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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2160
ANALYSIS OF LUNG CANCER USING MULTILAYER PERCEPTRON
CLASSIFIER
LEKSHMY G KUMAR1, M. MOHAMMED KASIM2, S MOHAN3, Dr. V JAYARAJ4
1PG Scholar, Department of Electronics and Communication Engineering, Nehru Institute of
Engineering and Technology
2,3Assistant Professor, Dept. of Electronics and Communication Engineering, Nehru Institute of
Engineering and Technology
4Professor and Head, Dept. of Electronics and Communication Engineering, Nehru Institute of
Engineering and Technology
------------------------------------------------------------------------***-----------------------------------------------------------------------
ABSTRACT:- Lung cancer is one of the most increasing
diseases in the rapidly changing world. This disease can be
cured in the initial stage. It should be identified at the early
stage for the diagnosis purposes. Thepredictionoflungdisease
stages can be done using image processing techniques. The
proposed algorithm consists of segmentation process using
watershed segmentation and lung nodule detectionusingedge
detection method .The segmented lungs are subjectedtowards
the feature extraction process which includes the Gray Level
Co-occurance (GLCM) algorithm. The main prediction can be
done using the classifier process. The classifier which includes
in the proposed work is the multilayer Perceptron neural
network classifier. The classes of the tumor level can be
predicted using the neural network. This prediction would
indicate the early stage of the cancer and it will be helpful for
the treatment of the cancerous unit in the human body. Once
the tumor is detected, the tumor affected part canbeidentified
using morphological operations which include various
algorithms. A morphological operation consists of filling,
dilation, open and close. This technique will give the total area
affected and the region where the lung are affected. Thus, the
achieved accuracy level of the proposed work is 90%.
KEYWORDS: Watershed segmentation, Edge detection,
Gray Level Co-occurance Matrix (GLCM), Back
Propagation Neural Network.
SECTION I
INTRODUCTION
Image processing is the trending technique which is used to
predict the disease within the living things. One of the
common diseases in the world after the heart disease is the
cancer. Lung cancer is the single most inimical cause of
cancer related deaths [1]. The symptomsoflungcancercome
into light at the final stage. So it is very tough to identify in
its beginning stage. For this reason, the death percentage is
very high for lung cancer in comparison with all other types
of cancer. The two kind of lung disease which develop and
spread in an unexpected way, are littlecell lungmalignancies
(SCLC) and non-littlecell lungtumors(NSCLC)[2].Prediction
and diagnosis of lung cancer is mainly done using computed
tomography (CT)images. Disease in the patient as soon as
possible, especially in tumors [3].In our proposed work we
have collected database images from NCBI database. It
consists of various angles of CT scan images of different
patients. Lung cancer occurs in all type of living things
including any type of gender. According to World Health
Organization (WHO) lung cancer stood at first position
among other type of cancers such as liver cancer, gastric
cancer, colorectal cancer, breast cancer and esophagus
cancer. According to National Cancer Institute (NCI), in US,
159260 cancerous deaths among 224210 are found due to
lung cancer only. In India, 87% of male and 85% of female
are suffered from lung due to smoking. The main cause of
lung cancer is the addiction of smoking cigarettes,
carcinogenic environment such as radioactive gas and also
air pollution. Based on its histopathy, lung cancersareoftwo
types: Small Cell Lungcancer (SCLC)andNon-Small Cell Lung
cancer (NSCLC). Around 80 % of deaths are due to lung
cancer of NSCLC type [4].The main aim of the proposed work
is to detect the lung cancer with the CT scan images. This
would increase the accuracy of the prediction process. The
paper is ordered as following: In section II, the existing
approaches for lung cancer detection is reviewed with its
result and future scope. Section III,describesmethodologyof
proposed system. Section IV, results of the proposed
approach are discussed and finally section V, concludes the
paper with, the analysis and findings from the approach.
SECTION II
LITERATURE SURVEY
Various works had been undergone in the lung cancer
detection and prediction. A detailed survey of lung cancer
classification using Support Vector Machine (SVM) is
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2161
represented in [6].From the represented technique, lung
cancer classified as normal, benign and malignant Tumors.
The segmentation techniques for lung cancer detectionin CT
scan images are presented in [7].The classification process
includes Artificial Neural network, Multilayer perceptron
technique and multilayered preceptron techniques which is
included in[8].The major classification of lung cancer is
carried out using Artificial Neural Network and Fuzzy
Clustering Methods investigated by [9].The major research
has been invented by Almas Pathan, Bairu Saptalkar to
predict the lung cancer using Neural Network by taking the
dataset as an X-ray format[10].Many research had been by
Zagreb, Croastia based on the classification of asthma and
chronic obstructive pulmonary disease(COPD) intheformof
fuzzy rules and they have training phases.[11].The main aim
of the proposed work is based on the segmentation using
Watershed segmentation and classification using Multilayer
perceptron Neural Networks.
SECTION III
METHODOLOGY
A.DATABASE
Input database images are collected from the the Cancer
Archieve database. The Cancer Archieve database which
consists of large number of lung cancer patients records at
the different locations in lungs. As we have trained around
100 images from the collecteddatabaseandthetestingphase
is carried out using 50 database images. The CT scan images
which consists of normal lung images as well as abnormal
lung images are as shown in the figure 1(a)
Figure 1 Abnormal lung
B.METHODS
The detection process is carried out using initial pre-
processing stage. Pre-processing method consists of gray-
scale conversion and filtering process. Input CT scan images
was converted into gray scale image where the pixel ranges
from 0 to 255.Filtering process was carried out using gabor
filter to remove the noise in the input image.FFT algorithmis
used work on Fourier transform in the image. It is used in
filter in the proposed work. Segmentation process is carried
out using DT-CWT technique. Watershed segmentation is
used for segmentation process. Segmentation is carried out
to find the region of interest. Extracted Region feature are
calculated using GLCM (Gray Level Co-occurance
Matrix).Various features are extracted from the GLCMwhich
is included as homogeneity, energy,contrast,correlation, and
variance. The Result of GLCM feature extraction can be
trained in the training phase using Neural Networks. The
Neural Networks which is used for training the givendataset
is the Multilayer perceptron Neural Network. By using the
Multilayer perceptron Neural Network the accuracy level of
the proposed algorithm can be increased and the training
phase time will be lesser as compared with the other neural
networks. The above process can be carried using step by
step method as shown in the figure.2
Figure 2 Proposed work
C.RESULTS AND DISCUSSION
Image pre-processing methods includes four major
processing blocks such as image processing, image
segmentation, feature extraction and classification.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2162
1. IMAGE-PREPROCESSING
The processing stage consists of getting the input CT scan
image from the collected database is shown in figure
4(a).The CT scan image may have the regularize pixels range
of 207x207.The pre-processing stage consists of Gray scale
conversion which converts the input Ct scan image into gray
scale range as shown in the figure 4(b).
Figure 4 gray-scale image.
The color conversion process is carried out using filtering
process. These filtering process consists of gabor filtering
and FFT filtering algorithm. Gaborfilterisusedto removethe
noise for the processed Gray scale image as shown in the
figure 4(c)
Figure 4(c) filtered image
FFT filtering algorithm is carried out to undergo noise
removal using Fast Fourier Transform technique. Thus the
Pre-Processing stage is followed using image segmentation
process.
2. IMAGE SEGMENTATION
Image segmentation is used to find out the region of the
cancer affected part. The area of the cancer affected can be
calculated using water shed segmentation. The computed as
a water shed segmentation compound transform[12]usedto
separate the two Discrete Wavelet Transform of the tree of
the Decompositions. DT-CWT removes the fissures and
detect the cancer affected region using the Discrete Wavelet
Transform. The segmented part of the gray scale image
undergoes the feature extraction process. The tumor
segmented image is shown in figure 5
Figure 5 segmented tumor image
3. FEATURE EXTRACTION
The proposed method feature extraction process consists of
GLCM algorithm. The GLCM consists of following equations.
Contrast = (1)
Energy= (2)
Entropy = (3)
Usually the angles used are 0°,45 °, 90 °, and 135 0 [13].
GLCM features extraction used in the proposed work can be
energy, contrast, and entropy.
D. CLASSIFICATION
The extracted feature undergoes the training stage using the
classifiers. The Classifiers included in the proposed work is
Multilayer perceptron Neural Network classifier.
Classification process consists of training as well as testing
phase. Training in the proposed system undergoes using
Multilayer Perceptron Neural Network which include
different target value and they have different classification.
The classification process which is included as normal lung
cancer images as the value of 1’s and the abnormal or
defected lung as the value of 0’s.Testingcanbeallocatedwith
The initial parameters and the weight of the Neural
network(learning rate 0.3, hidden layer value 20; and epoch
1000). In the proposed work, considering learning rate 0.3,
hidden layer value 20, and epoch 1000.This would increase
the accuracy and the specificity level of the proposed work.
The percentage of the training and validation done can be
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2163
90% in the confusion matrix. The classification can 90% in
the confusion matrix. The classification can be shown in
figure6.
Figure.6 Classification
The Performance measure can be carried out by calculating
the accuracy, sensitivity and specificity of the proposed
algorithm. Performance measure can shown in the figure 7
Figure.7 performance measure
IV. CONCLUSION
Various image processing stage has been carried out to
detect the lung cancer and the area affected by the cancer.
The testing phase is carried out with 50 Database CT images
and the training phase is carried out using 50% database CT
images. Thus, the accuracy of the proposed work canbe90%
done. In order to obtain higher accuracy, further research is
needed by improving the preprocessing process, image
segmentation, feature extraction and learning process.
REFERENCES
[1]. Multi-Stage Lung Cancer Detection and Prediction Using
Multi-class SVM Classifier by Janee Alam in the year of 2000.
[2] Hybrid Approach For Feature Extraction of Lung Cancer
Detection by Ms. Twinkal Patel in ‘2nd International
Conference on Inventive CommunicationandComputational
Technologies’ in the year of 2018.
[3] A New Strategy to Detect Lung Cancer on CT Images by
Ling ling Li, Yuan Wu*, Yi Yang, Lian Li in ‘3rd IEEE
International Conference on Image,VisionandComputing’in
2018.
[4] Multi-Layer Perceptron based Lung tumor classification
by Sneha Potghan in ‘2nd International conference on
Electronics, Communication and Aerospace Technology’ in
the year of 2018.
[5] BLB (Brain/Lung Cancer DetectionandSegmentation and
Breast Dense Calculation) by Bassma El-Sherbiny, Nardeen
Nabil, Seif Hassab EL-Naby, Youssef Emad, Nada Ayman,
Taraggy Mohiy and Ashraf AbdelRaouf in IEEE in the year of
2018.
[6] American Cancer Society. (2013). What are the risk
factors for non-small cell lung cancer?. 19 Desember 2013. <
http : // www. cancer. org>.
[7] Ancuceanu, R. V., and Victoria, I, 2004, Pharmacologically
Active Natural CompoundsforLungCancer,Altem.Med. Rev.,
9,4,402-419
[8] M.S.Tarawneh, “Lung Cancer Detection Using Image
Processing Techniques”, Leonardo Electronic Journal of
Practices and Technologies, Issue 20, pp. 147-158, January-
June 2012.
[9] Kusumadewi, S.. Membangun Jaringan Syaraf Tinian
dengan Matlab dan Exel Link. Yogyakarta: Graha Emu.
“Detection and Classification of Lung Cancer Using Artificial
Neural Network”, International Journal on Advanced
ComputerEngineeringandCommunicationTechnology Vol-1
Issue:
[10]. Imran Ali, Waseem.A.WaniandKishoreSaleem,“Cancer
Scenario in India with Future Perspectives,”Cancer Therapy,
8, pp. 56 - 70, 2011. [11] Beadsmoore CJ, Screaton NJ,
“Classification, staging and prognosis of lung cancer,”
European Journal of Radiology, 4(1), pp. 8 - 17, 2003.
[12] Todd M.Blodgett, Ajeet S. Mehta, Amar S.Mehta, Charles
M. Laymon, Jonathan Carney, David W. Townsend, “PET/CT
artifacts” Clinical Imaging, 35, pp. 49 - 63, 2011.
[13] Robert M Haralick, K.Shanmugam and Its’hak Dinstein,
“Textural Features for Image Classification,” IEEE
Transactions on Systems, Man and Cybernetics,3(6),pp.610
- 621, 1973.
[14] S.A. Patil, M.B. Kuchanur, “Lung Cancer Classification
using Image Processing,” International Journal of
Engineering and Innovative Technology(IJEIT),2(3),pp. 37 –
4.

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  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2160 ANALYSIS OF LUNG CANCER USING MULTILAYER PERCEPTRON CLASSIFIER LEKSHMY G KUMAR1, M. MOHAMMED KASIM2, S MOHAN3, Dr. V JAYARAJ4 1PG Scholar, Department of Electronics and Communication Engineering, Nehru Institute of Engineering and Technology 2,3Assistant Professor, Dept. of Electronics and Communication Engineering, Nehru Institute of Engineering and Technology 4Professor and Head, Dept. of Electronics and Communication Engineering, Nehru Institute of Engineering and Technology ------------------------------------------------------------------------***----------------------------------------------------------------------- ABSTRACT:- Lung cancer is one of the most increasing diseases in the rapidly changing world. This disease can be cured in the initial stage. It should be identified at the early stage for the diagnosis purposes. Thepredictionoflungdisease stages can be done using image processing techniques. The proposed algorithm consists of segmentation process using watershed segmentation and lung nodule detectionusingedge detection method .The segmented lungs are subjectedtowards the feature extraction process which includes the Gray Level Co-occurance (GLCM) algorithm. The main prediction can be done using the classifier process. The classifier which includes in the proposed work is the multilayer Perceptron neural network classifier. The classes of the tumor level can be predicted using the neural network. This prediction would indicate the early stage of the cancer and it will be helpful for the treatment of the cancerous unit in the human body. Once the tumor is detected, the tumor affected part canbeidentified using morphological operations which include various algorithms. A morphological operation consists of filling, dilation, open and close. This technique will give the total area affected and the region where the lung are affected. Thus, the achieved accuracy level of the proposed work is 90%. KEYWORDS: Watershed segmentation, Edge detection, Gray Level Co-occurance Matrix (GLCM), Back Propagation Neural Network. SECTION I INTRODUCTION Image processing is the trending technique which is used to predict the disease within the living things. One of the common diseases in the world after the heart disease is the cancer. Lung cancer is the single most inimical cause of cancer related deaths [1]. The symptomsoflungcancercome into light at the final stage. So it is very tough to identify in its beginning stage. For this reason, the death percentage is very high for lung cancer in comparison with all other types of cancer. The two kind of lung disease which develop and spread in an unexpected way, are littlecell lungmalignancies (SCLC) and non-littlecell lungtumors(NSCLC)[2].Prediction and diagnosis of lung cancer is mainly done using computed tomography (CT)images. Disease in the patient as soon as possible, especially in tumors [3].In our proposed work we have collected database images from NCBI database. It consists of various angles of CT scan images of different patients. Lung cancer occurs in all type of living things including any type of gender. According to World Health Organization (WHO) lung cancer stood at first position among other type of cancers such as liver cancer, gastric cancer, colorectal cancer, breast cancer and esophagus cancer. According to National Cancer Institute (NCI), in US, 159260 cancerous deaths among 224210 are found due to lung cancer only. In India, 87% of male and 85% of female are suffered from lung due to smoking. The main cause of lung cancer is the addiction of smoking cigarettes, carcinogenic environment such as radioactive gas and also air pollution. Based on its histopathy, lung cancersareoftwo types: Small Cell Lungcancer (SCLC)andNon-Small Cell Lung cancer (NSCLC). Around 80 % of deaths are due to lung cancer of NSCLC type [4].The main aim of the proposed work is to detect the lung cancer with the CT scan images. This would increase the accuracy of the prediction process. The paper is ordered as following: In section II, the existing approaches for lung cancer detection is reviewed with its result and future scope. Section III,describesmethodologyof proposed system. Section IV, results of the proposed approach are discussed and finally section V, concludes the paper with, the analysis and findings from the approach. SECTION II LITERATURE SURVEY Various works had been undergone in the lung cancer detection and prediction. A detailed survey of lung cancer classification using Support Vector Machine (SVM) is
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2161 represented in [6].From the represented technique, lung cancer classified as normal, benign and malignant Tumors. The segmentation techniques for lung cancer detectionin CT scan images are presented in [7].The classification process includes Artificial Neural network, Multilayer perceptron technique and multilayered preceptron techniques which is included in[8].The major classification of lung cancer is carried out using Artificial Neural Network and Fuzzy Clustering Methods investigated by [9].The major research has been invented by Almas Pathan, Bairu Saptalkar to predict the lung cancer using Neural Network by taking the dataset as an X-ray format[10].Many research had been by Zagreb, Croastia based on the classification of asthma and chronic obstructive pulmonary disease(COPD) intheformof fuzzy rules and they have training phases.[11].The main aim of the proposed work is based on the segmentation using Watershed segmentation and classification using Multilayer perceptron Neural Networks. SECTION III METHODOLOGY A.DATABASE Input database images are collected from the the Cancer Archieve database. The Cancer Archieve database which consists of large number of lung cancer patients records at the different locations in lungs. As we have trained around 100 images from the collecteddatabaseandthetestingphase is carried out using 50 database images. The CT scan images which consists of normal lung images as well as abnormal lung images are as shown in the figure 1(a) Figure 1 Abnormal lung B.METHODS The detection process is carried out using initial pre- processing stage. Pre-processing method consists of gray- scale conversion and filtering process. Input CT scan images was converted into gray scale image where the pixel ranges from 0 to 255.Filtering process was carried out using gabor filter to remove the noise in the input image.FFT algorithmis used work on Fourier transform in the image. It is used in filter in the proposed work. Segmentation process is carried out using DT-CWT technique. Watershed segmentation is used for segmentation process. Segmentation is carried out to find the region of interest. Extracted Region feature are calculated using GLCM (Gray Level Co-occurance Matrix).Various features are extracted from the GLCMwhich is included as homogeneity, energy,contrast,correlation, and variance. The Result of GLCM feature extraction can be trained in the training phase using Neural Networks. The Neural Networks which is used for training the givendataset is the Multilayer perceptron Neural Network. By using the Multilayer perceptron Neural Network the accuracy level of the proposed algorithm can be increased and the training phase time will be lesser as compared with the other neural networks. The above process can be carried using step by step method as shown in the figure.2 Figure 2 Proposed work C.RESULTS AND DISCUSSION Image pre-processing methods includes four major processing blocks such as image processing, image segmentation, feature extraction and classification.
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2162 1. IMAGE-PREPROCESSING The processing stage consists of getting the input CT scan image from the collected database is shown in figure 4(a).The CT scan image may have the regularize pixels range of 207x207.The pre-processing stage consists of Gray scale conversion which converts the input Ct scan image into gray scale range as shown in the figure 4(b). Figure 4 gray-scale image. The color conversion process is carried out using filtering process. These filtering process consists of gabor filtering and FFT filtering algorithm. Gaborfilterisusedto removethe noise for the processed Gray scale image as shown in the figure 4(c) Figure 4(c) filtered image FFT filtering algorithm is carried out to undergo noise removal using Fast Fourier Transform technique. Thus the Pre-Processing stage is followed using image segmentation process. 2. IMAGE SEGMENTATION Image segmentation is used to find out the region of the cancer affected part. The area of the cancer affected can be calculated using water shed segmentation. The computed as a water shed segmentation compound transform[12]usedto separate the two Discrete Wavelet Transform of the tree of the Decompositions. DT-CWT removes the fissures and detect the cancer affected region using the Discrete Wavelet Transform. The segmented part of the gray scale image undergoes the feature extraction process. The tumor segmented image is shown in figure 5 Figure 5 segmented tumor image 3. FEATURE EXTRACTION The proposed method feature extraction process consists of GLCM algorithm. The GLCM consists of following equations. Contrast = (1) Energy= (2) Entropy = (3) Usually the angles used are 0°,45 °, 90 °, and 135 0 [13]. GLCM features extraction used in the proposed work can be energy, contrast, and entropy. D. CLASSIFICATION The extracted feature undergoes the training stage using the classifiers. The Classifiers included in the proposed work is Multilayer perceptron Neural Network classifier. Classification process consists of training as well as testing phase. Training in the proposed system undergoes using Multilayer Perceptron Neural Network which include different target value and they have different classification. The classification process which is included as normal lung cancer images as the value of 1’s and the abnormal or defected lung as the value of 0’s.Testingcanbeallocatedwith The initial parameters and the weight of the Neural network(learning rate 0.3, hidden layer value 20; and epoch 1000). In the proposed work, considering learning rate 0.3, hidden layer value 20, and epoch 1000.This would increase the accuracy and the specificity level of the proposed work. The percentage of the training and validation done can be
  • 4. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 05 | May 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2163 90% in the confusion matrix. The classification can 90% in the confusion matrix. The classification can be shown in figure6. Figure.6 Classification The Performance measure can be carried out by calculating the accuracy, sensitivity and specificity of the proposed algorithm. Performance measure can shown in the figure 7 Figure.7 performance measure IV. CONCLUSION Various image processing stage has been carried out to detect the lung cancer and the area affected by the cancer. The testing phase is carried out with 50 Database CT images and the training phase is carried out using 50% database CT images. Thus, the accuracy of the proposed work canbe90% done. In order to obtain higher accuracy, further research is needed by improving the preprocessing process, image segmentation, feature extraction and learning process. REFERENCES [1]. Multi-Stage Lung Cancer Detection and Prediction Using Multi-class SVM Classifier by Janee Alam in the year of 2000. [2] Hybrid Approach For Feature Extraction of Lung Cancer Detection by Ms. Twinkal Patel in ‘2nd International Conference on Inventive CommunicationandComputational Technologies’ in the year of 2018. [3] A New Strategy to Detect Lung Cancer on CT Images by Ling ling Li, Yuan Wu*, Yi Yang, Lian Li in ‘3rd IEEE International Conference on Image,VisionandComputing’in 2018. [4] Multi-Layer Perceptron based Lung tumor classification by Sneha Potghan in ‘2nd International conference on Electronics, Communication and Aerospace Technology’ in the year of 2018. [5] BLB (Brain/Lung Cancer DetectionandSegmentation and Breast Dense Calculation) by Bassma El-Sherbiny, Nardeen Nabil, Seif Hassab EL-Naby, Youssef Emad, Nada Ayman, Taraggy Mohiy and Ashraf AbdelRaouf in IEEE in the year of 2018. [6] American Cancer Society. (2013). What are the risk factors for non-small cell lung cancer?. 19 Desember 2013. < http : // www. cancer. org>. [7] Ancuceanu, R. V., and Victoria, I, 2004, Pharmacologically Active Natural CompoundsforLungCancer,Altem.Med. Rev., 9,4,402-419 [8] M.S.Tarawneh, “Lung Cancer Detection Using Image Processing Techniques”, Leonardo Electronic Journal of Practices and Technologies, Issue 20, pp. 147-158, January- June 2012. [9] Kusumadewi, S.. Membangun Jaringan Syaraf Tinian dengan Matlab dan Exel Link. Yogyakarta: Graha Emu. “Detection and Classification of Lung Cancer Using Artificial Neural Network”, International Journal on Advanced ComputerEngineeringandCommunicationTechnology Vol-1 Issue: [10]. Imran Ali, Waseem.A.WaniandKishoreSaleem,“Cancer Scenario in India with Future Perspectives,”Cancer Therapy, 8, pp. 56 - 70, 2011. [11] Beadsmoore CJ, Screaton NJ, “Classification, staging and prognosis of lung cancer,” European Journal of Radiology, 4(1), pp. 8 - 17, 2003. [12] Todd M.Blodgett, Ajeet S. Mehta, Amar S.Mehta, Charles M. Laymon, Jonathan Carney, David W. Townsend, “PET/CT artifacts” Clinical Imaging, 35, pp. 49 - 63, 2011. [13] Robert M Haralick, K.Shanmugam and Its’hak Dinstein, “Textural Features for Image Classification,” IEEE Transactions on Systems, Man and Cybernetics,3(6),pp.610 - 621, 1973. [14] S.A. Patil, M.B. Kuchanur, “Lung Cancer Classification using Image Processing,” International Journal of Engineering and Innovative Technology(IJEIT),2(3),pp. 37 – 4.