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Programme(
 15.00&h &RegistraFon&                  Welcome!
 15.30&h &Social&media:&the&big&picture,(Lykle(de(Vries&(De&Ondernemers)&
          &How&have&Social&Media&changed&the&world?&Including&interesFng&cases&that&are&relevant&&
          &to&Life&Sciences.&
 16.00&h& &Best&pracFces,&examples&from&entrepreneurs&and&scienFsts:&
                    &Erik(Vollebregt&(Axon&Lawyers)&will&outline&how&he&uses&blogs&and&twi;er&to&reach&
maandag 23 april 12 &his&audience&and&clients.&
wifi: UMCU-GASTEN




maandag 23 april 12
@UtrechtLS
                       #SMiLS




maandag 23 april 12
Schedule
                      •   15.30 Social media: the big picture,
                          How have Social Media changed the world?

                      •   16.00 Best practices:

                          •   Erik Vollebregt (Axon Lawyers)

                          •   Sijme Zeilemaker (to-BBB)

                          •   Martijn van Oijen (Assistant Professor of
                              Medicine, Division of Digestive Diseases,
                              #UCLA)

                      •   17.00 Drink & Hands-on help

maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
Who...



maandag 23 april 12
recent numbers



maandag 23 april 12
45%
                      http://www.imedicalapps.com/2012/04/report-demonstrates-healthcare-organizations-failing-capitalize-social-media/




maandag 23 april 12
45%
                      http://www.imedicalapps.com/2012/04/report-demonstrates-healthcare-organizations-failing-capitalize-social-media/




maandag 23 april 12
The Big Picture



maandag 23 april 12
let’s get introduced



maandag 23 april 12
Lykle de Vries




                      @lykle




                                     foto: Judith van der Meulen

maandag 23 april 12
maandag 23 april 12
New Business Development
                          Open Innovation
                        Social Media Strategy


maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
What about Social
                          Media?


maandag 23 april 12
http://www.youtube.com/watch?v=lFZ0z5Fm-Ng

maandag 23 april 12
http://www.flickr.com/photos/jorge-11/4817642638/in/photostream/

maandag 23 april 12
Radio


                              http://www.flickr.com/photos/imh/3297961043/

maandag 23 april 12
TV


                           http://www.flickr.com/photos/roadsidepictures/276395210/

maandag 23 april 12
http://www.flickr.com/photos/inju/112082907/


maandag 23 april 12
http://www.storytellersmediagroup.com/

maandag 23 april 12
http://www.flickr.com/photos/fdtate/5823000083/in/photostream/
maandag 23 april 12
http://www.flickr.com/photos/scott_rtw/1350993666/



maandag 23 april 12
Closed
                       Selective
                      Controlling

                                    http://www.flickr.com/photos/scott_rtw/1350993666/



maandag 23 april 12
http://www.flickr.com/photos/perspective/76640090/in/photostream/

maandag 23 april 12
maandag 23 april 12
http://www.flickr.com/photos/antjeverena/3368703708/in/photostream/
maandag 23 april 12
http://www.flickr.com/photos/antjeverena/3368703708/in/photostream/


maandag 23 april 12
http://www.flickr.com/photos/scott_rtw/1350993666/



maandag 23 april 12
Open
                       Random
                      Supportive

                                   http://www.flickr.com/photos/scott_rtw/1350993666/



maandag 23 april 12
some examples



maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
How to apply



maandag 23 april 12
http://www.flickr.com/photos/ter-burg/5846043943/in/photostream/

maandag 23 april 12
http://www4.picturepush.com/photo/a/2856902/img/foto-voor-
                                  bij-mijn-gedichten-/Poezie-album.jpg


maandag 23 april 12
http://www.flickr.com/photos/renaissancechambara/3122900531/in/photostream/

maandag 23 april 12
http://smash-gtennis.nl/wp-content/uploads/2012/01/IMG_95711.jpg

maandag 23 april 12
what about bad news?



maandag 23 april 12
People connect
             online with their
              offline friends.

            People love to
          connect to people.




                                 38
maandag 23 april 12
Positive experiences
                are bigger conversation
                 starters than negative
                experiences. People like
                     positive stuff.




                                           39
maandag 23 april 12
People prefer to
                        share positive
                      brand experiences
                       on social media




maandag 23 april 12
PwC Health Research Institute – Social media “likes” healthcare
                                                                     People prefer to
                                                                                        5
  Chart Pack
                                                                      share positive
                                                                    brand experiences
                                                                     on social media




maandag 23 april 12
Some more examples



maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
maandag 23 april 12
How to apply



maandag 23 april 12
http://www.flickr.com/photos/jamesjordan/2649170201/


maandag 23 april 12
Best Practices



maandag 23 april 12
Erik Vollebregt



maandag 23 april 12
SOCIAL MEDIA IN
             LIFE SCIENCES


             Presentatienaam   Presentator
             datum             www.axonadvocaten.nl



maandag 23 april 12
Overview
             • 2 twitter accounts
                      • @axonlawyers
                      • meddevlegal
             • LinkedIn accounts (+ one In account)
             • 2 websites
                      • Axonlawyers.com
                      • AELSLF.eu
             • 2 blogs
                      • Medicaldeviceslegal.com
                      • Biotechlegal.wordpress.com
             • Mailinglist to email fed from CRM system




maandag 23 april 12
maandag 23 april 12
Our philosophy

             Information wants to be free, so we offer free, relevant, expert content
             • No stupid paywalls etc
             People retweet and forward our information because it’s relevant to them or to
             others
             • They feel that any message is worthwhile
             We seek to exploit multipliers via other parties and deploy content in as many
             channels as possible
             • Always retain rights on published contents




maandag 23 april 12
Sijme Zeilemaker



maandag 23 april 12
Social Media @to_BBB




        Sijme Zeilemaker
        Business Development Associate




                      to-BBB technologies BV    Sijme Zeilemaker                 Phone   +31 71 33 222 56   E-mail   SijmeZeilemaker@toBBB.com
                      Leiden, The Netherlands   Business Development Associate   Fax     +31 84 83 134 09   Web      www.toBBB.com


maandag 23 april 12
Brief introduction



        • to-BBB: Blood-Brain Barrier
        • G-Technology: safely enhancing drug delivery to the brain
        • Strategy:
              – Develop off-patent compounds for brain indications
              – Collaborate with big pharma on patented compounds
        • Lead product: brain-targeted chemotherapy (2B3-101)
              – Significant brain tumor reduction in preclinical testing
              – Started dose-escalation clinical phase I/IIa trial in 2011
              – Patients with solid tumors and brain metastases
              – Patients with primary brain tumor glioma
        • Many potential products in pipeline

maandag 23 april 12
Corporate Communication Profile



     GSK, Janssen, Genzyme, etc.
    Smaller CNS/oncology biotech
                                                                    Patients hoping for a cure




               Venture Capital
                 Private equity
               Grant providers


                                                                       Volkskrant, FD, Telegraa
                                                                       International journals


eiden, UvA, VU, UU, Erasmus
nternational research groups




                                                                    Job vacancies
                                                                    Internships
                              CROs
                         Consultants



 maandag 23 april 12
Corporate Communication Profile

                         WEBSITE                                    ?

     GSK, Janssen, Genzyme, etc.
    Smaller CNS/oncology biotech
                                                                        Patients hoping for a cure




               Venture Capital
                 Private equity
               Grant providers


                                                                           Volkskrant, FD, Telegraa
                                                                           International journals


eiden, UvA, VU, UU, Erasmus
nternational research groups




                                                                        Job vacancies
                                                                        Internships
                              CROs
                         Consultants



 maandag 23 april 12
Social Media?


        • May 2011
              – to-BBB only had an inactive LinkedIn company page
              – Decision to look into social media
              – Search for comparable companies:
                      • Some small biotechs use Twitter
                      • Most small biotech & big pharma have LinkedIn
                      • Most big pharma use Twitter
                      • Some big pharma have Facebook page

        • Decision to go for social media platform
              – LinkedIn, Facebook & Twitter
              – Connect media by synchronizing messages to all - with
        • September 2011: launch social media platform
        • October 2011: launch new website tobbb.com

maandag 23 april 12
Social Media Platform

        • Using Hootsuite to send messages to all social media
        • Schedule messages in Publisher
        • Minimizing effort -> maximizing exposure




maandag 23 april 12
Social Media Platform




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website


   • Announce who is attending events




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website


   • Announce who is attending events

   • Announce who is giving presentations




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website


   • Announce who is attending events

   • Announce who is giving presentations

   • Retweet exposure to-BBB by others




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website


   • Announce who is attending events

   • Announce who is giving presentations

   • Retweet exposure to-BBB by others

   • Retweet interesting associated messages




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website


   • Announce who is attending events

   • Announce who is giving presentations

   • Retweet exposure to-BBB by others

   • Retweet interesting associated messages

   • Vacancies & internships




maandag 23 april 12
Social Media Platform

   • to-BBB press releases – also on website

   • Press/media coverage – also on website


   • Announce who is attending events

   • Announce who is giving presentations

   • Retweet exposure to-BBB by others

   • Retweet interesting associated messages

   • Vacancies & internships

   • Charity activities – Hersenstichting,

        STOPhersentumoren.nl

maandag 23 april 12
Statistical Output




maandag 23 april 12
Statistical Output

        • Followers: growing…




maandag 23 april 12
Statistical Output

        • Followers: growing…




maandag 23 april 12
Statistical Output

        • Followers: growing…




maandag 23 april 12
Statistical Output

        • Followers: growing…




maandag 23 april 12
Statistical Output

        • Followers: growing…




maandag 23 april 12
Statistical Output

        • Followers: growing…




maandag 23 april 12
Statistical Output

        • Followers: growing…




        • Exposure: growing…
                      Twitter Clicks

               50

               38

               25

               13

                 0
                  Sep Oct Nov Dec Jan Feb Mar Apr
maandag 23 april 12
Favorites

        • The more visual, the better…
              – Movie from BIO-Europe Spring
              – Movie from Medisch Contact
              – Interview articles in newspapers
        • Event announcements
              – Not by clicks, but feedback in real life


        • Interesting: minor interest in important press releases




maandag 23 april 12
Complementary to website and each other




maandag 23 april 12
Tips & Tricks

        • Social Media can consume 2-80 hrs/week
        • Work smart -> integrate social media platform
        • Adds dimension to company website and press releases
        • Lay out some ground rules with management
        • Stay positive!




maandag 23 april 12
Outstanding questions




maandag 23 april 12
Outstanding questions


        Discussion points




maandag 23 april 12
Outstanding questions


        Discussion points
        •How to involve patient organizations –
        and even individual patients?




maandag 23 april 12
Outstanding questions


        Discussion points
        •How to involve patient organizations –
        and even individual patients?
        •How to attract scientists to company?




maandag 23 april 12
Outstanding questions


        Discussion points
        •How to involve patient organizations –
        and even individual patients?
        •How to attract scientists to company?
        •How to significantly increase exposure/
        followers?




maandag 23 april 12
Follow us!




                      to-BBB technologies BV    Sijme Zeilemaker                 Phone   +31 71 33 222 56   E-mail   SijmeZeilemaker@toBBB.com
                      Leiden, The Netherlands   Business Development Associate   Fax     +31 84 83 134 09   Web      www.toBBB.com


maandag 23 april 12
Martijn van Oijen



maandag 23 april 12
@martijnvanoijen



   #SocialMedica


maandag 23 april 12
@martijnvanoijen



   #SocialMedica


maandag 23 april 12
1 2 3
                  Introducing
                 #SocialMedica
                                      #SocialMedica
                                       version 1.0           Future
                                                             plans




                          Identification of patients, their needs and demands
                      by use of available data from Social Network platforms




maandag 23 april 12
Overview




                      1 2 3
                  Introducing
                 #SocialMedica
                                      #SocialMedica
                                       version 1.0           Future
                                                             plans




                          Identification of patients, their needs and demands
                      by use of available data from Social Network platforms




maandag 23 april 12
1             Introducing
                                    #SocialMedica


           “Crohn's is kicking me over and over again this month. I hope I don't have to increase
                                                                                      treatment”




maandag 23 april 12
1992:
                       - Encyclopedia
                       - Talk to
                      neighbors
                       - Call your family
          Rationale




                                    2012:
                                     - Google /
                                    Wikipedia
                                     - Social Media

maandag 23 april 12
#SocialMedica: Using Social Media
                      to increase quality of healthcare


                       Healthcare
                       clinic
          Rationale




                           Patient




maandag 23 april 12
#SocialMedica: Using Social Media
                      to increase quality of healthcare


                       Healthcare           Provider
                       clinic
          Rationale




                           Patient




maandag 23 april 12
#SocialMedica: Using Social Media
                      to increase quality of healthcare


                       Healthcare           Provider
                       clinic
          Rationale




                           Patient          Provider




                           Patient           Patient

maandag 23 april 12
2       #SocialMedica version
                              1.0


                 The use of Twitter to identify patients with Crohn’s
                                                              disease



maandag 23 april 12
Introducing Twitter

                      Micro-blogging:
                      • ‘Tweet’: 140 characters
                      • ‘Re-tweet’: Republished tweet
          Twitter




maandag 23 april 12
Feasibility study:
                              – Are we able to identify
          Aim of the study



                               Crohn’s patients on Twitter?
                              – Is it a useful tool for
                               measurement of disease
                               activity and unmet needs?




maandag 23 april 12
Tweets with
                                          “Crohn”
                                         N=6,084


                               Language = English and Dutch
                                        N=5,421




                      Original tweets                   Re-tweets
                      N=2,236 (41%)                   N=3,185 (59%)




maandag 23 april 12
Tweets with
                                              “Crohn”
                                             N=6,084


                                    Language = English and Dutch
                                             N=5,421




                         Original tweets                    Re-tweets
                         N=2,236 (41%)                    N=3,185 (59%)




         Patients      Friends or       Non-Profit or      Healthcare      Pharma/
       N=987 (44%)     Relatives        Foundations       Professionals    Biotech
                      N=484 (22%)       N=432 (19%)       N=167 (7%)      N=137 (6%)


                                                                          Unclassified
                                                                           N=29(1%)

maandag 23 april 12
Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Orginal tweets




                                       Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Orginal tweets




                                       Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Orginal tweets


                      ‘I haven't eaten food in 2 days and no appetite
                         whatsoever. I’m used to this with #Crohn's’




                                                         Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Orginal tweets




              ‘Found out my friend is in the hospital with Crohn's and
                   has to have a bowel resection. I never knew :(‘



                                                    Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Orginal tweets




                                       Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Patient’ tweets




                                        Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Patient’ tweets




                                        Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Patient’ tweets

         @genag515 Wish I was full of energy and joys.. But on Social Security right
           now due to crohn's, I hope I’m going back to work very soon




                                                           Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Patient’ tweets




                                        Van Oijen et al. (DDW 2012)
maandag 23 april 12
Results – Patient’ tweets




                      ‘Seizure caused by low calcium, VitD & magnesium. But I
                             don't have any direct Crohn's symptoms now.’




                                                            Van Oijen et al. (DDW 2012)
maandag 23 april 12
Conclusion

       • Patients identifiably
             • Patient’ tweets largest category
                • Coping & limitations in daily activity
                • Disease activity

       • Twitter feasible to be a new data source for
         research




                                                    Van Oijen et al. (DDW 2012)
maandag 23 april 12
‘#Crohn's will not keep me
     down! Well maybe sitting..’



maandag 23 april 12
‘#Crohn's will not keep me
     down! Well maybe sitting..’



maandag 23 april 12
3     Future plans



             Real-time automated measurement of patients’ geotagged
                                                             reports



maandag 23 april 12
#SocialMedica, version 2.0
                                       Feasibility

                                         Automated processes

                                         Linking to other platforms

                                         Follow over time

                                         Geotagging




maandag 23 april 12
Tweets
          #SocialMedica, version 2.0   Containing
                                        ‘Crohn’




maandag 23 april 12
Tweets
          #SocialMedica, version 2.0   Containing
                                        ‘Crohn’

                                          NLP




                                        Dynamic
                                         Cohort




maandag 23 april 12
Tweets
          #SocialMedica, version 2.0          Containing
                                               ‘Crohn’

                                                   NLP




                                                  Dynamic
                                                   Cohort




                                       Facebook    LinkedIn   YELP

maandag 23 april 12
Tweets
          #SocialMedica, version 2.0          Containing
                                               ‘Crohn’

                                                   NLP



                                                                      Follow
                                                  Dynamic            over time
                                                   Cohort




                                       Facebook    LinkedIn   YELP

maandag 23 april 12
Twitter density – Los




maandag 23 april 12
                      Angeles
Twitter density -




maandag 23 april 12
                      Amsterdam
Acknowledgements

                             Rachel Huisman, MD         Victoria Sheen, MD
                             Mirthe van der Valk, MD    Rusha Modi, MD
                             Lieske Scholtus            Corey Arnold, PhD
                             Vincent de Widt            Eric Fischer, MCS
                             Herma Fidder, MD PhD       Garth Fuller, MPH
                                                        Brennan Spiegel, MD MSHS




                                                       Bart Kokke
                                                       Stef de Jong


maandag 23 april 12
@martijnvanoijen



   #SocialMedica


maandag 23 april 12
@martijnvanoijen



   #SocialMedica


maandag 23 april 12
Wrap-up



maandag 23 april 12
http://www.flickr.com/photos/scott_rtw/1350993666/



maandag 23 april 12
Open
                       Random
                      Supportive

                                   http://www.flickr.com/photos/scott_rtw/1350993666/



maandag 23 april 12
http://www.flickr.com/photos/jamesjordan/2649170201/


maandag 23 april 12
maandag 23 april 12
Webinars!
                       7, 14, 21 May
                         20.00 h


maandag 23 april 12
maandag 23 april 12
Saskia Ebeling
                      Aernout van Haarst
                           Irma Vijn
                      Annika van Rosmalen
maandag 23 april 12
Programme(
 15.00&h &RegistraFon&         Enjoy the drinks!
 15.30&h &Social&media:&the&big&picture,(Lykle(de(Vries&(De&Ondernemers)&
          &How&have&Social&Media&changed&the&world?&Including&interesFng&cases&that&are&relevant&&
          &to&Life&Sciences.&
 16.00&h& &Best&pracFces,&examples&from&entrepreneurs&and&scienFsts:&
                    &Erik(Vollebregt&(Axon&Lawyers)&will&outline&how&he&uses&blogs&and&twi;er&to&reach&
maandag 23 april 12 &his&audience&and&clients.&

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