1. Institute of Molecular Biology & Biotechnology Technologies Models Services … in the postgenomic era

2. IMBB Investigates ... Gene expression under stress & in differentiation The nervous system aging & neurodegeneration Development & differentiation Protein trafficking & molecular machines Mosquitoes and malaria

3. IMBB Develops ... Insect control systems ( Minos Biosystems , Bayer) DNA microchip prognostics ( Breast cancer ) New antibiotics (Pfitzer) Gene silencing technologies ( Crop protection ) Protein products ( Enzymes & Biopharmaceuticals) Acoustic biosensors

4. Computational Biology & Biomedical Informatics (IMBB-ICS) Molecular imaging & tomography (IESL - IMBB) Nano-biotechnology (ΙΜΒΒ- ICE/HT-IESL ) IMBB Promotes ... Interdisciplinary research

5. IMBB-Industry collaborations A variety of business models SecA inhibitors Pfizer Bayer SmithKlein Beecham BOEHRINGER MANNHEIM Chitin deacetylation Secretion Biotechnology Molecular Biology Enzymes Chitin synthase inhibitors Chitozyme, Marine Biopolymers BioLabs NEW ENGLAND

7. The E. coli bacterium – 4.200 genes “ If we understand the biology of E. coli we will know the biology of the elephant” [J. Monod]

8. H 2 O lipid Bacterial secretion of proteins H 2 O T3S Sec

10. Decision Diagram for the Exploitation of Scientific Discoveries Scientific Discovery Is it Useful? Invention Yes No Does it have an economic Potential? Yes Scientific Publication No Intellectual Property Does it need Protection? Yes No Patent Application No Business Secrete Does is provide Entrepreneurial Basis? No No Yes Technology Transfer Business Plan

11. Drosophila and Genetics – life with 14.000 genes

12. Identification of insect chitin synthases BAYER AG Protection of IPR by patents (EPO, JPO, USPTO) Chitin exists in the cuticle and the peritrophic membrane of insects Chitin synthesis is a prime target for of pest control agents { Epicuticle (cuticulin layer) Exocuticle { Endocuticle { Epidermis { Procuticle (chitin and proteins) Synthesis zone Hemolymph

14. Decision Diagram for the Exploitation of Scientific Discoveries Scientific Discovery Is it Useful? Invention Yes No Does it have an economic Potential? Yes Scientific Publication No Intellectual Property Does it need Protection? Yes No Patent Application No Business Secrete Does is provide Entrepreneurial Basis? No No Yes Technology Transfer Business Plan

15. MINOS trangenesis technologies Medfly SIT control

16. Minos + HGH Insect Protein Factories larvae purification HGH Mass rearing facility 500 tons / week yields HGH

17. The mouse – 35.000 genes THE model for human disease Genetic tranformation of mouse

18. IMBB-FORTH Products & Services MINOTECH Biotechnology IMMUNOLOGY PRODUCTS Hormonal immunodiagnostics Reproductive management of cows Procedure employed by DELTA S.A. MICROCHEMISTRY PRODUCTS Custom DNA oligonucleotides SERVICES DNA sequencing GMO testing PRODUCTS DNA restriction enzymes DNA modification enzymes Cytokines SERVICES Fermentation Protein expression Protein purification

19. Science & Technology Parks and Innovation Policies in Greece Myths and Reality

20. “ Lefkippos” Technology Park of Attica Technology & Culture Park - Lavrion Thessaloniki Technology Park Science & Technology Park - Epirus Patras Science Park Science & Technology Park of Crete University of Ioannina University of Patras Foundation for Research & Technology - Hellas The Centre for Research & Technology Hellas NCRS “Demokritos” National Technical University of Athens

22. Can low-tech environments favor the Development of Science and Technology Parks?

23. Main Objectives of Science and Technology Parks Technology transfer Regional or National Development

24. The Different Groups Interested in Science Parks Universities-Research Centers Government-Politicians Industry Venture Capital

26. Objectives of the Government: Development - - - Creation of new jobs Improve the image of an area Increase the average income

27. Prerequisites Strategy for regional development Economic Incentives Industrial situation Degree of unemployment in area Degree of education in area Image of area Local politicians

28. Objectives of the industry Increase the number of suppliers, or potential clients Increase the number of inhabitants in the region and their average income Synergy with new firms Possibility for the location of subsidiaries of existing companies Improve image of area

29. Prerequisites Type of industry in area (big industry which needs suppliers, or small industries which need more clients) Size of companies Degree of R&D in companies Degree of high-tech of companies

30. Venture Capital

31. Spontaneous Development Silicon Valley MIT Univ. of Stanford Route 128

32. - - - - Association with centers of excellence of different universities and Research Centers Select locations that have commercial, geographical or financial advantages Organization and management Access to International Technology Transfer and Venture Capital