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ERA-NETs 2013 Interfacultary Centre of Biomaterials – Univ. Liège

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ERA-NETs 2013

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ERA-NETs 2013 Interfacultary Centre of Biomaterials – Univ. Liège

  1. 1. Interfacultary Centre of Biomaterials – Univ. Liège www.ceib.ulg.ac.be 4 departements – staff ~ 30 p1. Polymer synthesis• biodegradable polyesters• functionalized poly(methyl)acrylate2. Polymer processing• Hydrogels• Film• Dispersed materials : micelles, nano-microparticles• drug immobilisation3. Analytical• Solubility, Mw determination• Stability, release kinetics study• Particle characterisation4. In vitro toxicity• Hemocompatibiliy 1• Animal cell tox
  2. 2. Particle Drug Delivery Drug formulationGENERALORGANISATION OF In vitro testingTHE RESEARCHPolymer synthesis Cell therapy – Tissue engineering In vivo testing VALORISATION : Patents – Close collaboration with industries – Analytical services 2
  3. 3. Biodegradable polyesters Macromolecular engineering with controlled polymerisation mechanism of cyclic monomers such as lactides, lactones. Novel architectures: block graft, random star-branched copolymers PolymerTECH : more than 300 different polymer samples available Material type : thermoplastics, hydrogels, amphiphilic gels Batch size : from g to 100 g ; in the near future : Kg scale facilities with reactive extrusion polymerisationSynthetic polyelectrolytes Living radical polymerisation of acrylic monomers Stimuli-responsive polymers. Functionalized polymers with reactive groups for synthesisof bioconjugates and fluorescent labelling of biomaterials. Strongly adhering polymers 3 Bulk polymerisation and purification in aqueous medium
  4. 4. Tissue engineering 4
  5. 5. Research project proposals 5
  6. 6. Amphiphilic Biodegradable and biocompatible Hydrogels for Tissue engineering and Drug Delivery Increase the softness of the material by increasing it’s hydrophilicity L - H - L L - H - L hydrophobe hydrophile 250 15 min 24 h 1 semaine 200 Prise de masse [%] 150 100 50 H 0 0 10 20 30 40 50 60 70 Proportion molaire de PEO [%] 6
  7. 7. Biocompatibility Preclinical trials Histological evaluation after 2 weeks of implantation (subcutaneous on rat) With comonomer No comonomerMembrane without comonomer is broken
  8. 8. Degradable textiles and stem cells. Multifilament Monofilament Multifilament Monofilament Osteoblast cells Stem cellsCell appearance after a 24 hours incubation with 3D textile (Confocal microscopyafter fibers morphology analysis (LIVE/DEAD Kit´s labeling)
  9. 9. Biocompatible biodegradable composite gel / textile for tissue engineering
  10. 10. Biocompatible nanocarrier for drug delivery systems Protein drug (Human Insulin)  Poly (ethylene oxide) O -BiocompatibilityH3CO -Hydrophilicity O C O - Eliminable through kidney n m  Poly-e-(caprolactone) PEO PCL -Biodegradability, -Compatibility with a wide range of other polymer -Relatively low cost. -High crystallinity
  11. 11. 11
  12. 12. Fluorescent polymer labellingPurposes :1. Biodistribution / bioelimination studies2. Intracellular trafficking studiesMain objective : new biocompatible polymers as possiblereplacement for classical non degradable polyethyethyleneoxide Techniques : 1. FACS analysis 2. Confocal microscopy 12
  13. 13. Prof. Christian GRANDFILS www.ceib.ulg.ac.be C.Grandfils@ulg.ac.be 13
  14. 14. MATERIA NOVA … in short
  15. 15. Materia-Nova : R&D centre Site INITIALIS Mons • since 2000Site NATISS • non-profit organizationGhislenghien • 90 employees • turnover 2011 : 8,5 Mio€ • pure project financing • 2011: member of EMRA
  16. 16. Business model « Materia-Nova » SMPC SDM SCMN INFLUX CHIPS BIOTECH P. Dubois M. Olivier R.Lazzaroni P. Damman R. Snyders R. Wattiez Fondamental Research Applied Research INDUSTRY
  17. 17. Fields of expertise NanotechnologiesPlasma technologies Electrochemistry Polymers Sol-gels (Nano-)composites Structured Biopolymers surfaces Biodegradation Modelisation Synthesis Biotechnology Devices
  18. 18. Our mission Research programs in collaboration with industrial partners Strategic partnership with multinational companies ... but also : Tests et analyses Scientific advice and consultancies
  19. 19. PartnersAGC Galactic NittoArcelorMittal Galvapower Group RoquetteArkema Goodyear SojitzBAT Husqvarna SolvayBeaulieu Inergy SRCBTN Kabelwerk Eupen Techspace AeroEssilor Knauf TotalESE Lhoist ToyotaEvian Matrio VallourecFaurecia Nexans WhirlpoolFuterro NMC …
  20. 20. BCRC, CERTECH, CTP & MATERIA NOVAwww.emra.eu
  21. 21. Contact Luc LANGER General Manager Avenue Nicolas Copernic, 1 B-7000 Mons, Belgium Tel: +32 65 554902 e-mail: Luc.Langer@materianova.be Web: www.materianova.be

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