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Endobiogeny a Global Overview
1. ASEMIP
Endobiogeny: A global approach
to systems biology
Kamyar M. Hedayat, MD
President, American Society of Endobiogenic
Medicine and Integrative Physiology
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
2. ASEMIP
INTRODUCTION
““Living systems are organized in such a way that they form multi-leveled
structures, each level consisting of subsytems which are wholes in regard
to their parts, and parts with respect to the larger wholes ”--Fritjof Capra,
The turning point: science, society and the rising culture, p. 43
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
4. ASEMIP
Systems Theory
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
“Systems theory
looks at the world in
terms of the
interrelatedness and
interdependence of
all phenomenon, and
in this framework an
integrated whole
whose properties
cannot be reduced
to those of its parts
is called a system.”
Fritjof Capra, The turning point:
science, society and the rising
culture, p. 43
5. ASEMIP
Determining level of study
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
7. ASEMIP
A false dichotomy
Reductionism
Quantitative
Function of the parts
Hierarchy
Categorical
Separate
Independent
Static
Control
Holism
Qualitative
Function of the System
Relationships
Individualized
Interconnected
Interdependence
Dynamic
Creative chaos
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
ENDOBIOGENY
8. ASEMIP
Endobiogeny: A theory of terrain
• Terrain: functional expression of structural
constitution in its internal equilibrium
– Constitution: Genetic heritage, potential capacity
of the structure
– Structure: materialized constitutive elements that
assure life. The achievement of constitution
– Function: all the biologic and metabolic
mechanics that assure functioning of structure
and dynamics of the organism
9. ASEMIP
Manager of the System
• In order to ensure the integrity of the system,
the manager must possess 3 qualities:
1) Ubiquity of interaction with each structural
element
2) Constancy of relationship with those elements
3) Auto-regulation.
• The Endocrine system is the manager of the
terrain and the system most worthy of study
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
10. ASEMIP
Towards an Integrative Physiology
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
METABOLISM
CATABOLISM ANABOLISMANABOLISM CATABOLISM
CRH
ACTH
ADRENALS
LHRH
FSH LH
GONADS
TRH
TSH
THYROID
GHRH
GH PL
PANCREASπΣ
αΣ
βΣ
Corticotropic Gonadotropic Thyrotropic Somatotropic
ANS
ENDOCRINE MANAGEMENT
12. ASEMIP
Elements of the
Endobiogenic Method
• Theory of Terrain
• History
• Physical Exam
• Systems-based biomarker interpretation
• Treatment
– Rational clinical phytotherapy
– Alimentation
– Lifestyle
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
13. ASEMIP
THE BIOLOGY OF FUNCTIONS
"The new mathematics...is one of
relationships and patterns. It is
qualitative rather than quantitative
and thus embodies the shift of
emphasis that is characteristic of
systems thinking—from objects to
relationships, from quantity to
quality, from substance to pattern."
Fritjof Capra
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
14. ASEMIP
Need to use blood-based
biomarkers
Advantages
• Objective
• Quantitative
• Accurate
• Reproducible
• Minimally invasive
Short-comings
• Binary
• Reductionist
• Confusion of
– Cause vs. Effect
– Cause vs. Effect vs.
Mechanism
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
15. ASEMIP
Wisdom of using blood
Blood and Physiology
• The life of the flesh is in the
blood (Lev. 17:10)
• The blood is the life (Deut
12:23)
Blood, Thought and Emotions
• And indeed We have
created man, and We know
whatever thoughts his inner
self develops, and We are
closer to him than (his)
jugular vein. (50:16)
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
17. ASEMIP
Table 1: Biomarkers
Origin Biomarker
Bone Marrow
Red blood cell
White blood cell, total
Neutrophil
Lymphocytes
Eosinophils
Monocytes
Basophils
Hemoglobin
Platelets
Marrow-Blood interaction Erythrocyte sedimentation rate
Bone Stroma Enzymes
Osteocalcin
Alkaline phosphatase bone isoenzyme
General Enzymes Lactate dehydrogenase
Creatine phosphokinase
Endocrine: Pituitary Thyroid stimulating hormone
Electrolytes
Potassium
Calcium, total serum
70% bone
and blood
30% other
18. ASEMIP
Direct and Indirect ratios
Direct Indices
• Direct relationship of
biomarkers
• Genital Ratio (GR)
– RBC/WBC
• Adaptation Index
– Eosinophils/Monocytes
Indirect Indices
• Indirect relationship of
direct indexes and other
indirect indexes
• Genital ratio corrected
=(RBC/PMI) / (WBC/LMI)
19. ASEMIP
CASE STUDIES IN PINEAL PHYSIOLOGY
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
20. ASEMIP
Pineal physiology:
Seasonal entrainment
• Seasonal entrainment
– Shorter duration of light, greater production of
melatonin
– Pineal adapts adrenal gland to increase activity
during the winter months
– Pineal adapts thyroid in similar fashion
• Cosmobiology: evaluates the effects of
cosmologic events such as solar flares and
lunar cycles on human physiology
22. ASEMIP
Pineal Physiology
πΣ Serotonin Melatonin
CRF ACTH Cortisol Adaptation, Alertness,
Memory
Sleep
(-) βMSH
Dopamine TRH
Imagination,
Rumination, Expansive,
tangential thinking,
emotional labiality,
explosive energy
Executive thinking, Rational
thought, pleasure and reward
Thyroid Drive, Energy, Cell turnover
and “spring cleaning”
αΣ
Impulsivity,
Extroversion
Hyperalertness,
Increased perception
and intake of stimuli
23. ASEMIP
Review of clinical studies of melatonin and
neuropsychiatric disorders
Disorder Melatonin-AM Melatonin-PM
Mania -
Anorexia
Bulemia -
Schizophrenia - Blunted peak
Depression -
Seizures -
Aging -
Alzheimer’s -
Verster GC. Melatonin and its agonists, circadian rhythms and psychiatry. Afr J
Psychiatry (Johannesbg). Feb 2009;12(1):42-46.
24. ASEMIP
Indices relevant to Pineal
function
• Corticotropic
– ACTH index
– Corisol index
– Adrenal cortex index
• Thyrotropic
– Thyroid metabolic index
– Thyroid yield
– TRH/TSH index
• Somatotropic
– Prolactin index
– Peripheral Serotonin
• Pineal Gland
– Adaptogen index: relative
level of participation of pineal gland
in adaptation
– βMSH/αMSH: Relative level
of participation of pineal vs.
pituitary in adaptation
25. ASEMIP
Case 1: Insufficient pineal adaptation
10 year old boy hearing voices, death wish
• 10 yo boy with anxiety, death wish from voices in head
• H/O: Severe atopy: food allergies, environmental
allergies, asthma, arrested growth, < 5% for weight
• Symptoms
– ANXIETY: mood swings, sad, but cannot express exactly
what makes him feel that way; stated he wanted to kill
himself due to feeling overwhelmed from hearing voices.
Claims to have had visions since 2 years of age, telepathy,
empathic
– Asthma: daily use with constant dyspnea
– Fatigue: chronic, cannot play at recess, tired in school
26. ASEMIP
Case 1: Insufficient Pineal adaptation
• Treatment:
– Mind blend: California poppy, Annual Mercury, Cassis
buds, Lithy tree buds, DOSE: 2.5 ml tid
• 48 hours: Voices and death wish resolved
– Treatment for asthma started 2 weeks later after biology of
functions performed
• 3 months: full energy, need for daily asthma inhaler
resolved—went 6 months before requiring again
• 12 months: Happy, healthy boy, gaining weight (6 lbs),
growing in height (5.5’’), expanding list of tolerable
foods, mild asthma with colds
27. ASEMIP
Case 1: Biology of Functions
Index Value Low High
Adrenal cortex 1.62 2.7 3.3
Evoked Histamine 10,221 20 60
Thyroid metabolic 1.64 3.5 5.5
Thyroid yield 0.79 2 3
bMSH/aMSH 1.87 6 8
Prolactin 4.81 0.8 1.2
Peripheral Serotonin 0.22 1.5 7.5
28. ASEMIP
Case Study 2: Excessive Pineal activity
Cyclic Dysthymia
• Chief Complaints: Hormonal and mood fluctuations
• Symptoms
– EMOTIONS: Phases last for months at a time:
• Depressed, chornic fatigue easily irritated, brain fog
• Suddenly improves during ovulation
– 15: ADRENAL FATIGUE with late onset of puberty
– 18-26: Anxiety attacks after caffeine or chocolate
– 34: nearly died from traumatic birth with severe hemorrhaging
became hypersensitive to noise;
– 36: 8th month of pregnancy: insomnia, anemia (Hg 10), anxiety,
panic attacks--started on Armor thyroid which worsened her
situation; Child born with trisomy 21
– SLEEP: Variable: Cannot shut off mind when tries to sleep, hard
to fall asleep; Dreams: Vivid, engaging, but not fatiguing
29. ASEMIP
Case Study 2 (cont):
Pineal Over-adaptation
• Based on history, physical exam and biology of
functions, started on following treatment
• #1: Nervous tension: California poppy, Salad burnett,
Yarrow, White deadnettle, Artichoke leaf, 2.5 ml BID
• #2: Mood swings: Strawberry leaf, Gypsywort, Arnica,
Buggleweed, Pichi, 2.5 ml bid
• Magnesium oligoelement: 20 drops qAM
• 6 weeks: reduction in amplitude of swings
• 7 months: increased functionality and delayed onset of
cyclic dysthymia and as above
30. ASEMIP
Case 2: Biology of functions
10 months on treatment
Index 8/30/11 6/29/12 Low High
Adrenal Cortex 1.83 6.51 2.7 3.3
Thyroid index 8.93 7.94 3.5 5.5
Thyroid yield 4.85 2.93 2 3
TRH/TSH 31.13 0.19 0.33 1.7
bMSH/aMSH 9.72 9.37 6 8
Thyroid relaunching
corrected
1.5 0.75 0.1 0.5
Insulin index 10.67 4.28 1.5 5
Insulin resistance 0.07 0.11 0.75 1.25
33. ASEMIP
Endobiogeny around the world
• Europe
– France: Home of Endobiogeny
– UK: taught in conjunction with Middlesex University
– Lithuania: Taught through affiliation with medical
school (starting 2014)
• Americas
– US: Fellowship underway
– Mexico: Official form of medicine, used by public
health system
• North Africa
– Tunisia: Masters degree in endobiogeny
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
34. ASEMIP
Areas of research
• Cancer
• Autoimmune disorders
• Neuro-psychiatric disorders
• Cardiovascular disorders
• Septic Shock
• PTSD
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
35. ASEMIP
Conclusions
• Endobiogeny is a theory of terrain
• Offers a Global systems approach to biology
– Quantitative
– Qualitative
– Humanistic
– Clinical solutions open to all forms of treatment,
prefers medicinal plants, diet, lifestyle
(c) 2013 American Society of Endobiogenic
Medicine and Integrative Physiology
Editor's Notes
The image on the left illustrates the focused view of a reductionist model. It looks at the part at the expense of the wholeThe image on the right illustrates the holistic view, which contextualizes man within the circadian cycle and appreciates the dynamism of his physiology, but lacks a reflective analysis of the particular components of adaptability and adaptation
If one accepts the premise that the human organism is a true system, the level of activity of this system must be considered. Most researchers engaging in systems research are going down the level of systems analysis to the most basic rather than going up to higher levels of complexity. Biological information is encoded in a multi-scale information hierarchy: DNA, RNA, proteins, interactions, biological networks, cells, tissues and organs, individuals and, finally, ecologies. The important point is that the environment impinges upon each of these levels of the hierarchy and modulates the digital informational output from the genome. Thus, systems-level investigations demand the collection of data at each relevant level of the hierarchy between the phenotypic measurement (features of the cell) and the core digital genome—Leroy Hood et al., Institute for Systems Biology39In a global systems approach, if one takes the eye, we can demonstrate how a global systems approach contextualizes retinal cells within a larger context while appreciating every level of the system. The images, from top left clockwise:Top Left: Retinal cellsTop Right: Contextualization of retinal cells within the entire occular apparatusBottom Right: Contextualization of the eye within the context of light/dark variations, pineal glandBottom Left: Contextualization of the eye, the pineal gland, and adaptability at the level of the adrenals and the thyroid
It is a false dichotomy to chose between reductionism and holism. Endobiogeny encompasses both, which his what is required for a global approach to systems theory.
From the unicity of metabolism arises the dualism of Catabolism and Anabolism. From Dualism arises Multiplicity in the alternation of two sets of catabolic and anabolic endocrine axes. From this arises further multiplicity of central and peripheral activity in its strictly vertical control mechanisms of classical feedback loops.
The image in the top right illustrates the network of relationships between various proteins within a single cell within a 24 hour period of time.
Over 60% of the biomarkers used in the BoF are derived from the bone marrow, from these three types of cells
NocturnalAnti-oxidant: most powerful endogenousAnti-inflammatory, free radical scavengerAnti-tumoral: Night-shift nurses have a higher incidence of breast cancer than day-shift nursesReorganizes cerebral connectionsDiurnalProtects skin against UV damageStimulates pancreatic enzymesGastric motility (patients with Irritable Bowel have low AM melatonin levels)Adrenal adaptability (c.f. next slide)Thyroid adaptability (c.f. next slide)
First animation: Melatonin in its well-known role in sleepSecond Animation: Hypo-functioning pineal activity in the face of insufficient adrenal activity: relaunching of Alpha, CRF, ACTH Third animation: Hypo-functioning pineal activity in the face of thyroid insufficiencyFourth animation: Hyper-functioning pineal activity and relaunching of DA and TRH by diversion of Serotonin away from metabolism into Melatonin
