The document provides 10 insights from William N. Thorndike Jr on best practices for CEOs and business leaders. Some of the key points include that iconoclast CEOs focus independently on optimizing long-term company value, attract talent through fresh perspectives and energy, run decentralized organizations to maximize team strengths, carefully select the COO to balance autonomy and budget rigor, identify hurdle rates for projects to meet return targets, and be disciplined in capital allocation aligned to return targets.