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Jason M. Walker,[object Object],Chapter 13,[object Object],[object Object]
Latent Viral Infection
Persistent Viral infections,[object Object]
The transformation of Normal Cells into Tumor Cells,[object Object],When activated, oncogenes transforms normal cells into cancerous cells.,[object Object],Viruses capable of producing tumors are called oncogenic viruses.,[object Object],Several DNA viruses and retroviruses are oncogenic.,[object Object],The genetic material of oncogenic viruses become integrated into the host cell’s DNA.,[object Object],Transformed cells lose contact inhibition, contain virus specific antigens (TSTA and T antigen), exhibit chromosome and abnormalities, and can produce tumors when injected into susceptible animals.,[object Object]
DNA Oncogenic Viruses ,[object Object],Oncogenic viruses are found among:,[object Object],Adenoviridae,[object Object],Herpesviridae,[object Object],Poxviridae,[object Object],Papovaviridae,[object Object]
[object Object],(Burkitt’s lymphoma),[object Object],(Nasopharyngeal carcinoma),[object Object]
RNA Oncogenic Viruses	,[object Object],Among the RNA viruses, only retroviruses seem to be oncogenic.  ,[object Object],The virus’s ability to produce tumors is related to the production of reverse transcriptase.  The DNA synthesized from the viral RNA becomes incorporated as a provirus into the host cell’s DNA.,[object Object],A provirus can remain latent, can produce viruses, or can transform the host cell.,[object Object]
Chickenpox (Varicellovirus),[object Object],Chickenpox is one of the classic childhood diseases, and one of the most contagious. The affected child or adult may develop hundreds of itchy, fluid-filled blisters that burst and form crusts. Chickenpox is caused by a virus.,[object Object]
Latent Viral Infections,[object Object],A latent viral infection is one in which the virus remains in the host cell for long periods without producing an infection.,[object Object],Examples are cold sores and shingles.,[object Object]
Persistent Viral Infections,[object Object],Persistent viral infections are disease process that occur over a long period and are generally fatal.,[object Object],Persistent viral infections are caused by conventional viruses; viruses accumulate over a long period. ,[object Object]

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