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cellular respiration
(Cellular
respiration)




    ATP
ATP (Adenosine triphosphate)
Pi

     ATP     Pi


       ATP
ATP
ATP

    ATP
phosphorelation
H2O


      kcal/mole




      Hydrolysis
–

–
Inner Matrix
Outer Membrance




                                 Inner Membrance
          -

                  –
              ,             ,
1.                  (glycolysis)


     Acetyl_ CoA)

                      (Krebs cycle)
•
•

          (Emden)
              (Meyerhof)
          (parnas)
•                     EMP pathway
    EMP
•




    C H   O   6O ---> 6CO   6H O
•
                     (pyruvic acid)
        (pyruvate)
    2C3H4O3
•
mitochondria
pyruvate           mitochondria




 Net: 2 Pyruvate     2 Acetyl CoA   2NADH
           2C2O
Krebs cycle

mitochondria
matrix
2 Krebs cycle / 1 Glucose
2 Acetyl CoA     4CO2
+ 6NADH2
               e- transport chain
+2 FADH2
+ 2 ATP (substrate level
phosphorylation)
The pathway of
electron transport
 ETC
 electron carrier
 molecules          e-)
        inner
 mitochondrial
 membrane
        e-
 e-
 H+

       intermembrane
O2                    e-
                            H+
                H2O
½ O2 +   2e-   + 2H+        H20



ETC                        ATP
                              H+
gradient
     mitochondria


phosphorylation
Review: how each molecules of glucose yields many ATP
molecules during cellular respiration
C

acetyl Co.A
         O2

                  PGAL

                         O2

                   O2    O2
•   -oxidation
•     n          C
• beta-oxidation
           beta
•            n                 C

•                              beta -oxidation n 2-1
• beta -oxidation                                   5
  ATP
•           fatty acylCoA    n2                    kreb
  cycle
• kreb cycle 1              12 ATP
•                                          1 ATP
•                   ATP                        1
•               C               16
               ATP
•   ATP n 2-1 5+ n 2 12 - 1
•   ATP 16/2-1 5+ 16/2 12 – 1
•   ATP 7 5+ 8 12 – 1
•   ATP 35+96 – 1
•   ATP 131- 1
•   ATP 130
•


                       -NH2

             NH3

•
    urea
•          uric acid
(NH )


       pyruvic acid   acetyl co.A   α-ketoglutaric
acid
20
Fermentation
       (Backup ATP production)

Glycolysis   Pyruvate      Lactate (animal)
                            CO2 + alcohol (yeast)


                 product
  enzyme
       fermentation       ATP
NADH         fermantation
         NAD+          glycolysis
Alcohol fermentation (yeast)
Lactic acid fermentation (animal cell)
Pyruvate as a key junction in catabolism


                             Glycolysis
                             pyruvate


                             fermentation
                                   aerobic
                             cellular
                             respiration

                                           O2
         fermantation
                         ATP
        muscle cell        fermentation

fermentation                        ATP       lactate
   muscle cell

                                              O2
            lactate
           pyruvate
                     glucose
       anaerobic        alcohol       alcohol


                              fermentation

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การหายใจระดับเซลล์

  • 4. Pi ATP Pi ATP
  • 5. ATP
  • 6. ATP ATP phosphorelation
  • 7. H2O kcal/mole Hydrolysis
  • 9. Inner Matrix Outer Membrance Inner Membrance - – , ,
  • 10.
  • 11. 1. (glycolysis) Acetyl_ CoA) (Krebs cycle)
  • 12. • • (Emden) (Meyerhof) (parnas) • EMP pathway EMP
  • 13. C H O 6O ---> 6CO 6H O
  • 14.
  • 15.
  • 16. (pyruvic acid) (pyruvate) 2C3H4O3 •
  • 17.
  • 18. mitochondria pyruvate mitochondria Net: 2 Pyruvate 2 Acetyl CoA 2NADH 2C2O
  • 20. 2 Krebs cycle / 1 Glucose 2 Acetyl CoA 4CO2 + 6NADH2 e- transport chain +2 FADH2 + 2 ATP (substrate level phosphorylation)
  • 21. The pathway of electron transport ETC electron carrier molecules e-) inner mitochondrial membrane  e- e- H+ intermembrane
  • 22. O2 e- H+ H2O ½ O2 + 2e- + 2H+ H20 ETC ATP H+ gradient mitochondria phosphorylation
  • 23. Review: how each molecules of glucose yields many ATP molecules during cellular respiration
  • 24. C acetyl Co.A O2 PGAL O2 O2 O2
  • 25.
  • 26. -oxidation • n C
  • 27. • beta-oxidation beta • n C • beta -oxidation n 2-1 • beta -oxidation 5 ATP • fatty acylCoA n2 kreb cycle • kreb cycle 1 12 ATP • 1 ATP • ATP 1
  • 28. C 16 ATP • ATP n 2-1 5+ n 2 12 - 1 • ATP 16/2-1 5+ 16/2 12 – 1 • ATP 7 5+ 8 12 – 1 • ATP 35+96 – 1 • ATP 131- 1 • ATP 130
  • 29. -NH2 NH3 • urea • uric acid
  • 30. (NH ) pyruvic acid acetyl co.A α-ketoglutaric acid
  • 31. 20
  • 32.
  • 33. Fermentation (Backup ATP production) Glycolysis Pyruvate Lactate (animal) CO2 + alcohol (yeast) product enzyme
  • 34. fermentation ATP NADH fermantation NAD+ glycolysis
  • 36. Lactic acid fermentation (animal cell)
  • 37. Pyruvate as a key junction in catabolism Glycolysis pyruvate fermentation aerobic cellular respiration O2
  • 38. fermantation ATP muscle cell fermentation fermentation ATP lactate muscle cell O2 lactate pyruvate  glucose anaerobic alcohol alcohol  fermentation