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<ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>When good neurons go bad…
Introduction
100 billion
Neurons are Communication Cells Dendrites Nucleus Axon Myelin Sheath Schwann Cell Node of Ranvier Axon Terminal Cell Body ...
Thought and Behaviour
The Receptive Zone
<ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 2: Receptor Trafficking
MOR Gene Disruption of MOR gene disrupts function of morphine Matthes et al., (1996); Sora et al., (1997); Loh et al., (19...
The Life Cycle of a Receptor
Morphine Morphine Endorphin Mu-Opioid Peptide Receptor
MOP Receptors The fate of the MOP receptor depends on what binds to it. No Treatment Endorphin Heroin
Mice with designer genes RMOR s:  R ecycling  M u- O pioid  R eceptor Knock-in Mouse Line RMOR MOR
Knock-in vs. Wild-type
KI mice show reduced withdrawal behaviours. +/+ -/-
<ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 3: Receptor Expression
Structural changes in the “addicted” neurons Robinson and Kolb (1997)
Dopamine and Reward  Cue Response Reward DOPAMINE (DA)
Chronic cocaine reduces DA receptor availability Healthy Brain Addicted Brain
Social Rank Morgan et al., (2002)   Nat. Neurosci Social rank correlated with DA receptor function and subsequent vulnerab...
<ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 4: Myelin Sheath
The Action Potential
Multiple Sclerosis <ul><li>A myelination disorder </li></ul><ul><li>Immune breakdown of myelin </li></ul><ul><li>Oligodend...
Prognosis Disease progression worsens throughout life
Life Expectancy Life expectancy 5-10 years lower than average There is no known cure
Causes and Therapies <ul><li>Genetic and Environmental </li></ul><ul><li>Not explicitly hereditary, but influenced by gene...
<ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 5: Mirror Neurons
New Caledonian Crow http://www.sciencemag.org/feature/data/crow/weirmovie.mov
Motor Neurons
Prediction
Empathy
Child Development Awww, you know that tickles!
Theory of Mind
Monkey See, Monkey Do
 
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Neuroscience i cm

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Neuroscience i cm

  1. 1. <ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>When good neurons go bad…
  2. 2. Introduction
  3. 3. 100 billion
  4. 4. Neurons are Communication Cells Dendrites Nucleus Axon Myelin Sheath Schwann Cell Node of Ranvier Axon Terminal Cell Body (Soma)
  5. 5. Thought and Behaviour
  6. 6. The Receptive Zone
  7. 7. <ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 2: Receptor Trafficking
  8. 8. MOR Gene Disruption of MOR gene disrupts function of morphine Matthes et al., (1996); Sora et al., (1997); Loh et al., (1998); Monory et al., (2000)
  9. 9. The Life Cycle of a Receptor
  10. 10. Morphine Morphine Endorphin Mu-Opioid Peptide Receptor
  11. 11. MOP Receptors The fate of the MOP receptor depends on what binds to it. No Treatment Endorphin Heroin
  12. 12. Mice with designer genes RMOR s: R ecycling M u- O pioid R eceptor Knock-in Mouse Line RMOR MOR
  13. 13. Knock-in vs. Wild-type
  14. 14. KI mice show reduced withdrawal behaviours. +/+ -/-
  15. 15. <ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 3: Receptor Expression
  16. 16. Structural changes in the “addicted” neurons Robinson and Kolb (1997)
  17. 17. Dopamine and Reward Cue Response Reward DOPAMINE (DA)
  18. 18. Chronic cocaine reduces DA receptor availability Healthy Brain Addicted Brain
  19. 19. Social Rank Morgan et al., (2002) Nat. Neurosci Social rank correlated with DA receptor function and subsequent vulnerability to addiction
  20. 20. <ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 4: Myelin Sheath
  21. 21. The Action Potential
  22. 22. Multiple Sclerosis <ul><li>A myelination disorder </li></ul><ul><li>Immune breakdown of myelin </li></ul><ul><li>Oligodendrocytes reproduce thinner, weaker myelin </li></ul><ul><li>Plaques and scars forms in the white matter </li></ul>
  23. 23. Prognosis Disease progression worsens throughout life
  24. 24. Life Expectancy Life expectancy 5-10 years lower than average There is no known cure
  25. 25. Causes and Therapies <ul><li>Genetic and Environmental </li></ul><ul><li>Not explicitly hereditary, but influenced by genes </li></ul><ul><li>A number of environmental risk factors </li></ul><ul><li>Numerous Therapies </li></ul><ul><li>Drug therapies tend to target only specific symptoms </li></ul>
  26. 26. <ul><li>IntroPsych 1XX3 Live Lecture </li></ul><ul><li>Neuroscience I </li></ul>Module 5: Mirror Neurons
  27. 27. New Caledonian Crow http://www.sciencemag.org/feature/data/crow/weirmovie.mov
  28. 28. Motor Neurons
  29. 29. Prediction
  30. 30. Empathy
  31. 31. Child Development Awww, you know that tickles!
  32. 32. Theory of Mind
  33. 33. Monkey See, Monkey Do

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