The realization that DNA lies behind all the cell's activities led to the development of molecular biology. The technology that uses tandem repeats of individuals is known as DNA fingerprinting. DNA fingerprinting or DNA profile are encrypted sets of numbers that reflect a person's DNA makeup, which can also be used as the person's identifier. DNA fingerprinting is a tool used to unravel all the mysteries associated with the oral cavity and its manifestations during diseased conditions. The technical advances in molecular biology have propelled the analysis of the DNA into routine usage in crime laboratories for rapid and early diagnosis. The anatomical location of teeth and the extent to which teeth may suffer environmental changes and still provide useful DNA material has propelled forensic odontology. The arrival of DNA fingerprinting has revolutionised the concept of identification. It is reasonable to anticipate the future advances in DNA technology will reduce the time and cost factor for identification of unknown deceased.