This document discusses considerations for weed and herbicide management in no-till systems. It covers how tillage affects weed germination by disturbing the soil environment. Crop residue retention influences weed emergence through temperature, moisture and chemical effects. The efficacy of pre-emergent herbicides improves with more soil disturbance from tillage, as it increases herbicide incorporation. In no-till systems, herbicides work through positional selectivity as minimal soil is thrown, separating seeds from herbicide treatment. Application guidelines recommend optimizing herbicide rates based on soil disturbance from the seeding equipment and integrating herbicides with other integrated weed management practices to reduce weed populations and herbicide resistance.