How do healthcare organizations create a systemwide focus on outcomes improvement? They build a healthcare outcomes improvement engine—a mechanism designed to drive successful and sustainable change. Creating this outcomes improvement engine requires four critical components: Engaging executives around outcomes improvement. Prioritizing opportunities most likely to succeed. Adequately staffing initiatives. Communicating success early and often. Once up and running, multidisciplinary engagement and standardized improvement processes fuel the outcomes improvement engine in its mission to produce sustainable, scalable improvement.