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FLUID DISTURBANCES
1. W A T E R I S
5 0 % O F B O D Y W E I G H T I N W O M E N
6 0 % I N M E N
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FLUID DISTURBANCES
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2. Intracellular fluid (ICF)
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• Largest compartment – 60%
• Main cation – potassium
• Anions - phosphates and bicarbonate
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7. If 1 L of solute-free water is lost from the body, how
much fluid is lost by the ICF compartment?
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Water ICF : ECF = 2:1 ratio
Solute-free water loss
Twofold greater reduction in the ICF compartment
than the ECF compartment
Volume loss
ICF = 667 mL
ECF = 333 mL
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8. Lose of 1L of iso-osmotic fluid
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ECF compartment will decrease by 1 L
Na+ is largely restricted to the ECF
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9. Osmolality and osmolarity
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Often used interchangeably
Osmolality
Number of solutes per mass of water
Osmolarity
Number of moles of solute in a liter of solution
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10. Solutes
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Extracellular and intracellular solutes (or
osmoles)
Markedly different
Water
Moves across cell membranes
Distributes between ICF and ECF
Until the osmolality is the same
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