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Wuhan Coronavirus
Chen-Hanson Ting
SVFIG
February 22, 2020
Wuhan Coronavirus
 Wuhan Coronavirus can be cured
by taking 10 grams of vitamin C
every 4 hours, until diarrhea.
 Flucan be cured by taking 5 grams
of vitamin C every 4 hours, until
diarrhea.
Wuhan Coronavirus
 Wuhan Coronavirus is now named
COVID-19, replacing SARS-CoV-2.
 The pandemic now exceeds the
size and seriousness of SRAS in
2003.
 We still do not know its origin.
Wuhan Coronavirus
 Rumors have that it was
manufactured in Wuhan P4 Lab.
 It is sequenced in many
laboratories in many countries.
 It is suspected to evolve
continually.
Wuhan Coronavirus
 It is suspected to have evolved in
hosts like bats, snakes, and
pangolins.
 Relations to other coronaviruses:
 SARS 79%
 Bat Coronavirus 80%
 Bat RaTG13 96%
Compare Viral Genomes
 Have the best tools to compare
genomes.
 My Exhaustive Pattern Search
algorithm can be used to identify
repeated sequences in two similar
genomes.
Genomes of SARS-CoV-2
 I have the best tools to compare
genomes.
 My Exhaustive Pattern Search
algorithm can be used to identify
repeated sequences in two similar
genomes.
Genomes of COVID-19
ID Matches Differences
MN908947 29883 0
MN938384 29758 60
MN975262 29771 100
MN985325 29802 60
MN988668 29861 0
MN988669 29861 0
LC521925 29769 59
LR757995 29811 41
LR757996 29848 0
LR757998 29806 40
SARS-CoV 1618 28113
MERS-CoV 5 30023
Genomes of COVID-19
 COVID-19 genomes are very different
from these of MERS-CoV and SARS-
CoV.
 3 COVID-19 are identical to the
Reference Sequence.
 20 differences are caused by 1
different nucleotide.
 6 COVID-19 differ from the Reference
Sequence by <6 nucleotides.
Genomes of CoVs
Name ID Length
Bat-sl-CoVZC45 MG772933 29802
Bat-sl-CoVZXC21 MG772934 29732
Bat-RaTG13 MN996532 29855
Human CoV-229E NC_002645 27317
Human SARS-Cov NC_004718 29751
Human CoV-NL63 NC_005831 27553
Human CoV-OC43 NC_006213 30741
Human CoV-HKU1 NC_006577 29926
Human MERS-CoV NC_019843 30119
Human COVID-19 NC_045512 29903
Matches in CoV Genomes
Name ZC45 ZXC21 RaTG13 229E SARS NL63 OC43 HKU1 MERS COVID
ZC45 29782 19509 4593 13 2444 0 7 8 5 4741
ZXC21 19509 29712 4584 11 2563 0 13 7 2 4674
RaTG13 4587 4578 29835 4 1597 0 5 3 13 14946
229E 27 25 2427297 25 85 24 5 4 24
SARS 2442 2561 1601 9 29731 1 7 5 1 1618
NL63 0 0 0 85 1 27533 4 14 2 1
OC43 9 15 13 12 11 4 30721 313 14 18
HKU1 8 7 3 5 5 14 313 29906 7 18
MERS 5 2 13 4 1 2 14 7 30099 1
COVID 4748 4681 14959 17 1627 1 23 18 1 29883
Matches in CoV Genomes
 COVID-19 genomes are very different
from other coronaviruses.
 Best matches to COVID-19 sequences:
 Bat RaTG13 14959
 Bat CoVCZC45 4748
 Bat CoVCZXC21 4681
 Human SARS-CoV 1627
SARS-CoV-2 Engineered?
 COVID-19 genome is most closely
related to Bat RaTG13.
 It is so much different from all other
coronaviruses that it is unlikely to be
engineered.
 It is difficult to prove either way unless
we have the exact sources from which
COVID-19 is assembled.
COVID-19
COVID-19
COVID-19
COVID-19 Genome
Structure of Coronavirus
 It has the look of a C60 Fullerene
or Buckminsterfullerene molecule.
 Fullerene is formed from graphite.
 A plain sheet of graphite buckled
under heat to form a ball.
Fullerene
Fullerene from Graphite
Fullerene
Fullerene
Demo
 Folding a Fullerene
Coronavirus Genome
 It has the look of a C60 Fullerene
or Buckminsterfullerene molecule.
 Fullerene is formed from graphite.
 A plain sheet of graphite buckled
under heat to form a ball.
Questions?
Thank You!

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Wuhan Coronavirus by Chen-Hanson Ting on February 22, 2020.

  • 2. Wuhan Coronavirus  Wuhan Coronavirus can be cured by taking 10 grams of vitamin C every 4 hours, until diarrhea.  Flucan be cured by taking 5 grams of vitamin C every 4 hours, until diarrhea.
  • 3. Wuhan Coronavirus  Wuhan Coronavirus is now named COVID-19, replacing SARS-CoV-2.  The pandemic now exceeds the size and seriousness of SRAS in 2003.  We still do not know its origin.
  • 4. Wuhan Coronavirus  Rumors have that it was manufactured in Wuhan P4 Lab.  It is sequenced in many laboratories in many countries.  It is suspected to evolve continually.
  • 5. Wuhan Coronavirus  It is suspected to have evolved in hosts like bats, snakes, and pangolins.  Relations to other coronaviruses:  SARS 79%  Bat Coronavirus 80%  Bat RaTG13 96%
  • 6. Compare Viral Genomes  Have the best tools to compare genomes.  My Exhaustive Pattern Search algorithm can be used to identify repeated sequences in two similar genomes.
  • 7. Genomes of SARS-CoV-2  I have the best tools to compare genomes.  My Exhaustive Pattern Search algorithm can be used to identify repeated sequences in two similar genomes.
  • 8. Genomes of COVID-19 ID Matches Differences MN908947 29883 0 MN938384 29758 60 MN975262 29771 100 MN985325 29802 60 MN988668 29861 0 MN988669 29861 0 LC521925 29769 59 LR757995 29811 41 LR757996 29848 0 LR757998 29806 40 SARS-CoV 1618 28113 MERS-CoV 5 30023
  • 9. Genomes of COVID-19  COVID-19 genomes are very different from these of MERS-CoV and SARS- CoV.  3 COVID-19 are identical to the Reference Sequence.  20 differences are caused by 1 different nucleotide.  6 COVID-19 differ from the Reference Sequence by <6 nucleotides.
  • 10. Genomes of CoVs Name ID Length Bat-sl-CoVZC45 MG772933 29802 Bat-sl-CoVZXC21 MG772934 29732 Bat-RaTG13 MN996532 29855 Human CoV-229E NC_002645 27317 Human SARS-Cov NC_004718 29751 Human CoV-NL63 NC_005831 27553 Human CoV-OC43 NC_006213 30741 Human CoV-HKU1 NC_006577 29926 Human MERS-CoV NC_019843 30119 Human COVID-19 NC_045512 29903
  • 11. Matches in CoV Genomes Name ZC45 ZXC21 RaTG13 229E SARS NL63 OC43 HKU1 MERS COVID ZC45 29782 19509 4593 13 2444 0 7 8 5 4741 ZXC21 19509 29712 4584 11 2563 0 13 7 2 4674 RaTG13 4587 4578 29835 4 1597 0 5 3 13 14946 229E 27 25 2427297 25 85 24 5 4 24 SARS 2442 2561 1601 9 29731 1 7 5 1 1618 NL63 0 0 0 85 1 27533 4 14 2 1 OC43 9 15 13 12 11 4 30721 313 14 18 HKU1 8 7 3 5 5 14 313 29906 7 18 MERS 5 2 13 4 1 2 14 7 30099 1 COVID 4748 4681 14959 17 1627 1 23 18 1 29883
  • 12. Matches in CoV Genomes  COVID-19 genomes are very different from other coronaviruses.  Best matches to COVID-19 sequences:  Bat RaTG13 14959  Bat CoVCZC45 4748  Bat CoVCZXC21 4681  Human SARS-CoV 1627
  • 13. SARS-CoV-2 Engineered?  COVID-19 genome is most closely related to Bat RaTG13.  It is so much different from all other coronaviruses that it is unlikely to be engineered.  It is difficult to prove either way unless we have the exact sources from which COVID-19 is assembled.
  • 18. Structure of Coronavirus  It has the look of a C60 Fullerene or Buckminsterfullerene molecule.  Fullerene is formed from graphite.  A plain sheet of graphite buckled under heat to form a ball.
  • 23. Demo  Folding a Fullerene
  • 24. Coronavirus Genome  It has the look of a C60 Fullerene or Buckminsterfullerene molecule.  Fullerene is formed from graphite.  A plain sheet of graphite buckled under heat to form a ball.