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Midline 
Swellings of the 
Neck
Aetiology 
• Congenital 
• Infectious 
• Inflammatory 
• Neoplastic
• Inflammatory 
o Reactive 
lymphadenopathy 
o Thyroiditis 
• Neoplastic 
o Thyroid 
o Parathyroid 
o Pharyngeal/larynge 
al 
• Congenital 
o Thyroglossal duct 
cyst 
o Laryngocoele 
o Dermoid cyst 
• Infectious 
o Ludwig’s Angina
Thyroglossal Duct Cyst 
• Moves on protrusion of 
tongue 
• Increases in size during 
URTI 
• Treatment – Sistrunk’s 
operation 
• Fibrous cyst due to 
persistence of 
thyroglossal duct 
• Cystic midline swelling 
• Rounded – 2-3 cm 
diameter
Laryngocele 
• Dilatation of laryngeal 
saccule 
• Extends between 
thyroid cartilage and 
ventricle 
• Treatment - excision
Ludwig’s Angina 
• Infection of 
submandibular 
space 
• Aetiology 
o Dental infections 
o Submandibular 
sialadenitis 
o Injuries of oral mucosa 
o Fractures of mandible
Clinical Features 
Odynophagia with Trismus 
Localised infection Spread of infection 
Localised to sublingual 
space 
Structures in floor of 
mouth are swollen 
Tongue pushed up and 
back 
Submental & submaxillary 
regions become swollen, tender. 
Cellulitis, laryngeal oedema 
Tongue pushed up and back
Treatment Complications 
• Systemic antibiotics 
• Incision & drainage 
o Intraoral 
o External 
• Tracheostomy 
• Spread of infection 
• Airway obstruction 
• Septicaemia 
• Aspiration 
pneumonia
Sublingual Dermoid Cyst 
• Almost always benign. 
• Management: 
Complete surgical 
removal without 
spillage of contents. 
• Midline swelling 
• Does not move on 
protrusion of tongue 
• Contains 
developmentally 
mature and well-differentiated 
tissue.
Reactive 
Lymphadenopathy 
• History of local infection 
or generalised viral 
illness. 
• Should resolve 
spontaneously. 
• No specific treatment 
required. 
• By far the most 
common cause of 
neck swellings. 
• Affects all age groups. 
• Tender to touch.
Thyroid Swelling 
• Most likely due to 
hyperthyroidism or 
hypothyroidism. 
• Thyroid disease F > M. 
• Typically young female 
patients.
• Moves upwards on 
swallowing. 
• Accompanied by 
thyroid symptoms. 
• FNA may be useful to 
rule-out more sinister 
pathology. 
• Manage underlying 
thyroid disorder.
Laryngeal Malignancy 
Growth of anterior commissure 
and subglottic region 
Spreads through cricothyroid 
membrane 
Produces midline swelling
• May invade thyroid 
cartilage 
o Perichondritis 
o Tender on palpation 
• Thyroid gland and 
strap muscles may 
also be invaded
Treatment 
• Radiotherapy 
• Surgery 
o Conservation 
laryngeal surgery 
o Total laryngectomy 
• Combined therapy 
• Endoscopic CO2 
laser excision 
• Organ 
preservation 
• Depends on 
o Site of lesion 
o Extent of lesion 
o Metastasis 
• Nodal 
• Distant
Thank you

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Midline swellings of the neck

  • 2. Aetiology • Congenital • Infectious • Inflammatory • Neoplastic
  • 3. • Inflammatory o Reactive lymphadenopathy o Thyroiditis • Neoplastic o Thyroid o Parathyroid o Pharyngeal/larynge al • Congenital o Thyroglossal duct cyst o Laryngocoele o Dermoid cyst • Infectious o Ludwig’s Angina
  • 4. Thyroglossal Duct Cyst • Moves on protrusion of tongue • Increases in size during URTI • Treatment – Sistrunk’s operation • Fibrous cyst due to persistence of thyroglossal duct • Cystic midline swelling • Rounded – 2-3 cm diameter
  • 5.
  • 6. Laryngocele • Dilatation of laryngeal saccule • Extends between thyroid cartilage and ventricle • Treatment - excision
  • 7. Ludwig’s Angina • Infection of submandibular space • Aetiology o Dental infections o Submandibular sialadenitis o Injuries of oral mucosa o Fractures of mandible
  • 8. Clinical Features Odynophagia with Trismus Localised infection Spread of infection Localised to sublingual space Structures in floor of mouth are swollen Tongue pushed up and back Submental & submaxillary regions become swollen, tender. Cellulitis, laryngeal oedema Tongue pushed up and back
  • 9. Treatment Complications • Systemic antibiotics • Incision & drainage o Intraoral o External • Tracheostomy • Spread of infection • Airway obstruction • Septicaemia • Aspiration pneumonia
  • 10. Sublingual Dermoid Cyst • Almost always benign. • Management: Complete surgical removal without spillage of contents. • Midline swelling • Does not move on protrusion of tongue • Contains developmentally mature and well-differentiated tissue.
  • 11. Reactive Lymphadenopathy • History of local infection or generalised viral illness. • Should resolve spontaneously. • No specific treatment required. • By far the most common cause of neck swellings. • Affects all age groups. • Tender to touch.
  • 12.
  • 13. Thyroid Swelling • Most likely due to hyperthyroidism or hypothyroidism. • Thyroid disease F > M. • Typically young female patients.
  • 14. • Moves upwards on swallowing. • Accompanied by thyroid symptoms. • FNA may be useful to rule-out more sinister pathology. • Manage underlying thyroid disorder.
  • 15. Laryngeal Malignancy Growth of anterior commissure and subglottic region Spreads through cricothyroid membrane Produces midline swelling
  • 16. • May invade thyroid cartilage o Perichondritis o Tender on palpation • Thyroid gland and strap muscles may also be invaded
  • 17. Treatment • Radiotherapy • Surgery o Conservation laryngeal surgery o Total laryngectomy • Combined therapy • Endoscopic CO2 laser excision • Organ preservation • Depends on o Site of lesion o Extent of lesion o Metastasis • Nodal • Distant