1. Malabsorption of iron, folate,
calcium and fat soluble vitamins
results in iron deficiency, folate
deficiency and reduced bone
density

2. Infants and young children
present with diarrhoea,
abdominal distension and
FAILURE TO THRIVE

3.  Calcium malabsorption
 Vitamin D malabsorption
 Secondary hyperparathyroidism
 Failure of peak bone density as child
 Reduced gonadal function in men
 Autoimmunity

4.  Delayed menarche
 Premature menopause
 Amenorrhoea
 recurrent miscarriages
 Infertility & low birthweight babies
 Increased perinatal mortality

5.  Coeliac Disease
 Diabetes Mellitus
 Autoimmune Thyroid Disease / MS
 Rheumatoid Arthritis / Psoriasis
 Glomerulonephritis
Antibodies disappear on a gluten free diet

6. Anaemia
Allergies
Thyroid Disease
Lactose Intolerance
IBS, CFS

7.  IDDM
 Addisons
 Thyroid disease
Disease
 Sjogrens  Cardiomyopathy
Disease
 Neurological
 Renal Disease
disorders
 Autoimmune
liver disease

8.  Antibodies against gliadin
(IgA-AGA, IgG-AGA)
 Endomysial antibody (IgA-EMA)
 Tissue transglutaminase antibody
(IgA-tTG)
 Total IgA

9. Malignant diseases are more
frequent in coeliacs
 Small bowel CA
 Oesophageal & oropharangeal CA
 Non-Hogkins lymphoma

10.  Autistic children respond to
gluten-free,casein-free diet
 Improved speech, social behaviour,
sleeping habits
 Food peptides affect ADHD
 Depression & morphine-like
exorphins

11. Oats are not toxic to
patients with Coeliac
Disease or Dermatitis
Herpetiformis

12.  Genetic link (HLA-DQ2 and HLA-DQ8)
in patients with coeliac disease
 Alpha-gliadin has immunoreactve
peptides
 Hyphal wall protein (HWP 1) in
C. albicans. Similar epitopes in gliadin

14.  Yeasts adhere to gut via transglutaminases
 Gliadin deamidated via transglutaminases
 Yeast & gluten provide T-cell epitopes
(reactive peptides which trigger antibodies)
 Autoreactive antibodies form against tissue
transglutaminases and endomysium peptides

15.  Increased candida overgrowth
 Damage to gut
 Increased exposure of transglutaminases
 Increased binding of candida HWP 1
 Tissue transaminases (autoantigen)
recognised by autoreactive antibodies

16.  Introduce gluten while breast feeding
 Small quantities of gluten only
 Keep breast feeding after gluten exposure
 Breast feeding at exposure increases oral
tolerance
 Breast feeding protects against Diabetes
type 1, IBS and Leukaemia

17. Uncommon,
 Milk Allergy
Small amounts trigger
IgE mediated
Reactions sudden
Common
 Milk Normal amounts trigger
Intolerance
Not IgE mediated
Skin tests Negative
Reactions delayed (4-26 days)

18.  Masking- Remove dust, mould, dogs etc
 Glue ear- Are parents atopic?
 IBS- Milk & wheat increase rectal PGʼs
 Asthma- Look for milk addiction
 Eczema- >2 allergens (related to asthma)

21. Total Fat (% total energy)
No IHD IHD
Framington 38.8 40.0
Puerto Rico (urban) 36.6 37.7
Puerto Rico (rural) 32.2 32.0
Honolulu 33.3 35.2
London 40.5 40.0
Zutphen 41.7 41.8
Ireland/Boston 38.5 39.4
Caerphilly 40.1 40.9

22.  Glucose-Galactose (disaccharide)
 12g per 250ml milk
 Reduced in yogurt/fermented milk
 Absent in hard cheese
 Intolerance when lactase deficient

23. Examination of 23,207 sets of coronary
arteries and aortas revealed severity of
atherosclerosis was related to:
 Highest daily milk consumption
 hose with highest lactase activity
T

25. Men 55-64 yrs had the same
cholesterol and sat. fat intake
(1950-1980) but IHD mortality
was highest in Finland. Why?
(Wine and ethanol intake was the same)
The Finns drank 3.4 times
more milk

26. During 1972-92 there was a
dramatic decline in IHD in
Finland as milk consumption
declined .
 Cheese intake increased 3
times during this period

27.  Japan,China, Greenland Eskimos
(heavy smokers, low wine intake)
 Masai of East Africa (drink fermented
milk low in lactose)
 South African Blacks, Afro-Carribeans,
Prima Indians, Shri Lankans (low
milk,low lactose)
North Indians, Pakistanis and British have elevated
IHD, high milk intake and high lactase levels

28. Milk intake - 66% less than UK
Fat intake - 33% more than UK
Cheese intake 300% more than fresh milk
Lactase activity:
Northern France - 50% less than Europe
Southern France - 25% less than Europe

29. Galactose (and Fructose)
preferentially glycate proteins
especially LDL.
This makes LDL more
susceptible to oxidation and
thus atherosclerosis

31. Is high lactose
consumption merely
a marker for β-casein
intake?

33. “The rate of β-Casein A1
consumption (excluding
cheese) is a more accurate
predictor of heart disease….
Than that reported for
traditional risk factors”

34. A survey of 39 centres in 26 countries
 CHOLESTEROL
 BLOOD PRESSURE
 SATURATED FATS
 OBESITY
Varied in relative contribution to illness

36. 600
500
400
Relative
Indidence of 300
Diabetes
200
100
0
Low Milk High Milk
Diet Diet

37. 40
35 Ulcer with
30 Sippy
% 25 Ulcer with no
Relative Sippy
Incidence of 20
Myocardial No Ulcer
Infarct 15
10
5
0
USA Britain

40. 3.5
3
A1
2.5
Relative 2
Incidence of
Heart Disease 1.5 CHD
A1 CHD
1
0.5
0
Toulouse Belfast

44. Rennet and subsequent
enzymatic action as cheese
ages causes alterations to
the cheese protein structure
causing cross-linking of
casein molecules.
Casomorphin-7 is absent in most cheeses

45.  Casein causes heart disease in animals
 Casein accelerates hypercholesterolaemia
and atherosclerosis in animals
 Apo E deficient atherosclerosis prone mice
get more lesions
 Longevity in animals decreased by casein
(compared with soy and whey)
 Pigs fed casein have elevated homocysteine