2. A Research Career: There WasA Research Career: There Was
Always Another Research QuestionAlways Another Research Question
Martha J Lentz, PhD, RN
Scholarship Day May 2013
College of Nursing
University of New Mexico

3. Polar PlotPolar Plot

4. Temperature & Sleep CycleTemperature & Sleep Cycle

5. Hester McLaws Fund UW SON
American Nurses Foundation

6. Mostly I learned, without helpMostly I learned, without help
even a small study is not possible.even a small study is not possible.

7. Perimenstrual SymptomsPerimenstrual Symptoms
NU1054
National Center for Nursing Research
National Institutes of Health
Nancy Woods PhD, RN, FAAN

8. Test-Retest Reliability &
Stability Estimates
Test retest reliability
r =r12r23/r13
Stability estimates
s12=r13/r23
s23=r13/r12
s13=r13
2
/r12r23

9. Fluid Retention
Reliability coefficient r = .74
Stability coefficient s13 = .55

10. Fluid
Standard cycle days
252321191715131197531
Meanscore
12
10
8
6
4
2
0
Group
Low sx
PMS
PMM

11. Home Sleep
NR-01118, P30 NR 004001
National Institute of Nursing Research National
Institutes of Health
Joan Shaver, PhD, RN, FAAN

12. In Home Sleep RecordingIn Home Sleep Recording

13. Home Study-Insomnia TypesHome Study-Insomnia Types
Self-reported Insomnia N=101
Of These
PP-type (3 noc <85% Slp Efficiency) N=33
SO-type (3 noc >88% & 0 noc <85%) N=18
Unclassified (fewer 3 noc <85%) N=50
Self-reported good sleep N=30
Of These
Control (3 noc >88% & 0 noc <85%) N=14

14. What is sleep?What is sleep?
Self-report the experience of sleep
PSG- brain wave activity
Actigraphy movement

15. What does saying I have goodWhat does saying I have good
sleep or poor sleep mean?sleep or poor sleep mean?
Good sleep is what I am used to experiencing
Poor sleep, if different from past experience
Does PSG poor sleep arise from same
mechanism in self-reported good and poor
sleepers?
Are subtle PSG differences making the mis-
match of self-report and PSG sleep quality?

16. Delta Deprivation
UW School of Nursing Intramural Fund
P30 NR 004001

17. Delta
Alpha
Alpha/Delta
Delta

18. Jim Rothermel, Res Scientist & Stacy Riffle, RN Res. Nurse

19. Median Percent of Delta
Activity vs Baseline Night
0
10
20
30
40
50
60
70
80
Night 1 Night 2 Night 3
n= 12

20. Bodily Feelings Scale
Musculoskeletal
13.5
14
14.5
15
15.5
16
16.5
17
17.5
Baseline Morning 1 Morning 2 Morning 3
p<.01
p<.01
n= 12

21. Median Pressure in KG to
Report of Pain
0
1
2
3
4
5
6
Baseline Morning
1
Morning
2
Morning
3
p<.02
n= 7

22. Sleep In Women With and
Without Fibromyalgia
NR-04001, P30 NR 004001
National Institute of Nursing Research
National Institutes of Health

23. MacroMacro SleepSleep MeasuresMeasures
Fibromyalgia
n = 33
Control
n = 30
Sleep Period Time (min) 454.4±53.4 454.8±30.0
Total Sleep Time (min) 392.8±55.3 429.2±28.9
REM (min) 89.8±32.6 105.3±20.0
SWS 10.4% ± 8.5 12.2% ± 5.8
Wake (min) 58.9±40.5 25.3±11.2

24. Sleep Spindles in NREM Stage 2 in
Fibromyalgia and Control Women
Sleep Spindle Variables Fibromyalgia
n = 33
Control
n = 30
Number/minute in Stage 2, (± SD)* 3.85 ± 2.1 5.4 ± 2.9
Duration, mean seconds, (± SD)** 1.2 ± 0.2 1.1 ± 0.2
Spindle Time/epoch Stage 2, (± SD) *** 1.7 ± 1.2 2.7 ± 1.8
•Data are from C3; t-test, * P ≤ 0.02; ** P ≤ 0.03; *** P ≤ 0.02.

25. Growth Hormone Across NocGrowth Hormone Across Noc
By GroupBy Group

26. Delta Increase
UW School of Nursing Intramural Fund
P30 NR 004001
National Institute of Nursing Research
National Institutes of Health

27. Ways to Increase SWS
Sleep Delay
Whole Body Warming

28. Delta After Whole BodyDelta After Whole Body
WarmingWarming
Non-REM Cycle
4.003.002.001.00
Sum
600.00
400.00
200.00
0.00
Warming
Baseline

29. Armitage CFS Twin Sleep
Delay Delta

30. Nocturnal Asthma in Children
UW School of Nursing Intramural Fund
NR-08238, P30 NR 004001, T32 NR007106
National Institute of Nursing Research
National Institutes of Health
Gail Kieckhfer, PhD, ARNP

31. Study Procedures
At Home for 1 Week
Daily Peak Flow
Daily Symptom Diary
Wrist Actigraphy

32. Laboratory Procedures
PSG

33. Laboratory Procedures
Pulmonary
Function
FEV 1
FEV 25-75
eNo

34. FEV 25-75FEV 25-75
session
UB+8
hours
after
sleep
onset
UB+4 hrs
after
sleep
onset
usual
bedtime
(UB)
Mean
110
100
90
80
70
60
50
UB+8
hours
after
sleep
onset
UB+4 hrs
after
sleep
onset
usual
bedtime
(UB)
Does the child have a diagnosis of asthma?
yesno
Error bars: 95% CI
fef25_75 sleep delay
night
fef25_75 baseline
night

35. eNOeNO
session
UB+8
hours
after
sleep
onset
UB+4 hrs
after
sleep
onset
usual
bedtime
(UB)
Mean
35.00
30.00
25.00
20.00
15.00
10.00
5.00
UB+8
hours
after
sleep
onset
UB+4 hrs
after
sleep
onset
usual
bedtime
(UB)
Does the child have a diagnosis of asthma?"
yesno
Error bars: 95% CI
MNO sleep delay night
MNO baseline night

36. Contingent Probability
Night Cough
Child Report
Parent
Report
Not at
all
A little
bit
Some
what
A lot
Not at
all 95%
100%
A little
bit
A little
bit
A lot
NR
100%
Without Asthma
75%
100%
With Asthma

37. Contingent Probability
Night Cough
Child Report
Parent
Report
Not at
all
A little
bit
Some
what
A lot
Not at
all 95%
15% 4% 2% 100%
A little
bit
A little
bit
A lot
NR
100%
Without Asthma
75%
100%
With Asthma

38. NapsNaps
Non-
Nappers
N=37
Nappers
N=17
Asthma N (%) N (%)
Yes 15 (40.5) 12 (70.6) p<0.05
No 22 (59.5) 5 (29.4)

39. Mean SD Mean SD
P
value
sleep onset 22.35 (0.83) 23.09 (1.33) 0.04 *
sleep offset 7.36 (0.85) 7.52 (0.87) 0.52
total sleep, min 465.47 (41.22) 437.60 (54.42) 0.04 *
sleep onset var. 0.64 (0.36) 1.08 (0.53) <0.01 *
Actigraphy Variables
Non-
Nappers
N=37
Nappers
N=17

40. Mean SD Mean SD
P
value
sleep onset 22.35 (0.83) 23.09 (1.33) 0.04 *
total sleep, min 465.47 (41.22) 437.60 (54.42) 0.04 *
sleep onset var. 0.64 (0.36) 1.08 (0.53) <0.01 *
Actigraphy Variables
Non-
Nappers
N=37
Nappers
N=17

41. Mean SD Mean SD
P
value
sleep onset 22.35 (0.83) 23.09 (1.33) 0.04 *
sleep onset var. 0.64 (0.36) 1.08 (0.53) <0.01 *
Actigraphy Variables
Non-
Nappers
N=37
Nappers
N=17

42. Motivational Interviewing

43. Talk Research
Clarify & Sharpen Concepts
Deepen and Extend Conceptual
Relationships
Identify Implicit Assumptions
Get to Core of What We Know