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Auto-antibodies

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Auto-antibodies

  1. 1. List of Auto Antibodies Antibody Disease Prevalence (%) Anti-dsDNA SLE 70 Anti-nuclear Antibodies SLE Systemic Sclerosis (SS) Sjogren’s Polymyositis Dermatomyositis RA JIA Autoimmune hepatitis Drug-induced lupus Myasthenia gravis Idiopathic Pulmonary Fibrosis Diabetes mellitus Infective mononucleosis Normal pop 95 70 80 40 40 30 Variable 100 >95 50 30 25 5-10 8 Anti-histone Drug induced lupus - Anti-centromeric Limited SS 70 Anti-Ro (SS-A) SLE Sjogrens 40-60 60-90 Anti-La (SS-B) SLE Sjogren’s 15 35-85 Anti-Sm SLE 10-25 (Caucasian) 30-50 (Black African) Anti-UI-RNP SLE Overlap syndrome 30 Anti-JO (anti-synthetase) Polymyositis Dermatomyositis 30 Anti-CCP Rheumatoid arthritis Anti-topoisomerase 1 (Scl-70) Diffuse cutaneous SS 30 ANCA (anti-neutrophil cytoplasmic antibodies) Vasculitis (esp small vessel): -Microscopic polyangiitis -Wegeners granulomatosis -Churg Strauss syndrome 90% Anti-acetylcholine receptor Myasthenia gravis Anti-mitochondrial Primary biliary sclerosis Anti-GBM Goodpasture’s syndrome

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