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Health IT: The Big Picture
Nawanan Theera-Ampornpunt, MD, PhD
Healthcare CIO Program, Ramathibodi Hospital Administration School
Jul 10, 2014 SlideShare.net/Nawanan
Except 
where citing 
other works
2
Manufacturing
Image Source: Guardian.co.uk
3
Banking
Image Source: http://www.oknation.net/blog/phuketpost/2013/10/19/entry-3
4
Health care
ER - Image Source: nj.com
5
(At an undisclosed nearby hospital)
Health care
6
• Life-or-Death
• Many & varied stakeholders
• Strong professional values
• Evolving standards of care
• Fragmented, poorly-coordinated systems
• Large, ever-growing & changing body of
knowledge
• High volume, low resources, little time
Why Health care Isn’t Like Any Others?
7
• Large variations & contextual dependence
Why Health care Isn’t Like Any Others?
Input Process Output
Patient
Presentation
Decision-
Making
Biological
Responses
8
But...Are We That Different?
Input Process Output
Transfer
Banking
Value-Add
- Security
- Convenience
- Customer Service
Location A Location B
9
Input Process Output
Assembling
Manufacturing
Raw
Materials
Finished
Goods
Value-Add
- Innovation
- Design
- QC
But...Are We That Different?
10
But...Are We That Different?
Input Process Output
Patient Care
Health care
Sick Patient Well Patient
Value-Add
- Technology & medications
- Clinical knowledge & skills
- Quality of care; process improvement
- Information
11
Information is Everywhere in Medicine
Shortliffe EH. Biomedical informatics in the education of
physicians. JAMA. 2010 Sep 15;304(11):1227-8.
12
The Anatomy of Health IT
Health 
Information
Technology
Goal
Value‐Add
Means
13
Various Forms of Health IT
Hospital Information System (HIS) Computerized Provider Order Entry (CPOE)
Electronic
Health
Records
(EHRs)
Picture Archiving and
Communication System
(PACS)
14
Still Many Other Forms of Health IT
m-Health
Health Information
Exchange (HIE)
Biosurveillance
Information Retrieval
Telemedicine &
Telehealth
Images from Apple Inc., Geekzone.co.nz, Google, Microsoft, PubMed.gov, and American Telecare, Inc.
Personal Health Records
(PHRs)
15
• Life-or-Death
• Many & varied stakeholders
• Strong professional values
• Evolving standards of care
• Fragmented, poorly-coordinated systems
• Large, ever-growing & changing body of
knowledge
• High volume, low resources, little time
Why Health care Isn’t Like Any Others?
16
Back to
something simple...
17
What Clinicians Want?
To treat & to
care for their
patients to their
best abilities,
given limited
time &
resources
Image Source: http://en.wikipedia.org/wiki/File:Newborn_Examination_1967.jpg (Nevit Dilmen)
18
High Quality Care
• Safe
• Timely
• Effective
• Patient-Centered
• Efficient
• Equitable
Institute of Medicine, Committee on Quality of Health Care in America. Crossing the quality chasm:
a new health system for the 21st century. Washington, DC: National Academy Press; 2001. 337 p.
19
Information is Everywhere in Healthcare
Shortliffe EH. Biomedical informatics in the education of
physicians. JAMA. 2010 Sep 15;304(11):1227-8.
20
“Information” in Medicine
Shortliffe EH. Biomedical informatics in the education of physicians. JAMA. 2010 Sep 15;304(11):1227-8.
21
(IOM, 2001)(IOM, 2000) (IOM, 2011)
Landmark IOM Reports
22
Landmark IOM Reports: Summary
• Humans are not perfect and are bound to 
make errors
• High‐light problems in the U.S. health care 
system that systematically contributes to 
medical errors and poor quality
• Recommends reform that would change 
how health care works and how 
technology innovations can help improve 
quality/safety
23
Why We Need Health IT
• Health care is very complex (and inefficient)
• Health care is information‐rich
• Quality of care depends on timely 
availability & quality of information
• Clinical knowledge body is too large to be in 
any clinician’s brain, and the short time 
during a visit makes it worse
• “To err is human”
• Practice guidelines are put “on‐the‐shelf”
24
Image Source: (Left) http://docwhisperer.wordpress.com/2007/05/31/sleepy-heads/
(Right) http://graphics8.nytimes.com/images/2008/12/05/health/chen_600.jpg
To Err is Human 1: Attention
25Image Source: Suthan Srisangkaew, Department of Pathology, Facutly of Medicine Ramathibodi Hospital, Mahidol University
To Err is Human 2: Memory
26
To Err is Human 3: Cognition
• Cognitive Errors - Example: Decoy Pricing
The Economist Purchase Options
• Economist.com subscription $59
• Print subscription $125
• Print & web subscription $125
Ariely (2008)
16
0
84
The Economist Purchase Options
• Economist.com subscription $59
• Print & web subscription $125
68
32
# of
People
# of
People
27
• It already happens....
(Mamede et al., 2010; Croskerry, 2003;
Klein, 2005)
• What if health IT can help?
What If This Happens in Healthcare?
28
Cognitive Biases in Healthcare
Mamede S, van Gog T, van den Berge K, Rikers RM, van Saase JL, van Guldener C, Schmidt HG. Effect of
availability bias and reflective reasoning on diagnostic accuracy among internal medicine residents. JAMA.
2010 Sep 15;304(11):1198-203.
29
Cognitive Biases in Healthcare
Croskerry P. The importance of cognitive errors in diagnosis and strategies to minimize them.
Acad Med. 2003 Aug;78(8):775-80.
30
Cognitive Biases in Healthcare
Klein JG. Five pitfalls in decisions about diagnosis and prescribing. BMJ. 2005 Apr 2;330(7494):781-3.
“Everyone makes mistakes. But our
reliance on cognitive processes prone to
bias makes treatment errors more likely
than we think”
31
• Medication Errors
–Drug Allergies
–Drug Interactions
• Ineffective or inappropriate treatment
• Redundant orders
• Failure to follow clinical practice guidelines
Common Errors
32
We need “Change”
“...we need to upgrade our medical
records by switching from a paper to
an electronic system of record
keeping...”
President Barack Obama
June 15, 2009
33
The Anatomy of Health IT Revisited
Health 
Information
Technology
Goal
Value‐Add
Means
34
Ultimate Goals of Health IT
•Individual’s Health
•Population’s Health
•Organization’s Health
35
Dimensions of Quality Health Care
• Safety
• Timeliness
• Effectiveness
• Efficiency
• Equity
• Patient‐centeredness
(IOM, 2001)
36
CLASS EXERCISE #2
For each of Institute of Medicine’s 
6 dimensions of quality health care, 
suggest ways health IT can help.
Safety Timeliness Effectiveness
Efficiency Equity Patient‐centeredness
37
Safety?
38
Safety
• Legible handwriting
• Proper display of patient information (e.g. abnormal labs)
• Alerts
– Drug‐Allergy Checks
– Drug‐Drug Interaction Checks
– Drug‐Lab Interaction Checks
• Dose calculator
• Prevention of medication errors
• Timely information
– Histories
– Diagnoses/Problem List
– Labs
– Medication List
39
Timeliness?
40
Timeliness
• Timely information for emergencies, transfers, normal visits
– Histories
– Diagnoses/Problem List
– Labs
– Medication List
• Effective communications between providers
• Effective triage & patient monitoring
41
Effectiveness?
42
Effectiveness
• Reminders/advice for
– Guideline adherence
– Preventive care
– Specialist consults
• Templates/forms
– Order sets
– Care planning, nursing assessments & interventions, 
nursing documentation
• Availability of patient information
• Continuity of care (even in referrals)
• Effective display of information (e.g. graphs, user‐friendly 
screens)
• Assistance in decision‐making (e.g. differential diagnosis)
• Access to evidence/references at the point of care
43
Efficiency?
44
Efficiency
• Fast/lean/efficient processes of care
– Automation ‐> faster care, fewer workers
– Process redesigns/reengineering (e.g. parallel processes/access)
– Changes in role assignments ‐> productivity gains or more time for patient
• Predictable patterns/“Just‐in‐time” (staffing, resource allocation, 
inventory, bed management)
• Flexibility “Organizational slacks” (buffers)
• Drug‐formulary checks & policy enforcement
• Reduction of redundant tests
• Efficient management of bed occupancy/hospital capacity
• Cost‐savings & time‐savings from preventable errors
• Space‐savings (e.g. medical records, PACS)
• Effective communications
45
Equity?
46
Equity
• Reduction of barriers to care, improved access 
to care
– Physical barriers (telemedicine, tele‐consultation)
– Structural barriers (information exchange among 
hospitals)
– Functional barriers (information access by patients, 
networks of patients)
– Cultural barriers (tailored information for different 
patients)
47
Patient-Centeredness?
48
Patient-Centeredness
• Patient’s access to
– Own clinical information
– General health information
– Tailored health information
• Patient engagement/compliance
• Patient empowerment
– Patients’ networking & knowledge sharing
• Patient satisfaction with quality & efficient care
• Patient’s control of information (privacy)
49
Documented Benefits of Health IT
• Literature suggests improvement through
– Guideline adherence (Shiffman et al, 1999;Chaudhry et al, 2006)
– Better documentation (Shiffman et al, 1999)
– Practitioner decision making or process of care 
(Balas et al, 1996;Kaushal et al, 2003;Garg et al, 2005)
– Medication safety
(Kaushal et al, 2003;Chaudhry et al, 2006;van Rosse et al, 2009)
– Patient surveillance & monitoring (Chaudhry et al, 2006)
– Patient education/reminder (Balas et al, 1996)
– Cost  savings and better financial performance 
(Parente & Dunbar, 2001;Chaudhry et al, 2006;Amarasingham et al, 2009;
Borzekowski, 2009)
50
But...
• “Don’t implement technology just for technology’s 
sake.”
• “Don’t make use of excellent technology. 
Make excellent use of technology.”
(Tangwongsan, Supachai. Personal communication, 2005.)
• “Health care IT is not a panacea for all that ails 
medicine.” (Hersh, 2004)
• “We worry, however, that [electronic records] are 
being touted as a panacea for nearly all the ills of 
modern medicine.”
(Hartzband & Groopman, 2008)
51
Common “Goals” for Adopting HIT
“Computerize”“Go paperless”
“Digital Hospital”
“Modernize”
“Get a HIS”
“Have EMRs”
“Share data”
52
The Common Denominator
•Health Information Technology
•Electronic Health Records
•Health Information Exchange
53
Some Misconceptions about HIT
Current 
Environment
Bad
New, Modern, 
Electronic 
Environment
Good
If
Then
Always
54
Fundamental Theorem of Informatics
(Friedman, 2009)
55
Various Ways to Measure Success
• DeLone & McLean (1992;2003)
56
Take-Home Messages
• Health IT has documented benefits to 
quality & efficiency of care
• Implementing health IT will not 
automatically fix all problems
• Health IT is not without risks
• Find the ways health IT can help
• Focus on the ultimate goals
• Benefits of health IT may vary by 
context
57
NEXT
Health IT in 
Hospital Settings
58
References
• Amarasingham R, Plantinga L, Diener‐West M, Gaskin DJ, Powe NR. Clinical information 
technologies and inpatient outcomes: a multiple hospital study. Arch Intern Med. 
2009;169(2):108‐14.
• Balas EA, Austin SM, Mitchell JA, Ewigman BG, Bopp KD, Brown GD. The clinical value of 
computerized information services. A review of 98 randomized clinical trials. Arch Fam
Med. 1996;5(5):271‐8.
• Borzekowski R. Measuring the cost impact of hospital information systems: 1987‐1994. J 
Health Econ. 2009;28(5):939‐49.
• Chaudhry B, Wang J, Wu S, Maglione M, Mojica W, Roth E, Morton SC, Shekelle PG. 
Systematic review: impact of health information technology on quality, efficiency, and 
costs of medical care. Ann Intern Med. 2006;144(10):742‐52.
• DeLone WH, McLean ER. Information systems success: the quest for the dependent 
variable. Inform Syst Res. 1992 Mar;3(1):60‐95. 
• Friedman CP. A "fundamental theorem" of biomedical informatics. 
J Am Med Inform Assoc. 2009 Apr;16(2):169‐70.
• Garg AX, Adhikari NKJ, McDonald H, Rosas‐Arellano MP, Devereaux PJ, Beyene J, et al. 
Effects of computerized clinical decision support systems on practitioner performance 
and patient outcomes: a systematic review. JAMA. 2005;293(10):1223‐38.
• Hartzband P, Groopman J. Off the record‐‐avoiding the pitfalls of going electronic. N Engl
J Med. 2008 Apr 17;358(16):1656‐1658. 
59
References
• Hersh W. Health care information technology: progress and barriers. JAMA. 2004 Nov 
10:292(18):2273‐4.
• Institute of Medicine, Committee on Quality of Health Care in America. To err is human: 
building a safer health system. Kohn LT, Corrigan JM, Donaldson MS, editors. 
Washington, DC: National Academy Press; 2000. 287 p.
• Institute of Medicine, Committee on Quality of Health Care in America. Crossing the 
quality chasm: a new health system for the 21st century. Washington, DC: National 
Academy Press; 2001. 337 p.
• Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and 
clinical decision support systems on medication safety: a systematic review. Arch. Intern. 
Med. 2003;163(12):1409‐16.
• Parente ST, Dunbar JL. Is health information technology investment related to the 
financial performance of US hospitals? An exploratory analysis. Int J Healthc Technol
Manag. 2001;3(1):48‐58.
• Shiffman RN, Liaw Y, Brandt CA, Corb GJ. Computer‐based guideline implementation 
systems: a systematic review of functionality and effectiveness. J Am Med Inform Assoc. 
1999;6(2):104‐14.
• Van Rosse F, Maat B, Rademaker CMA, van Vught AJ, Egberts ACG, Bollen CW. The effect 
of computerized physician order entry on medication prescription errors and clinical 
outcome in pediatric and intensive care: a systematic review. Pediatrics. 
2009;123(4):1184‐90.

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Health IT: The Big Picture

  • 1. 1 Health IT: The Big Picture Nawanan Theera-Ampornpunt, MD, PhD Healthcare CIO Program, Ramathibodi Hospital Administration School Jul 10, 2014 SlideShare.net/Nawanan Except  where citing  other works
  • 4. 4 Health care ER - Image Source: nj.com
  • 5. 5 (At an undisclosed nearby hospital) Health care
  • 6. 6 • Life-or-Death • Many & varied stakeholders • Strong professional values • Evolving standards of care • Fragmented, poorly-coordinated systems • Large, ever-growing & changing body of knowledge • High volume, low resources, little time Why Health care Isn’t Like Any Others?
  • 7. 7 • Large variations & contextual dependence Why Health care Isn’t Like Any Others? Input Process Output Patient Presentation Decision- Making Biological Responses
  • 8. 8 But...Are We That Different? Input Process Output Transfer Banking Value-Add - Security - Convenience - Customer Service Location A Location B
  • 10. 10 But...Are We That Different? Input Process Output Patient Care Health care Sick Patient Well Patient Value-Add - Technology & medications - Clinical knowledge & skills - Quality of care; process improvement - Information
  • 11. 11 Information is Everywhere in Medicine Shortliffe EH. Biomedical informatics in the education of physicians. JAMA. 2010 Sep 15;304(11):1227-8.
  • 12. 12 The Anatomy of Health IT Health  Information Technology Goal Value‐Add Means
  • 13. 13 Various Forms of Health IT Hospital Information System (HIS) Computerized Provider Order Entry (CPOE) Electronic Health Records (EHRs) Picture Archiving and Communication System (PACS)
  • 14. 14 Still Many Other Forms of Health IT m-Health Health Information Exchange (HIE) Biosurveillance Information Retrieval Telemedicine & Telehealth Images from Apple Inc., Geekzone.co.nz, Google, Microsoft, PubMed.gov, and American Telecare, Inc. Personal Health Records (PHRs)
  • 15. 15 • Life-or-Death • Many & varied stakeholders • Strong professional values • Evolving standards of care • Fragmented, poorly-coordinated systems • Large, ever-growing & changing body of knowledge • High volume, low resources, little time Why Health care Isn’t Like Any Others?
  • 17. 17 What Clinicians Want? To treat & to care for their patients to their best abilities, given limited time & resources Image Source: http://en.wikipedia.org/wiki/File:Newborn_Examination_1967.jpg (Nevit Dilmen)
  • 18. 18 High Quality Care • Safe • Timely • Effective • Patient-Centered • Efficient • Equitable Institute of Medicine, Committee on Quality of Health Care in America. Crossing the quality chasm: a new health system for the 21st century. Washington, DC: National Academy Press; 2001. 337 p.
  • 19. 19 Information is Everywhere in Healthcare Shortliffe EH. Biomedical informatics in the education of physicians. JAMA. 2010 Sep 15;304(11):1227-8.
  • 20. 20 “Information” in Medicine Shortliffe EH. Biomedical informatics in the education of physicians. JAMA. 2010 Sep 15;304(11):1227-8.
  • 21. 21 (IOM, 2001)(IOM, 2000) (IOM, 2011) Landmark IOM Reports
  • 22. 22 Landmark IOM Reports: Summary • Humans are not perfect and are bound to  make errors • High‐light problems in the U.S. health care  system that systematically contributes to  medical errors and poor quality • Recommends reform that would change  how health care works and how  technology innovations can help improve  quality/safety
  • 23. 23 Why We Need Health IT • Health care is very complex (and inefficient) • Health care is information‐rich • Quality of care depends on timely  availability & quality of information • Clinical knowledge body is too large to be in  any clinician’s brain, and the short time  during a visit makes it worse • “To err is human” • Practice guidelines are put “on‐the‐shelf”
  • 24. 24 Image Source: (Left) http://docwhisperer.wordpress.com/2007/05/31/sleepy-heads/ (Right) http://graphics8.nytimes.com/images/2008/12/05/health/chen_600.jpg To Err is Human 1: Attention
  • 25. 25Image Source: Suthan Srisangkaew, Department of Pathology, Facutly of Medicine Ramathibodi Hospital, Mahidol University To Err is Human 2: Memory
  • 26. 26 To Err is Human 3: Cognition • Cognitive Errors - Example: Decoy Pricing The Economist Purchase Options • Economist.com subscription $59 • Print subscription $125 • Print & web subscription $125 Ariely (2008) 16 0 84 The Economist Purchase Options • Economist.com subscription $59 • Print & web subscription $125 68 32 # of People # of People
  • 27. 27 • It already happens.... (Mamede et al., 2010; Croskerry, 2003; Klein, 2005) • What if health IT can help? What If This Happens in Healthcare?
  • 28. 28 Cognitive Biases in Healthcare Mamede S, van Gog T, van den Berge K, Rikers RM, van Saase JL, van Guldener C, Schmidt HG. Effect of availability bias and reflective reasoning on diagnostic accuracy among internal medicine residents. JAMA. 2010 Sep 15;304(11):1198-203.
  • 29. 29 Cognitive Biases in Healthcare Croskerry P. The importance of cognitive errors in diagnosis and strategies to minimize them. Acad Med. 2003 Aug;78(8):775-80.
  • 30. 30 Cognitive Biases in Healthcare Klein JG. Five pitfalls in decisions about diagnosis and prescribing. BMJ. 2005 Apr 2;330(7494):781-3. “Everyone makes mistakes. But our reliance on cognitive processes prone to bias makes treatment errors more likely than we think”
  • 31. 31 • Medication Errors –Drug Allergies –Drug Interactions • Ineffective or inappropriate treatment • Redundant orders • Failure to follow clinical practice guidelines Common Errors
  • 32. 32 We need “Change” “...we need to upgrade our medical records by switching from a paper to an electronic system of record keeping...” President Barack Obama June 15, 2009
  • 33. 33 The Anatomy of Health IT Revisited Health  Information Technology Goal Value‐Add Means
  • 34. 34 Ultimate Goals of Health IT •Individual’s Health •Population’s Health •Organization’s Health
  • 35. 35 Dimensions of Quality Health Care • Safety • Timeliness • Effectiveness • Efficiency • Equity • Patient‐centeredness (IOM, 2001)
  • 38. 38 Safety • Legible handwriting • Proper display of patient information (e.g. abnormal labs) • Alerts – Drug‐Allergy Checks – Drug‐Drug Interaction Checks – Drug‐Lab Interaction Checks • Dose calculator • Prevention of medication errors • Timely information – Histories – Diagnoses/Problem List – Labs – Medication List
  • 40. 40 Timeliness • Timely information for emergencies, transfers, normal visits – Histories – Diagnoses/Problem List – Labs – Medication List • Effective communications between providers • Effective triage & patient monitoring
  • 42. 42 Effectiveness • Reminders/advice for – Guideline adherence – Preventive care – Specialist consults • Templates/forms – Order sets – Care planning, nursing assessments & interventions,  nursing documentation • Availability of patient information • Continuity of care (even in referrals) • Effective display of information (e.g. graphs, user‐friendly  screens) • Assistance in decision‐making (e.g. differential diagnosis) • Access to evidence/references at the point of care
  • 44. 44 Efficiency • Fast/lean/efficient processes of care – Automation ‐> faster care, fewer workers – Process redesigns/reengineering (e.g. parallel processes/access) – Changes in role assignments ‐> productivity gains or more time for patient • Predictable patterns/“Just‐in‐time” (staffing, resource allocation,  inventory, bed management) • Flexibility “Organizational slacks” (buffers) • Drug‐formulary checks & policy enforcement • Reduction of redundant tests • Efficient management of bed occupancy/hospital capacity • Cost‐savings & time‐savings from preventable errors • Space‐savings (e.g. medical records, PACS) • Effective communications
  • 46. 46 Equity • Reduction of barriers to care, improved access  to care – Physical barriers (telemedicine, tele‐consultation) – Structural barriers (information exchange among  hospitals) – Functional barriers (information access by patients,  networks of patients) – Cultural barriers (tailored information for different  patients)
  • 48. 48 Patient-Centeredness • Patient’s access to – Own clinical information – General health information – Tailored health information • Patient engagement/compliance • Patient empowerment – Patients’ networking & knowledge sharing • Patient satisfaction with quality & efficient care • Patient’s control of information (privacy)
  • 49. 49 Documented Benefits of Health IT • Literature suggests improvement through – Guideline adherence (Shiffman et al, 1999;Chaudhry et al, 2006) – Better documentation (Shiffman et al, 1999) – Practitioner decision making or process of care  (Balas et al, 1996;Kaushal et al, 2003;Garg et al, 2005) – Medication safety (Kaushal et al, 2003;Chaudhry et al, 2006;van Rosse et al, 2009) – Patient surveillance & monitoring (Chaudhry et al, 2006) – Patient education/reminder (Balas et al, 1996) – Cost  savings and better financial performance  (Parente & Dunbar, 2001;Chaudhry et al, 2006;Amarasingham et al, 2009; Borzekowski, 2009)
  • 50. 50 But... • “Don’t implement technology just for technology’s  sake.” • “Don’t make use of excellent technology.  Make excellent use of technology.” (Tangwongsan, Supachai. Personal communication, 2005.) • “Health care IT is not a panacea for all that ails  medicine.” (Hersh, 2004) • “We worry, however, that [electronic records] are  being touted as a panacea for nearly all the ills of  modern medicine.” (Hartzband & Groopman, 2008)
  • 51. 51 Common “Goals” for Adopting HIT “Computerize”“Go paperless” “Digital Hospital” “Modernize” “Get a HIS” “Have EMRs” “Share data”
  • 52. 52 The Common Denominator •Health Information Technology •Electronic Health Records •Health Information Exchange
  • 53. 53 Some Misconceptions about HIT Current  Environment Bad New, Modern,  Electronic  Environment Good If Then Always
  • 54. 54 Fundamental Theorem of Informatics (Friedman, 2009)
  • 55. 55 Various Ways to Measure Success • DeLone & McLean (1992;2003)
  • 56. 56 Take-Home Messages • Health IT has documented benefits to  quality & efficiency of care • Implementing health IT will not  automatically fix all problems • Health IT is not without risks • Find the ways health IT can help • Focus on the ultimate goals • Benefits of health IT may vary by  context
  • 58. 58 References • Amarasingham R, Plantinga L, Diener‐West M, Gaskin DJ, Powe NR. Clinical information  technologies and inpatient outcomes: a multiple hospital study. Arch Intern Med.  2009;169(2):108‐14. • Balas EA, Austin SM, Mitchell JA, Ewigman BG, Bopp KD, Brown GD. The clinical value of  computerized information services. A review of 98 randomized clinical trials. Arch Fam Med. 1996;5(5):271‐8. • Borzekowski R. Measuring the cost impact of hospital information systems: 1987‐1994. J  Health Econ. 2009;28(5):939‐49. • Chaudhry B, Wang J, Wu S, Maglione M, Mojica W, Roth E, Morton SC, Shekelle PG.  Systematic review: impact of health information technology on quality, efficiency, and  costs of medical care. Ann Intern Med. 2006;144(10):742‐52. • DeLone WH, McLean ER. Information systems success: the quest for the dependent  variable. Inform Syst Res. 1992 Mar;3(1):60‐95.  • Friedman CP. A "fundamental theorem" of biomedical informatics.  J Am Med Inform Assoc. 2009 Apr;16(2):169‐70. • Garg AX, Adhikari NKJ, McDonald H, Rosas‐Arellano MP, Devereaux PJ, Beyene J, et al.  Effects of computerized clinical decision support systems on practitioner performance  and patient outcomes: a systematic review. JAMA. 2005;293(10):1223‐38. • Hartzband P, Groopman J. Off the record‐‐avoiding the pitfalls of going electronic. N Engl J Med. 2008 Apr 17;358(16):1656‐1658. 
  • 59. 59 References • Hersh W. Health care information technology: progress and barriers. JAMA. 2004 Nov  10:292(18):2273‐4. • Institute of Medicine, Committee on Quality of Health Care in America. To err is human:  building a safer health system. Kohn LT, Corrigan JM, Donaldson MS, editors.  Washington, DC: National Academy Press; 2000. 287 p. • Institute of Medicine, Committee on Quality of Health Care in America. Crossing the  quality chasm: a new health system for the 21st century. Washington, DC: National  Academy Press; 2001. 337 p. • Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and  clinical decision support systems on medication safety: a systematic review. Arch. Intern.  Med. 2003;163(12):1409‐16. • Parente ST, Dunbar JL. Is health information technology investment related to the  financial performance of US hospitals? An exploratory analysis. Int J Healthc Technol Manag. 2001;3(1):48‐58. • Shiffman RN, Liaw Y, Brandt CA, Corb GJ. Computer‐based guideline implementation  systems: a systematic review of functionality and effectiveness. J Am Med Inform Assoc.  1999;6(2):104‐14. • Van Rosse F, Maat B, Rademaker CMA, van Vught AJ, Egberts ACG, Bollen CW. The effect  of computerized physician order entry on medication prescription errors and clinical  outcome in pediatric and intensive care: a systematic review. Pediatrics.  2009;123(4):1184‐90.