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Cancer Pain Management:
Specialized Care
Dr. David Flamer, MD FRCPC
Assistant Professor, University of Toronto
Department of Anesthesia and Pain Management
Co-Director, Cancer Pain Clinic, Princess Margaret Hospital
Associate Director, Wasser Pain Management Clinic, Mount
Sinai Hospital
david.flamer@uhn.ca
• Significant improvement in cancer mortality over past 30
years has led to refractory pain being an important
consequence
✓ Direct tumor invasion
✓ Metastatic bone pain
✓ Visceral distention, obstruction
✓ Nerve compression and infiltration
✓ Chemotherapy-related
✓ Radiation-related
✓ Post-surgical pain
Paice JA, Von Roenn JH. Under- or overtreatment of pain in the patient with cancer: How to achieve proper balance. J Clin Oncol. 2014
What causes cancer pain?
What causes cancer pain?
American Cancer Society
Cancer Survivors by Site
WHO 3-Step Analgesic Ladder
“Despite the clear WHO recommendations, cancer pain still is a major problem”
Epidemiology of Cancer Pain
•WHO Cancer Pain Ladder for Adults can effectively manage 80-
90% of cancer pain
•10 - 20% have inadequate pain relief despite comprehensive
medical management
•Evidence shows that early access can decrease pain scores and
improve quality of life
•Current opioid crisis further highlights the importance of
incorporating novel pain management strategies
Burton et al. Chronic pain in the cancer survivor: A new frontier. Pain Med. 2007
Amr et al. Neurolytic sympathectomy in the management of cancer pain - Time effect: A prospective, randomized multicenter study. J Pain
Symptom Manage. 2014
Lema MJ. Invasive analgesia techniques for advanced cancer pain. Surg Onc Clin N Am. 2001
Cancer Pain: A Challenging Problem
Opioid Crisis:
Recent Challenges in Cancer Patients
Distinctive features of cancer pain:
• Unique causes and overlapping types of pain
• Severity is dynamic and fluctuates throughout
treatment
• Both acute and chronic pain concerns
• Differing goals of care (palliative vs not)
• Multiple specialists, multiple medical co-
morbidities, complex medications
Cancer Pain ≠ Chronic Pain
Need for Specialized Cancer Pain
Management
Available in Ontario (limited
access)
• Peripheral nerve injections
• Nerve destruction
techniques
• Vertebral augmentation
• Spinal cord stimulation (+++
limited)
Health Canada approved – not
funded in ON
• Peripheral nerve stimulation
• Neuraxial therapy
(intrathecal and epidural
drug delivery)
Novel Therapies for Cancer Pain
19, 03/15/19 © 2019 National Comprehensive Cancer Network®
(NCCN®
), All rights reserved. NCCN Guidelines®
and this illustration may not be reproduced in any form without the express written permission of NCCN.
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®
)
Adult Cancer Pain
Version 2.2019 — March 15, 2019
Continue
NCCN.org
Role of Multidisciplinary Cancer Pain Management:
Local and International Guidelines

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Dr. David Flamer – Cancer Pain Management: Specialized Care

  • 1. Cancer Pain Management: Specialized Care Dr. David Flamer, MD FRCPC Assistant Professor, University of Toronto Department of Anesthesia and Pain Management Co-Director, Cancer Pain Clinic, Princess Margaret Hospital Associate Director, Wasser Pain Management Clinic, Mount Sinai Hospital david.flamer@uhn.ca
  • 2. • Significant improvement in cancer mortality over past 30 years has led to refractory pain being an important consequence ✓ Direct tumor invasion ✓ Metastatic bone pain ✓ Visceral distention, obstruction ✓ Nerve compression and infiltration ✓ Chemotherapy-related ✓ Radiation-related ✓ Post-surgical pain Paice JA, Von Roenn JH. Under- or overtreatment of pain in the patient with cancer: How to achieve proper balance. J Clin Oncol. 2014 What causes cancer pain?
  • 4. American Cancer Society Cancer Survivors by Site
  • 6. “Despite the clear WHO recommendations, cancer pain still is a major problem” Epidemiology of Cancer Pain
  • 7. •WHO Cancer Pain Ladder for Adults can effectively manage 80- 90% of cancer pain •10 - 20% have inadequate pain relief despite comprehensive medical management •Evidence shows that early access can decrease pain scores and improve quality of life •Current opioid crisis further highlights the importance of incorporating novel pain management strategies Burton et al. Chronic pain in the cancer survivor: A new frontier. Pain Med. 2007 Amr et al. Neurolytic sympathectomy in the management of cancer pain - Time effect: A prospective, randomized multicenter study. J Pain Symptom Manage. 2014 Lema MJ. Invasive analgesia techniques for advanced cancer pain. Surg Onc Clin N Am. 2001 Cancer Pain: A Challenging Problem
  • 8. Opioid Crisis: Recent Challenges in Cancer Patients
  • 9. Distinctive features of cancer pain: • Unique causes and overlapping types of pain • Severity is dynamic and fluctuates throughout treatment • Both acute and chronic pain concerns • Differing goals of care (palliative vs not) • Multiple specialists, multiple medical co- morbidities, complex medications Cancer Pain ≠ Chronic Pain
  • 10. Need for Specialized Cancer Pain Management
  • 11. Available in Ontario (limited access) • Peripheral nerve injections • Nerve destruction techniques • Vertebral augmentation • Spinal cord stimulation (+++ limited) Health Canada approved – not funded in ON • Peripheral nerve stimulation • Neuraxial therapy (intrathecal and epidural drug delivery) Novel Therapies for Cancer Pain
  • 12. 19, 03/15/19 © 2019 National Comprehensive Cancer Network® (NCCN® ), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines® ) Adult Cancer Pain Version 2.2019 — March 15, 2019 Continue NCCN.org Role of Multidisciplinary Cancer Pain Management: Local and International Guidelines