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Amyotrophic Lateral Sclerosis

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The powerpoint details the effects that this dreadfull disease can impose upon those affected.

Publié dans : Formation, Santé & Médecine
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Amyotrophic Lateral Sclerosis

  1. 1. By Diana Rodriguez and Hugo Mendez 1 1
  2. 2.  Amyotrophic Lateral Sclerosis is defined as a debilitative disease that disrupts the functions of the motor neurons causing complications within the patient that include: Rapidly progressing weakness, muscle atrophy, muscle spasticity, difficulty speaking (Dysathria), difficulty swallowing ( dysphagia), and difficulty breathing (dyspnea). 2
  3. 3.  The cause has not yet been fully concluded although certain researchers believe the disease is produced through a mutation within the gene that produces the SOD1(superoxide dismutase) enzyme which aids within mitochondrial purification. It is theorized that the mutation causes the accumulation of free radicals which catalyze motor neuron degeneration. Scientists also theorize the involvement of several factors contribute to the development of Amyotrophic lateral sclerosis, these include: electric Shock, military Service, chemical exposure, and cranial trauma. 3 3
  4. 4.   The only medication that has provided results seems to be the medication Rilutek. Rilutek only seems to slow the progression of the disease, but it presents certain dangers toward the patient’s liver health. Other Pharmaceutical treatments may be prescribed in order to relieve fatigue and muscle spasticity. The patient will also need to receive Physical and speech therapy in order to delay muscular degeneration and promote independence. The treatments consist of physical rehabilitation sessions that assist patients with tasks such as walking and other physical endeavors and speech therapy which instruct the patient upon the procedures that will allow them to communicate during the progression of their illness. Individuals affected will also need respiratory assistance due to their failing respiratory muscles. 4 4
  5. 5.  There is no way in which Amyotrophic Lateral Sclerosis can be prevented. 5 5
  6. 6.  As many as 20,000-30,000 individuals within the united states are affected by Amyotrophic Lateral Sclerosis and 5,000 individuals are diagnosed every year. Amyotrophic Lateral Sclerosis is the most common neuromuscular diseases worldwide. Amyotrophic Lateral Sclerosis commonly affects individuals between the ages of 40-60, men are affected at a higher quantity than women. 6 6
  7. 7.             1824-Charles Bell writes a report about Amyotrophic Lateral Sclerosis. 1850- English scientist Augustus Waller describes the appearance of shriveled nerve fibers. 1869-French Physician Jean-Martin Charcot first describes ALS in scientific literature. 1881- “Amyotrophic Lateral Sclerosis” is translated into English and translated in a three-volume edition of Lectures on the Diseases of the Nervous System. 1939-ALS is recognized within the united states due to Lou Gerhig’s case. 1950’s-ALS epedemic occurs among the Chamorro people within Guam. 1991-Researchers link chromosome 21 to Familial Amyotrophic Lateral Sclerosis. 1993-SOD1 gene on chromosome 21 is connected to the development of Familial Amyotrophic Lateral Sclerosis. 1996_ Rilutek is approved by the FDA in order to treat the disease. 1998- A criteria is developed in order to diagnose the disease. 1999-The revised ALS functional rating scale is approved. 2011-Non coding repeat expansions within C9ORF72 are found to be a major cause of ALS and fronto temporal dementia. 7 7
  8. 8. 8 8
  9. 9. http://www.youtube.com/watch? v=pQNnGq35PWg 9 9
  10. 10. http://www.nmh.org/nm/podcast-als-newknowledge 10
  11. 11.   http://en.wikipedia.org/wiki/Amyotrophi c_lateral_sclerosis http://www.ninds.nih.gov/disorders/amy otrophiclateralsclerosis/detail_ALS.htm# 240444842 11

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