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Smoking and The Heart
                   PBRC


Publication # 64                                                                                                          December 2009



Introduction
The Heart is one of the        three times greater           heart disease, multiple
most vital organs in the       chance of developing          cancers, heart attacks,
human body. It regulates       heart disease or having a     stroke, and vascular
all blood flow in the body.    heart attack than non-        diseases.
Without it, we would not       smokers.
                                                             Smoking creates free rad-
get adequate oxygen and
                               Even secondhand smoke is      icals in the body that cause
               blood to the
                               dangerous. Studies show       oxidative damage in the
               tissues.
                               that people who are           bloodstream and in the
               There are       consistently exposed to       organs. The oxidative
               multiple fac-   secondhand smoke tend to      damage can cause
                                                                                                     Inside this issue:
               tors that can   have have an increased        emphysema and lung
               effect the      risk for cardiovascular       cancer.
               performance     diseases.                                                             THE FACTS ABOUT WHAT   2
                                                             Smoking causes coronary                 SMOKING DOES TO
of the heart. One of the
                               According to the Surgeon      heart disease, the leading              YOUR HEART
actions that can hinder
                               General, smoking harms        cause of death in the Unit-
heart health and
                               almost every organ in the     ed States*. Cigarette                   THE BENEFITS OF        3
performance is smoking.                                                                              QUITTING SMOKING
                               body, and reduces the         smokers are 2–4 times
The Surgeon General has        overall health of smokers.    more likely to develop cor-
named smoking the                                            onary heart disease than
                               Smoking contributes to
“leading preventable                                         nonsmokers.
                               many diseases and
cause of disease and
                               disorders. Smoking
deaths in the United
                               increases the risk for ath-   * CDC
States.” In addition, if you
                               erosclerosis, coronary
smoke, you have a two to


Top 5 Reasons Why You Should Not Smoke
1. Smoking                         in the United States.          cholesterol (HDL), which
   can lead                                                       help to clear out bad
                               3. Secondhand smoking is
   to lung                                                        cholesterol (LDL) in the
                                  harmful. Of the more
   and other                                                      bloodstream.
                                  than 4,000 chemicals
   cancers.
                                  that have been             5. Smoking harms nearly
   The more
                                  identified in                 every organ of the
   you smoke, the greater
                                  secondhand tobacco            body and diminishes a
   the risk of disease.
                                  smoke, at least 250           person’s overall
2. Smoking contributes to         are known to be harm-         health.
   the development of             ful, and 50 of these
   Coronary Heart                 are known to cause
   Disease and Stroke,            cancer.                    Reducing Tobacco Use: A Report of the
                                                             Surgeon General. U.S. DHHS, PHS,
   the first and third                                       CDC, NCCDPHP, Office on Smok-
                               4. Cigarettes lower the
   leading cause of death                                    ing and Health, 2000.
                                  levels of good
Smoking and The Heart
                    The Facts About What Smoking Does To Your Heart
                       According to research,      Smoking can promote            promoting plaque
                       if you smoke, have high     the development of             buildup in the arteries.
                       cholesterol, and high       atherosclerosis, or            This will eventually
                       blood pressure, your        hardening of arteries.         lead to atherosclerosis.
                       risk of having a heart      Over time, this causes         Smokers have a great-
                       attack is eight times       coronary heart disease,
                                                                                  er risk of being diag-
                       more than that of a         stroke, and artery
                                                                                  nosed with peripheral
                       nonsmoker.                  disease.
                                                                                  vascular disease, which
                       The toxins produced by      Carbon monoxide, a             causes the blood ves-
                       cigarettes are carried      product of tobacco             sels in both the legs or
                       throughout the body.        smoke, tends to                feet to become
                                                   increase LDL cholesterol       blocked.
                       Tobacco has a major
                                                   and white blood cells          Smokers have an
                       role in the development
Carbon                                             levels and increase
                       of preventable cardio-                                     increased risk for var-
monoxide, a                                        other risks for heart
                       vascular disease.                                          ious types of cancer,
product of                                         disease, while also
                                                                                  such as colorectal and
tobacco smoke          Smoking pipes or            reducing the hearts
(as well as                                                                       ovarian cancer.
                       cigars increases the risk   ability to carry oxygen
chemical plant         of death from coronary      to the tissues and             Many smokers feel that
smoke and car
                       heart disease and           organs.                        smoking relaxes them.
exhaust), tends
to boost LDL           stroke, but to a lesser                                    The feeling of relaxa-
                                                   A single cigarette can
cholesterol            extent than that of cig-                                   tion may be due to
                                                   impair circulation for
levels, as well        arette smokers.                                            deep breathing from
                                                   up to forty-five minutes
as levels of                                                                      inhaling. However, nic-
white blood            Cigarette smoking is an     by constricting small
                                                                                  otine is a stimulant
cells and other        important risk factor       blood vessels.
                                                                                  which increases heart
risks for heart        that leads to coronary      Smoking can cause              rate, respiration and
disease; not to        heart disease.                                             metabolism.
mention, it also                                   abdominal aortic
reduces the            Cigarette smoking has       aneurysms, which are           Nicotine stimulates the
hearts ability to      been connected to all       bulges in the wall of          release of many chemi-
carry oxygen to        types of sudden             the aorta near the             cal messengers in the
the tissues and        cardiac death in both       stomach. It is the             brain including acetyl-
other organs.          men and women.              thirteenth leading             choline, norepinephrine,
                                                   cause of death in he           epinephrine, vasopressin,
                       Switching to low tar
                                                   United States*.                arginine, dopamine, au-
                       nicotine cigarettes ra-
                                                                                  tocrine agents, and beta-
                       ther than normal ciga-      Smokers are ten times
                                                                                  endorphin, which are
                       rettes, does not reduce     more likely than non-          responsible for nico-
                       the risk of coronary        smokers to develop             tine's effects.
                       heart disease.              peripheral vascular
                                                   disease.
                       The nicotine in ciga-                                  *O'Connor, RE. eMedicine, 2009
                       rettes promotes insulin     Cigarette smokers have
                       resistance, a pre-          raised fibrinogen levels
                       diabetic condition          and platelet counts.
                       identified by high          This causes the blood to
                       blood sugar and insulin.    be more sticky,


                    Page 2
Publication # 64
The Benefits of Quitting Smoking
                                  decreases the workload on       lung cancer.
                                  the heart, and eventually
                                                                  There is a decrease in
                                  will decrease the risk of
                                                                  blood pressure and heart
                                  having a heart attack.
                                                                  rate after stopping
                                  The cessation of smoking        smoking. This improves
                                  greatly reduces the risk of     heart health and
                                  death or a second heart         productivity.
                                  attack in adults who have       A study on men smokers
                                  coronary heart disease.         shows an improvement in
                                  According to American           exercise tolerance and
Nicotine is an extremely
                                  Heart Association,              increased pressure in the
addictive chemical which
                                  individuals will have           extremities in the group that      After one year of being
makes it very difficult to stop
smoking. Studies show that        heightened sense of smell       stopped smoking compared           “smoke free”, the risk of
                                                                  to the group that continued to     coronary artery disease
nicotine activates the circuits   and taste, and an improved
                                                                  smoke.                              will have decreased by
in the brain that regulate        digestive system after
pleasurable feelings. This is     stopping smoking.               There are other benefits from                half!
done by a chemical called                                         stopping smoking. These are:
dopamine, which is increased      Stopping smoking will cause     cleaner environment,
by nicotine. When smokers         improved well being, lung       improved personal hygiene,
inhale, the nicotine reaches      function and immune             decreased sinus problems,
the brain faster than drugs       system.                         less heartburn or acid
that enter the body                                               indigestion, better circulation,
                                  Within two to three years
intravenously.                                                    and increased energy!
                                  after stopping smoking, the
Stopping smoking is not           risk of having a heart          After you stop smoking *:             After 15 years
                                                                                                        of abstinence,
easy, but there are many          attack will be the same as      1 Year After Quitting                 the risk is
aides such as gums, patch-        a person who has never          Your added risk of coronary           similar to
es, pills and shots that re-      smoked.                         heart disease is half that of a       that for
duce the desire for ciga-                                         smoker’s.                             people
                                  There is a decrease in the
rettes.                                                                                                 who've never
                                  risk for stroke after           5 Years After Quitting                smoked.
There are many benefits to        smoking cessation. After 5      Your stroke risk is reduced to
quitting smoking. Some of         to15 years, former smokers      that of a nonsmoker’s 5-15
these include a reduced           have the same risk of hav-      years after quitting.
chance of being diagnosed         ing a stroke as a nonsmoker     10 Years After Quitting               AHA
with diabetes, cancer, or         would.                          Your lung cancer death rate is
heart disease.                                                    about half that of a smoker’s.
                                  According to research,          Your risk of cancers of the
Nicotine, one of thousands of     after five years of not         mouth, throat, esophagus,
chemicals found in cigarettes,    smoking, patients have a        bladder, kidney, and
causes the blood vessels to       21 percent reduction in the     pancreas decreases.
constrict. This narrowing of      risk for lung cancer, when
the vessels increases blood                                       15 Years After Quitting
                                  compared with current           Your risk of coronary heart
pressure.                         smokers. Those who have         disease is back to that of a
Within twenty-four hours of       not smoked for 20 to 30         nonsmoker’s.
stopping smoking, blood           years or more, have an 87
pressure and pulse rate will      percent reduction in the risk
drop to normal. This              of being diagnosed with         * CDC


                                                                                          Page 3
PBRC




                                                  About Pennington
 The Pennington Biomedical Research Center is a world-renowned                   Pennington Biomedical Research
 nutrition research center.                                                                  Center
                                                                                       6400 Perkins Road
 Mission:                                                                            Baton Rouge, LA 70808
 To promote healthier lives through research and education in nutri-                     (225) 763-2500
 tion and preventive medicine.                                                            www.pbrc.edu

 The Pennington Center has several research areas, including:

       Clinical Obesity Research
       Experimental Obesity
       Functional Foods
       Health and Performance Enhancement
       Nutrition and Chronic Diseases
       Nutrition and the Brain
       Dementia, Alzheimer’s and healthy aging
       Diet, exercise, weight loss and weight loss maintenance

 The research fostered in these areas can have a profound impact on      Pennington Nutrition Series No 64, 2009
 healthy living and on the prevention of common chronic diseases,        Authors
 such as heart .disease, cancer, diabetes, hypertension and osteoporo-
 sis.
                                                                         Heli J. Roy, PhD, RD
 The Division of Education provides education and information to         Beth Kalicki
 the scientific community and the public about research findings,
 training programs and research areas, and coordinates educational
 events for the public on various health issues.                         Division of Education
 We invite people of all ages and backgrounds to participate in the      Pennington Biomedical Research Center
 exciting research studies being conducted at the Pennington Center      12/09
 in Baton Rouge, Louisiana. If you would like to take part, visit the
 clinical trials web page at www.pbrc.edu or call (225) 763-3000

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Smoking and the heart newsletter

  • 1. Smoking and The Heart PBRC Publication # 64 December 2009 Introduction The Heart is one of the three times greater heart disease, multiple most vital organs in the chance of developing cancers, heart attacks, human body. It regulates heart disease or having a stroke, and vascular all blood flow in the body. heart attack than non- diseases. Without it, we would not smokers. Smoking creates free rad- get adequate oxygen and Even secondhand smoke is icals in the body that cause blood to the dangerous. Studies show oxidative damage in the tissues. that people who are bloodstream and in the There are consistently exposed to organs. The oxidative multiple fac- secondhand smoke tend to damage can cause Inside this issue: tors that can have have an increased emphysema and lung effect the risk for cardiovascular cancer. performance diseases. THE FACTS ABOUT WHAT 2 Smoking causes coronary SMOKING DOES TO of the heart. One of the According to the Surgeon heart disease, the leading YOUR HEART actions that can hinder General, smoking harms cause of death in the Unit- heart health and almost every organ in the ed States*. Cigarette THE BENEFITS OF 3 performance is smoking. QUITTING SMOKING body, and reduces the smokers are 2–4 times The Surgeon General has overall health of smokers. more likely to develop cor- named smoking the onary heart disease than Smoking contributes to “leading preventable nonsmokers. many diseases and cause of disease and disorders. Smoking deaths in the United increases the risk for ath- * CDC States.” In addition, if you erosclerosis, coronary smoke, you have a two to Top 5 Reasons Why You Should Not Smoke 1. Smoking in the United States. cholesterol (HDL), which can lead help to clear out bad 3. Secondhand smoking is to lung cholesterol (LDL) in the harmful. Of the more and other bloodstream. than 4,000 chemicals cancers. that have been 5. Smoking harms nearly The more identified in every organ of the you smoke, the greater secondhand tobacco body and diminishes a the risk of disease. smoke, at least 250 person’s overall 2. Smoking contributes to are known to be harm- health. the development of ful, and 50 of these Coronary Heart are known to cause Disease and Stroke, cancer. Reducing Tobacco Use: A Report of the Surgeon General. U.S. DHHS, PHS, the first and third CDC, NCCDPHP, Office on Smok- 4. Cigarettes lower the leading cause of death ing and Health, 2000. levels of good
  • 2. Smoking and The Heart The Facts About What Smoking Does To Your Heart According to research, Smoking can promote promoting plaque if you smoke, have high the development of buildup in the arteries. cholesterol, and high atherosclerosis, or This will eventually blood pressure, your hardening of arteries. lead to atherosclerosis. risk of having a heart Over time, this causes Smokers have a great- attack is eight times coronary heart disease, er risk of being diag- more than that of a stroke, and artery nosed with peripheral nonsmoker. disease. vascular disease, which The toxins produced by Carbon monoxide, a causes the blood ves- cigarettes are carried product of tobacco sels in both the legs or throughout the body. smoke, tends to feet to become increase LDL cholesterol blocked. Tobacco has a major and white blood cells Smokers have an role in the development Carbon levels and increase of preventable cardio- increased risk for var- monoxide, a other risks for heart vascular disease. ious types of cancer, product of disease, while also such as colorectal and tobacco smoke Smoking pipes or reducing the hearts (as well as ovarian cancer. cigars increases the risk ability to carry oxygen chemical plant of death from coronary to the tissues and Many smokers feel that smoke and car heart disease and organs. smoking relaxes them. exhaust), tends to boost LDL stroke, but to a lesser The feeling of relaxa- A single cigarette can cholesterol extent than that of cig- tion may be due to impair circulation for levels, as well arette smokers. deep breathing from up to forty-five minutes as levels of inhaling. However, nic- white blood Cigarette smoking is an by constricting small otine is a stimulant cells and other important risk factor blood vessels. which increases heart risks for heart that leads to coronary Smoking can cause rate, respiration and disease; not to heart disease. metabolism. mention, it also abdominal aortic reduces the Cigarette smoking has aneurysms, which are Nicotine stimulates the hearts ability to been connected to all bulges in the wall of release of many chemi- carry oxygen to types of sudden the aorta near the cal messengers in the the tissues and cardiac death in both stomach. It is the brain including acetyl- other organs. men and women. thirteenth leading choline, norepinephrine, cause of death in he epinephrine, vasopressin, Switching to low tar United States*. arginine, dopamine, au- nicotine cigarettes ra- tocrine agents, and beta- ther than normal ciga- Smokers are ten times endorphin, which are rettes, does not reduce more likely than non- responsible for nico- the risk of coronary smokers to develop tine's effects. heart disease. peripheral vascular disease. The nicotine in ciga- *O'Connor, RE. eMedicine, 2009 rettes promotes insulin Cigarette smokers have resistance, a pre- raised fibrinogen levels diabetic condition and platelet counts. identified by high This causes the blood to blood sugar and insulin. be more sticky, Page 2
  • 3. Publication # 64 The Benefits of Quitting Smoking decreases the workload on lung cancer. the heart, and eventually There is a decrease in will decrease the risk of blood pressure and heart having a heart attack. rate after stopping The cessation of smoking smoking. This improves greatly reduces the risk of heart health and death or a second heart productivity. attack in adults who have A study on men smokers coronary heart disease. shows an improvement in According to American exercise tolerance and Nicotine is an extremely Heart Association, increased pressure in the addictive chemical which individuals will have extremities in the group that After one year of being makes it very difficult to stop smoking. Studies show that heightened sense of smell stopped smoking compared “smoke free”, the risk of to the group that continued to coronary artery disease nicotine activates the circuits and taste, and an improved smoke. will have decreased by in the brain that regulate digestive system after pleasurable feelings. This is stopping smoking. There are other benefits from half! done by a chemical called stopping smoking. These are: dopamine, which is increased Stopping smoking will cause cleaner environment, by nicotine. When smokers improved well being, lung improved personal hygiene, inhale, the nicotine reaches function and immune decreased sinus problems, the brain faster than drugs system. less heartburn or acid that enter the body indigestion, better circulation, Within two to three years intravenously. and increased energy! after stopping smoking, the Stopping smoking is not risk of having a heart After you stop smoking *: After 15 years of abstinence, easy, but there are many attack will be the same as 1 Year After Quitting the risk is aides such as gums, patch- a person who has never Your added risk of coronary similar to es, pills and shots that re- smoked. heart disease is half that of a that for duce the desire for ciga- smoker’s. people There is a decrease in the rettes. who've never risk for stroke after 5 Years After Quitting smoked. There are many benefits to smoking cessation. After 5 Your stroke risk is reduced to quitting smoking. Some of to15 years, former smokers that of a nonsmoker’s 5-15 these include a reduced have the same risk of hav- years after quitting. chance of being diagnosed ing a stroke as a nonsmoker 10 Years After Quitting AHA with diabetes, cancer, or would. Your lung cancer death rate is heart disease. about half that of a smoker’s. According to research, Your risk of cancers of the Nicotine, one of thousands of after five years of not mouth, throat, esophagus, chemicals found in cigarettes, smoking, patients have a bladder, kidney, and causes the blood vessels to 21 percent reduction in the pancreas decreases. constrict. This narrowing of risk for lung cancer, when the vessels increases blood 15 Years After Quitting compared with current Your risk of coronary heart pressure. smokers. Those who have disease is back to that of a Within twenty-four hours of not smoked for 20 to 30 nonsmoker’s. stopping smoking, blood years or more, have an 87 pressure and pulse rate will percent reduction in the risk drop to normal. This of being diagnosed with * CDC Page 3
  • 4. PBRC About Pennington The Pennington Biomedical Research Center is a world-renowned Pennington Biomedical Research nutrition research center. Center 6400 Perkins Road Mission: Baton Rouge, LA 70808 To promote healthier lives through research and education in nutri- (225) 763-2500 tion and preventive medicine. www.pbrc.edu The Pennington Center has several research areas, including: Clinical Obesity Research Experimental Obesity Functional Foods Health and Performance Enhancement Nutrition and Chronic Diseases Nutrition and the Brain Dementia, Alzheimer’s and healthy aging Diet, exercise, weight loss and weight loss maintenance The research fostered in these areas can have a profound impact on Pennington Nutrition Series No 64, 2009 healthy living and on the prevention of common chronic diseases, Authors such as heart .disease, cancer, diabetes, hypertension and osteoporo- sis. Heli J. Roy, PhD, RD The Division of Education provides education and information to Beth Kalicki the scientific community and the public about research findings, training programs and research areas, and coordinates educational events for the public on various health issues. Division of Education We invite people of all ages and backgrounds to participate in the Pennington Biomedical Research Center exciting research studies being conducted at the Pennington Center 12/09 in Baton Rouge, Louisiana. If you would like to take part, visit the clinical trials web page at www.pbrc.edu or call (225) 763-3000