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Dan’s Soapbox 1
What’s hot in EM?
Dr Smith’s ECG Blog
58 year old man, intermittent chest
pain for 2 weeks
Pain settled spontaneously. Serial
Troponins negative
ST elevation Vs early repolarisation
• Benign early repolarisation
– Widespread concave ST elevation ST
– Most commonly V2 – V5
– Notching is common at J point
– Rare > 50 years
– ST elevation is usually less than 2mm in precordial
leads, but can be more
– < 0.5mm in limb leads
– No reciprical ST segment changes
– Normal R wave progression
– Changes are relatively stable
Repeat ECG 12 hours later!!!
How good is it?
• Retrospective review
• Subtle anterior STEMI admitted to cardiology with
proven LAD occlusion Vs ED coded non cardiac chest
pain with BER
• Mathematical formula comparing:
– Height of ST elevation
– QTc interval
– R wave progression
• Actual calculation
– (1.196 x ST-segment elevation 60 ms after the J point in
lead V3 in mm) + (0.059 x QTc in ms) - (0.326 x R-wave
amplitude in lead V4 in mm)
Seems Complicated?
• The greater the ST elevation  more likely to be
STEMI
• The longer the QTC  more likely to be STEMI
• Poor R wave progression (small R wave in V4) 
more likely to be a STEMI
– A value of >23.4 was found to predict STEMI
– </= 23.4 predicted early repolarization
• Sensitivity 86%
• Specificity 91%
Learning Points
• Significant LAD occlusion with dynamic ECG changes can still have
negative high sensitivity troponins
• Don’t wait 12 hours for repeat ECG if any concerns
• Try to learn some features that suggest BEP:
– Widespread concave ST elevation ST
– Most commonly V2 – V5
– Notching is common at J point
– Rare > 50 years
– ST elevation is usually:
• less than 2mm in precordial leads (but can be more!)
• < 0.5mm in limb leads
– No reciprical ST segment changes
– Normal R wave progression
– Changes are relatively stable
• Download SubtleSTEMI and give it a try
PESIT TRIAL
PESIT
• Cross sectional multi-centre study
• All patients with 1st
episode syncope admitted
from ED
• All then got D dimer testing and Wells score
• Negative D dimer and PE unlikey wells score
 testing stopped
• +ve D dimer or PE likely Wells score  CTPA
or Ventilation Perfusion Scan
PESIT
• 2584 patients presented to ED with syncope
• 717 (27.7%) patients admitted
• Of these 157 excluded
• 560 patients included in study
• > 75% over 70 years old
• 58.9% had PE ruled out on Well’s score / D
dimer
• 17.3% had diagnosed PE
Clot Burden
– 41.7% Main Pulmonary artery
– 25% Lobar Artery
– 26.4% Segmental Artery
– 6.9% Subsegmental Artery
Discussion
Discussion
• 1/6 pick up rate of PE for syncope sounds high
• Remember that lots of people were sent home – so actually < 4% of
patients presenting with syncope to ED
• PE was much more likely if:
– Tachopnoea
– Tachycardiac
– Hypotensive
– Clinical signs of DVT
– Active cancer
• You would hope we would expect PE in syncope ?cause if any of these
features
• Did finding the PE also find the cause of syncope?
– 26% segmental, 7% subsegemental
– Much debate about the relevance of diagnosing these
• False +ve rate high
• clinical significance of diagnosis uncertain
References
• http://hqmeded-ecg.blogspot.com.au/2017/02/chest-
pain-st-elevation-and-negative.html
• http://lifeinthefastlane.com/ecg-library/benign-early-
repolarisation/
• http://www.emdocs.net/ber-vs-anterior-stemi/
• http://www.annemergmed.com/article/S0196-
0644(12)00160-6/pdf
• http://heart.bmj.com/content/94/12/1620.full
• http://sinaiem.org/clot-or-not-what-are-we-going-to-
do-about-pesit/

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Dan's Soapbox 1 - What's Hot in EM

  • 3. 58 year old man, intermittent chest pain for 2 weeks
  • 4. Pain settled spontaneously. Serial Troponins negative
  • 5. ST elevation Vs early repolarisation • Benign early repolarisation – Widespread concave ST elevation ST – Most commonly V2 – V5 – Notching is common at J point – Rare > 50 years – ST elevation is usually less than 2mm in precordial leads, but can be more – < 0.5mm in limb leads – No reciprical ST segment changes – Normal R wave progression – Changes are relatively stable
  • 6.
  • 7.
  • 8. Repeat ECG 12 hours later!!!
  • 9.
  • 10.
  • 11. How good is it? • Retrospective review • Subtle anterior STEMI admitted to cardiology with proven LAD occlusion Vs ED coded non cardiac chest pain with BER • Mathematical formula comparing: – Height of ST elevation – QTc interval – R wave progression • Actual calculation – (1.196 x ST-segment elevation 60 ms after the J point in lead V3 in mm) + (0.059 x QTc in ms) - (0.326 x R-wave amplitude in lead V4 in mm)
  • 12. Seems Complicated? • The greater the ST elevation  more likely to be STEMI • The longer the QTC  more likely to be STEMI • Poor R wave progression (small R wave in V4)  more likely to be a STEMI – A value of >23.4 was found to predict STEMI – </= 23.4 predicted early repolarization • Sensitivity 86% • Specificity 91%
  • 13. Learning Points • Significant LAD occlusion with dynamic ECG changes can still have negative high sensitivity troponins • Don’t wait 12 hours for repeat ECG if any concerns • Try to learn some features that suggest BEP: – Widespread concave ST elevation ST – Most commonly V2 – V5 – Notching is common at J point – Rare > 50 years – ST elevation is usually: • less than 2mm in precordial leads (but can be more!) • < 0.5mm in limb leads – No reciprical ST segment changes – Normal R wave progression – Changes are relatively stable • Download SubtleSTEMI and give it a try
  • 14.
  • 16. PESIT • Cross sectional multi-centre study • All patients with 1st episode syncope admitted from ED • All then got D dimer testing and Wells score • Negative D dimer and PE unlikey wells score  testing stopped • +ve D dimer or PE likely Wells score  CTPA or Ventilation Perfusion Scan
  • 17. PESIT • 2584 patients presented to ED with syncope • 717 (27.7%) patients admitted • Of these 157 excluded • 560 patients included in study • > 75% over 70 years old • 58.9% had PE ruled out on Well’s score / D dimer • 17.3% had diagnosed PE
  • 18. Clot Burden – 41.7% Main Pulmonary artery – 25% Lobar Artery – 26.4% Segmental Artery – 6.9% Subsegmental Artery
  • 19.
  • 20.
  • 22. Discussion • 1/6 pick up rate of PE for syncope sounds high • Remember that lots of people were sent home – so actually < 4% of patients presenting with syncope to ED • PE was much more likely if: – Tachopnoea – Tachycardiac – Hypotensive – Clinical signs of DVT – Active cancer • You would hope we would expect PE in syncope ?cause if any of these features • Did finding the PE also find the cause of syncope? – 26% segmental, 7% subsegemental – Much debate about the relevance of diagnosing these • False +ve rate high • clinical significance of diagnosis uncertain
  • 23. References • http://hqmeded-ecg.blogspot.com.au/2017/02/chest- pain-st-elevation-and-negative.html • http://lifeinthefastlane.com/ecg-library/benign-early- repolarisation/ • http://www.emdocs.net/ber-vs-anterior-stemi/ • http://www.annemergmed.com/article/S0196- 0644(12)00160-6/pdf • http://heart.bmj.com/content/94/12/1620.full • http://sinaiem.org/clot-or-not-what-are-we-going-to- do-about-pesit/

Editor's Notes

  1. Beckman Coulter Access AccuTnI+3 Troponin I on DXL 600 – high sensitivity troponin Do you send home, admit. Depends on histroy ?worsening angina Is this ST elevation or high take off
  2. Generalised concave ST – V1 – 5, II, III, AVF Notching at j point II, III, AVF
  3. Dynamic changes, went to cath lab – 80% LAD occlusion.
  4. Pulmonary embolism syncope italian trial