This document outlines the evolution of antipsychotic drugs from 1954 to present day. It provides information on key drugs such as chlorpromazine (1954), the first successful antipsychotic; haloperidol (1967), a typical antipsychotic of the phenothiazine group; clozapine (1960), the first atypical antipsychotic; and risperidone (1993), olanzapine (1996), quetiapine (1997), ziprasidone (2001), and aripiprazole (2002), which were among the first second-generation atypical antipsychotics approved. It also mentions amisulpride (2007), an atypical antipsychotic launched in India.

1. Chlorpromazine
1954
Trifluoperazine
1958
Haloperidol
1967Clozapine
1960
Risperidone
1993
Olanzapine
1996
Quetiapine
1997
Ziprasidone
2001
Aripiprazole
2002
Amisulpride
2007*
First successful antipsychotic
that revolutionized the
treatment of schizoph reni a
Dr. Henri Leborit discovered
this drug and used as an
anesthetic agent in surgery
Approved in 1954 for treatment
Typical antipsychotic drug
of the phenothiazine group
S t u d i e s s u g g e s t t h a t
Trifluoperazine may be able
to reverse addiction to opioids.
First atypical antipsychotic
developed in 1959 and
m a r k e t e d i n 1 9 6 0
Approved by USFDA in 1989
for Treatment-resistant
schizophrenia
Developed in 1957 and
i n t r o d u c e d i n 1 9 6 7
Approved by USFDA in 1988
Enrolled in the WHO List of
Essential Medicines
Approved by USFDA in 1993
f o r t h e t r e a t m e n t o f
s c h i z o p h r e n i a
In 2006 - approved for the use
in autistic children and in
2007 for treatment of
schizophrenia in children
above 13–18 yrs.
Appro ve d by USFDA for
t h e t r e a t m e n t o f
s c h i z o p h r e n i a i n 1 9 9 6
Olanzapine in combination with
Fluoxetine is approved for the
treatme nt of De pressive
episodes in Bipolar Disorders
The most widely prescibed
antipsychotic
Approved by USFDA for treatment
o f s c h i z o p h r e n i a i n 1 9 9 7
In 2004, Approved for the treatment
o f M a n i a - a s s o c i a t e d w i t h
Bipolar Disorder
th
5 atypical antipsychotic to gain
USFDA approval for the
treatment of schizophrenia.
Shows beneficial effects on
negative symptoms and
symptoms of depression
Ziprasidone received a (black
box) due to the fact that it
increases the QT interval
Approved by USFDA in 2002 for
the treatment of schizophrenia
Has uni que mechani sm of
action as it acts as a dopamine
stabilizer
Approved in 1988 in
most of the European
countries.
*Launched in India, 2007
Highly selective towards
D2 and D3 receptors
SIZONORM FORTE
SIZONORM PLUS
SIZONORM-10
Trifluperazine 5mg +
Trihexyphenidyl 2mg+
Chlorpromazine 50mg Tablets
Trifluoperazine 5mg +
Trihexyphenidyl 2mg Tablets
Trifluoperazine 10mg +
Trihexyphenidyl 2mg Tablets
HALOBIDHaloperidol 0.25/1.5/5/10/20mg
Tablets
REFRACTClozapine 25/50/100mg Tablets
D O NRisperidone 0.5/1/2/3/4 mg Tablets
OLAPIN
OLAPIN PLUS/FORTE
Olanzapine 2.5/5/7.5/10/15/20 mg
Tablets
Olanzapine 5 mg / 10 mg +
Fluoxetine Hcl 20 mg Tablets
PSYNILQuetiapine 25/50/100/200/300 mg Tablets
Aripiprazole 5/10/15/20/30 mg Tablets
!Sizopr de
Amisulpride
50/100/200 mg Tablets
EVOLUTION OF ANTIPSYCHOTICS