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Introduction
 The successful treatment of patients
suffering from complete clefts of the lip
and palate requires a contin...
Alveolus Means Trough
(Latin Word); Trough
Containing Tooth Buds.
 Various Forms of Cleft Alveolus
 Cleft between laterals & canine (most
common)Tessier classification: No.4
(Tessiers, 1...
History
 In 1901 – Von Eiselberg: Used pedicled flap (bone of little
finger) to fill alveolar cleft.
 In 1908 – Lexur: F...
 1960 – Schuchardt & Pfeifer: Primary ABG using rib graft
at the time of lip closure.
 1964–Pruzansky: Bone grafting sho...
Developmental Anatomy
of
Alveolar Bone Premaxilla is a separate skeletal unit
(Moss )
 It develops from median nasal pro...
PHARYNGEAL ARCHES
 Pharyngeal arches developes in the 4TH
and 5TH week.
 5 Pharyngeal arches
 Each arch contains cartil...
 At about24 days – 1st arch –maxillary
and mandibular process
 At about 28 days – lateral medial and
fronto nasal proces...
 At Birth
 Premaxilla remains separate from maxilla
by suture
 Closure of suture starts from 6-7 years of
age
Site of a...
 Cleft Alveolus due to
 Failure of fusion of MNP &
maxillaryprocess
 Ossification centres in the premaxilla &
maxilla c...
Derivatives of the first pair of
the six pharyngeal arches
Maxillary prominence
Mandibular prominence
Facial development
Aetiology
 Hereditary
 Environmental
 Hereditary
 Less than 40% of cleft lip & palate are
of genetic origin
 Unaffected parents with a child who
has a cleft...
 Environmental
 Infection (Rubella & Toxoplasmosis)
 Drugs – steroid, BZD, anticonsulsants
 Smokers
Incidence of Cleft
 1:750 births in USA
 Caucasians 1:1000 births
 African American 1:2000 births
 Asians 1:500 births...
Treatment Goals and
Objectives
 Patient may Complaints of
 Food or fluid coming out of their nose
 Inability to blow ba...
 Mobility & overgrowth of premaxilla in
bilateral case
 Lack of support for the ala, base of the
nose & lip (Columella i...
Rationale for Closure of Cleft
Alveolus
 To provide stability for maxillary arch
 Mainly in mobile premaxilla – bilatera...
 Establishment of functional nasal airway
 To support accurate nasolabial
reconstruction
 Periodontal support for teeth...
Timing of ABG
 Primary (0–2.5 years, usually at the
time of lip repair)
 Early secondary (2–5 years, before
the eruption...
Primary ABG
 primary alveolar bone grafting as that
which is performed simultaneously
with lip repair
 any grafting that...
 Primary grafting performed at the time
of lip repair has failed to result in
acceptable outcome.
 Long-term studies sho...
 Primary grafting performed after the
closure of the lip and before the
closure of the palate has proven
successful in a ...
 Advantage
 Early maxillary arch stabilization
 Improved arch form with out collapse
 Teeth adjacent to cleft erupt in...
Reasons for Maxillary Growth
Disturbance
 Disruption of vomer – premaxillary
suture
 Extensive mucoperiosteal stripping
...
Early Secondary ABG
 2 – 6 years of age
 To provide support for eruption of
laterals
Disadvantage
 Significant transver...
Secondary
ABG
 9-11 years
 most commonly done before eruption
of canine
 When ½ to 2/3rd of canine root has
formed
 On...
 Rationale for grafting and for timing of grafting
during this time period include the following:
 Minimal maxillary gro...
 Bone volume may be improved by
eruption of the tooth into the newly
grafted bone
 Grafting during this phase allows
pla...
 Factors Contributing to timing of
Grafting During the mixed dentition
 Dental age vs chronologic age
 Presence and pos...
 The graft be determined on the basis of
dental rather than chronologic age.
 If a lateral incisor is present and appear...
 The maxillary permanent central incisor will
often erupt in a rotated and angled position If
a decision is made to rotat...
Late Secondary Grafting
 Patients older than12 years of age
who undergo grafting have been
reported to have decreased suc...
Pre Vs Post surgical
orthodontics
 Controversy exists regarding the use of
orthopedic expansion of the cleft
segments and...
 Orthodontic movement of the erupted
teeth adjacent to the cleft is another
controversial topic
 Some authors suggest th...
History & Physical
Examination
Focused examination on:
 Any previous repair
 Oro nasal fistula
 Alar support
 Size of ...
Radiographic Evaluation
 OPG
 Occlusal view
 Peri apical view
Pre Surgical Preparation of a
Patient
 The Premaxillary Segment in bilateral
case stabilized by arch wire, Since
mobile p...
 Supernumerary or Retained Deciduous
teeth in cleft area should be removed
atleast 6 – 8 week before surgery to
ensure ad...
Treatment options for cleft
alveolus
 Bone grafting
 Gingivo periosteoplasty
 Distraction osteogenesis
OPTIONS FOR ABG
 AUTOGENOUS
◦ ILIAC BONE
◦ RIB
◦ TIBIA
◦ CALVARIUM
◦ SYMPHYSIS
 ALLOPLASTIC
 ALLOGENIC
CANCELLOUS BONE CORTICAL BONE
Early vascularization Not Completely revascularised
for 2 months
Increased number of viable
...
Graft use for ABG
Site Advantages Disadvantages
Iliac
crest
•Large quantity of
cancellous bone.
•Decreased operative-
time...
Site Advantages Disadvantages
Proximal
tibia
•Adequate cancellous
bone
•Minimal soft tissue
dissection
•Two team approach
...
Site Advantages Disadvantages
Cranial bone
•Incision hidden
in hair bearing
area
•Minimal postop
discomfort
•Sparse cancel...
Type Advantages Disadvantages
Allogenic:
derived from a
genetically
unrelated
member of same
species
(osteoconductive
, os...
Surgical technique
 Three basic surgical principles must
be satisfied for the successful
treatment of the alveolar cleft ...
Unilateral alveolar cleft
Incision line for an
oblique sliding flap
(dashed line)
The closure of the nasal mucosa
and the introduction of the bone
graft to the alveolar defect.
Depiction of the nasal
muco...
Final mucosal
closure of the
oblique sliding flap.
A palatal splint placed
over the closure area
to prevent formation of
a...
Bilateral alveolar cleft repair
A bilateral alveolar
cleft palate
Needle palpation of the
bony edges of the
alveolar cleft...
The incision line
(dashed line)
Elevation of the nasal mucosa
on the left and closure of the
nasal mucosa on the right.
Pl...
Palatal depiction of the movement of the adjacent
mucosa in the oblique sliding flap technique
Mucosal closure in a bilateral alveolar
cleft.
Final closure of the bilateral alveolar
cleft repair using a oblique sliding flap
technique
Post-operative instructions
 Liquid diet 7 days
 Avoidance of trauma to the site
 Antibiotics & nasal decongestants
 M...
Complications
 Failure of bone grafts (Mainly in
mobile
premaxilla)
 Infection
 Wound breakdown & loss of graft
(incomp...
Success of
ABG
 Good nasal side closure
 Use of adequate amount of cancellous
bone
 A water tight oral side closure
 A...
Gingivo-Periosteoplasty
 Boneless primary bone graft
 Relies on the osteoinductive capabilities of
the periosteum
 Skoo...
 Advantages
 Repairs the cleft in
anatomic way by a
precise reconstruction
of the functional
matrix(mucoperiosteal
matri...
Distraction osteogenesis
 Advantage
 No need for bone graft
 No donor site morbidity
 Minimal surgical time
 Bone hei...
 Disadvantage
 Long treatment requires patient co-
operation & close follow-up
Conclusion
 Although the repair of the alveolar cleft
may be one of the last considerations
in the global treatment of a ...
References
 Peterson 2nd edition vol II
 OUTLINE OF ORAL &MAXILLOFACIAL
SURGERY- Peterwardbooth vol II
 Oral Maxillofac...
 alveolar bone grafting
 alveolar bone grafting
 alveolar bone grafting
 alveolar bone grafting
 alveolar bone grafting
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alveolar bone grafting

alveolar bone grafting

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alveolar bone grafting

  1. 1. Introduction  The successful treatment of patients suffering from complete clefts of the lip and palate requires a continuous interdisciplinary therapy from birth until early adulthood, which involves the application of all available operative and conservative procedures for treatment.  The osseous closure of the alveolar cleft, is required for the formation of a regular upper dental arch, occupies a special position within the whole concept of cleft lip and palate therapy.
  2. 2. Alveolus Means Trough (Latin Word); Trough Containing Tooth Buds.
  3. 3.  Various Forms of Cleft Alveolus  Cleft between laterals & canine (most common)Tessier classification: No.4 (Tessiers, 1976)  Cleft between centrals& Laterals Tessier No.3 cleft  Between centrals Tessier No.0 cleft  More distally in the maxillary arch Tessier No.5& No.7
  4. 4. History  In 1901 – Von Eiselberg: Used pedicled flap (bone of little finger) to fill alveolar cleft.  In 1908 – Lexur: Free bone graft in cleft  1914 – Drachter: Ist successful bone graft using tibial bone and periosteum.  1931 – Veau: Classification of cleft & attempted tibial bone graft in alveolar cleft.  1950 – Schmid: Successful ABG using iliac bone graft  1955 – Johanson & Nordin: Primary ABG using tibial bone in a stage procedure lip, palate, alveolus – closure by 1 yr. of age.
  5. 5.  1960 – Schuchardt & Pfeifer: Primary ABG using rib graft at the time of lip closure.  1964–Pruzansky: Bone grafting should be delayed until after eruption of permanent dentition  1968–Jolley: Detrimental effects of early bone graft on maxillary growth  1972–Boyne&Sands: Protocol for secondary ABG  1983–Wolfe et al: Favourable result with calvarial bone  1987–Nique&Fonseca: ABG with allogenic bone
  6. 6. Developmental Anatomy of Alveolar Bone Premaxilla is a separate skeletal unit (Moss )  It develops from median nasal process  Fusion of premaxilla with maxilla (at Canine region)  Starts 8th week in utero
  7. 7. PHARYNGEAL ARCHES  Pharyngeal arches developes in the 4TH and 5TH week.  5 Pharyngeal arches  Each arch contains cartilagenous muscular and nerve components  Pre maxilla and maxilla developes from 1st arch
  8. 8.  At about24 days – 1st arch –maxillary and mandibular process  At about 28 days – lateral medial and fronto nasal process  Formation of middle portion of lip upper and portion of maxilla and primary palate
  9. 9.  At Birth  Premaxilla remains separate from maxilla by suture  Closure of suture starts from 6-7 years of age Site of active osteogenesis  Antero Posterior Development of Premaxilla influenced by  Intrinsic activity of membrananous bone  Vomer - premaxillary suture  Nasolabial muscles  Tongue Posture & Function  Tooth development
  10. 10.  Cleft Alveolus due to  Failure of fusion of MNP & maxillaryprocess  Ossification centres in the premaxilla & maxilla cannot migrate & fuse cause cleft alveolus  Vertical growth still active upto 9-10 years  Transverse & AP Growth 95% Completed at 8yrs.
  11. 11. Derivatives of the first pair of the six pharyngeal arches Maxillary prominence Mandibular prominence Facial development
  12. 12. Aetiology  Hereditary  Environmental
  13. 13.  Hereditary  Less than 40% of cleft lip & palate are of genetic origin  Unaffected parents with a child who has a cleft have a chance of (4.4%) a second child with cleft  If one parent has a cleft there is 3.2% chance that first born will have a cleft.
  14. 14.  Environmental  Infection (Rubella & Toxoplasmosis)  Drugs – steroid, BZD, anticonsulsants  Smokers
  15. 15. Incidence of Cleft  1:750 births in USA  Caucasians 1:1000 births  African American 1:2000 births  Asians 1:500 births  Isolated cleft palate 1:2000 births  Isolated cleft lip : 32%  Lip & palate 68%  Palate 2:1 :  Side - Left : Right: Bilateral Þ 6:3:1
  16. 16. Treatment Goals and Objectives  Patient may Complaints of  Food or fluid coming out of their nose  Inability to blow balloon / suck a straw  A persistent smell / discharge from nose  Poor speech  Inability to clean their teeth in cleft area  Decayed / deformed teeth in cleft area  Missing / extra teeth in cleft area  Lack of bone support for teeth in cleft area  Poor alignment of teeth
  17. 17.  Mobility & overgrowth of premaxilla in bilateral case  Lack of support for the ala, base of the nose & lip (Columella in bilateral case)
  18. 18. Rationale for Closure of Cleft Alveolus  To provide stability for maxillary arch  Mainly in mobile premaxilla – bilateral case  To provides room for the canine and lateral incisors to erupt into the arch into stable alveolar bone and maintains bony support of teeth adjacent to the cleft.  To close oronasal fistula  To construct pyriform rim & to provide a better nasal symmetry  To prevent inferior turbinate prolapse into cleft
  19. 19.  Establishment of functional nasal airway  To support accurate nasolabial reconstruction  Periodontal support for teeth lining the cleft  Oral & dental health improved  Speech improved  Improved orthodontic result  Provide bony support for implant placement
  20. 20. Timing of ABG  Primary (0–2.5 years, usually at the time of lip repair)  Early secondary (2–5 years, before the eruption of permanent incisors)  Secondary (6–13 years, before the eruption of the permanent canines)  Late (> 13 years, after the eruption of the permanent canines)
  21. 21. Primary ABG  primary alveolar bone grafting as that which is performed simultaneously with lip repair  any grafting that is performed at less than 2 years of age is considered primary grafting.  primary grafting as grafting that is performed before the palate is repaired.
  22. 22.  Primary grafting performed at the time of lip repair has failed to result in acceptable outcome.  Long-term studies show ◦ abnormal maxillary development with maxillary retrognathia, ◦ concave profile, ◦ increased frequency of crossbite compared with patients without grafts.
  23. 23.  Primary grafting performed after the closure of the lip and before the closure of the palate has proven successful in a limited number of centers when a very specific protocol is followed.  Eppley B. Alveolar cleft bone grafting (part 1): Primary bone grafting. J Oral Maxillofac Surg 1996;54:74–82.  11. Rosenstein SW. Early bone grafting of alveolar cleft deformities. J Oral Maxillofac Surg 2003;61:1078–81.
  24. 24.  Advantage  Early maxillary arch stabilization  Improved arch form with out collapse  Teeth adjacent to cleft erupt into grafted bone.  Disadvantage  Maxillary growth affected(Sagittal & Transverse Growth )  Compensatory changes in mandible  increased lower facial height
  25. 25. Reasons for Maxillary Growth Disturbance  Disruption of vomer – premaxillary suture  Extensive mucoperiosteal stripping  scar formation  Vomerine flap disruption
  26. 26. Early Secondary ABG  2 – 6 years of age  To provide support for eruption of laterals Disadvantage  Significant transverse growth and sagittal growth may be affected  Literature not support the early secondary grafting
  27. 27. Secondary ABG  9-11 years  most commonly done before eruption of canine  When ½ to 2/3rd of canine root has formed  Only vertical growth remains at this age.  Physiological migration & spontaneous eruption through grafted bone observed.
  28. 28.  Rationale for grafting and for timing of grafting during this time period include the following:  Minimal maxillary growth after age 6 to 7 years  The effect of grafting at this time will result in minimal to no alteration of facial growth  Cooperation with orthodontic and perioperative care is predictable.  The donor site for graft harvest is of acceptable volume for predictable grafting with autogenous bone
  29. 29.  Bone volume may be improved by eruption of the tooth into the newly grafted bone  Grafting during this phase allows placement of the graft before eruption of permanent teeth into the cleft site - one of the primary goals of grafting.
  30. 30.  Factors Contributing to timing of Grafting During the mixed dentition  Dental age vs chronologic age  Presence and position of the lateral incisor  Degree of rotation/angulation of the  central incisor  Trauma/mobility of premaxillary segment  (bilateral clefts)  Size of the patient and of the cleft  Occlusion  Need for adjunctive procedures  Social issues
  31. 31.  The graft be determined on the basis of dental rather than chronologic age.  If a lateral incisor is present and appears to be well formed, earlier grafting may be beneficial  If the lateral incisor is located in the posterior segment, earlier grafting may be necessary to preserve the lateral incisor
  32. 32.  The maxillary permanent central incisor will often erupt in a rotated and angled position If a decision is made to rotate these teeth into alignment, it may be necessary to graft the alveolar defect prior to this orthodontic tooth movement  Large defects, later grafting is often better, to wait for growth of the patient and orthodontic alignment of the cleft segments.  Patients are often evaluated for velopharyngeal incompetence, minor esthetic revision of the nose or the lip, and pressure-equalizing tubes for otitis media
  33. 33. Late Secondary Grafting  Patients older than12 years of age who undergo grafting have been reported to have decreased success when evaluated using the Bergland scale, loss of osseous support of teeth adjacent to the cleft, and increased morbidity.
  34. 34. Pre Vs Post surgical orthodontics  Controversy exists regarding the use of orthopedic expansion of the cleft segments and the relationship between expansion and grafting  Most authors prefer presurgical expansion because of less resistance, improved access to the cleft for closure of the nasal floor, better postoperative hygiene, and less chance of reopening the oronasal fistula
  35. 35.  Orthodontic movement of the erupted teeth adjacent to the cleft is another controversial topic  Some authors suggest that aligning the teeth adjacent to the cleft produces better hygiene and an improved result
  36. 36. History & Physical Examination Focused examination on:  Any previous repair  Oro nasal fistula  Alar support  Size of alveolar defect  Mal positioned teeth in cleft region  Alignment / cross bite of teeth  Position & mobility of premaxilla  Adequacy of soft tissue for tension free closure  Oral hygiene
  37. 37. Radiographic Evaluation  OPG  Occlusal view  Peri apical view
  38. 38. Pre Surgical Preparation of a Patient  The Premaxillary Segment in bilateral case stabilized by arch wire, Since mobile premaxilla will cause the grafted bone fail to consolidate.  Oral Hygiene Prophylaxis  Ortho treatment -Correction of cross bite & alignment of arch
  39. 39.  Supernumerary or Retained Deciduous teeth in cleft area should be removed atleast 6 – 8 week before surgery to ensure adequate width & continuity of soft tissue flaps.
  40. 40. Treatment options for cleft alveolus  Bone grafting  Gingivo periosteoplasty  Distraction osteogenesis
  41. 41. OPTIONS FOR ABG  AUTOGENOUS ◦ ILIAC BONE ◦ RIB ◦ TIBIA ◦ CALVARIUM ◦ SYMPHYSIS  ALLOPLASTIC  ALLOGENIC
  42. 42. CANCELLOUS BONE CORTICAL BONE Early vascularization Not Completely revascularised for 2 months Increased number of viable cells Relatively less Apposition followed by resorbtion Resorbtion followed by apposition Completely replaced by new bone Remains as composite of new & necrotic bone Greater mechanical strength earlier More susceptible to infection
  43. 43. Graft use for ABG Site Advantages Disadvantages Iliac crest •Large quantity of cancellous bone. •Decreased operative- time with 2 team approach. •No growth disturbance •Easy to condense & pack •Proven successful •Mild transient gait disturbance •Donor site morbidity reported in literature
  44. 44. Site Advantages Disadvantages Proximal tibia •Adequate cancellous bone •Minimal soft tissue dissection •Two team approach • Mild post-op discomfort •Less bone than iliac bone •Interferes with growth •(due to epiphyseal growth •plate) Rib Two team approach possible Mainly used in primary ABG •Poor source of cancellous bone •Post-op-pain •Visible scar •Associated morbidity •Un predictable result
  45. 45. Site Advantages Disadvantages Cranial bone •Incision hidden in hair bearing area •Minimal postop discomfort •Sparse cancellous bone •Increased operative time •Associated morbidity •Poor results than ilium (less cellular) •Stigma & fear for patient Mandible symphysis Same operative field Rapid post-op recovery No external scar •Sparse amount of •cancellous bone •Associated morbidity •Poor result than
  46. 46. Type Advantages Disadvantages Allogenic: derived from a genetically unrelated member of same species (osteoconductive , osteoinductive Comparable to autogenous Allows for eruption of teeth Avoids donor site morbidity No osteogenic potential Delayed incorporation Alloplastic: inert foreign body material (osteoconductive , osteoinductive Avoids donor site morbidity Delayed healing Inability of teeth to erupt
  47. 47. Surgical technique  Three basic surgical principles must be satisfied for the successful treatment of the alveolar cleft grafting:  (1) closure of oronasal fistula,  (2) adequate volume of graft material,  (3) water tight and tension-free closure.
  48. 48. Unilateral alveolar cleft Incision line for an oblique sliding flap (dashed line)
  49. 49. The closure of the nasal mucosa and the introduction of the bone graft to the alveolar defect. Depiction of the nasal mucosa flap along with the closure of the oral mucosa.
  50. 50. Final mucosal closure of the oblique sliding flap. A palatal splint placed over the closure area to prevent formation of a hematoma and stabilize the bone graft.
  51. 51. Bilateral alveolar cleft repair A bilateral alveolar cleft palate Needle palpation of the bony edges of the alveolar cleft while injecting local anesthesia
  52. 52. The incision line (dashed line) Elevation of the nasal mucosa on the left and closure of the nasal mucosa on the right. Placement of the bone graft over the closed
  53. 53. Palatal depiction of the movement of the adjacent mucosa in the oblique sliding flap technique
  54. 54. Mucosal closure in a bilateral alveolar cleft.
  55. 55. Final closure of the bilateral alveolar cleft repair using a oblique sliding flap technique
  56. 56. Post-operative instructions  Liquid diet 7 days  Avoidance of trauma to the site  Antibiotics & nasal decongestants  Meticulous oral hygiene with chlorhexidine
  57. 57. Complications  Failure of bone grafts (Mainly in mobile premaxilla)  Infection  Wound breakdown & loss of graft (incomplete oral/nasal closure)  External root resorbtion  Bone loss  Residual fistula
  58. 58. Success of ABG  Good nasal side closure  Use of adequate amount of cancellous bone  A water tight oral side closure  Adequate amount of attached mucosa in the area of cleft for development of normal periodontal attachment of erupting canine
  59. 59. Gingivo-Periosteoplasty  Boneless primary bone graft  Relies on the osteoinductive capabilities of the periosteum  Skoog T: The use of periosteum and surgicel for bone restoration in congenital clefts of the maxilla. Scan J Plast Reconst Surg 1: 113, 1967  Wood RJ, Grayson BH, Cutting CB: Gingivoperiosteoplasty and midfacial growth. Cleft Palate Craniofac J 34:17-20, 1997  Carstens MH: Functional matrix cleft repair: principles and techniques. Clin Plast Surg 31:159-189, 2004
  60. 60.  Advantages  Repairs the cleft in anatomic way by a precise reconstruction of the functional matrix(mucoperiosteal matrix of maxilla)  Avoids the need for ABG
  61. 61. Distraction osteogenesis  Advantage  No need for bone graft  No donor site morbidity  Minimal surgical time  Bone height & width similar to normal adjacent alveolus  Dental implants possible  Final orthodontic tooth movement is good  Minimal morbidity
  62. 62.  Disadvantage  Long treatment requires patient co- operation & close follow-up
  63. 63. Conclusion  Although the repair of the alveolar cleft may be one of the last considerations in the global treatment of a cleft patient, if these goals are achieved, it provides tremendous enhancement of oral function and aesthetics for a cleft patient.
  64. 64. References  Peterson 2nd edition vol II  OUTLINE OF ORAL &MAXILLOFACIAL SURGERY- Peterwardbooth vol II  Oral Maxillofacial Surg Clin N Am 14 (2002) 477–490  Medical embryology by langman

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