7. Bengin salivary glad tuomar Malignant salivery galnd tumor
On set Slow -growing Sometimes fast growing
consistency Soft or Rubbery Hard
Incidence of type 85% of parotid tumors 45%of minor s.g
Covering epithelium Don’t ulcerate May ulcerate and invade bone
mobility Not fixed to underlying structuress
Fixed to the underlying structures
Involvement of nerve No involvement of nerve May cause cranial nerve paralysis
9. What is Mucoepidermoid Carcinoma of
Salivary Gland?
A Mucoepidermoid Carcinoma (MEC) is a type of malignant glandular
epithelial tumor affecting either the major or minor salivary glands.
It contains both epidermoid cells type and mucous secreting cells in
varying proportions.
It is observed in a wide age category of children and adults
MEC constitutes the most common primary tumor affecting the
salivary glands.
It accounts for about 5% of all salivary gland tumors arise in the
parotid gland. However their realitve incidence is higher in minor
salivary gland for about 10-15% of tumors
10. Site
Extraoral :- parotid gland(most common site)
Intraoral :- the palate being the site of predilection of minor salivary gland followed by lower lip, floor
of the mouth ,tongue and retromolar area respectively)
Palate> buccal mucosa> tongue> & retromolar area - intraorally
Intraosseous :- Man>max: 3times
Gender
both genders are affected, a slight female predominance is noted
Age
Generally, the mean age for these carcinomas is 47 years, however, there exists
a broad age range, and is one of the few salivary gland malignancies occurring in childhood
Etiology
The cause of formation of this salivary gland malignancy is generally unknown, but may be due to
genetic factors. No definitive risk factors are observed, though salivary gland cancers are known to be
influenced by factors such as exposure to radiation sources
11. clinical feature:-
slowly enlarging painless mass which
simulate the pleomorphic adenoma but never
exceed 5 cm in diameter
It is not completely encapsulated and
often contain cyctic cavities which may be
filled with mucoid material
It is fluctuant swelling and red or blue
in color
may be mistaken as mucocele.
Low Grade Tumor :-
12. Blue-pigmented mass of the posterior
lateral hard palate.
Mucoepidermoid carcinoma.
Mass of the tongue
13.
14. High Grade Tumor :-
clinical feature :-
grows rapidly and cause pain particulary in late
stage
In the parotid gland facial palsy involvement indicate
poor prognosis
Trismus, Drainage of ear, dysphagia, numbness of
adjacent areas & ulceration (minor salivary gland)
typical feature include fixation ulceration, and
involvement of Metastasize regional lymph nodes
Distant metastases to lung, bone, brain & sub-
17. Histopathological features:
Characterized by: variety of cell types and often in cystic
Patterns
Composed of-
a)mucous secreting cells
b)epidermoid cells
c)intermediate cells
Grades:
a) low grade
b) intermediate grade
c) high grade
18. Histopathological Grades are based on-
Amount of cyst formation
Degree of cytoplasmic atypia
Relative number of mucous, epidermoid &
intermediate cells.
The three types of cell – together forms cystic
space or solid masses or cords
19. MICROSCOPIC FEATURES :-
The name is a contraction of epidermiod and mucus -
secreating cell
a close
association
bettwen mucus
and epidermoid
Mucoepidermoid carcinoma. At higher power the
finely
granular mucous cells are seen to the right with the
underlying epidermoid cells to the left.
20.
21. It is believed to arise from
salivary duct system
Normal duct- lining epithelium
neoplastic transformation
23. LOW GRADE TUMOR
(well differentiated tumors tumor) show large number of
mucous secreting cells
Numerous cystic spaces
Small number of intermediate
and epidermoid cells
with few cellular atypia
28. HIGH GRADE TUMOR
•Solid nests or cords
•Mitotic activity
•Prominent nuclear pleomorphism
•Cystic component is very less
•Glandular component rare, necrosis & perineural
invasion may be present
31. lowspace
low grade. Note intracystic space
Intermediate grade
Hyperchromatic nuclei &
Several microcystic spaces
High grade
Focal necrosis
32. •Intraosseous mucoepidermoid carcinoma
it may develop rarely in the jaw.
Origin of salivary gland tissue
maxillary mucoepidermoid carcinoma
may arise from the gland of the sinus lining
Mandbibular lesion from odontogenic epithelium especially that lined
dentigerous cyst or from ectopic entrapped
•Man>max: 3times
Histologically low-grade cancers
Radiographically seen as uniocular or multiocular
lesions.
Variant of tumor
33. Treatment
•Conservative excision – preservation of facial nerve – low
& intermediate grade of parotid.
•Complete – submandibular gland
•Radical neck dissection – evidences of cervical node
metastasis & T3 lesion
•Postoperative radiotherapy & Chemotherapy – may be
used for high grade malignancy.
•Low grade lesion – 92 %, 5 yr cure rate
•Intermediate and high grade – 49 %, 5 year cure rate