This document provides an overview of pancreatitis and pancreatic pseudocysts. It defines acute and chronic pancreatitis, describes the pathogenesis involving premature activation of pancreatic enzymes, and lists common causes like gallstones. Signs and symptoms include abdominal pain while complications involve local issues like pseudocysts or systemic problems. Diagnosis involves blood tests, imaging, and assessing severity with tools like BISAP score. Management focuses on supportive care, treating underlying causes, and draining complications surgically or minimally invasively. Pseudocysts are pancreatic fluid collections that often resolve on their own but sometimes require intervention.
6. • Acute Pancreatitis**: inflammatory condition of
the pancreas of an acute presentation characterized
clinically by abdominal pain and elevated levels of
pancreatic enzymes in the blood.
• Chronic Pancreatitis: is a continuing inflammatory
disease of the pancreas characterised by irreversible
morphological changes typically causing pain and/or
permanent loss of function. Can also have an acute on
chronic presentation.
7. Pathological Classification
• Are of two types:
• Interstitial oedematous pancreatitis: vast
majority (90-95%)
• most often referred to simply as "acute
pancreatitis" or "uncomplicated pancreatitis“
• Necrotising pancreatitis: necrosis develops
within the pancreas and/or peripancreatic
tissue
8. Blast from the Past:
• Alexander the Great
• Reginald Huber Fitz – On Acute Pancreatitis
• Eugene Lindsey Opie – Gallstone lodging
• Chiari - Autodigestion
9. ACUTE PANCREATITIS
• DEFINITION: A group of reversible lesions due to inflammation of the pancreas
clinically charactersied by abdominal pain and elevated levels of pancreatic
enzymes in the blood. It is medical emergency, and requires to be treated as
soon as possible.
• GENDER PREDILECTION: Generally M>F
In males more often related to alcohol
In females more often related to biliary tract disease
Idiopathic pancreatitis no clear gender predilection
• INCIDENCE: Young men and elderly women
• MORTALITY RATE: Mild pancreatitis >1%, Severe cases - 10-30%
• CAUSE OF DEATH: Multi-organ Dysfunction Syndrome
10. AETIOLOGY
• Gall stones - 50 to 70% cases
• Alcoholism - 25%
• Post ERCP - ***
• Abdominal trauma
• Post biliary , upper gastrointestinal or cardiothoracic
surgery
• Ampullary tumour
• Drugs like corticosteroids, azathioprine, asparaginase,
valproic acid, thiazides, oestrogens
12. PATHOGENESIS : AUTO ACTIVATION AND AUTO DIGESTION
•Two -mild pancreatitis
• -severe pancreatitis,
•Division is based whether the predominant response to cell injury
is inflammation or necrosis, respectively.
•In mild pancreatitis - inflammation and edema of the pancreas
•In severe pancreatitis – also features of necrosis and secondary
injury to extrapancreatic organs.
•Both types share a common mechanism of abnormal inhibition of
secretion of zymogens and inappropriate activation of pancreatic
zymogens inside the pancreas, most notably trypsinogen.
13.
14. CLINICAL FEATURES
The most common symptoms and signs include:
Severe epigastric pain (50% cases) radiating to the back, chest,
flanks, and lower abdomen, relieved by leaning forward, that
feels worse after eating
Nausea, vomiting, diarrhea and loss of appetite
Fever/chills
Hemodynamic instability, including shock- cold clammy extremities,
rapid low volume pulse, tachycardia
In severe case may present with tenderness, guarding, rebound
tenderness.
Respiratory symptoms: Tachypnoea, respiratory distress
Hiccups
15.
16. COMPLICATIONS/SEQUELAE
1)LOCAL: usually develop after first week
• Acute fluid collection
• Sterile pancreatic necrosis
• Infected pancreatic necrosis
• Pancreatic abcess
• Pseudocyst
• Pancreatic ascites
• Pancreatic effusion
• Haemorrhage
• Portal/Splenic vein thrombosis
• Pseudoaneurysm
**In the long run, repeated attacks- chronic pancreatitis with irreversible damage
17.
18.
19. 2) SYSTEMIC: more common in the first one week
• Cardiovascular: Shock, arrythmias
• Pulmonary : ARDS
• Renal failure
• Gastrointestinal: Ileus, peritonitis
• Neurological : visual disturbances, confusion, irritability, encephalopathy,
coma
• Miscellaneous: Subcutaneous fat necrosis, arthralgia
Others include :
Haematological: DIC
Metabolic: hyperglycaemia, hypocalcaemia, hyperlipidaemia
20.
21. DIAGNOSIS
Proper history, clinical examination, confirmation by investigations
According to the American College of Gastroenterology's
guidelines, there are three criteria that must be present to
diagnose acute pancreatitis, including:
•Severe abdominal pain
•Amylase or lipase levels that are three times higher than the
upper limit of normal
•"Characteristic" abdominal imaging results
22. 1. Blood
• CBC - neutrophil leucocytosis, thrombocytopenia (DIC)
• BUN
• Clotting profile- prolonged in DIC
• Glucose - hyperglycaemia in severe cases
• Electrolytes: Calcium levels -decreased, Potassium levels
• ABG – (hypoxemia) , pH (lactic acidosis – shock)
• FDP like D-dimer– raised in DIC
• Triglycerides
• C-reactive protein
• IgG4 – autoimmune pancreatitis
INVESTIGATIONS
23. 2. Urine
-24h urine ouput
-Microscopy: Casts
- Urinary amylase
-Glycosuria (10% cases)
*Trypsin and its precursor trypsinogen-2 in both the urine and the peritoneal fluid have
been evaluated as possible markers for acute pancreatitis (especially post-ERCP
pancreatitis) but are not widely used.
*Although not currently in use clinically, polymorphisms in the chemokine monocyte
chemotactic protein 1 (MCP-1) gene may also predict severity. This is the first gene
identified that plays a role strictly in predicting the severity of disease.
3. Biochemical investigations
- Liver function tests: Increased liver enzymes, ALT,ALP, GGT ( gallstones)
- Direct bilirubin : Increase in CBD block
- Renal function tests: Creatinine, BUN, Urea
- Serum amylase: (amylase P): Increased (3-4 times normal diagnostic but
not specific)
- Serum lipase: Increased- more specific
24. 4. Radiological
•X rays :-
-Non specific signs – generalised or local ileus (sentinel loop), a colon
cut off sign, renal halo sign, calcified gallstones/pancreatic
calcifications
USG abdomen:- With in 24 hours- for gallstones, rule out a/c
cholecystitis, CBD dilatation diagnosis of vascular complications, i.e.
thrombosis, hypoechoic lesions may indicate necrotic change
•CT Abdomen with contrast:- phlegmon(inflammatory mass),
pseudocyst or abscess(complications of acute pancreatitis)
25. CT:
typical findings:
-focal or diffuse parenchymal enlargement
-calcifications may be seen within the parenchyma
-changes in density because of oedema
-indistinct pancreatic margins owing to inflammation
-surrounding retroperitoneal fat stranding
liquefactive necrosis of pancreatic parenchyma: lack of
parenchymal enhancement
infected necrosis
abscess formation : circumscribed fluid collection, little or no
necrotic tissues
haemorrhage: high-attenuation fluid in the retroperitoneum or
peripancreatic tissues
26. •MRI :- Contrast-enhanced MR is equivalent to CT in the
assessment of pancreatitis.
•ERCP :- Identification and removal of gallstones.
•EUS:- not frequent, used to ultrasonographically visualize
pancreas, bile tree, useful for stones, does not have
complications of ERCP. More sensitive to pick up
microlithiasis and periampullary lesions.
•MRCP:- not frequently used, used for detection of
gallstones.
27. Assessment of Severity
• AIM: to define patients with severe pancreatitis
• Based on history, clinical assessment , investigations - scoring
systems –
Ranson score, Glasgow scale, APACHE II, BISAP, Balthazar
scoring
•Grade severity , provide adequate appropriate
treatment/interventions, ward off/better control of another
attack
28.
29.
30. This calculator evaluates the following Clinical Criteria:
BUN >25 mg/dL (8.9 mmol/L)
Impairment of mental status with a Glasgow coma score <15
SIRS (systemic inflammatory response syndrome)
Age >60 years old
Pleural effusion
Each determinant is given one point
SIRS is defined as 2 or more of the following variables;
Fever of more than 38°C (100.4°F) or less than 36°C (96.8°F)
Heart rate of more than 90 beats per minute
Respiratory rate of more than 20 breaths per minute or arterial carbon dioxide tension
(PaCO2) of less than 32mm Hg
Abnormal white blood cell count (>12,000/µL or < 4,000/µL or >10% immature [band]
forms)
Bedside index of severity in acute
pancreatitis (BISAP) score
33. MANAGEMENT
Early management
Management of risk factors
Management of complications
Early Management: aims to provide immediate care and resuscitation
•Admission to HDU/ICU
•Analgesia
•Aggressive fluid rehydration, electrolyte imbalance correction
•Oxygenation
•Monitoring vitals, CVP, urine output, blood gases
34. • Frequent monitoring : haematological + biochemical parameters-
RFT, LFT, clotting profile, serum Calcium, blood sugar levels
• NG drainage
•Antibiotic prophylaxis
• CT scan : essential for organ failure, clinical deterioration or signs
or sepsis develops
• ERCP within 72 hours for severe gallstone pancreatitis or signs of
cholangitis
• Supportive therapy for organ failure if it develops – inotropes,
ventilatory support, haemofiltration, etc
• If nutritional support is required consider enteral feeding using NG
tube
36. If conservative measures fail especially in very severe cases–
B) NECROSECTOMY- thorough removal of necrotic tissues and
collections
•Based on clinical symptoms and imaging studies via endoscopy/ midline
laparotomy
•Asso high morbidity and mortality
•If tail and body involved – left flank approach
•If gallstones are cause – Cholecystectomy- endoscopic/laparotomy
•After Necrosectomy- more necrotic tissue may form, re-exploration may
be needed
37. C) Management of Post Necrosectomy necrotic tissue:
Closed continuous lavage of Berger:
Tube drains are left in and the raw areas flushed
Closed drainage: Incision is closed but cavity is packed with
gauze filled Penrose drains and closed suction drains.
The Penrose drains are brought out through the flank and slowly
pulled out and removed after 7 days.
Open packing: Incision is left open and cavity packed with
intention of returning to the OT at regular intervals and repacking
until there is a clean granulation cavity.
38. Closure and relaparotomy: incision is closed with drains with intention of
performing a series of planned relaparotomies every 48-72 hours until raw area
granulates
3) Pancreatic ascites: Wide bore needle drainage, NG tubing, Octreotide
4) Pancreatic effusion: Imaging guided percutaneous drainage
5) Haemorrhage : Fatal, embolisation and surgery
6) Portal/Splenic vein thrombosis:
If Portal HTN – esophageal banding/sclerosing agents,
In case of thrombocytosis – antiplatelets like aspirin, clopidogrel, systemic anticoagulation
– double edged sword?
39. DIFFERENTIAL DIAGNOSIS
•Perforated peptic ulcer
•Biliary colic-------------
•Acute cholecystitis----
•Pneumonia----------------
•Pleuritic pain--------------
•Myocardial infarction---
•Oesophageal spasm-----
•Perforated viscus
•Acute mesentric ischaemia
•Acute respiratory distress syndrome
*rule out any cause of acute abdomen
Right upper quadrant pain
Radiation to
chest
40. PANCREATIC PSEUDOCYST
Definition: Is a collection of amylase rich fluid enclosed in a wall of fibrous or granulation
tissue.
Aetiology: after an attack of acute pancreatitis**, in chronic pancreatitis, and post
pancreatic trauma
Pathogenesis: Formation >/= 4 weeks from the onset of acute pancreatitis. Thick fibrous
capsule – no true epithelial lining. Due to ductal distruption, strictures, calculi, tumours.
Composition: Similar electrolyte concentrations to plasma
High concentration of amylase, lipase, and trypsin.
Occurrence: Most common cystic lesions of pancreas, accounting for 75-80% of such
masses
Single *, maybe multiple, or loculated
Location: Lesser peritoneal sac in proximity to the pancreas
Large pseudocysts can extend into the paracolic gutters, pelvis, mediastinum, neck or
scrotum
41.
42. CLINICAL FEATURES
•Asymptomatic when small
•Symptoms
Abdominal pain > 3 weeks (80 – 90%)
Nausea / vomiting
Early satiety
Bloating, indigestion
•Signs:
Abdominal fullness
Tenderness
Palpable mass in the abdomen
Peritoneal signs suggesting rupture of the cyst or infection
Fever
Scleral icterus
Pleural effusion
43. COMPLICATIONS/SEQUELAE:
Infection: Abscess, systemic sepsis
Rupture: Into gutGI bleeding, internal fistula
Into peritoneum Peritonitis
Enlargement: Bowel obstruction, biliary compression,
pain
Erosion into vessel: Haemorrhage into the cyst,
haemoperitoneum
44. DIAGNOSIS
Clinically suspicion in case :
•Episode of pancreatitis fails to resolve
•Amylase levels persistantly high
•Persistent abdominal pain
•Epigastric mass palpated after pancreatitis
45. INVESTIGATIONS
Labs: Persistently elevated serum amylase
Cyst fluid analysis(EUS+A): Carcinoembryonic antigen (CEA) and CEA-125 (low
in pseudocysts and elevated in tumors); fluid viscosity (low in pseudocysts and
elevated in tumors); amylase (usually high in pseudocysts and low in tumors)CEA
(cystic neoplasm)
Radiological Investigations
•Plain X-ray: Not very useful
•Ultrasound TransAbd: 75 -90% sensitive
•EUS: helps plan therapy, not useful for Dx
•CT : Most accurate (sensitivity 90-100%)
•MRI –detection of solid component of cyst and in differentiating between
organized necrosis and a pseudocyst
46.
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49.
50. NATURAL HISTORY OF PSEUDOCYST:
•~50% resolve spontaneously
•Nearly all <4cm resolve spontaneously
•Those >6cm, >12weeks duration asso c/c
pancreatitis persist, necessitate
intervention
• Multiple cysts – few spontaneously resolve
51. MANAGEMENT
If asymptomatic/small – wait for spontaneous resolution
DEFINITIVE TREATMENT DRAINAGE
INDICATIONS :
Complications
Symptoms
Concern about possible malignancy
• 3 approaches to drain a pseudocyst:
Percutaneous
Endoscopic
Surgical**
52. A) PERCUTANEOUS DRAINAGE:
1) Percutaneous catheter drainage:
Done under USG/CT guidance, but has several disadvantages.
High recurrence rate, contraindicated In cysts that are communicating with duct lumen-
Pancreticocutaneous fistula- and in neoplastic cysts
Hence not common
2)Percutaneous transgastric cystgastrostomy: radiological guidance
Recurrence <15%
B) ENDOSCOPIC DRAINAGE:
1) Under EUS guidance
2) ERCP and Stenting of Ampulla – communicating cyst
53. C) SURGICAL DRAINAGE: cystogastrostomy
•most preferred, least recurrence rate ( <5%), best for complicated
pseudocysts
•Open incision laparotomy or laproscopy (also shows similar rates)
58. “Never in medical history have so
many owed so much to a single
stone”. – Reginald Huber Fitz
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67. The following are the latest terms according to the updated Atlanta
classification to describe fluid collections associated with acute
pancreatitis:
fluid collections in interstitial oedematous pancreatitis
acute peripancreatic fluid collections (APFC): in the first 4
weeks: non-encapsulated peripancreatic fluid collections
pseudocysts: develop after 4 weeks; encapsulated
peripancreatic or remote fluid collections
fluid collections in necrotising pancreatitis
acute necrotic collections (ANCs): in the first 4 weeks; non-
encapsulated heterogeneous non-liquefied material
walled-off necrosis (WON or WOPN): develop after 4 weeks;
encapsulated heterogeneous non-liquefied material
68. Peritonitis
Signs that are less common, and indicate severe disease, include:
Pleural effusions:
Grey-Turner's sign (hemorrhagic discoloration of the flanks)
Cullen's sign (hemorrhagic discoloration of the umbilicus)
Grünwald sign
Körte's sign )
Kamenchik's sign
Mayo-Robson's sign )
Mayo-Robson's point - a point on border of inner 2/3 with the external 1/3 of
the line that represents the bisection of the left upper abdominal quadrant,
where tenderness on pressure exists in disease of the pancreas. At this point the
tail of pancreas is projected on the abdominal wall.