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Biology in Focus Chapter 5
1.
CAMPBELL BIOLOGY IN
FOCUS © 2014 Pearson Education, Inc. Urry • Cain • Wasserman • Minorsky • Jackson • Reece Lecture Presentations by Kathleen Fitzpatrick and Nicole Tunbridge 5 Membrane Transport and Cell Signaling
2.
Overview: Life at
the Edge The plasma membrane separates the living cell from its surroundings The plasma membrane exhibits selective permeability, allowing some substances to cross it more easily than others © 2014 Pearson Education, Inc. Video: Membrane and Aquaporin
3.
Figure 5.1 © 2014
Pearson Education, Inc.
4.
CONCEPT 5.1: Cellular
membranes are fluid mosaics of lipids and proteins Phospholipids are the most abundant lipid in most membranes Phospholipids are amphipathic molecules, containing hydrophobic and hydrophilic regions A phospholipid bilayer can exist as a stable boundary between two aqueous compartments © 2014 Pearson Education, Inc.
5.
Figure 5.2 Glyco- protein Glycolipid Fibers of
extra- cellular matrix (ECM) Carbohydrate Cholesterol Microfilaments of cytoskeleton Peripheral proteins Integral protein EXTRACELLULAR SIDE OF MEMBRANE CYTOPLASMIC SIDE OF MEMBRANE © 2014 Pearson Education, Inc.
6.
Figure 5.2a Glyco- protein Fibers of
extra- cellular matrix (ECM) Carbohydrate Cholesterol Microfilaments of cytoskeleton © 2014 Pearson Education, Inc.
7.
Figure 5.2b Glycolipid Peripheral proteins Integral protein EXTRACELLULAR SIDE OF MEMBRANE CYTOPLASMIC
SIDE OF MEMBRANE © 2014 Pearson Education, Inc.
8.
Most membrane
proteins are also amphipathic and reside in the bilayer with their hydrophilic portions protruding The fluid mosaic model states that the membrane is a mosaic of protein molecules bobbing in a fluid bilayer of phospholipids Groups of certain proteins or certain lipids may associate in long-lasting, specialized patches © 2014 Pearson Education, Inc.
9.
Figure 5.3 Hydrophobic tail Hydrophilic head WATER WATER © 2014
Pearson Education, Inc.
10.
The Fluidity of
Membranes Most of the lipids and some proteins in a membrane can shift about laterally The lateral movement of phospholipids is rapid; proteins move more slowly Some proteins move in a directed manner; others seem to be anchored in place © 2014 Pearson Education, Inc.
11.
Figure 5.4-1 Results Mouse cell Human
cell Membrane proteins © 2014 Pearson Education, Inc.
12.
Figure 5.4-2 Results Mouse cell Human
cell Hybrid cell Membrane proteins © 2014 Pearson Education, Inc.
13.
Figure 5.4-3 Results Mouse cell Human
cell Hybrid cell Membrane proteins Mixed proteins after 1 hour © 2014 Pearson Education, Inc.
14.
As temperatures
cool, membranes switch from a fluid state to a solid state The temperature at which a membrane solidifies depends on the types of lipids A membrane remains fluid to a lower temperature if it is rich in phospholipids with unsaturated hydrocarbon tails Membranes must be fluid to work properly; they are usually about as fluid as salad oil © 2014 Pearson Education, Inc.
15.
Figure 5.5 Fluid Unsaturated tails
prevent packing. Cholesterol Viscous Saturated tails pack together. (a) Unsaturated versus saturated hydrocarbon tails (b) Cholesterol reduces membrane fluidity at moderate temperatures, but at low temperatures hinders solidification. © 2014 Pearson Education, Inc.
16.
The steroid
cholesterol has different effects on membrane fluidity at different temperatures At warm temperatures (such as 37o C), cholesterol restrains movement of phospholipids At cool temperatures, it maintains fluidity by preventing tight packing © 2014 Pearson Education, Inc.
17.
Evolution of Differences
in Membrane Lipid Composition Variations in lipid composition of cell membranes of many species appear to be adaptations to specific environmental conditions Ability to change the lipid compositions in response to temperature changes has evolved in organisms that live where temperatures vary © 2014 Pearson Education, Inc.
18.
Membrane Proteins and
Their Functions A membrane is a collage of different proteins, often grouped together, embedded in the fluid matrix of the lipid bilayer Proteins determine most of the membrane’s specific functions © 2014 Pearson Education, Inc.
19.
Integral proteins
penetrate the hydrophobic interior of the lipid bilayer Integral proteins that span the membrane are called transmembrane proteins The hydrophobic regions of an integral protein consist of one or more stretches of nonpolar amino acids, often coiled into α helices Peripheral proteins are loosely bound to the surface of the membrane © 2014 Pearson Education, Inc.
20.
Figure 5.6 N-terminus C-terminus α helix CYTOPLASMIC SIDE EXTRACELLULAR SIDE ©
2014 Pearson Education, Inc.
21.
Six major
functions of membrane proteins Transport Enzymatic activity Attachment to the cytoskeleton and extracellular matrix (ECM) Cell-cell recognition Intercellular joining Signal transduction © 2014 Pearson Education, Inc.
22.
Figure 5.7 Signaling molecule (a) Transport
(b) Enzymatic activity ATP (c) Attachment to the cytoskeleton and extra- cellular matrix (ECM) Receptor (f) Signal transduction(e) Intercellular joining(d) Cell-cell recognition Glyco- protein Enzymes © 2014 Pearson Education, Inc.
23.
Figure 5.7a (a) Transport
(b) Enzymatic activity ATP (c) Attachment to the cytoskeleton and extra- cellular matrix (ECM) Enzymes © 2014 Pearson Education, Inc.
24.
Figure 5.7b Signaling molecule Receptor (f) Signal
transduction(e) Intercellular joining(d) Cell-cell recognition Glyco- protein © 2014 Pearson Education, Inc.
25.
The Role of
Membrane Carbohydrates in Cell-Cell Recognition Cells recognize each other by binding to surface molecules, often containing carbohydrates, on the extracellular surface of the plasma membrane Membrane carbohydrates may be covalently bonded to lipids (forming glycolipids) or, more commonly, to proteins (forming glycoproteins) Carbohydrates on the external side of the plasma membrane vary among species, individuals, and even cell types in an individual © 2014 Pearson Education, Inc.
26.
Synthesis and Sidedness
of Membranes Membranes have distinct inside and outside faces The asymmetrical distribution of proteins, lipids, and associated carbohydrates in the plasma membrane is determined when the membrane is built by the ER and Golgi apparatus © 2014 Pearson Education, Inc.
27.
Figure 5.8 Golgi apparatus Vesicle Cytoplasmic face Plasma
membrane: ER Secretory protein Transmembrane glycoproteins Transmembrane glycoprotein ER lumen Glycolipid Extracellular face Membrane glycolipid Secreted protein © 2014 Pearson Education, Inc.
28.
CONCEPT 5.2: Membrane
structure results in selective permeability A cell must regulate transport of substances across cellular boundaries Plasma membranes are selectively permeable, regulating the cell’s molecular traffic © 2014 Pearson Education, Inc.
29.
The Permeability of
the Lipid Bilayer Hydrophobic (nonpolar) molecules, such as hydrocarbons, can dissolve in the lipid bilayer of the membrane and cross it easily Polar molecules, such as sugars, do not cross the membrane easily © 2014 Pearson Education, Inc.
30.
Transport Proteins Transport
proteins allow passage of hydrophilic substances across the membrane Some transport proteins, called channel proteins, have a hydrophilic channel that certain molecules or ions can use as a tunnel Channel proteins called aquaporins facilitate the passage of water © 2014 Pearson Education, Inc.
31.
Other transport
proteins, called carrier proteins, bind to molecules and change shape to shuttle them across the membrane A transport protein is specific for the substance it moves © 2014 Pearson Education, Inc.
32.
CONCEPT 5.3: Passive
transport is diffusion of a substance across a membrane with no energy investment Diffusion is the tendency for molecules to spread out evenly into the available space Although each molecule moves randomly, diffusion of a population of molecules may be directional At dynamic equilibrium, as many molecules cross the membrane in one direction as in the other © 2014 Pearson Education, Inc. Animation: Diffusion
33.
Figure 5.9 Molecules of
dye Net diffusion WATER (a) Diffusion of one solute Net diffusion Net diffusion Net diffusion Net diffusion Net diffusion Equilibrium (b) Diffusion of two solutes Equilibrium Equilibrium Membrane (cross section) © 2014 Pearson Education, Inc.
34.
Substances diffuse
down their concentration gradient, from where it is more concentrated to where it is less concentrated No work must be done to move substances down the concentration gradient The diffusion of a substance across a biological membrane is passive transport because no energy is expended by the cell to make it happen © 2014 Pearson Education, Inc.
35.
Effects of Osmosis
on Water Balance Osmosis is the diffusion of free water across a selectively permeable membrane Water diffuses across a membrane from the region of lower solute concentration to the region of higher solute concentration until the solute concentration is equal on both sides © 2014 Pearson Education, Inc. Animation: Membrane Selectivity Animation: Osmosis
36.
Figure 5.10 Sugar molecule Lower concentration of solute
(sugar) Higher concentration of solute H2O Selectively permeable membrane More similar concen- trations of solute Osmosis © 2014 Pearson Education, Inc.
37.
Figure 5.10a Sugar molecule Lower concentration of solute
(sugar) Higher concentration of solute H2O More similar concen- trations of solute © 2014 Pearson Education, Inc.
38.
Figure 5.10b Selectively permeable membrane Osmosis Water molecules can
pass through pores, but sugar molecules cannot. Water molecules cluster around sugar molecules. This side has fewer solute mol- ecules, more free water molecules. This side has more solute mol- ecules, fewer free water molecules. © 2014 Pearson Education, Inc.
39.
Water Balance of
Cells Without Walls Tonicity is the ability of a surrounding solution to cause a cell to gain or lose water Isotonic solution: Solute concentration is the same as inside the cell; no net water movement across the plasma membrane Hypertonic solution: Solute concentration is greater than that inside the cell; cell loses water Hypotonic solution: Solute concentration is less than that inside the cell; cell gains water Video: Turgid Elodea © 2014 Pearson Education, Inc.
40.
Figure 5.11 Turgid (normal)
Flaccid Lysed Cell wall Normal H2O H2O H2O H2O H2O H2O Plasmolyzed Shriveled H2O H2O HypertonicIsotonicHypotonic AnimalcellPlantcell © 2014 Pearson Education, Inc.
41.
Hypertonic or
hypotonic environments create osmotic problems for organisms Osmoregulation, the control of solute concentrations and water balance, is a necessary adaptation for life in such environments The protist Paramecium caudatum, which is hypertonic to its pondwater environment, has a contractile vacuole that can pump excess water out of the cell © 2014 Pearson Education, Inc. Video: Chlamydomonas Video: Paramecium Vacuole
42.
Figure 5.12 Contractile vacuole 50
µm © 2014 Pearson Education, Inc.
43.
Water Balance of
Cells with Walls Cell walls help maintain water balance A plant cell in a hypotonic solution swells until the wall opposes uptake; the cell is now turgid (very firm) If a plant cell and its surroundings are isotonic, there is no net movement of water into the cell; the cell becomes flaccid (limp), and the plant may wilt In a hypertonic environment, plant cells lose water; eventually, the membrane pulls away from the wall, a usually lethal effect called plasmolysis © 2014 Pearson Education, Inc.
44.
Figure 5.11 Turgid (normal)
Flaccid Lysed Cell wall Normal H2O H2O H2O H2O H2O H2O Plasmolyzed Shriveled H2O H2O HypertonicIsotonicHypotonic AnimalcellPlantcell © 2014 Pearson Education, Inc.
45.
Facilitated Diffusion: Passive
Transport Aided by Proteins In facilitated diffusion, transport proteins speed the passive movement of molecules across the plasma membrane Channel proteins provide corridors that allow a specific molecule or ion to cross the membrane Channel proteins include Aquaporins, for facilitated diffusion of water Ion channels that open or close in response to a stimulus (gated channels) © 2014 Pearson Education, Inc. Video: Aquaporins Video: Membrane and Aquaporin
46.
Figure 5.13 Carrier protein (b)
A carrier protein Channel protein (a) A channel protein Solute Solute CYTOPLASM EXTRA- CELLULAR FLUID © 2014 Pearson Education, Inc.
47.
Carrier proteins
undergo a subtle change in shape that translocates the solute-binding site across the membrane The shape change may be triggered by binding and release of the transported molecule No net energy input is required © 2014 Pearson Education, Inc.
48.
CONCEPT 5.4: Active
transport uses energy to move solutes against their gradients Facilitated diffusion speeds transport of a solute by providing efficient passage through the membrane but does not alter the direction of transport Some transport proteins, however, can move solutes against their concentration gradients © 2014 Pearson Education, Inc.
49.
The Need for
Energy in Active Transport Active transport moves substances against their concentration gradients Active transport requires energy, usually in the form of ATP © 2014 Pearson Education, Inc.
50.
Active transport
allows cells to maintain concentration gradients that differ from their surroundings The sodium-potassium pump is one type of active transport system © 2014 Pearson Education, Inc. Animation: Active Transport Video: Sodium-Potassium Pump Video: Membrane Transport
51.
Figure 5.14 [K+ ] high EXTRACELLULAR FLUID CYTOPLASM [Na+ ]
low [K+ ] low [Na+ ] high ADP1 2 3 45 6 © 2014 Pearson Education, Inc.
52.
Figure 5.14a [K+ ] high EXTRACELLULAR FLUID CYTOPLASM [Na+ ]
low [K+ ] low [Na+ ] high 21 Na+ binding stimulates phosphorylation by ATP. Cytoplasmic Na+ binds to the sodium-potassium pump. The affinity for Na+ is high when the protein has this shape. ADP © 2014 Pearson Education, Inc.
53.
The new shape
has a high affinity for K+ , which binds on the extracellular side and triggers release of the phosphate group. Figure 5.14b 43 Phosphorylation leads to a change in protein shape, reducing its affinity for Na+ , which is released outside. © 2014 Pearson Education, Inc.
54.
Figure 5.14c 65 Loss
of the phosphate group restores the protein’s original shape, which has a lower affinity for K+ . K+ is released; affinity for Na+ is high again, and the cycle repeats. © 2014 Pearson Education, Inc.
55.
Figure 5.15 Diffusion Facilitated diffusion Passive
transport Active transport © 2014 Pearson Education, Inc.
56.
How Ion Pumps
Maintain Membrane Potential Membrane potential is the voltage across a membrane Voltage is created by differences in the distribution of positive and negative ions across a membrane © 2014 Pearson Education, Inc.
57.
Two combined
forces, collectively called the electrochemical gradient, drive the diffusion of ions across a membrane A chemical force (the ion’s concentration gradient) An electrical force (the effect of the membrane potential on the ion’s movement) © 2014 Pearson Education, Inc.
58.
An electrogenic
pump is a transport protein that generates voltage across a membrane The sodium-potassium pump is the major electrogenic pump of animal cells The main electrogenic pump of plants, fungi, and bacteria is a proton pump Electrogenic pumps help store energy that can be used for cellular work © 2014 Pearson Education, Inc.
59.
Figure 5.16 EXTRACELLULAR FLUID CYTOPLASM Proton pump ©
2014 Pearson Education, Inc.
60.
Cotransport: Coupled Transport
by a Membrane Protein Cotransport occurs when active transport of a solute indirectly drives transport of other solutes Plant cells use the gradient of hydrogen ions generated by proton pumps to drive active transport of nutrients into the cell © 2014 Pearson Education, Inc.
61.
Figure 5.17 Sucrose Proton pump Sucrose-H+ cotransporter Diffusion
of H+ Sucrose © 2014 Pearson Education, Inc.
62.
CONCEPT 5.5: Bulk
transport across the plasma membrane occurs by exocytosis and endocytosis Small solutes and water enter or leave the cell through the lipid bilayer or by means of transport proteins Large molecules, such as polysaccharides and proteins, cross the membrane in bulk by means of vesicles Bulk transport requires energy © 2014 Pearson Education, Inc.
63.
Exocytosis In exocytosis,
transport vesicles migrate to the membrane, fuse with it, and release their contents Many secretory cells use exocytosis to export products © 2014 Pearson Education, Inc.
64.
Endocytosis In endocytosis,
the cell takes in molecules and particulate matter by forming new vesicles from the plasma membrane Endocytosis is a reversal of exocytosis, involving different proteins There are three types of endocytosis Phagocytosis (“cellular eating”) Pinocytosis (“cellular drinking”) Receptor-mediated endocytosis © 2014 Pearson Education, Inc.
65.
Endocytosis © 2014 Pearson
Education, Inc. Animation: Exocytosis Endocytosis Introduction Animation: Exocytosis Animation: Phagocytosis Video: Phagocytosis Animation: Pinocytosis Animation: Receptor-Mediated Endocytosis
66.
Figure 5.18 Phagocytosis Pinocytosis Receptor-Mediated Endocytosis ReceptorPlasma membrane Coat protein Coated pit Coated vesicleFood vacuole “Food” or
other particle CYTOPLASM Pseudopodium Solutes EXTRACELLULAR FLUID © 2014 Pearson Education, Inc.
67.
Figure 5.18a Phagocytosis Food vacuole “Food” or other particle CYTOPLASM Pseudopodium Solutes EXTRACELLULAR FLUID Pseudopodium of
amoeba An amoeba engulfing a bacterium via phagocytosis (TEM) Bacterium Food vacuole 1µm © 2014 Pearson Education, Inc.
68.
Figure 5.18b Pinocytosis Plasma membrane Coat protein Coated pit Coated vesicle Pinocytotic vesicles
forming (TEMs) 0.25µm © 2014 Pearson Education, Inc.
69.
Figure 5.18c Top: A
coated pit Bottom: A coated vesicle forming during receptor- mediated endocytosis (TEMs) 0.25µm Receptor-Mediated Endocytosis Receptor Plasma membrane Coat protein © 2014 Pearson Education, Inc.
70.
Figure 5.18d Pseudopodium of amoeba An
amoeba engulfing a bacterium via phagocytosis (TEM) Bacterium Food vacuole 1µm © 2014 Pearson Education, Inc.
71.
Figure 5.18e Pinocytotic vesicles
forming (TEMs) 0.25µm © 2014 Pearson Education, Inc.
72.
Figure 5.18f Top: A
coated pit Bottom: A coated vesicle forming during receptor- mediated endocytosis (TEMs)0.25µm Plasma membrane Coat protein © 2014 Pearson Education, Inc.
73.
CONCEPT 5.6: The
plasma membrane plays a key role in most cell signaling In multicellular organisms, cell-to-cell communication allows the cells of the body to coordinate their activities Communication between cells is also essential for many unicellular organisms © 2014 Pearson Education, Inc.
74.
Local and Long-Distance
Signaling Eukaryotic cells may communicate by direct contact Animal and plant cells have junctions that directly connect the cytoplasm of adjacent cells These are called gap junctions (animal cells) and plasmodesmata (plant cells) The free passage of substances in the cytosol from one cell to another is a type of local signaling © 2014 Pearson Education, Inc.
75.
In many
other cases of local signaling, messenger molecules are secreted by a signaling cell These messenger molecules, called local regulators, travel only short distances One class of these, growth factors, stimulates nearby cells to grow and divide This type of local signaling in animal cells is called paracrine signaling © 2014 Pearson Education, Inc.
76.
Figure 5.19 Local regulator diffuses
through extracellular fluid. Secreting cell Secretory vesicle Target cell Local signaling Long-distance signaling Target cell is stimulated. Electrical signal along nerve cell triggers release of neuro- transmitter. Neurotransmitter diffuses across synapse. (a) Paracrine signaling (b) Synaptic signaling Endocrine cell Target cell specifically binds hormone. (c) Endocrine (hormonal) signaling Hormone travels in bloodstream. Blood vessel © 2014 Pearson Education, Inc.
77.
Figure 5.19a Local regulator diffuses
through extracellular fluid. Secreting cell Secretory vesicle Target cell Local signaling (a) Paracrine signaling © 2014 Pearson Education, Inc.
78.
Another more
specialized type of local signaling occurs in the animal nervous system This synaptic signaling consists of an electrical signal moving along a nerve cell that triggers secretion of neurotransmitter molecules These diffuse across the space between the nerve cell and its target, triggering a response in the target cell © 2014 Pearson Education, Inc.
79.
Figure 5.19b Target cell is
stimulated. Electrical signal along nerve cell triggers release of neuro- transmitter. Neurotransmitter diffuses across synapse. (b) Synaptic signaling Local signaling © 2014 Pearson Education, Inc.
80.
In long-distance
signaling, plants and animals use chemicals called hormones In hormonal signaling in animals (called endocrine signaling), specialized cells release hormone molecules that travel via the circulatory system Hormones vary widely in size and shape © 2014 Pearson Education, Inc.
81.
Figure 5.19c Long-distance signaling Endocrine
cell Target cell specifically binds hormone. (c) Endocrine (hormonal) signaling Hormone travels in bloodstream. Blood vessel © 2014 Pearson Education, Inc.
82.
The Three Stages
of Cell Signaling: A Preview Earl W. Sutherland discovered how the hormone epinephrine acts on cells Sutherland suggested that cells receiving signals undergo three processes Reception Transduction Response © 2014 Pearson Education, Inc. Animation: Signaling Overview
83.
Figure 5.20-1 EXTRACELLULAR FLUID Plasma
membrane Reception Receptor Signaling molecule CYTOPLASM © 2014 Pearson Education, Inc.
84.
Figure 5.20-2 EXTRACELLULAR FLUID CYTOPLASM Plasma membrane Reception
Transduction Relay molecules Receptor Signaling molecule © 2014 Pearson Education, Inc.
85.
Figure 5.20-3 EXTRACELLULAR FLUID CYTOPLASM Plasma membrane ResponseReception
Transduction Relay molecules Activation Receptor Signaling molecule © 2014 Pearson Education, Inc.
86.
Reception, the Binding
of a Signaling Molecule to a Receptor Protein The binding between a signal molecule (ligand) and receptor is highly specific Ligand binding generally causes a shape change in the receptor Many receptors are directly activated by this shape change Most signal receptors are plasma membrane proteins © 2014 Pearson Education, Inc.
87.
Receptors in the
Plasma Membrane Most water-soluble signal molecules bind to specific sites on receptor proteins that span the plasma membrane There are two main types of membrane receptors G protein-coupled receptors Ligand-gated ion channels © 2014 Pearson Education, Inc.
88.
G protein-coupled
receptors (GPCRs) are plasma membrane receptors that work with the help of a G protein G proteins bind to the energy-rich molecule GTP The G protein acts as an on-off switch: If GTP is bound to the G protein, the G protein is inactive Many G proteins are very similar in structure GPCR pathways are extremely diverse in function © 2014 Pearson Education, Inc.
89.
Figure 5.21-1 CYTOPLASM Plasma membrane Activated G
protein Signaling molecule Inactive enzymeActivated GPCR 1 © 2014 Pearson Education, Inc.
90.
Figure 5.21-2 CYTOPLASM Plasma membrane Activated G
protein Cellular response Activated enzyme Signaling molecule Inactive enzymeActivated GPCR 1 2 © 2014 Pearson Education, Inc.
91.
A ligand-gated
ion channel receptor acts as a “gate” for ions when the receptor changes shape When a signal molecule binds as a ligand to the receptor, the gate allows specific ions, such as Na+ or Ca2+ , through a channel in the receptor Ligand-gated ion channels are very important in the nervous system The diffusion of ions through open channels may trigger an electric signal © 2014 Pearson Education, Inc.
92.
Figure 5.22-1 Ions Plasma membrane Signaling molecule (ligand) 1 Gate closed Ligand-gated ion channel
receptor © 2014 Pearson Education, Inc.
93.
Figure 5.22-2 Ions Plasma membrane Signaling molecule (ligand) 1 Cellular response Gate open Gate closed Ligand-gated ion channel
receptor 2 © 2014 Pearson Education, Inc.
94.
Figure 5.22-3 Ions Plasma membrane Signaling molecule (ligand) 1 Cellular response Gate open Gate closed Gate closed Ligand-gated ion
channel receptor 2 3 © 2014 Pearson Education, Inc.
95.
Intracellular Receptors Intracellular
receptor proteins are found in the cytosol or nucleus of target cells Small or hydrophobic chemical messengers can readily cross the membrane and activate receptors Examples of hydrophobic messengers are the steroid and thyroid hormones of animals and nitric oxide (NO) in both plants and animals © 2014 Pearson Education, Inc.
96.
Testosterone behaves
similarly to other steroid hormones Only cells that contain receptors for testosterone can respond to it The hormone binds the receptor protein and activates it The active form of the receptor enters the nucleus, acts as a transcription factor, and activates genes needed for male sex characteristics © 2014 Pearson Education, Inc.
97.
Figure 5.23 DNA Plasma membrane Hormone- receptor complex Receptor protein New protein Hormone (testosterone) mRNA EXTRA- CELLULAR FLUID CYTOPLASM NUCLEUS © 2014
Pearson Education, Inc.
98.
Figure 5.23a Plasma membrane Hormone- receptor complex Receptor protein Hormone (testosterone) EXTRA- CELLULAR FLUID CYTOPLASM NUCLEUS © 2014
Pearson Education, Inc.
99.
Figure 5.23b DNA Hormone- receptor complex New protein mRNA CYTOPLASM NUCLEUS © 2014
Pearson Education, Inc.
100.
Transduction by Cascades
of Molecular Interactions Signal transduction usually involves multiple steps Multistep pathways can amplify a signal: A few molecules can produce a large cellular response Multistep pathways provide more opportunities for coordination and regulation of the cellular response than simpler systems do © 2014 Pearson Education, Inc.
101.
The molecules
that relay a signal from receptor to response are mostly proteins Like falling dominoes, the receptor activates another protein, which activates another, and so on, until the protein producing the response is activated At each step, the signal is transduced into a different form, usually a shape change in a protein © 2014 Pearson Education, Inc.
102.
Protein Phosphorylation and
Dephosphorylation Phosphorylation and dephosphorylation are a widespread cellular mechanism for regulating protein activity Protein kinases transfer phosphates from ATP to protein, a process called phosphorylation The addition of phosphate groups often changes the form of a protein from inactive to active © 2014 Pearson Education, Inc.
103.
Figure 5.24 Receptor Signaling molecule Activated
relay molecule Inactive protein kinase 1 Phosphorylation cascade Inactive protein kinase 2 Active protein kinase 1 Active protein kinase 2 Active protein Inactive protein Cellular response ADP ADP © 2014 Pearson Education, Inc.
104.
Figure 5.24a Receptor Signaling molecule Activated
relay molecule Inactive protein kinase 1 Active protein kinase 1 © 2014 Pearson Education, Inc.
105.
Figure 5.24b Inactive protein kinase 2 Active protein kinase
1 Active protein kinase 2 ADP © 2014 Pearson Education, Inc.
106.
Figure 5.24c Active protein kinase 2 Active protein Inactive protein Cellular response ADP ©
2014 Pearson Education, Inc.
107.
Protein phosphatases
remove the phosphates from proteins, a process called dephosphorylation Phosphatases provide a mechanism for turning off the signal transduction pathway They also make protein kinases available for reuse, enabling the cell to respond to the signal again © 2014 Pearson Education, Inc.
108.
Small Molecules and
Ions as Second Messengers The extracellular signal molecule (ligand) that binds to the receptor is a pathway’s “first messenger” Second messengers are small, nonprotein, water- soluble molecules or ions that spread throughout a cell by diffusion Cyclic AMP and calcium ions are common second messengers © 2014 Pearson Education, Inc.
109.
Cyclic AMP
(cAMP) is one of the most widely used second messengers Adenylyl cyclase, an enzyme in the plasma membrane, rapidly converts ATP to cAMP in response to a number of extracellular signals The immediate effect of cAMP is usually the activation of protein kinase A, which then phosphorylates a variety of other proteins © 2014 Pearson Education, Inc.
110.
Figure 5.25 G protein-coupled receptor Protein kinase
A Second messenger Cellular responses Adenylyl cyclaseG protein First messenger (signaling molecule such as epinephrine) © 2014 Pearson Education, Inc.
111.
Response: Regulation of
Transcription or Cytoplasmic Activities Ultimately, a signal transduction pathway leads to regulation of one or more cellular activities The response may occur in the cytoplasm or in the nucleus Many signaling pathways regulate the synthesis of enzymes or other proteins, usually by turning genes on or off in the nucleus The final activated molecule in the signaling pathway may function as a transcription factor © 2014 Pearson Education, Inc.
112.
Figure 5.26 Phosphorylation cascade Inactive transcription factor NUCLEUS CYTOPLASM DNA mRNA Gene Active transcription factor Response Reception Transduction Growth
factor Receptor © 2014 Pearson Education, Inc.
113.
Figure 5.26a Phosphorylation cascade CYTOPLASM Reception Transduction Growth factor Receptor Inactive transcription factor ©
2014 Pearson Education, Inc.
114.
Figure 5.26b Phosphorylation cascade Inactive transcription factor NUCLEUS CYTOPLASM DNA mRNA Gene Active transcription factor Response Transduction ©
2014 Pearson Education, Inc.
115.
Other pathways
regulate the activity of enzymes rather than their synthesis, such as the opening of an ion channel or a change in cell metabolism © 2014 Pearson Education, Inc.
116.
The Evolution of
Cell Signaling Biologists have discovered some universal mechanisms of cellular regulation, evidence of the evolutionary relatedness of all life Scientists think that signaling mechanisms first evolved in ancient prokaryotes and single-celled eukaryotes These mechanisms were adopted for new uses in their multicellular descendants © 2014 Pearson Education, Inc.
117.
Figure 5.UN01 Incubation time
(min) 6030 40 5010 200 60 40 20 0 100 80 1-month-old guinea pig 15-day-old guinea pig Glucose Uptake Over Time in Guinea Pig Red Blood Cells Concentrationofradioactiveglucose(mM) © 2014 Pearson Education, Inc.
118.
Figure 5.UN02 Severe disease LDL receptor Mild disease Normal cell LDL ©
2014 Pearson Education, Inc.
119.
Figure 5.UN03 Channel protein Carrier protein Passive transport: Facilitated
diffusion © 2014 Pearson Education, Inc.
120.
Figure 5.UN04 Active transport ©
2014 Pearson Education, Inc.
121.
Figure 5.UN05 Signaling molecule Activation of cellular response Relay
molecules Receptor Reception Transduction Response1 2 3 © 2014 Pearson Education, Inc.
Editor's Notes
Figure 5.1 How do cell membrane proteins help regulate chemical traffic?
Figure 5.2 Current model of an animal cell’s plasma membrane (cutaway view)
Figure 5.2a Current model of an animal cell’s plasma membrane (cutaway view) (part 1)
Figure 5.2b Current model of an animal cell’s plasma membrane (cutaway view) (part 2)
Figure 5.3 Phospholipid bilayer (cross section)
Figure 5.4-1 Inquiry: Do membrane proteins move? (step 1)
Figure 5.4-2 Inquiry: Do membrane proteins move? (step 2)
Figure 5.4-3 Inquiry: Do membrane proteins move? (step 3)
Figure 5.5 Factors that affect membrane fluidity
Figure 5.6 The structure of a transmembrane protein
Figure 5.7 Some functions of membrane proteins
Figure 5.7a Some functions of membrane proteins (part 1: transport, enzymatic activity, and attachment to the cytoskeleton and ECM)
Figure 5.7b Some functions of membrane proteins (part 2: cell-cell recognition, intercellular joining, and signal transduction)
Figure 5.8 Synthesis of membrane components and their orientation in the membrane
Figure 5.9 The diffusion of solutes across a synthetic membrane
Figure 5.10 Osmosis
Figure 5.10a Osmosis (part 1)
Figure 5.10b Osmosis (part 2)
Figure 5.11 The water balance of living cells
Figure 5.12 The contractile vacuole of Paramecium caudatum
Figure 5.11 The water balance of living cells
Figure 5.13 Two types of transport proteins that carry out facilitated diffusion
Figure 5.14 The sodium-potassium pump: a specific case of active transport
Figure 5.14a The sodium-potassium pump: a specific case of active transport (part 1: Na+ binding)
Figure 5.14b The sodium-potassium pump: a specific case of active transport (part 2: K+ binding)
Figure 5.14c The sodium-potassium pump: a specific case of active transport (part 3: K+ release)
Figure 5.15 Review: passive and active transport
Figure 5.16 A proton pump
Figure 5.17 Cotransport: active transport driven by a concentration gradient
Figure 5.18 Exploring endocytosis in animal cells
Figure 5.18a Exploring endocytosis in animal cells (part 1: phagocytosis)
Figure 5.18b Exploring endocytosis in animal cells (part 2: pinocytosis)
Figure 5.18c Exploring endocytosis in animal cells (part 3: receptor-mediated endocytosis)
Figure 5.18d Exploring endocytosis in animal cells (part 4: phagocytosis TEM)
Figure 5.18e Exploring endocytosis in animal cells (part 5: pinocytosis TEMs)
Figure 5.18f Exploring endocytosis in animal cells (part 6: receptor-mediated endocytosis TEMs)
Figure 5.19 Local and long-distance cell signaling by secreted molecules in animals
Figure 5.19a Local and long-distance cell signaling by secreted molecules in animals (part 1: local signaling, paracrine)
Figure 5.19b Local and long-distance cell signaling by secreted molecules in animals (part 2: local signaling, synaptic)
Figure 5.19c Local and long-distance cell signaling by secreted molecules in animals (part 3: long distance signaling, endocrine)
Figure 5.20-1 Overview of cell signaling (step 1)
Figure 5.20-2 Overview of cell signaling (step 2)
Figure 5.20-3 Overview of cell signaling (step 3)
Figure 5.21-1 A G protein-coupled receptor (GPCR) in action (step 1)
Figure 5.21-2 A G protein-coupled receptor (GPCR) in action (step 2)
Figure 5.22-1 Ion channel receptor (step 1)
Figure 5.22-2 Ion channel receptor (step 2)
Figure 5.22-3 Ion channel receptor (step 3)
Figure 5.23 Steroid hormone interacting with an intracellular receptor
Figure 5.23a Steroid hormone interacting with an intracellular receptor (part 1: cytoplasm)
Figure 5.23b Steroid hormone interacting with an intracellular receptor (part 2: nucleus)
Figure 5.24 A phosphorylation cascade
Figure 5.24a A phosphorylation cascade (part 1: cascade initiation)
Figure 5.24b A phosphorylation cascade (part 2: activating pk2)
Figure 5.24c A phosphorylation cascade (part 3: cellular response)
Figure 5.25 cAMP as a second messenger in a G protein signaling pathway
Figure 5.26 Nuclear response to a signal: the activation of a specific gene by a growth factor
Figure 5.26a Nuclear response to a signal: the activation of a specific gene by a growth factor (part 1)
Figure 5.26b Nuclear response to a signal: the activation of a specific gene by a growth factor (part 2)
Figure 5.UN01 Skills exercise: interpreting a graph with two sets of data
Figure 5.UN02 In-text figure, hypercholesterolemia, p. 106
Figure 5.UN03 Summary of key concepts: diffusion across a membrane
Figure 5.UN04 Summary of key concepts: active transport
Figure 5.UN05 Summary of key concepts: cell signaling
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