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CV Jennifer Ko 10.2015

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215 Alden Lane · Cleveland, Ohio · 44143
Phone 216.965.5134 · Email koj2@ccf.org; jennifersusanko@yahoo.com
Jennifer Susan...
• 1st
Place Best Resident/Fellow Poster Presentation at the American Society of
Dermatopathology 50th
Annual Meeting; Octo...
Wu L, Zepp J, Ko JS, Zhao J, Chen X, Gu G, Towne J, Ouyang W, Sen G, Stark G, Su B,
Gastman B, Liu C, Li X. “A novel IL-17...
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CV Jennifer Ko 10.2015

  1. 1. 215 Alden Lane · Cleveland, Ohio · 44143 Phone 216.965.5134 · Email koj2@ccf.org; jennifersusanko@yahoo.com Jennifer Susan Ko Education and Training 2014 – 2015 Fellowship Dermatopathology, Cleveland Clinic, Cleveland, OH 2010 – 2014 Residency Anatomic and Clinical Pathology, Cleveland Clinic 2005 – 2010 Doctor of Philosophy Case Western Reserve University, Cleveland, OH 2004 – 2010 Clinical Scholar Experimental Therapeutics in Oncology and Immunology, Cleveland Clinic 2003 – 2004 Internship General Internal Medicine, Cleveland Clinic 1999 – 2003 Doctor of Medicine Northeastern Ohio Universities College of Medicine (NEOUCOM), Rootstown, Ohio 1997 – 1999 Bachelor of Science University of Akron, Akron, Ohio Certifications and Licenses State Medical Board of Ohio License Number 35.087166 American Board of Pathology, Specialty Certification, Anatomic and Clinical Pathology Date July 30, 2014 American Board of Pathology, Subspecialty Certification, Dermatopathology Date September 28, 2015 Honors and Awards Fellowship • 1st Place Best Resident/Fellow Poster Presentation at the American Society of Dermatopathology 51st Annual Meeting; November 6th -9th 2015; Chicago Il, USA. • Scholarship, World Congress of Dermatology 23rd Annual Meeting, June 8th -13th 2015; Vancouver, Canada. • Gold Presentation Winner, Annual Research Day in the Department of Dermatology, Cleveland Clinic; May 19th 2015; Cleveland, Ohio. • 1st Place Best Resident/Fellow Presentation, Cleveland Society of Pathology; May 27th; Cleveland, Ohio. Residency
  2. 2. • 1st Place Best Resident/Fellow Poster Presentation at the American Society of Dermatopathology 50th Annual Meeting; October 10th -13th 2014; Washington DC, USA. Graduate (Doctoral) • Fellowship Award, Moffitt Cancer Center, Molecular Targets for Cancer Therapy: Regulatory Myeloid Suppressor Cells in Health and Disease • Summa cum laude graduate Medical School • Alpha Omega Alpha (AOA), medical honor society • NEOUCOM Pasteur Award, for excellence in microbiology, immunology, and infectious disease • American Medical Women’s Association Janet M. Glascow Memorial Achievement Citation Undergraduate • Presidential Scholarship • Summa cum laude graduate Research and Other Experience 1/2005 – 6/2010 Graduate Student (Doctoral) James H. Finke Cleveland Clinic Lerner Research Institute, Dept. of Immunology; and Case Western Reserve University, Dept. of Pathology 8/2006 – 6/2010 Myeloid-derived Suppressor Cell accumulation in tumor-bearing hosts 1/2005 - 8/2006 Tumor-secreted ganglioside suppression of immune cell function 7/2004 – 6/2010 Clinical Scholar- Experimental Therapeutics in Melanoma Ernest C. Borden Cleveland Clinic Taussig Cancer Institute Summer 2001 Research Elective John J. Docherty NEOUCOM Dept. of Microbiology and Immunology 9/2000 – 5/2001 Teaching Assistant, Biochemistry Phillip W. Westerman, Professor Emeritus NEOUCOM Dept. of Biochemistry Publications Ko JS, Prieto VG, Elson P, Vilain RE, Pulitzer M, Scolyer RA, Reynolds JP, Piliang M, Ernstoff MS, Gastman M, Billings SD. "Histologic pattern of Merkel cell carcinoma sentinel lymph node metastasis improves stratification of Stage III patients" Accepted for publication in Modern Pathology. Ko JS, Billings SD. “Diagnostically challenging epithelioid vascular tumors.” Surg Pathol Clin. 2015 Sep;8(3):331-51. Jennifer Ko 2/10
  3. 3. Wu L, Zepp J, Ko JS, Zhao J, Chen X, Gu G, Towne J, Ouyang W, Sen G, Stark G, Su B, Gastman B, Liu C, Li X. “A novel IL-17 signaling pathway through the TRAF4-MEKK3-ERK5 axis for keratinocyte proliferation and tumorigenesis.” Accepted at J Exp Med. Mahata B, Biswas S, Rayman P, Chahlavi A, Ko J, Bhattacharjee A, Li YT, Li Y, Das T, Sa G, Raychaudhuri B, Vogelbaum MA, Tannenbaum C, Finke JH, Biswas K. "GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway." PLoS One. 2015 Jul 30;7:e0134425. Ko JS, Billings SD, Lanigan CP, Buehler D, Fernandez AP, Tubbs RR. “Fully Automated Dual- Color Dual-Hapten Silver In-Situ Hybridization Staining for MYC Amplification: a Diagnostic Tool for Discriminating Secondary Angiosarcoma” J Cutan Pathol. 2014, 41(3): 286-92. Finke JH, Rayman PA, Ko JS, Bradley JM, Gendler SJ, Cohen PA. “Modification of the Tumor Microenvironment as a Novel Target of Renal Cell Carcinoma Therapeutics.” Cancer J 2013 19(4): 353-64. Ko JS, Falzarano SM, Walker E, Streator-Smith K, Stephenson AJ, Klein E, Magi-Galluzzi C. “Prostate cancer patients older than 70 years treated by radical prostatectomy have higher biochemical recurrence rate than their matched younger counterpart.” Prostate 2013, 73(8): 897- 903. Ko JS, Fernandez AP, Anderson KA, Burdick LM, Billings SD, Procop GW, McMahon JT, Bergfeld WF, Piliang MP. “Morphologic mimickers of Cryptococcus occurring within inflammatory infiltrates in the setting of neutrophilic dermatoses: a series of 3 cases highlighting clinical dilemmas associated with a novel histologic pitfall.” J Cutan Pathol 2013, 40(1): 38-45. Wang C, Wu L, Bulek K, Martin B, Zepp J, Kang Z, Liu C, Herjan T, Misra S, Carman J, Gao J, Dongre A, Han S, Bunting K, Ko JS, Xiao H, Kuchroo V, Ouyang W, Li X. “The psoriasis- associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.” Nat Immunol. 2013, 14(1): 72-81. Cohen PA, Ko JS, Storkus WJ, Spencer CD, Bradley JM, Gorman JE, McCurry DB, Zorro- Manrique S, Dominguez AL, Pathangey LB, Rayman PA, Rini BI, Gendler SJ, and Finke JH. “Myeloid-derived suppressor cells adhere to physiologic STAT3- vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape.” Immunol Invest. 2012, 41(6-7): 680-710. Martin ST, Ko JS, Plesec TP, Ananthakrishnan L, Remzi FH. “Colonic duplication mimicking fistulizing Crohn’s Colitis.” Inflamm. Bowel Dis. 2011, 17(8):E103-5. Finke J, Ko J, Rini B, and Cohen P. “TKI and the Immune Response: Is there Potential for Combination Therapy?” Kid Cancer J 2011, 9(1): 23-34. Jennifer Ko 3/10
  4. 4. Raychaudhuri B, Rayman P, Ireland J, Ko J, Rini BI, Borden E, Garcia J, Vogelbaum MA, and Finke J. “Myeloid derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma.” Neuro. Oncol. 2011, 13(6):591-599. Finke J, Ko J, Rini B, Rayman P, Ireland J and Cohen P. “MDSC as a mechanism of tumor escape form sunitinib mediated anti-angiogenic therapy.” Int Immunopharmacol 2011, 11(7):856-861. Bose A, Taylor JL, Alber S, Watkins SC, Garcia JA, Rini, BI, Ko JS, Cohen PA, Finke JH and Storkus WJ. “Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination.” Int. J. Cancer 2011, 129(9): 2158-70. Ko J, Rayman P, Ireland J, Swaidani S, Li G, Bunting KD, Rini B, Cohen P, Finke J. “Direct and differential suppression of MDSC subsets by sunitinib is compartmentally constrained.” Cancer Res. 2010, 70(9): 3526-36. Seliger B, Massa C, Rini B, Ko J, Finke J. “Antitumor and immune-adjuvant activities of protein-tyrosine kinase inhibitors.” Trends Mol. Med. 2010, 16(4): 184-92. Ko J, Zea A, Rini B, Ireland J, Elson P, Cohen P, Golshayan A, Rayman P, Wood L, Garcia J, Driecer R, Bukowski R, Finke J. “Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients.” Clin. Cancer Res. 2009, 15(6): 2148-57. Ko J, Bukowski R, Finke J. “Myeloid-derived suppressor cells: a novel therapeutic target.” Curr. Oncol. Rep. 2009, 11(2): 87-93. Biswas S, Richmond A, Biswas K, Ko J, Ghosh S, Simmons M, Rayman P, Rini B, Gill I, Tannenbaum C, Finke J. “Elevated levels of select gangliosides in T cells from renal cell carcinoma patients is associated with T cell dysfunction.” J. Immunol. 2009, 183(8): 5050-8. Salas R, Ko J, Finke J. Immunobiology of metastatic renal cell carcinoma. In: Rini B and Campbell S (Eds.) Renal Cell Carcinoma. Hamilton, Ontario: BD Becker Inc; 2008: 167-179. Docherty JJ, Smith JS, Fu MM, Stoner T, Booth T. “Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice.” Antiviral Res. 2004, 61(1): 19-26. Smith JS, Brodell RT. “Improved therapy for atopic eczema. New immunomodulators clear the rash with few side effects.” Postgrad Med 2004, 115(1):35-7. Abstracts and Posters Ko JS, Gastman B, Bergfeld W. A 1-year pathology review of facial allotransplantation resulting from granulomatosis with polyangiitis and malignant pyoderma. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Ko JS, Daniels B, Emanuel P, Billings SD. Breaking bad dogma: the diversity of spindle cell lipomas in women. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Jennifer Ko 4/10
  5. 5. Ko JS, Billings SD. Utility of Sox10 immunohistochemical staining to distinguish non-ossifying fibromyxoid tumor from epithelioid schwannoma. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Minca E, Billings SD, Ko JS. Significance of epidermal mitoses in challenging melanocytic proliferations. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Feasel P, Billings B, Fernandez A, Piliang M, Bergfeld W, Ko JS. Can direct immunofluorescence (DIF) testing of bullous disorders be streamlined? – a single institution experience with bullous pemphigoid (BP). The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Uberti G, Billings S, Goldblum J, Ko JS. Desmoplastic Granular Cell Tumor, a Rare Variant with Unique Diagnostic Challenges. Duel in Dermatopathology. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. DiCarlo C, Uchin J, Piliang M, Ko JS. Longitudinal Biopsies over Many Years Culminating in a Rare and Instructive Case of Atypical Galli-Galli Disease. Duel in Dermatopathology. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. McHugh K, Tetzlaff M, Billings S, Ko JS. Ultra-late (32 years) recurrence of atypical Spitz tumor as pleomorphic melanoma with a favorable immune signature: non- experimental evidence of immune equilibrium. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Nomani, L, Billings, SD, Naous, R, Ko JS. Neurotropic desmoplastic melanoma with an epithelioid façade masquerades as epithelioid schwannoma. The American Society of Dermatopathology 52nd Annual Meeting; 2015 October 8-11; San Francisco, CA. Ko JS, Prieto VG, Vilain R, Scolyer R, Reynolds JP, Billings SD. Histologic Pattern of Merkel Cell Carcinoma Sentinel Lymph Node Metastasis and Patient Immune Status Significantly Impacts Disease Outcome. United States and Canadian Academy of Pathology Annual Meeting; 2015 March 21-27; Boston, MA, USA. Ko JS, Billings SD. Significance of histologic pattern of Merkel cell carcinoma (MCC) metastasis in sentinel lymph node biopsies (SLNBx) and patient immune status in disease outcome. The American Society of Dermatopathology 51st Annual Meeting; 2014 November 6- 9; Chicago, Il. Ko JS, Miner A, Bergfeld W. Ectopic Paget’s disease of the neck associated with underlying cutaneous apocrine carcinoma. The American Society of Dermatopathology 51st Annual Meeting; 2014 November 6-9; Chicago, Il. Ko JS, Cheah A, Billings SD. Life on the edge: A series of two cases of amelanotic spindle cell melanoma with sarcomatoid dedifferentiation. The American Society of Dermatopathology 51st Annual Meeting; 2014 November 6-9; Chicago, Il. Jennifer Ko 5/10
  6. 6. Ko JS, Rayman P, Yang Y, Gopalan B, Finke F. Differential gene expression in G- MDSC and neutrophils from renal cell carcinoma patients. Society for Immunotherapy of Cancer 29th Annual Meeting: 2014 November 8-10; National Harbor, MD, USA. Ko JS, Rayman P, Borden EC, Obery D, Lindner D, Finke JH. Proangiogenic Neutrophilic- Myeloid-Derived Suppressor Cells Emerge Via Two Parallel Pathways in Renal Cell Carcinoma and Melanoma. Society for Immunotherapy of Cancer 28th Annual Meeting: 2013 November 8- 10; National Harbor, MD, USA. Obery DR, Rayman PA, Yang Y, Ko JS, Finke JH. Neutrophils from renal cell carcinoma patients show increased expression of immunosuppressive and angiogenic gene profile. Society for Immunotherapy of Cancer 28th Annual Meeting: 2013 November 8-10; National Harbor, MD, USA. Ko JS, Rayman P, Borden EC, Lindner D, Finke J. Neutrophilic myeloid-derived suppressor cells and conventional neutrophils suppress t-cells and promote angiogenesis in malignant melanoma. The American Society of Dermatopathology 50th Annual Meeting; 2013 October 10- 13; Washington DC, USA. Ko JS and Fernandez AP. Multicentric reticulohistiocytosis: case report and review of a mechanistically and therapeutically elusive disease. The American Society of Dermatopathology 50th Annual Meeting; 2013 October 10-13; Washington DC, USA. Ko JS, Kyei A, Keller E, Piliang MP. Bullous acrodermatitis enteropathica with atypical histopathology: an increasingly important diagnostic consideration. The American Society of Dermatopathology 50th Annual Meeting; 2013 October 10-13; Washington DC, USA. Ko JS and Billings SD. Perineuriomatous nevus: a newly recognized variant. 16th Joint Meeting of the International Society of Dermatopathology; 2012 February 27-March 1; Miami, Fl, USA. Ko JS, Fernandez AP, Anderson K, Burdick LM, Billings SD, Procop GW, McMahon JT, Bergfeld WF, and Piliang MP. Morphologic mimicry of Cryptococcus in the setting of neutrophilic dermatoses: a series of 3 cases highlighting a novel histologic pitfall. The American Society of Dermatopathology 49th Annual Meeting; 2012 October 11-14; Chicago, Il., USA. Ko JS, SD Billings, L Durkin, Lin J, W-L Wang, AJ Lazar, ED His. Immunohistochemical staining for p-ERK: A potential screening tool for BRAF mutations in melanoma. United States and Canadian Academy of Pathology 101st Annual Meeting; 2012 March 17-23; Vancouver, BC, Canada. Ko JS, SD Billings, AP Fernandez, CP Lanigan, RR Tubbs. Fully Automated Dual ISH (DDISH) Staining for MYC Amplification: a Diagnostic Tool for Discriminating Secondary Angiosarcoma. United States and Canadian Academy of Pathology 101st Annual Meeting; 2012 March 17-23; Vancouver, BC, Canada. Ko JS, Falzarano SM, Walker E, Streator Smith K, Klein EA, Magi-Galluzzi C. Prostate cancer in patients older than 70 years treated by radical prostatectomy: clinicopathologic analysis and Jennifer Ko 6/10
  7. 7. outcome. United States and Canadian Academy of Pathology 101st Annual Meeting; 2012 March 17-23; Vancouver, BC, Canada. Ko J, Procop G, Bhaskaran A, Desai H, McMahon J, Farver C. Nodular Pulmonary Granuloma Formation by Acanthamoeba in a Patient Receiving Rituximab Therapy. College of American Pathologists Annual Meeting; 2011 September 11-14; Grapevine, TX. Ko J, Rayman P, Cohen P, Nolan B, Biswas S, Biswas K, Tannenbaum C, Lindner D, Borden E, Rini B, and Finke J. Tumor-derived Products Dynamically Convert Neutrophils into CD15+ Myeloid-Derived Suppressor Cells via Sunitinib-Sensitive and Insensitive Mechanisms. Regulatory Myeloid Cells, an International Immunopharmacology Conference; 2010 October 21- 24; Washington DC. Ko J, Rayman P, Jacobs B, Ireland J, Lindner D, Finke J, Borden E. Dual Mechanistic Function of MDSC Subsets in Melanoma. American Society of Clinical Oncology Annual Meeting; 2010 June 4-8; Chicago, IL. Ko J, Rini B, Ireland J, Rayman P, Cohen P, Finke J. Sunitinib-mediated MDSC inhibition reverses tumor-induced immune suppression. American Association for Cancer Research 100th Annual Meeting; 2009 April 18-22; Denver, CO. Biswas K, Chahlavi A, Biswas S, Ko J, Rayman P, Das T, Sa G, Tannenbaum C, Vogelbaum M, Finke J. Glioblastoma-derived gangliosides induce T cell death by activating the caspase cascade and degradation of the anti-apoptotic RelA and Bcl2. American Association for Cancer Research 100th Annual Meeting; 2009 April 18-22; Denver, CO. Ko J, Salas R, Ireland J, Rayman P, Rini B, Finke J, Cohen P. Myeloid-specific immune cell impact of sunitinib reverses tumor-induced immune suppression. Molecular Targets for Cancer Therapy: 5th Biennial Meeting; 2009 March 12-15; Moffitt Cancer Center, Clearwater Beach, Florida. Rayman P, Ko J, Cohen P, Finke J. Tumor-derived products dynamically activate CD15+ subset of myeloid-derived suppressor cells. Molecular Targets for Cancer Therapy: 5th Biennial Meeting; 2009 March 12-15; Moffitt Cancer Center, Clearwater Beach, Florida. Ko J, Zea A, Rini B, Ireland J, Elson P, Cohen P, Golshayan A, Rayman P, Wood L, Garcia J, Driecer R, Bukowski R, Finke J. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in metastatic renal cell carcinoma patients. American Association for Cancer Research Annual Meeting; 2008 April 12-16; San Diego, CA. Salas R, Ireland J, Ko J, Elson P, Garcia J, Wood L, Bukowski R, Rini B, Finke J. Immune cell changes in the peripheral blood of metastatic renal cell carcinoma patients treated with sunitinib or temsirolimus. American Society of Clinical Oncology Annual Meeting; 2008 May 30-June 3; Chicago, Il. George S, Rayman P, Biswas S, Garcia J, Ko J, Wood L, Smith-Williams T, Elson P, Driecer R, Rini B, Bukowski R, Finke J. Expression of Flt3 and VEGFR1 on myeloid-derived suppressor cells in renal cell carcinoma patients. American Society of Clinical Oncology Annual Meeting; 2008 May 30-June 3; Chicago, Il. Jennifer Ko 7/10
  8. 8. Ko J, Biswas S, Biswas K, Finke J, Tannenbaum C. Gangliosides derived from renal and brain tumor lines inhibit T lymphocyte proliferation and dendritic cell maturation. American Association for Cancer Research Annual Meeting; 2006 April 1-5; Washington DC. Oral Presentations/Invited Speaker Oral Platform Presentation, “Worse outcome in melanoma patients recently pregnant: decreased T-cell programmed death receptor-1 (PD-1) expression in primary tumors suggests immune ignorance,” World Congress of Dermatology 23rd Annual Meeting, June 8th-13th,Vancouver, Canada. Oral Platform Presentation, “Cutaneous Manifestations in Inflammatory Bowel Disease: A Single Institutional Study of 209 Patients.” United States and Canadian Academy of Pathology Annual Meeting; 2015 March 21-27; Boston, MA, USA. Oral Platform Presentation, “Worse outcome in melanoma patients recently pregnant: decreased T-cell programmed death receptor-1 (PD-1) expression in primary tumors suggests immune ignorance,” The American Society of Dermatopathology 51st Annual Meeting, November 8, 2014, Chicago, Il. Oral Presentation, Duel in Dermatopathology, “Menkes disease: a clinical case and review,” The American Society of Dermatopathology 50th Annual Meeting, October 10, 2013, Washington DC. Faculty Presentation, “What You Need to Know about Innate Immunity,” Society for Immunotherapy of Cancer (SITC) CME Course- Advances in Cancer Immunotherapy: from Bench to Bedside and Back. October 4, 2013, Cleveland, Ohio. Oral Presentation, Duel in Dermatopathology, “Sweet’s Syndrome in the setting of AML containing a Morphologic Mimicker of Cryptococcus,” The American Society of Dermatopathology 48th Annual Meeting, October 20, 2011, Seattle, WA. Oral Presentation, “Tumor-derived Products dynamically Convert Neutrophils into n-MDSC via Sunitinib-Sensitive and Insensitive Mechanisms,” International Immunopharmacology Conference on Regulatory Myeloid Cells, October 24, 2010, Washington DC. Invited Speaker, “Myeloid Derived Suppressor Cells in Cancer Progression; Promotion of T-cell Immunity by the TKI Sunitinib” Taussig Cancer Institute GU Cancers Preceptorship: Renal Cell Carcinoma: Pathology, Diagnosis and Treatment, September 14, 2010, Cleveland Clinic, Cleveland, Ohio. Invited Speaker, “Mechanisms of Myeloid-Derived Suppressor Cell Accumulation in Cancer and Susceptibility to Reversal by Sunitinib,” Translational Hematology and Oncology Research Lecture Series, June 1, 2010, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH. Oral Presentation, “Sunitinib mediated inhibition of myeloid-derived suppressor cells reverses tumor-induced immune suppression.” American Association for Cancer Research 100th Annual Meeting. April 19, 2009, Denver, CO. Jennifer Ko 8/10
  9. 9. Teaching Seminars/Lectures Seminar, “Contemporary Issues in the Management of Merkel Cell Carcinoma” Pathology and Laboratory Medicine Grand Rounds, February 26, 2015, Cleveland Clinic, Cleveland, OH. Seminar, “Tumor Immunology…You’ve come a long way baby!” Pathology and Laboratory Medicine Grand Rounds, October 24, 2013, Cleveland Clinic, Cleveland, OH. Seminar, “The Role of Th17 in Cancer” Continuing Education Lecture Series, August 1, 2013, Cleveland Clinic, Cleveland, OH. Seminar, “The Immunoscore: Coming to a Tumor Classification System Near You,” Pathology and Laboratory Medicine, June 19, 2013, Cleveland Clinic, Cleveland, OH. Seminar, “Laboratory Administration: Quality and Compliance,” Continuing Education Lecture Series, June 28, 2012, Cleveland Clinic, Cleveland, OH. Seminar, “Cutaneous Fungal Infections, from Bedside to Bench,” Continuing Education Lecture Series, April 6, 2012, Cleveland Clinic, Cleveland, OH. Seminar, “B-RAF Testing in Malignant Melanoma,” Pathology and Laboratory Medicine Grand Rounds, February 23, 2012, Cleveland Clinic, Cleveland, OH. Seminar, “Myeloid-Derived Suppressor Cells in Cancer Progression; Promotion of T-Cell Immunity by the Tyrosine Kinase Inhibitor Sunitinib.” Pathology and Laboratory Medicine Grand Rounds, June 10, 2011, Cleveland Clinic, Cleveland, OH. Medical student lectures, “Hematemesis and Dysphagia, Pathologic Correlation,” Clinical Rounds, 2011-2012, Cleveland Clinic Lerner College of Medicine, Cleveland, OH. Seminar, “Mechanisms of Myeloid-Derived Suppressor Cell Accumulation in Cancer and Susceptibility to Reversal by Sunitinib.” Case Western Reserve University Pathology and Immunology Lecture Series, October 12, 2009, CWRU, Cleveland, OH. Seminar, “Myeloid-derived suppressor cells and anti-angiogenic therapy.” Case Western Reserve University Pathology and Immunology Lecture Series, January 21, 2009, CWRU, Cleveland, OH. Seminar, “Myeloid-derived suppressor cells in renal cell carcinoma.” Immunology Lecture Series, October 1. 2008, Lerner Research Institute, Department of Immunology, Cleveland, OH. Seminar, “Tumor-derived gangliosides suppress T cell function.” Case Western Reserve University Pathology and Immunology Lecture Series, May 11, 2007, CWRU, Cleveland, OH. Publications Reviewed and Other Experience Formulation of Grants: Jennifer Ko 9/10
  10. 10. Pfizer Grant – “Defining the mechanisms by which sunitinib regulates T regulatory and myeloid- derived suppressor cells in renal cell carcinoma patients and improves T cell immunity.” Direct cost 120,000/year. NIH R01 – “Sunitinib modulation of cancer immunotherapy.” Direct cost 350,000/year. Research Program Council Grant- “Define the expression of Programmed Death (PD)-1 and Programmed Death Ligand (PD-L1) complex on myeloid and T cells in the blood and tumor of patients with renal cell carcinoma and assess the impact of TKI on their expression” Direct cost 20,000/year Review Manuscripts: Journal of Immunology, Clinical Cancer Research, Journal of Interferon and Cytokine Research, International Immunopharmocology, and Journal of Cutaneous Pathology. Internal Grant Reviewer, Research Program Council Professional Memberships • American Society of Dermatopathology (2012-present) • College of American Pathologists (2011-present) • American Society for Clinical Pathology (2011-present) • United States and Canadian Academy of Pathology (2011-present) • Association for Molecular Pathology (2011-present) • Cleveland Society of Pathologist (2010-present) • Society for Immunotherapy of Cancer (2013-present) Jennifer Ko 10/10

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