S I S
L E S S W E L L D E F I N E D. F O X P 3 C A N B E U S E D A S A G O O D
M A R K E R F O R M O U S E C D 4 + C D 2 5 + T C E L L S , A L T H O U G H
R E C E N T S T U D I E S H AV E A L S O S H O W N E V I D E N C E F O R
F O X P 3 E X P R E S S I O N I N C D 4 + C D 2 5 - T C E L L S . I N
H U M A N S , F O X P 3 I S A L S O E X P R E S S E D B Y R E C E N T L Y
A C T I VA T E D C O N V E N T I O N A L T - C E L L S A N D T H U S D O E S
N O T S P E C I F I C A L L Y I D E N T I F Y H U M A N T - R E G
. [ C I T A T I O N N E E D E D ] A N A D D I T I O N A L R E G U L A T O R Y T
C E L L S U B S E T , I N D U C E D R E G U L A T O R Y T C E L L S , A R E
A L S O N E E D E D F O R T O L E R A N C E A N D S U P P R E S S I O N
A L L T C E L L S C O M E F R O M P R O G E N I T O R C E L L S F R O M T H E
B O N E M A R R O W , W H I C H B E C O M E C O M M I T T E D T O T H E I R
L I N E A G E I N T H E T H Y M U S . A L L T C E L L S B E G I N A S C D 4 - C D 8 -
T C R - C E L L S A T T H E D N ( D O U B L E - N E G A T I V E ) S T A G E , W H E R E
A N I N D I V I D U A L C E L L W I L L R E A R R A N G E I T S T C E L L R E C E P T O R
G E N E S T O F O R M A U N I Q U E , F U N C T I O N A L M O L E C U L E , W H I C H
T H E Y , I N T U R N , T E S T A G A I N S T C E L L S I N T H E T H Y M I C
C O R T E X F O R A M I N I M A L L E V E L O F I N T E R A C T I O N W I T H S E L F -
M H C . I F T H E Y R E C E I V E T H E S E S I G N A L S , T H E Y P R O L I F E R A T E
A N D E X P R E S S B O T H C D 4 A N D C D 8 , B E C O M I N G D O U B L E -
P O S I T I V E C E L L S . T H E S E L E C T I O N O F T R E G S O C C U R S O N
R A D I O - R E S I S T A N T H A E M O P O I E T I C A L L Y - D E R I V E D M H C C L A S S
I I - E X P R E S S I N G C E L L S I N T H E M E D U L L A O R H A S S A L ’ S
C O R P U S C L E S I N T H E T H Y M U S . A T T H E D P ( D O U B L E - P O S I T I V E )
S T A G E , T H E Y A R E S E L E C T E D B Y T H E I R I N T E R A C T I O N W I T H
T H E C E L L S W I T H I N T H E T H Y M U S , B E G I N T H E T R A N S C R I P T I O N
O F F O X P 3 , A N D B E C O M E T R E G C E L L S , A L T H O U G H T H E Y M A Y
N O T B E G I N T O E X P R E S S F O X P 3 U N T I L T H E S I N G L E - P O S I T I V E
S T A G E , A T W H I C H P O I N T T H E Y A R E F U N C T I O N A L T R E G S .
T R E G D O N O T H A V E T H E L I M I T E D T C R E X P R E S S I O N O F N K T
O R Γ Δ T C E L L S ; T R E G H A V E A L A R G E R T C R D I V E R S I T Y T H A N
E F F E C T O R T C E L L S , B I A S E D T O W A R D S S E L F - P E P T I D E S .

Contenu connexe

Tendances

Quantum Computing - Emerging Frontiers
Quantum Computing - Emerging FrontiersQuantum Computing - Emerging Frontiers
Quantum Computing - Emerging FrontiersGokul Alex
 
Wine Bars in NYC: Chapter 2 by Geoffrey Byruch
Wine Bars in NYC: Chapter 2 by Geoffrey ByruchWine Bars in NYC: Chapter 2 by Geoffrey Byruch
Wine Bars in NYC: Chapter 2 by Geoffrey ByruchGeoffrey Byruch
 
El enemigo de la Productividad - La Procrastinación
El enemigo de la Productividad - La ProcrastinaciónEl enemigo de la Productividad - La Procrastinación
El enemigo de la Productividad - La ProcrastinaciónMelany Pareja Ramirez
 
The Micro Apartment Phenomena
The Micro Apartment Phenomena The Micro Apartment Phenomena
The Micro Apartment Phenomena Carter Boehm
 
Diffusez et vendez vos produits via Instagram
Diffusez et vendez vos produits via InstagramDiffusez et vendez vos produits via Instagram
Diffusez et vendez vos produits via InstagramWopawap
 
Training at altitude Wiggins
Training at altitude Wiggins Training at altitude Wiggins
Training at altitude Wiggins Jon Wiggins
 
Steve Rice: 5 of the Most Unique Golf Courses in the World
Steve Rice: 5 of the Most Unique Golf Courses in the WorldSteve Rice: 5 of the Most Unique Golf Courses in the World
Steve Rice: 5 of the Most Unique Golf Courses in the WorldSteve Rice Los Gatos
 
Melissa Keroack: 5 Of The World's Greatest Underwater Hotels
Melissa Keroack: 5 Of The World's Greatest Underwater HotelsMelissa Keroack: 5 Of The World's Greatest Underwater Hotels
Melissa Keroack: 5 Of The World's Greatest Underwater HotelsMelissa Keroack
 
Learning cities laitio
Learning cities laitioLearning cities laitio
Learning cities laitioTommi Laitio
 
Jack D Ryger: Most Advanced Ski Slopes Across The Globe
Jack D Ryger: Most Advanced Ski Slopes Across The GlobeJack D Ryger: Most Advanced Ski Slopes Across The Globe
Jack D Ryger: Most Advanced Ski Slopes Across The GlobeJack D. Ryger
 
How Recruiters Actually Read Cover Letters
How Recruiters Actually Read Cover LettersHow Recruiters Actually Read Cover Letters
How Recruiters Actually Read Cover LettersJeremy Schifeling
 
Essential Styling Tips for Men
Essential Styling Tips for Men Essential Styling Tips for Men
Essential Styling Tips for Men Amos Marcus Koh
 
The 7 Essential Secrets of the Tech Job Search
The 7 Essential Secrets of the Tech Job SearchThe 7 Essential Secrets of the Tech Job Search
The 7 Essential Secrets of the Tech Job SearchJeremy Schifeling
 
ISDS: The European Proposal of an Investment Court System
ISDS: The European Proposal of an Investment Court SystemISDS: The European Proposal of an Investment Court System
ISDS: The European Proposal of an Investment Court SystemMartina F. Ferracane
 
Tracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling Full
Tracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling FullTracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling Full
Tracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling FullTracey Rancifer
 
Susie Almaneih: 9 Tips For Pregnant Executive Moms
Susie Almaneih: 9 Tips For Pregnant Executive MomsSusie Almaneih: 9 Tips For Pregnant Executive Moms
Susie Almaneih: 9 Tips For Pregnant Executive MomsSusie Almaneih
 
Jack D. Ryger: The Need For Speed - 7 Places to Legally Race Your Car
Jack D. Ryger: The Need For Speed - 7 Places to Legally Race Your CarJack D. Ryger: The Need For Speed - 7 Places to Legally Race Your Car
Jack D. Ryger: The Need For Speed - 7 Places to Legally Race Your CarJack D. Ryger
 
Susie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved Now
Susie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved NowSusie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved Now
Susie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved NowSusie Almaneih
 
Digital Disruption & The Future of Work
Digital Disruption & The Future of WorkDigital Disruption & The Future of Work
Digital Disruption & The Future of WorkArturo Pelayo
 
Top 10 Places To Visit In London
Top 10 Places To Visit In LondonTop 10 Places To Visit In London
Top 10 Places To Visit In LondonBrett Cotham
 

Tendances (20)

Quantum Computing - Emerging Frontiers
Quantum Computing - Emerging FrontiersQuantum Computing - Emerging Frontiers
Quantum Computing - Emerging Frontiers
 
Wine Bars in NYC: Chapter 2 by Geoffrey Byruch
Wine Bars in NYC: Chapter 2 by Geoffrey ByruchWine Bars in NYC: Chapter 2 by Geoffrey Byruch
Wine Bars in NYC: Chapter 2 by Geoffrey Byruch
 
El enemigo de la Productividad - La Procrastinación
El enemigo de la Productividad - La ProcrastinaciónEl enemigo de la Productividad - La Procrastinación
El enemigo de la Productividad - La Procrastinación
 
The Micro Apartment Phenomena
The Micro Apartment Phenomena The Micro Apartment Phenomena
The Micro Apartment Phenomena
 
Diffusez et vendez vos produits via Instagram
Diffusez et vendez vos produits via InstagramDiffusez et vendez vos produits via Instagram
Diffusez et vendez vos produits via Instagram
 
Training at altitude Wiggins
Training at altitude Wiggins Training at altitude Wiggins
Training at altitude Wiggins
 
Steve Rice: 5 of the Most Unique Golf Courses in the World
Steve Rice: 5 of the Most Unique Golf Courses in the WorldSteve Rice: 5 of the Most Unique Golf Courses in the World
Steve Rice: 5 of the Most Unique Golf Courses in the World
 
Melissa Keroack: 5 Of The World's Greatest Underwater Hotels
Melissa Keroack: 5 Of The World's Greatest Underwater HotelsMelissa Keroack: 5 Of The World's Greatest Underwater Hotels
Melissa Keroack: 5 Of The World's Greatest Underwater Hotels
 
Learning cities laitio
Learning cities laitioLearning cities laitio
Learning cities laitio
 
Jack D Ryger: Most Advanced Ski Slopes Across The Globe
Jack D Ryger: Most Advanced Ski Slopes Across The GlobeJack D Ryger: Most Advanced Ski Slopes Across The Globe
Jack D Ryger: Most Advanced Ski Slopes Across The Globe
 
How Recruiters Actually Read Cover Letters
How Recruiters Actually Read Cover LettersHow Recruiters Actually Read Cover Letters
How Recruiters Actually Read Cover Letters
 
Essential Styling Tips for Men
Essential Styling Tips for Men Essential Styling Tips for Men
Essential Styling Tips for Men
 
The 7 Essential Secrets of the Tech Job Search
The 7 Essential Secrets of the Tech Job SearchThe 7 Essential Secrets of the Tech Job Search
The 7 Essential Secrets of the Tech Job Search
 
ISDS: The European Proposal of an Investment Court System
ISDS: The European Proposal of an Investment Court SystemISDS: The European Proposal of an Investment Court System
ISDS: The European Proposal of an Investment Court System
 
Tracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling Full
Tracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling FullTracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling Full
Tracey Rancifer: 14 Appetite-Suppressing Foods That Keep You Feeling Full
 
Susie Almaneih: 9 Tips For Pregnant Executive Moms
Susie Almaneih: 9 Tips For Pregnant Executive MomsSusie Almaneih: 9 Tips For Pregnant Executive Moms
Susie Almaneih: 9 Tips For Pregnant Executive Moms
 
Jack D. Ryger: The Need For Speed - 7 Places to Legally Race Your Car
Jack D. Ryger: The Need For Speed - 7 Places to Legally Race Your CarJack D. Ryger: The Need For Speed - 7 Places to Legally Race Your Car
Jack D. Ryger: The Need For Speed - 7 Places to Legally Race Your Car
 
Susie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved Now
Susie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved NowSusie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved Now
Susie Almaneih - Ready, Set, Recycle! 5 Ways to Get your Kids Involved Now
 
Digital Disruption & The Future of Work
Digital Disruption & The Future of WorkDigital Disruption & The Future of Work
Digital Disruption & The Future of Work
 
Top 10 Places To Visit In London
Top 10 Places To Visit In LondonTop 10 Places To Visit In London
Top 10 Places To Visit In London
 

En vedette

Regulatory T Cells and GVHD
Regulatory T Cells and GVHDRegulatory T Cells and GVHD
Regulatory T Cells and GVHDspa718
 
Control of immune response by regulatory T cells
Control of immune response by regulatory T cellsControl of immune response by regulatory T cells
Control of immune response by regulatory T cellsVICTOR MAESTRE RAMIREZ
 
T helper17 cells
T helper17 cellsT helper17 cells
T helper17 cellsjafar Ali
 
regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1
regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1
regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1Dat Tran, MD
 
LPN Basic Immune System Overview
LPN Basic Immune System OverviewLPN Basic Immune System Overview
LPN Basic Immune System Overviewcarrie9660
 
Helper t cell 17
Helper t cell 17Helper t cell 17
Helper t cell 17yoyosuky
 
Botched french drug trial leaves 1 brain dead
Botched french drug trial leaves 1 brain deadBotched french drug trial leaves 1 brain dead
Botched french drug trial leaves 1 brain deadOther Mother
 
Transplantation immunology
Transplantation immunologyTransplantation immunology
Transplantation immunologyHaris Saddique
 
T Cell Repertoire & Self Tolerance
T Cell Repertoire & Self ToleranceT Cell Repertoire & Self Tolerance
T Cell Repertoire & Self Toleranceraj kumar
 
Immunology chapter 8
Immunology chapter 8Immunology chapter 8
Immunology chapter 8Sarah Davies
 
Dendrimers for cancer therapy
Dendrimers for cancer therapyDendrimers for cancer therapy
Dendrimers for cancer therapyVijitha J
 
PTEN Proteins - Molecular Basis
PTEN Proteins -  Molecular BasisPTEN Proteins -  Molecular Basis
PTEN Proteins - Molecular BasisSimon Restrepo
 

En vedette (20)

Tregs
TregsTregs
Tregs
 
Ppt t reg cells
Ppt t reg cellsPpt t reg cells
Ppt t reg cells
 
Regulatory T Cells and GVHD
Regulatory T Cells and GVHDRegulatory T Cells and GVHD
Regulatory T Cells and GVHD
 
Regulatory t cells
Regulatory t cellsRegulatory t cells
Regulatory t cells
 
Control of immune response by regulatory T cells
Control of immune response by regulatory T cellsControl of immune response by regulatory T cells
Control of immune response by regulatory T cells
 
T reg
T regT reg
T reg
 
T helper17 cells
T helper17 cellsT helper17 cells
T helper17 cells
 
regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1
regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1
regulatory-t-cells-and-their-implications-in-graft-versus-host-disease-2-pdf-1
 
T cellppt
T cellpptT cellppt
T cellppt
 
LPN Basic Immune System Overview
LPN Basic Immune System OverviewLPN Basic Immune System Overview
LPN Basic Immune System Overview
 
Maths archana
Maths  archanaMaths  archana
Maths archana
 
Th17
Th17Th17
Th17
 
Helper t cell 17
Helper t cell 17Helper t cell 17
Helper t cell 17
 
Botched french drug trial leaves 1 brain dead
Botched french drug trial leaves 1 brain deadBotched french drug trial leaves 1 brain dead
Botched french drug trial leaves 1 brain dead
 
Transplantation immunology
Transplantation immunologyTransplantation immunology
Transplantation immunology
 
T Cell Repertoire & Self Tolerance
T Cell Repertoire & Self ToleranceT Cell Repertoire & Self Tolerance
T Cell Repertoire & Self Tolerance
 
Basic immunology
Basic immunologyBasic immunology
Basic immunology
 
Immunology chapter 8
Immunology chapter 8Immunology chapter 8
Immunology chapter 8
 
Dendrimers for cancer therapy
Dendrimers for cancer therapyDendrimers for cancer therapy
Dendrimers for cancer therapy
 
PTEN Proteins - Molecular Basis
PTEN Proteins -  Molecular BasisPTEN Proteins -  Molecular Basis
PTEN Proteins - Molecular Basis
 

Similaire à The regulatory t cells (tregs

Steve Rice: Plan A Trip To Montreal
Steve Rice: Plan A Trip To MontrealSteve Rice: Plan A Trip To Montreal
Steve Rice: Plan A Trip To MontrealSteve Rice Los Gatos
 
The Pavallion Dharamshala by HPCA
The Pavallion Dharamshala by HPCAThe Pavallion Dharamshala by HPCA
The Pavallion Dharamshala by HPCASanjay Kumar Thakur
 
Conduct Your Annual Year Review
Conduct Your Annual Year ReviewConduct Your Annual Year Review
Conduct Your Annual Year ReviewFred Cuellar
 
KHAJURAHO GROUP OF MONUMENTS
KHAJURAHO GROUP OF MONUMENTSKHAJURAHO GROUP OF MONUMENTS
KHAJURAHO GROUP OF MONUMENTSAndhra University
 
Introduction to facebook advertisement for beginners
Introduction to facebook advertisement for beginners Introduction to facebook advertisement for beginners
Introduction to facebook advertisement for beginners NupurSamaddar2
 
Understanding Focault's Concept of Power Through the 1975 Emergency
Understanding Focault's Concept of Power Through the 1975 EmergencyUnderstanding Focault's Concept of Power Through the 1975 Emergency
Understanding Focault's Concept of Power Through the 1975 EmergencySiddhanth Nadkarni
 
Meet Lorn Huxley
Meet Lorn HuxleyMeet Lorn Huxley
Meet Lorn HuxleyLorn Huxley
 
Wine Bars in NYC Chapter 3 by Geoffrey Byruch
Wine Bars in NYC Chapter 3 by Geoffrey ByruchWine Bars in NYC Chapter 3 by Geoffrey Byruch
Wine Bars in NYC Chapter 3 by Geoffrey ByruchGeoffrey Byruch
 
The Importance of Balance between Work and your Social Life by Scott Storick
The Importance of Balance between Work and your Social Life by Scott StorickThe Importance of Balance between Work and your Social Life by Scott Storick
The Importance of Balance between Work and your Social Life by Scott StorickScott Storick
 
El baloncesto fabian florian 10-6
El baloncesto fabian florian 10-6El baloncesto fabian florian 10-6
El baloncesto fabian florian 10-63142045980
 
Steve Rice: Fun Things To Do In Los Gatos
Steve Rice: Fun Things To Do In Los GatosSteve Rice: Fun Things To Do In Los Gatos
Steve Rice: Fun Things To Do In Los GatosSteve Rice Los Gatos
 
How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...
How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...
How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...Michael G. Sheppard
 
Sowk 388 Power Point Final
Sowk 388 Power Point FinalSowk 388 Power Point Final
Sowk 388 Power Point Finalsarahm2
 
Karl Marx (1818 1883)
Karl Marx (1818 1883)Karl Marx (1818 1883)
Karl Marx (1818 1883)mosteiro1972
 
Magnificent Bharat- Journey Through Ancient Monuments.pdf
Magnificent Bharat- Journey Through Ancient Monuments.pdfMagnificent Bharat- Journey Through Ancient Monuments.pdf
Magnificent Bharat- Journey Through Ancient Monuments.pdfSamirsinh Parmar
 
Diap. Historia del Constitucionalismo colombiano - copia.pptx
Diap. Historia del Constitucionalismo colombiano - copia.pptxDiap. Historia del Constitucionalismo colombiano - copia.pptx
Diap. Historia del Constitucionalismo colombiano - copia.pptxdiegomanrique36
 
Multi-Factor Authentication - Cyberroot Risk Advisory
Multi-Factor Authentication - Cyberroot Risk AdvisoryMulti-Factor Authentication - Cyberroot Risk Advisory
Multi-Factor Authentication - Cyberroot Risk AdvisoryCR Group
 
On Kittens, Makers and IOT
On Kittens, Makers and IOTOn Kittens, Makers and IOT
On Kittens, Makers and IOTElymar Apao
 

Similaire à The regulatory t cells (tregs (20)

Meal Plan of the Month
Meal Plan of the MonthMeal Plan of the Month
Meal Plan of the Month
 
Steve Rice: Plan A Trip To Montreal
Steve Rice: Plan A Trip To MontrealSteve Rice: Plan A Trip To Montreal
Steve Rice: Plan A Trip To Montreal
 
The Pavallion Dharamshala by HPCA
The Pavallion Dharamshala by HPCAThe Pavallion Dharamshala by HPCA
The Pavallion Dharamshala by HPCA
 
Conduct Your Annual Year Review
Conduct Your Annual Year ReviewConduct Your Annual Year Review
Conduct Your Annual Year Review
 
KHAJURAHO GROUP OF MONUMENTS
KHAJURAHO GROUP OF MONUMENTSKHAJURAHO GROUP OF MONUMENTS
KHAJURAHO GROUP OF MONUMENTS
 
Introduction to facebook advertisement for beginners
Introduction to facebook advertisement for beginners Introduction to facebook advertisement for beginners
Introduction to facebook advertisement for beginners
 
Understanding Focault's Concept of Power Through the 1975 Emergency
Understanding Focault's Concept of Power Through the 1975 EmergencyUnderstanding Focault's Concept of Power Through the 1975 Emergency
Understanding Focault's Concept of Power Through the 1975 Emergency
 
Meet Lorn Huxley
Meet Lorn HuxleyMeet Lorn Huxley
Meet Lorn Huxley
 
Wine Bars in NYC Chapter 3 by Geoffrey Byruch
Wine Bars in NYC Chapter 3 by Geoffrey ByruchWine Bars in NYC Chapter 3 by Geoffrey Byruch
Wine Bars in NYC Chapter 3 by Geoffrey Byruch
 
The Importance of Balance between Work and your Social Life by Scott Storick
The Importance of Balance between Work and your Social Life by Scott StorickThe Importance of Balance between Work and your Social Life by Scott Storick
The Importance of Balance between Work and your Social Life by Scott Storick
 
El baloncesto fabian florian 10-6
El baloncesto fabian florian 10-6El baloncesto fabian florian 10-6
El baloncesto fabian florian 10-6
 
Steve Rice: Fun Things To Do In Los Gatos
Steve Rice: Fun Things To Do In Los GatosSteve Rice: Fun Things To Do In Los Gatos
Steve Rice: Fun Things To Do In Los Gatos
 
How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...
How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...
How to Scaffold Your Unit Plan- Chapter 1 Bell-to-Bell Instructions by Michae...
 
Sowk 388 Power Point Final
Sowk 388 Power Point FinalSowk 388 Power Point Final
Sowk 388 Power Point Final
 
Karl Marx (1818 1883)
Karl Marx (1818 1883)Karl Marx (1818 1883)
Karl Marx (1818 1883)
 
Magnificent Bharat- Journey Through Ancient Monuments.pdf
Magnificent Bharat- Journey Through Ancient Monuments.pdfMagnificent Bharat- Journey Through Ancient Monuments.pdf
Magnificent Bharat- Journey Through Ancient Monuments.pdf
 
Diap. Historia del Constitucionalismo colombiano - copia.pptx
Diap. Historia del Constitucionalismo colombiano - copia.pptxDiap. Historia del Constitucionalismo colombiano - copia.pptx
Diap. Historia del Constitucionalismo colombiano - copia.pptx
 
Programacion estructurado
Programacion estructuradoProgramacion estructurado
Programacion estructurado
 
Multi-Factor Authentication - Cyberroot Risk Advisory
Multi-Factor Authentication - Cyberroot Risk AdvisoryMulti-Factor Authentication - Cyberroot Risk Advisory
Multi-Factor Authentication - Cyberroot Risk Advisory
 
On Kittens, Makers and IOT
On Kittens, Makers and IOTOn Kittens, Makers and IOT
On Kittens, Makers and IOT
 

Plus de eman youssif (20)

urine part1.pptx
urine part1.pptxurine part1.pptx
urine part1.pptx
 
para.pptx
para.pptxpara.pptx
para.pptx
 
hormones.pptx
hormones.pptxhormones.pptx
hormones.pptx
 
tumor marker.pptx
tumor marker.pptxtumor marker.pptx
tumor marker.pptx
 
Siwa oasis 1
Siwa oasis 1Siwa oasis 1
Siwa oasis 1
 
Siwa oasis journey
Siwa oasis journeySiwa oasis journey
Siwa oasis journey
 
Siwa
SiwaSiwa
Siwa
 
Nutrition and health
Nutrition and healthNutrition and health
Nutrition and health
 
Present perfect
Present perfectPresent perfect
Present perfect
 
Waste management
Waste managementWaste management
Waste management
 
Vr2
Vr2Vr2
Vr2
 
Black
BlackBlack
Black
 
Gluten
GlutenGluten
Gluten
 
Tm mccu
Tm mccuTm mccu
Tm mccu
 
Joghnson
JoghnsonJoghnson
Joghnson
 
Negot.
Negot.Negot.
Negot.
 
polymerase chain reaction
polymerase chain reactionpolymerase chain reaction
polymerase chain reaction
 
Apolipo proteins
Apolipo proteinsApolipo proteins
Apolipo proteins
 
Apolipo proteins
Apolipo proteinsApolipo proteins
Apolipo proteins
 
Apo lipoproteins structure and function
Apo lipoproteins structure and functionApo lipoproteins structure and function
Apo lipoproteins structure and function
 

Dernier

UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6DianaGray10
 
9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding Team9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding TeamAdam Moalla
 
COMPUTER 10: Lesson 7 - File Storage and Online Collaboration
COMPUTER 10: Lesson 7 - File Storage and Online CollaborationCOMPUTER 10: Lesson 7 - File Storage and Online Collaboration
COMPUTER 10: Lesson 7 - File Storage and Online Collaborationbruanjhuli
 
NIST Cybersecurity Framework (CSF) 2.0 Workshop
NIST Cybersecurity Framework (CSF) 2.0 WorkshopNIST Cybersecurity Framework (CSF) 2.0 Workshop
NIST Cybersecurity Framework (CSF) 2.0 WorkshopBachir Benyammi
 
Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024D Cloud Solutions
 
Designing A Time bound resource download URL
Designing A Time bound resource download URLDesigning A Time bound resource download URL
Designing A Time bound resource download URLRuncy Oommen
 
Crea il tuo assistente AI con lo Stregatto (open source python framework)
Crea il tuo assistente AI con lo Stregatto (open source python framework)Crea il tuo assistente AI con lo Stregatto (open source python framework)
Crea il tuo assistente AI con lo Stregatto (open source python framework)Commit University
 
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...DianaGray10
 
Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1DianaGray10
 
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDEADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDELiveplex
 
Nanopower In Semiconductor Industry.pdf
Nanopower  In Semiconductor Industry.pdfNanopower  In Semiconductor Industry.pdf
Nanopower In Semiconductor Industry.pdfPedro Manuel
 
Videogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdfVideogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdfinfogdgmi
 
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...Aggregage
 
AI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity WebinarAI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity WebinarPrecisely
 
Computer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and HazardsComputer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and HazardsSeth Reyes
 
Comparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and IstioComparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and IstioChristian Posta
 
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UbiTrack UK
 
Bird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystemBird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystemAsko Soukka
 
UiPath Community: AI for UiPath Automation Developers
UiPath Community: AI for UiPath Automation DevelopersUiPath Community: AI for UiPath Automation Developers
UiPath Community: AI for UiPath Automation DevelopersUiPathCommunity
 
UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8DianaGray10
 

Dernier (20)

UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6
 
9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding Team9 Steps For Building Winning Founding Team
9 Steps For Building Winning Founding Team
 
COMPUTER 10: Lesson 7 - File Storage and Online Collaboration
COMPUTER 10: Lesson 7 - File Storage and Online CollaborationCOMPUTER 10: Lesson 7 - File Storage and Online Collaboration
COMPUTER 10: Lesson 7 - File Storage and Online Collaboration
 
NIST Cybersecurity Framework (CSF) 2.0 Workshop
NIST Cybersecurity Framework (CSF) 2.0 WorkshopNIST Cybersecurity Framework (CSF) 2.0 Workshop
NIST Cybersecurity Framework (CSF) 2.0 Workshop
 
Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024
 
Designing A Time bound resource download URL
Designing A Time bound resource download URLDesigning A Time bound resource download URL
Designing A Time bound resource download URL
 
Crea il tuo assistente AI con lo Stregatto (open source python framework)
Crea il tuo assistente AI con lo Stregatto (open source python framework)Crea il tuo assistente AI con lo Stregatto (open source python framework)
Crea il tuo assistente AI con lo Stregatto (open source python framework)
 
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
Connector Corner: Extending LLM automation use cases with UiPath GenAI connec...
 
Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1
 
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDEADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
ADOPTING WEB 3 FOR YOUR BUSINESS: A STEP-BY-STEP GUIDE
 
Nanopower In Semiconductor Industry.pdf
Nanopower  In Semiconductor Industry.pdfNanopower  In Semiconductor Industry.pdf
Nanopower In Semiconductor Industry.pdf
 
Videogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdfVideogame localization & technology_ how to enhance the power of translation.pdf
Videogame localization & technology_ how to enhance the power of translation.pdf
 
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
 
AI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity WebinarAI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity Webinar
 
Computer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and HazardsComputer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and Hazards
 
Comparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and IstioComparing Sidecar-less Service Mesh from Cilium and Istio
Comparing Sidecar-less Service Mesh from Cilium and Istio
 
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
 
Bird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystemBird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystem
 
UiPath Community: AI for UiPath Automation Developers
UiPath Community: AI for UiPath Automation DevelopersUiPath Community: AI for UiPath Automation Developers
UiPath Community: AI for UiPath Automation Developers
 
UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8UiPath Studio Web workshop series - Day 8
UiPath Studio Web workshop series - Day 8
 

The regulatory t cells (tregs

  • 1. THE REGULATORY T CELLS (TREGS Eman youssif
  • 2. F O R M E R L Y K N O W N A S S U P P R E S S O R T C E L L S , A R E A S U B P O P U L A T I O N O F T C E L L S W H I C H M O D U L A T E T H E I M M U N E S Y S T E M , M A I N T A I N T O L E R A N C E T O S E L F - A N T I G E N S , A N D A B R O G A T E A U T O I M M U N E D I S E A S E . M O U S E M O D E L S H AV E S U G G E S T E D T H A T M O D U L A T I O N O F T R E G S C A N T R E A T A U T O I M M U N E D I S E A S E A N D C A N C E R , A N D F A C I L I T A T E O R G A N T R A N S P L A N T A T I O N .
  • 3. T R E G U L A T O R Y C E L L S A R E A C O M P O N E N T O F T H E I M M U N E S Y S T E M T H A T S U P P R E S S I M M U N E R E S P O N S E S O F O T H E R C E L L S . T H I S I S A N I M P O R T A N T " S E L F - C H E C K " B U I L T I N T O T H E I M M U N E S Y S T E M T O P R E V E N T E X C E S S I V E R E A C T I O N S . R E G U L A T O R Y T C E L L S C O M E I N M A N Y F O R M S W I T H T H E M O S T W E L L - U N D E R S T O O D B E I N G T H O S E T H A T E X P R E S S C D 4 , C D 2 5 , A N D F O X P 3 ( C D 4 + C D 2 5 + R E G U L A T O R Y T C E L L S , O R " T R E G S " ) . [ 1 ] T H E S E C E L L S A R E I N V O L V E D I N S H U T T I N G D O W N I M M U N E R E S P O N S E S A F T E R T H E Y H AV E S U C C E S S F U L L Y E L I M I N A T E D I N VA D I N G O R G A N I S M S , A N D A L S O I N P R E V E N T I N G A U T O I M M U N I T Y
  • 4. C D 4 + F O X P 3 + R E G U L A T O R Y T C E L L S H AV E B E E N C A L L E D " N A T U R A L L Y - O C C U R R I N G " R E G U L A T O R Y T C E L L S T O D I S T I N G U I S H T H E M F R O M " S U P P R E S S O R " T C E L L P O P U L A T I O N S T H A T A R E G E N E R A T E D I N V I T R O . A D D I T I O N A L S U P P R E S S O R T C E L L P O P U L A T I O N S I N C L U D E T R 1 , T H 3 , C D 8 + C D 2 8 - , A N D Q A - 1 R E S T R I C T E D T C E L L S . T H E C O N T R I B U T I O N O F T H E S E P O P U L A T I O N S T O S E L F - T O L E R A N C E A N D I M M U N E H O M E O S T A S I S I S L E S S W E L L D E F I N E D. F O X P 3 C A N B E U S E D A S A G O O D M A R K E R F O R M O U S E C D 4 + C D 2 5 + T C E L L S , A L T H O U G H R E C E N T S T U D I E S H AV E A L S O S H O W N E V I D E N C E F O R F O X P 3 E X P R E S S I O N I N C D 4 + C D 2 5 - T C E L L S . I N H U M A N S , F O X P 3 I S A L S O E X P R E S S E D B Y R E C E N T L Y A C T I VA T E D C O N V E N T I O N A L T - C E L L S A N D T H U S D O E S N O T S P E C I F I C A L L Y I D E N T I F Y H U M A N T - R E G . [ C I T A T I O N N E E D E D ] A N A D D I T I O N A L R E G U L A T O R Y T C E L L S U B S E T , I N D U C E D R E G U L A T O R Y T C E L L S , A R E A L S O N E E D E D F O R T O L E R A N C E A N D S U P P R E S S I O N
  • 5. A L L T C E L L S C O M E F R O M P R O G E N I T O R C E L L S F R O M T H E B O N E M A R R O W , W H I C H B E C O M E C O M M I T T E D T O T H E I R L I N E A G E I N T H E T H Y M U S . A L L T C E L L S B E G I N A S C D 4 - C D 8 - T C R - C E L L S A T T H E D N ( D O U B L E - N E G A T I V E ) S T A G E , W H E R E A N I N D I V I D U A L C E L L W I L L R E A R R A N G E I T S T C E L L R E C E P T O R G E N E S T O F O R M A U N I Q U E , F U N C T I O N A L M O L E C U L E , W H I C H T H E Y , I N T U R N , T E S T A G A I N S T C E L L S I N T H E T H Y M I C C O R T E X F O R A M I N I M A L L E V E L O F I N T E R A C T I O N W I T H S E L F - M H C . I F T H E Y R E C E I V E T H E S E S I G N A L S , T H E Y P R O L I F E R A T E A N D E X P R E S S B O T H C D 4 A N D C D 8 , B E C O M I N G D O U B L E - P O S I T I V E C E L L S . T H E S E L E C T I O N O F T R E G S O C C U R S O N R A D I O - R E S I S T A N T H A E M O P O I E T I C A L L Y - D E R I V E D M H C C L A S S I I - E X P R E S S I N G C E L L S I N T H E M E D U L L A O R H A S S A L ’ S C O R P U S C L E S I N T H E T H Y M U S . A T T H E D P ( D O U B L E - P O S I T I V E ) S T A G E , T H E Y A R E S E L E C T E D B Y T H E I R I N T E R A C T I O N W I T H T H E C E L L S W I T H I N T H E T H Y M U S , B E G I N T H E T R A N S C R I P T I O N O F F O X P 3 , A N D B E C O M E T R E G C E L L S , A L T H O U G H T H E Y M A Y N O T B E G I N T O E X P R E S S F O X P 3 U N T I L T H E S I N G L E - P O S I T I V E S T A G E , A T W H I C H P O I N T T H E Y A R E F U N C T I O N A L T R E G S . T R E G D O N O T H A V E T H E L I M I T E D T C R E X P R E S S I O N O F N K T O R Γ Δ T C E L L S ; T R E G H A V E A L A R G E R T C R D I V E R S I T Y T H A N E F F E C T O R T C E L L S , B I A S E D T O W A R D S S E L F - P E P T I D E S .