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The world of gene editing, which may occur in the future using CRISPR
What is CRISPR? Cutting up DNA and pasting new sequences back in. It allows us to do gene editing
The rise of CRISPR. CRISPR publications over the years have surged. And the scientist behind this great discovery is Jennifer Doudna.
CRISPR consists of 2 components: guide RNA and Cas9 protein
The steps to doing a CRISPR: 4 steps. Design specific guide RNA Combine guide RNA and Cas9 protein Guide RNA-Cas9 complex will target specific sites and cleave the target sequence Random repair mechanis knocks out gene
CRISPR has many applications: gene therapy, fuel, food, materials, etc.
CRISPR in medicine: curing HIV/AIDS Recent research has successfully eliminated HIV/AIDS in vitro
CRISPR in medicine: other applications Muscular dystrophy, cancer, and many more (cystic fibrosis, type 1 diabetes, etc)
CRISPR also has applications in agriculture and environment
The United Nations Environment Programme has stated 3 fundamental priorities in terms of future development in agriculture and environment Reduce hunger and poverty Improve nutrition, health, and rural livelihoods Facilitate social and environmental sustainability development
And CRISPR has the potential to address all of these goals. Think of growing crops that are more nutritious and more resistant to climate and pests, using gene editing
Some examples of research that has successfully utilized CRISPR to gene edit crops: 1. Arabidopsis thaliana 2. Tobacco plant
While the prospects of CRISPR look good, we have to remain cautious.
One concern of CRISPR is using CRISPR to gene edit the human embryo, like what a group of chinese scientists have done. This has serious implications on the issue of eugenics and designer babies.
And of course, there is the issue of safety as well, in both medicine and in agriculture. The potential side-effects of CRISPR and gene editing is still not known.
Perspectives for the future: CRISPR holds great promise for the future, possessing the potential to do great things: no hunger, no pollution, no disease. There are many applications with limitless potential. But we have to mindful of the ethical issues involving this technology. For example, is gene editing on human beings appropriate and ethically sound? Are there really no drawbacks?
References for the presentation
Setting New Frontiers
Cho Han, Chiang
National Taiwan University
1. Introduction to CRISPR and gene editing
2. Development of CRISPR: medicine, agriculture, environment
3. Pros and Cons of CRISPR
4. The future
Other medical applications
And Many more..
CRISPR in agriculture and environment
Reduce hunger and poverty
From: United Nations Environment Programme
Improve nutrition, health, and rural livelihoods
Facilitate social and environmental sustainability development
More resistant to climate and pests
CRISPR in agriculture and environment
Many applications, limitless potential
“With great power comes great responsibility”
1. Development and Applications of CRISPR-Cas9 for Genome Engineering
2. The CRISPR/Cas9 system for targeted genome editing
3. CRISPR IS COMING TO AGRICULTURE — WITH BIG IMPLICATIONS FOR FOOD, FARMERS,
CONSUMERS AND NATURE
4. Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal
5. Agriculture: A new breed of edits
6. CRISPR the disrupter