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SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
HISTORY:
•

In addition to the deformity
evident in the clinical photo, this animal
was lame and showed pain and
warmth on palpation of the lower limb.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
LESION/S AND DESCRIPTION
• calcification
• Hemorrhage
• Metaphyseal enlargement
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Basic disease process/es
• Inflammation
• Necrosis
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
DIAGNOSIS
• Hypertrophic osteodystrphy
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
BASIS/ BASES FOR THE DIAGNOSIS
• History
o Animal
o Breed
o Age
o Specimen
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Differential diagnosis and the reasons for
such.
• Panosteitis

It is a self-limiting developmental
disease of young, large and giant breeds
of dogs resulting in pain, lameness in one
or more limbs.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
• Hypertrophic Osteopathy (HO)
It is a condition that affects long
bones but is secondary to a primary
thoracic or abdominal mass. The bony
lesions are characterized by bilateral,
symmetrical swellings affecting the distal
extremities of the four limbs.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
• Etiological information
The cause of HOD is currently
unknown
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Methods of transmission of the etiology
and spread
Genetic component is suspected.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Other lesions present in the other organs
not shown in the picture
metastatic calcification of the
aorta, endocardium, lungs, and kidneys
at necropsy.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Other lesions present in the other organs
not shown in the picture
metastatic calcification of the
aorta, endocardium, lungs, and kidneys
at necropsy.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Clinical signs
• Anorexia
• Depression
• pyrexia

• weight loss.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Clinical signs
• Anorexia
• Depression
• pyrexia

• weight loss.
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Cause/s of death not necessarily
euthanasia
• Cardiac failure

• Respiratory failure
• Dehydration
SPECIMEN: POST-MORTEM VIEW OF
THE SAGITALLY-SPLIT DISTAL RADIUS OF
A 3-MONTH OLD GREAT DANE
Cause/s of death not necessarily
euthanasia
• Cardiac failure

• Respiratory failure
• Dehydration
Hypertrophic Osteodystrophy

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Hypertrophic Osteodystrophy

  • 1.
  • 2. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE HISTORY: • In addition to the deformity evident in the clinical photo, this animal was lame and showed pain and warmth on palpation of the lower limb.
  • 3. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE LESION/S AND DESCRIPTION • calcification • Hemorrhage • Metaphyseal enlargement
  • 4. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Basic disease process/es • Inflammation • Necrosis
  • 5. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE DIAGNOSIS • Hypertrophic osteodystrphy
  • 6. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE
  • 7. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE
  • 8. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE BASIS/ BASES FOR THE DIAGNOSIS • History o Animal o Breed o Age o Specimen
  • 9. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Differential diagnosis and the reasons for such. • Panosteitis It is a self-limiting developmental disease of young, large and giant breeds of dogs resulting in pain, lameness in one or more limbs.
  • 10. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE • Hypertrophic Osteopathy (HO) It is a condition that affects long bones but is secondary to a primary thoracic or abdominal mass. The bony lesions are characterized by bilateral, symmetrical swellings affecting the distal extremities of the four limbs.
  • 11. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE • Etiological information The cause of HOD is currently unknown
  • 12. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Methods of transmission of the etiology and spread Genetic component is suspected.
  • 13. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Other lesions present in the other organs not shown in the picture metastatic calcification of the aorta, endocardium, lungs, and kidneys at necropsy.
  • 14. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Other lesions present in the other organs not shown in the picture metastatic calcification of the aorta, endocardium, lungs, and kidneys at necropsy.
  • 15. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Clinical signs • Anorexia • Depression • pyrexia • weight loss.
  • 16. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Clinical signs • Anorexia • Depression • pyrexia • weight loss.
  • 17. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE
  • 18. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Cause/s of death not necessarily euthanasia • Cardiac failure • Respiratory failure • Dehydration
  • 19. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Cause/s of death not necessarily euthanasia • Cardiac failure • Respiratory failure • Dehydration

Editor's Notes

  1. HOD and PANO are both associated with dysfunction in long bone development.  There is significant inflammation, edema and bone pain that can progress to deformity and bone necrosis.