Ce diaporama a bien été signalé.
Nous utilisons votre profil LinkedIn et vos données d’activité pour vous proposer des publicités personnalisées et pertinentes. Vous pouvez changer vos préférences de publicités à tout moment.
Md : Obydulla Al Mamun
Id:131-29-500
9th(B)
Department Of Pharmacy
Daffodil International University
almamundcc94@gmail.co...
StrychnineStrychnine
 Strychnine is a highly toxic colorless,
bitter crystalline alkaloid used as
a pesticide, particular...
Types of Strychnine
 Alkaloid
 Stimulant of the central nervous system.
Natural Source
 Found in strychnos
nux-vomica.
 Strychnine (1.2 % ),
brucine (1.6 %)
 Strychnos ignatia –
more strychni...
Mechanism of Action
 An antagonist of glycine, a major inhibitory
neurotransmitter in the mammalian nervous system
Mechanism of Action
Pharmacological effect
 Increased reflex action
 Increased rate of respiration
 Enlargement of the capacity of the lung...
Pharmaceutical Applications
 Appetite stimulant and general tonic in small
doses
 Specific medicine nux vomica and tinct...
Side Effects
 Extremely poisonous (100
mg is fatal )
 Suffocation
 Tremors
 Convulsions
 Eariness
 Death usually tak...
Side Effects
Strychnine Poisoning
 The first effect of Strychnine poisoning is
stiffness of the face and neck muscle. In the
convulsio...
Treatment Of Poisoning
The main targets of the treatment of strychnine poisoning
are-
 Prevention of convulsion and Suppo...
Strychnine
Prochain SlideShare
Chargement dans…5
×

Strychnine

4 375 vues

Publié le

Md : Obydulla Al Mamun
Id:131-29-500
9th(B)
Department Of Pharmacy
Daffodil International University
almamundcc94@gmail.com

Publié dans : Santé & Médecine
  • Soyez le premier à commenter

Strychnine

  1. 1. Md : Obydulla Al Mamun Id:131-29-500 9th(B) Department Of Pharmacy Daffodil International University almamundcc94@gmail.com Md : Obydulla Al Mamun Id:131-29-500 9th(B) Department Of Pharmacy Daffodil International University almamundcc94@gmail.com
  2. 2. StrychnineStrychnine  Strychnine is a highly toxic colorless, bitter crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents .  Not used anymore because rats learn to avoid the bitter taste.
  3. 3. Types of Strychnine  Alkaloid  Stimulant of the central nervous system.
  4. 4. Natural Source  Found in strychnos nux-vomica.  Strychnine (1.2 % ), brucine (1.6 %)  Strychnos ignatia – more strychnine
  5. 5. Mechanism of Action  An antagonist of glycine, a major inhibitory neurotransmitter in the mammalian nervous system
  6. 6. Mechanism of Action
  7. 7. Pharmacological effect  Increased reflex action  Increased rate of respiration  Enlargement of the capacity of the lungs  Increased force, rate, and volume of the pulse  Raised arterial pressure  Increased sharpness to sight, hearing, and smell, and general irritation .
  8. 8. Pharmaceutical Applications  Appetite stimulant and general tonic in small doses  Specific medicine nux vomica and tinctura nucis vomicae  Pesticide/ vermin killer  Used in synthetic chemistry as optically- active bases to achieve optical resolution of racemic acids (along with brucine)
  9. 9. Side Effects  Extremely poisonous (100 mg is fatal )  Suffocation  Tremors  Convulsions  Eariness  Death usually taking place after three or four convulsions .  Death may occur during the interval from exhaustion, or paralytic asphyxia, or during the grip upon the respiratory muscles and the heart from cramp asphyxia .
  10. 10. Side Effects
  11. 11. Strychnine Poisoning  The first effect of Strychnine poisoning is stiffness of the face and neck muscle. In the convulsion, the body is arched in hyperextension so that the crown of the head and the heel can touch the ground.  Respiration ceases. Normally, death occurs after 2nd to 5th full convulsion.
  12. 12. Treatment Of Poisoning The main targets of the treatment of strychnine poisoning are-  Prevention of convulsion and Support of respiration.  Diazepam may be used as it is the most useful agent for this purpose because it antagonizes convulsion without causing respiratory depression.  Adequate respiratory ventilation is necessary for support of respiration

×